Noah Wolcott Palm, PhD
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Immunobiology
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Biography
Noah W. Palm is a Professor of Immunobiology at the Yale University School of Medicine. His laboratory focuses on illuminating the myriad interactions between the immune system and the gut microbiota in health and disease. Dr. Palm performed his doctoral work with Ruslan Medzhitov and his postdoctoral work with Richard Flavell, both at Yale University.
Last Updated on July 03, 2024.
Appointments
Immunobiology
ProfessorPrimary
Other Departments & Organizations
- Cancer Immunology
- Colton Center for Autoimmunity
- Human and Translational Immunology Program
- Immunobiology
- Immunology
- Liver Center
- Microbiology
- Program for Neuroinflammation
- Yale Cancer Center
- Yale Center for Systems and Engineering Immunology (CSEI)
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Fibrosis Program
Education & Training
- Postdoctoral Fellowship
- Yale University School of Medicine (2015)
- PhD
- Yale University, Immunobiology (2011)
- BA
- Macalester College, Biology (2004)
Research
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Overview
Medical Research Interests
Adaptive Immunity; Allergy and Immunology; Brain-Gut Axis; Gastrointestinal Tract; Homeostasis; Inflammation; Microbiota; Neuroimmunomodulation
ORCID
0000-0001-7262-9455- View Lab Website
Palm Lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Noah Wolcott Palm's published research.
Publications Timeline
A big-picture view of Noah Wolcott Palm's research output by year.
Research Interests
Research topics Noah Wolcott Palm is interested in exploring.
Deguang Song
Jason Crawford, PhD
Anjelica Martin Rajaniemi, BS, RLATG
Mytien Nguyen
Yi Yang
Aaron Ring
Former YSM
28Publications
3,063Citations
Microbiota
Inflammation
Publications
Featured Publications
Highly multiplexed bioactivity screening reveals human and microbiota metabolome-GPCRome interactions
Chen H, Rosen C, González-Hernández J, Song D, Potempa J, Ring A, Palm N. Highly multiplexed bioactivity screening reveals human and microbiota metabolome-GPCRome interactions. Cell 2023, 186: 3095-3110.e19. PMID: 37321219, PMCID: PMC10330796, DOI: 10.1016/j.cell.2023.05.024.Peer-Reviewed Original ResearchCitationsAltmetricCommensal microbiota from patients with inflammatory bowel disease produce genotoxic metabolites
Cao Y, Oh J, Xue M, Huh WJ, Wang J, Gonzalez-Hernandez JA, Rice TA, Martin AL, Song D, Crawford JM, Herzon SB, Palm NW. Commensal microbiota from patients with inflammatory bowel disease produce genotoxic metabolites. Science 2022, 378: eabm3233-eabm3233. PMID: 36302024, PMCID: PMC9993714, DOI: 10.1126/science.abm3233.Peer-Reviewed Original ResearchCitationsAltmetricWithin-host evolution of a gut pathobiont facilitates liver translocation
Yang Y, Nguyen M, Khetrapal V, Sonnert ND, Martin AL, Chen H, Kriegel MA, Palm NW. Within-host evolution of a gut pathobiont facilitates liver translocation. Nature 2022, 607: 563-570. PMID: 35831502, PMCID: PMC9308686, DOI: 10.1038/s41586-022-04949-x.Peer-Reviewed Original ResearchCitationsAltmetricInterspecies commensal interactions have nonlinear impacts on host immunity
Rice TA, Bielecka AA, Nguyen MT, Rosen CE, Song D, Sonnert ND, Yang Y, Cao Y, Khetrapal V, Catanzaro JR, Martin AL, Rashed SA, Leopold SR, Hao L, Yu X, van Dijk D, Ring AM, Flavell RA, de Zoete MR, Palm NW. Interspecies commensal interactions have nonlinear impacts on host immunity. Cell Host & Microbe 2022, 30: 988-1002.e6. PMID: 35640610, PMCID: PMC9283318, DOI: 10.1016/j.chom.2022.05.004.Peer-Reviewed Original ResearchCitationsAltmetricAutoreactivity in naïve human fetal B cells is associated with commensal bacteria recognition
