Cyprien Rivier, MD, MSc
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About
Research
Publications
2025
The Abbreviated Brain Care Score and Association With Incident Dementia, Stroke, and Late-Life Depression
Lazar R, Senff J, Bowen P, Jones C, Sheth K, Rivier C, Tack R, Reinders E, Sherman K, Anderson C, Rosand J, Singh S. The Abbreviated Brain Care Score and Association With Incident Dementia, Stroke, and Late-Life Depression. Neurology Open Access 2025, 1 DOI: 10.1212/wn9.0000000000000041.Peer-Reviewed Original ResearchU.S. public perceptions on whether risk of dementia and stroke can be modified through maintaining or changing lifestyle
Senff J, Shah-Ostrowski M, Tack R, Nunley C, Palys C, Ng S, Mallick A, Gutierrez-Martinez L, Duskin J, Kimball T, Prapiadou S, Marini S, Reinders E, Sherman K, Tinoble A, Brouwers H, Akhavan S, Towfighi A, Rivier C, Falcone G, Sheth K, Lazar R, Ibrahim S, Pikula A, Chemali Z, van Duijn C, Fricchione G, Tanzi R, Yechoor N, Anderson C, Greenaway V, Pouwels K, Rosand J, Singh S. U.S. public perceptions on whether risk of dementia and stroke can be modified through maintaining or changing lifestyle. BMC Public Health 2025, 25: 4191. PMID: 41316093, PMCID: PMC12664128, DOI: 10.1186/s12889-025-25077-x.Peer-Reviewed Original ResearchConceptsRisk of dementiaStroke riskChanging lifestylesLifestyle changesU.S. populationModifiable risk factorsEffective prevention strategiesDementia riskLevel of educationMultivariate logistic regression analysisCross-sectional cohortLogistic regression analysisHealthy lifestyleStroke casesEmployment statusMethodsA surveyBinary exposurePrevention strategiesDementiaLifestylePrimary outcomeBackgroundEpidemiological studiesRisk factorsParticipantsStrokeAdditive Effects of White Matter Hyperintensity and APOE ε4 Status on Risk of Incident Dementia in Two Large Longitudinal Cohorts
de Havenon A, Littig L, Clocchiatti‐Tuozzo S, Johnson I, Constantinescu S, Rivier C, Huo S, Kimberly W, Gomez‐Isla T, Kim Y, Stulberg E, Smith E, Rosand J, Falcone G, Sheth K, Brickman A. Additive Effects of White Matter Hyperintensity and APOE ε4 Status on Risk of Incident Dementia in Two Large Longitudinal Cohorts. Annals Of Neurology 2025 PMID: 41267647, DOI: 10.1002/ana.78103.Peer-Reviewed Original ResearchIncident all-cause dementiaDementia incidence ratesAll-cause dementiaApolipoprotein E e4 statusE4 statusHazard ratioRisk of incident all-cause dementiaRisk of incident dementiaWhite matter hyperintensitiesIncidence rateVascular risk managementDelay dementia onsetAdjusted hazard ratiosProspective cohort studyEffects of white matter hyperintensityApolipoprotein EAt-risk individualsCox proportional hazards modelsIncident dementiaDementia riskDementia onsetProportional hazards modelWhite matter hyperintensities burdensAtherosclerosis RiskARICSLAMF1 as a Risk Biomarker for Nontraumatic SAH: Evidence From a Multiomics Study.
Renedo D, Koo A, Sujijantarat N, Clocchiatti-Tuozzo S, Huo S, Acosta J, Hebert R, Gunel M, Sansing L, Sheth K, Falcone G, Matouk C, Rivier C. SLAMF1 as a Risk Biomarker for Nontraumatic SAH: Evidence From a Multiomics Study. Stroke 2025 PMID: 41221640, DOI: 10.1161/strokeaha.125.052604.Peer-Reviewed Original ResearchMendelian randomizationSubarachnoid hemorrhage riskIncident SAH casesNontraumatic subarachnoid hemorrhageSubarachnoid hemorrhageUK BiobankSmoking statusClinical priorityPrevention strategiesCellular expression profilesCox proportional hazards analysisProportional hazards analysisRisk predictionCis-protein quantitative trait lociCD4 naive cellsSAH casesRisk biomarkersSubarachnoid hemorrhage pathophysiologyAdaptive immune responsesHuman hematopoietic progenitorsFollow-upQuantitative trait lociSingle-cell transcriptome analysisRiskCerebrovascular eventsDifferential results of genetic risk scoring for multiple sclerosis in European and African American populations
Rivier C, Xu L, Clocchiatti-Tuozzo S, Zhao H, Ohno-Machado L, Hafler D, Falcone G, Longbrake E. Differential results of genetic risk scoring for multiple sclerosis in European and African American populations. Multiple Sclerosis Journal 2025, 31: 1304-1313. PMID: 40991630, PMCID: PMC12633797, DOI: 10.1177/13524585251377607.Peer-Reviewed Original ResearchConceptsGenetic risk scoreInternational ClassificationSystematized Nomenclature of MedicineAfrican ancestryRisk scoreCross-sectional studyHigh-risk individualsMultiple sclerosisSystematized NomenclatureAfrican American populationAfrican ancestry groupMS prevalenceAncestry groupsMS riskNomenclature of MedicineAmerican populationParticipantsAfrican participantsAncestryEuropean populationsClinical trialsDifferentiation resultsScoresIndividualsPopulationCharacterizing Stroke Clots Using Single‐Cell Sequencing
