Poliomyelitis in transgenic mice expressing CD155 under the control of the Tage4 promoter after oral and parenteral poliovirus inoculation
Khan S, Toyoda H, Linehan M, Iwasaki A, Nomoto A, Bernhardt G, Cello J, Wimmer E. Poliomyelitis in transgenic mice expressing CD155 under the control of the Tage4 promoter after oral and parenteral poliovirus inoculation. Journal Of General Virology 2014, 95: 1668-1676. PMID: 24784416, PMCID: PMC4103066, DOI: 10.1099/vir.0.064535-0.Peer-Reviewed Original ResearchConceptsTg mouse modelPeyer's patchesOral routeGastrointestinal tractMouse modelTransgenic miceImmunocompetent transgenic mouseHuman PV receptorCD155 tg miceSurface of enterocytesTgPVR21 miceCD155 expressionParenteral inoculationTg miceIntracerebral inoculationOral infectionYoung miceGut infectionLymphatic tissueGerminal centersPV infectionPV replicationPV receptorSmall intestineHuman CD155