Chen JW, Rice TA, Bannock JM, Bielecka AA, Strauss JD, Catanzaro JR, Wang H, Menard LC, Anolik JH, Palm NW, Meffre E. Autoreactivity in naïve human fetal B cells is associated with commensal bacteria recognition. Science 2020, 369: 320-325. PMID: 32675374, DOI: 10.1126/science.aay9733.Peer-Reviewed Original ResearchCitationsAltmetricA Forward Chemical Genetic Screen Reveals Gut Microbiota Metabolites That Modulate Host Physiology
Chen H, Nwe PK, Yang Y, Rosen CE, Bielecka AA, Kuchroo M, Cline GW, Kruse AC, Ring AM, Crawford JM, Palm NW. A Forward Chemical Genetic Screen Reveals Gut Microbiota Metabolites That Modulate Host Physiology. Cell 2019, 177: 1217-1231.e18. PMID: 31006530, PMCID: PMC6536006, DOI: 10.1016/j.cell.2019.03.036.Peer-Reviewed Original ResearchCitationsAltmetricImmunoglobulin A Coating Identifies Colitogenic Bacteria in Inflammatory Bowel Disease
Palm NW, de Zoete MR, Cullen TW, Barry NA, Stefanowski J, Hao L, Degnan PH, Hu J, Peter I, Zhang W, Ruggiero E, Cho JH, Goodman AL, Flavell RA. Immunoglobulin A Coating Identifies Colitogenic Bacteria in Inflammatory Bowel Disease. Cell 2014, 158: 1000-1010. PMID: 25171403, PMCID: PMC4174347, DOI: 10.1016/j.cell.2014.08.006.Peer-Reviewed Original ResearchCitationsAltmetric
2026
Commensal-derived acetylcholine enhances mucosal immune education
Song D, Duncan-Lowey B, Khetrapal V, Hamchand R, Deng T, Brown H, Wu A, Martin A, Bauer K, Zhao Y, Nguyen M, Sonnert N, Leopold S, Wu Q, Crawford J, Palm N. Commensal-derived acetylcholine enhances mucosal immune education. Nature 2026, 655: 1027-1036. PMID: 42236946, PMCID: PMC13391359, DOI: 10.1038/s41586-026-10592-7.Peer-Reviewed Original ResearchCitationsAltmetric
2025
A host-centric view of the microbiota metabolome
Yamada T, Palm N. A host-centric view of the microbiota metabolome. Immunity 2025, 58: 2940-2956. PMID: 41338199, DOI: 10.1016/j.immuni.2025.11.006.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricDiscovery of a Widespread Polyamine–Low-Molecular-Weight Thiol Hybrid Pathway in Clostridioides difficile
Hunt R, Oh J, Jain A, Kuo T, Berardi D, Jian W, Song D, Wu Q, Goodman A, Palm N, Zimmermann M, Johnson C, Crawford J. Discovery of a Widespread Polyamine–Low-Molecular-Weight Thiol Hybrid Pathway in Clostridioides difficile. ACS Infectious Diseases 2025, 11: 2246-2264. PMID: 40671632, PMCID: PMC12403189, DOI: 10.1021/acsinfecdis.5c00286.Peer-Reviewed Original ResearchCitationsAltmetric
Academic Achievements & Community Involvement
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Honors
honor Pew Scholar in the Biomedical Sciences
01/01/2019National AwardPew Charitable TrustsDetailsUnited Stateshonor Director's New Innovator Award (DP2)
01/01/2019National AwardNational Institutes of HealthDetailsUnited Stateshonor Smith Award for Excellence in Biomedical Research
01/01/2016Regional AwardRichard and Susan Smith Family FoundationDetailsUnited States
News & Links
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News
- July 29, 2026
The Hypothesis Fund to Support Palm’s Antibody Studies
- November 12, 2025
Twenty-Seven YSM Faculty Members Recognized for Highly Cited Research
- August 04, 2025
Non-Antibiotic Drugs Also Disrupt the Microbiome
- February 07, 2025Source: Yale News
Study Reveals How Gut Bacteria Might Trigger Autoimmune Diseases Like Lupus
Get In Touch
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Email
Academic Office Number
Mailing Address
Immunobiology
P.O. Box 208089
New Haven, CT 06520-8089
United States
Administrative Support
Locations
The Anlyan Center
Academic Office
300 Cedar Street, Ste 569, Rm C
New Haven, CT 06519
The Anlyan Center
Lab
300 Cedar Street, Ste 560
New Haven, CT 06519