2023
Peripheral signature of altered synaptic integrity in young onset cannabis use disorder: A proteomic study of circulating extracellular vesicles
Ganesh S, Lam T, Garcia-Milian R, D'Souza D, Nairn A, Elgert K, Eitan E, Ranganathan M. Peripheral signature of altered synaptic integrity in young onset cannabis use disorder: A proteomic study of circulating extracellular vesicles. The World Journal Of Biological Psychiatry 2023, 24: 603-613. PMID: 36994633, PMCID: PMC10471733, DOI: 10.1080/15622975.2023.2197039.Peer-Reviewed Original ResearchMeSH KeywordsExtracellular VesiclesHumansMarijuana AbusePilot ProjectsProteomicsSubstance-Related DisordersYoung AdultConceptsNeuron-derived extracellular vesiclesLabel-free quantification mass spectrometryProteomic studiesCannabis use disorderExtracellular vesiclesMass spectrometry proteomic analysisDifferential proteomic profilesAdapter proteinProteomic analysisPost-synaptic densityPeripheral signatureMolecular basisProteomic profilesProteinMarkers of neuropathologyBrain tissue samplesSynaptic pathologyVesiclesSynaptic integrityImmunoaffinity methodUse disordersFunctional integrityImportant insightsNeuropathologyPilot study
2020
Association of SLC1A1 Gene Polymorphism With Obsessive Compulsive Disorder in a Sample From Southern India
Shukla T, Nadella R, J. R, Ganesh S, Nestadt G, Purushottam M, Jain S, Reddy Y, Viswanath B. Association of SLC1A1 Gene Polymorphism With Obsessive Compulsive Disorder in a Sample From Southern India. Experimental And Clinical Psychopharmacology 2020, 28: 617-621. PMID: 31985241, DOI: 10.1037/pha0000348.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderTreatment responseAge of onsetSRI treatment responseSignificant associationClinical parametersMini International Neuropsychiatric InterviewGenotype/allele frequenciesSymptom dimensionsSpecialty OCD clinicAdequate trialFull respondersNeuropsychiatric InterviewHealthy controlsBrain volumeGene polymorphismsOCD clinicDisease severityCase-control association analysisSymptom severityOCD patientsOCD casesGenotype frequenciesCompulsive disorderAssociation
2019
Pellagra and Alcohol Dependence Syndrome: Findings From a Tertiary Care Addiction Treatment Centre in India
Narasimha V, Ganesh S, Reddy S, Shukla L, Mukherjee D, Kandasamy A, Chand P, Benegal V, Murthy P. Pellagra and Alcohol Dependence Syndrome: Findings From a Tertiary Care Addiction Treatment Centre in India. Alcohol And Alcoholism 2019, 54: 148-151. PMID: 30721993, DOI: 10.1093/alcalc/agz004.Peer-Reviewed Original ResearchConceptsAlcohol dependence syndromeAddiction treatment centersInpatient careHigh doseTreatment centersDependence syndromeLife-threatening comorbiditiesAcute medical conditionsDeficiency of niacinMulti-systemic diseaseMinority of casesTwo-thirdsPeripheral neuropathyClinical presentationParenteral vitaminDelirium tremensMultivitamin supplementsClassical triadComplete resolutionAssociated conditionMedical conditionsPrompt identificationHigh indexAlcohol dependenceComplete recovery
2017
BDNF gene and obsessive compulsive disorder risk, symptom dimensions and treatment response
J R, Ganesh S, Shukla T, Deolankar S, Nadella R, Sen S, Purushottam M, Reddy Y, Jain S, Viswanath B. BDNF gene and obsessive compulsive disorder risk, symptom dimensions and treatment response. Asian Journal Of Psychiatry 2017, 38: 65-69. PMID: 29079096, DOI: 10.1016/j.ajp.2017.10.014.Peer-Reviewed Original Research