Renedo D, Barak T, DeLong J, Acosta J, Sujijantarat N, Koo A, Rivier C, Clocchiatti-Tuozzo S, Huo S, Antonios J, Giles J, Falcone G, Sheth K, Hebert R, Gunel M, Sansing L, Navaratnam D, Matouk C. Characterizing Stroke Clots Using Single‐Cell Sequencing. Journal Of The American Heart Association 2025, 14: ejaha/2025/041738-t. PMID: 40878981, PMCID: PMC12553457, DOI: 10.1161/jaha.125.041738.Peer-Reviewed Original ResearchConceptsMulti-marker analysisGene expressionMulti-marker Analysis of GenoMic AnnotationCell type-specific gene expressionT cellsGenome-wide association studiesGene expression of cellsSingle-cell RNA sequencingPotential biomarkersTIMP1Genes associated with atherosclerosisHLA-DRB1*01Single-cell sequencingExpression of genesUpregulated expression of genesGene expression profilesCarotid atherosclerosisGenome annotationCD8 T cellsUpregulated expressionImmune cell compositionAssociation studiesNatural killer cellsImmune cell populationsLarge vessel occlusion strokePolygenic Resistance to Blood Pressure Treatment and Stroke Risk: Insights from the All of Us Research Program
Huo S, Rivier C, Clocchiatti‐Tuozzo S, Renedo D, Petersen N, de Havenon A, Meeker D, Zhao H, Ohno‐Machado L, Sheth K, Falcone G. Polygenic Resistance to Blood Pressure Treatment and Stroke Risk: Insights from the All of Us Research Program. Annals Of Neurology 2025 PMID: 40827941, DOI: 10.1002/ana.78009.Peer-Reviewed Original ResearchUs Research ProgramUncontrolled hypertensionSystolic BPGenetic riskSusceptibility to hypertensionRates of uncontrolled hypertensionPolygenic risk scoresAssociated with higher systolic BPOdds of uncontrolled hypertensionCox proportional hazards regressionUnited Kingdom BiobankGenetic association studiesHigh-risk individualsHigher systolic BPProportional hazards regressionBlood pressure treatmentIncident strokeStroke hazardBlood pressureHigher RatesSystolic blood pressureHypertensive adultsDiagnosed hypertensionBP medicationsHazards regressionAssociation of Polygenic Susceptibility to Hyperlipidemia With Cholesterol Control and Recurrent Stroke in Ischemic Stroke Survivors
Wu K, Huo S, Rivier C, Torres-Lopez V, Sharma R, de Havenon A, Worrall B, Sheth K, Falcone G. Association of Polygenic Susceptibility to Hyperlipidemia With Cholesterol Control and Recurrent Stroke in Ischemic Stroke Survivors. Neurology 2025, 105: e213966. PMID: 40825160, DOI: 10.1212/wnl.0000000000213966.Peer-Reviewed Original ResearchConceptsIschemic stroke survivorsStroke survivorsAssociated with riskSusceptible to hyperlipidemiaHigh riskUK BiobankResistant hyperlipidemiaCholesterol controlUncontrolled hyperlipidemiaSurvivors of ischemic strokeHigher risk of recurrent vascular eventsPolygenic risk scoresRisk factor controlRisk of recurrent vascular eventsAdverse genetic profileLow-density lipoprotein cholesterolRisk of acute coronary eventsGenetic association studiesRecurrent strokeClinical trajectoryGenetic risk variantsRisk of recurrent strokeAcute ischemic stroke survivorsPolygenic profilePrecision medicine toolsGlobal gender representation in neurointerventional surgery: a natural language processing analysis of journal publications
Renedo D, Koo A, Amllay A, Sujijantarat N, Fathima B, Haynes J, Falcone G, Sheth K, Fadel S, Johnson M, Hebert R, Rivier C, Matouk C. Global gender representation in neurointerventional surgery: a natural language processing analysis of journal publications. Journal Of NeuroInterventional Surgery 2025, jnis-2025-023956. PMID: 40813072, DOI: 10.1136/jnis-2025-023956.Peer-Reviewed Original ResearchNatural language processingNatural language processing methodsExtract metadataNatural language processing analysisLanguage processingArtificial intelligenceFemale last authorshipAcademic publishingAuthorship ratesFemale first authorshipAuthor affiliationJournal publicationsInstitutional affiliationFirst authorshipRepresentationSurgery journalsAPIAuthorshipProcess analysisMetadataFemale authorshipJournalsIntelligenceE-090 Acute ischemic stroke risk following cardiac interventions in the United States from 2016 to 2021
Koo A, Zhou L, Hameed I, Rivier C, Clocchiatti-Tuozzo S, Kamel H, Falcone G, Ney J, Sharma R, Matouk C, Yaghi S, Sheth K, de Havenon A. E-090 Acute ischemic stroke risk following cardiac interventions in the United States from 2016 to 2021. 2025, a153-a155. DOI: 10.1136/jnis-2025-snis.206.Peer-Reviewed Original Research
News
News
- June 24, 2025
Announcing the Center for Brain & Mind Health 2025 Pilot Grant Program Awardees
- November 20, 2024
Brain Bleeds: How Biological Sex Affects Severity and Outcomes
- July 15, 2024
Rivier Receives Ralph L. Sacco Scholarship for Brain Health
- July 05, 2023
Cyprien Rivier, MD, MSc Wins ESOC Young Research Investigator Award in Stroke
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