Clare Flannery, MD
Associate Professor of Obstetrics, Gynecology and Reproductive SciencesCards
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Obstetrics, Gynecology & Reproductive Sciences
PO Box 208020
New Haven, CT 06520-8020
United States
About
Titles
Associate Professor of Obstetrics, Gynecology and Reproductive Sciences
Biography
Dr. Flannery is an endocrinologist and Associate Professor with dual appointments in the Department of Obstetrics, Gynecology, and Reproductive Sciences (Reproductive Endocrinology) and the Department of Internal Medicine (Endocrinology). She received her undergraduate degree in Chemistry from Wellesley College in 1995 before obtaining her M.D. degree from Trinity College, Dublin in Ireland in 2001. She completed internship in medicine and surgery at St. James’s Hospital in Dublin Ireland, and then Internal Medicine residency in the Women’s Health Track at Jacobi Hospital, Albert Einstein College of Medicine in NY, where she also served as Chief Resident in Internal Medicine in 2005. She then went on to the Yale School of Medicine for her fellowship in Endocrinology & Metabolism. She pursued research fellowship at Yale, in the respective labs of Dr. Hugh Taylor, and of Dr. Gerald Shulman and Dr. Kitt Petersen, to combine interests in endometrial physiology and the pathophysiology of Type-2 diabetes mellitus. She was awarded an NIH K08 mentored career award then NIH R01 funding. Her translational research lab studies mechanisms for endometrial cancer development, and the effect of weight and diabetes on women's reproductive health. She sees patients with diabetes and endocrine disorders, with a specialty interest in diabetes prevention, weight management, Polycystic Ovary Syndrome, perimenopause, and gender-affirming hormone therapy.
Appointments
Obstetrics, Gynecology & Reproductive Sciences
Associate Professor on TermPrimaryEndocrinology
Associate Professor on TermSecondary
Other Departments & Organizations
- Cancer Signaling Networks
- Diabetes Center
- Diabetes Research Center
- Endocrinology
- Flannery Lab
- Internal Medicine
- MR Center
- Obstetrics, Gynecology & Reproductive Sciences
- Reproductive Endocrinology & Infertility
- Reproductive Sciences
- WHRY Pilot Project Program Investigators
- Women's Health Research at Yale
- Yale Cancer Center
- Yale Medicine
- Yale Ventures
Education & Training
- Research Fellowship
- Yale School of Medicine (2011)
- Fellowship
- Yale School of Medicine (2009)
- Chief Residency
- Jacobi Medical Center/Albert Einstein College (2006)
- Residency
- Jacobi Medical Center/Albert Einstein College (2005)
- Internship
- St. James Hospital Dublin, Ireland (2002)
- MD
- Trinity College (2001)
- BA
- Wellesley College (1995)
Research
Overview
Medical Research Interests
ORCID
0000-0002-0219-0907
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Shannon Whirledge, PhD, MSc
Yingqun Huang, MD, PhD
Katherine Cooke
Mario Kahn
Sylvie Dufour
Emre Seli, MD
Placenta
Endometrial Neoplasms
Diabetes Mellitus, Type 2
Endometrial Hyperplasia
Obesity
Publications
2023
Estradiol cycling drives female obesogenic adipocyte hyperplasia
del M. Saavedra-Peña R, Taylor N, Flannery C, Rodeheffer M. Estradiol cycling drives female obesogenic adipocyte hyperplasia. Cell Reports 2023, 42: 112390. PMID: 37053070, PMCID: PMC10567995, DOI: 10.1016/j.celrep.2023.112390.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsAdipocyte precursor cellsHigh-fat dietAdipocyte hyperplasiaHFD feedingVisceral WATDifferential fat distributionAdipose tissue distributionEstrogen receptor αWAT distributionFat distributionOvariectomized femalesHyperplasiaMice showEstrous cycleReceptor αTissue distributionPrecursor cellsObesityAPC proliferationTissue microenvironmentProliferationFemalesSexOnsetFeeding
2022
Hyperinsulinemia induces early and dyssynchronous puberty in lean female mice.
Saleh FL, Joshi AA, Tal A, Xu P, Hens J, Wong SL, Flannery C. Hyperinsulinemia induces early and dyssynchronous puberty in lean female mice. Journal Of Endocrinology 2022, 254: 121-135. PMID: 35904489, PMCID: PMC9837806, DOI: 10.1530/joe-21-0447.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsVaginal openingInsulin resistanceDay of VOIGF-1 levelsInsulin-like growth factor 1 receptorGreater insulin resistanceHigher insulin levelsEffect of hyperinsulinemiaGrowth factor 1 receptorGonadotropin-releasing hormoneLower body weightFactor 1 receptorReceptor isoform expressionMammary gland developmentLH levelsInsulin levelsInsulin receptor isoform expressionKisspeptin expressionChildhood obesityFemale miceHormone levelsEarly initiationHyperinsulinemiaBody weightOvarian follicles
2021
LOCAL ACTIVATION OF GLUCOCORTICOID SIGNALING IN UTERINE FIBROID CELLS DRIVES GROWTH
Glenn T, Silva E, Suarez P, Flannery C, Whirledge S. LOCAL ACTIVATION OF GLUCOCORTICOID SIGNALING IN UTERINE FIBROID CELLS DRIVES GROWTH. Fertility And Sterility 2021, 116: e419-e420. DOI: 10.1016/j.fertnstert.2021.07.1121.Peer-Reviewed Original ResearchIdentification of Cellular Damage in Uteri From Hyperinsulinemic Mice Treated With Unopposed Estradiol
Kelly K, Huang J, Joshi A, Tal A, Wong S, Flannery C. Identification of Cellular Damage in Uteri From Hyperinsulinemic Mice Treated With Unopposed Estradiol. Journal Of The Endocrine Society 2021, 5: a750-a751. DOI: 10.1210/jendso/bvab048.1526.Peer-Reviewed Original ResearchConceptsUnopposed estradiolWT miceMKR miceEndometrial adenocarcinomaNuclear atypiaExact testPlacebo-treated miceSetting of hyperinsulinemiaInsulin tolerance testingNormal-weight womenSetting of obesityEffects of estradiolCohort of miceFischer's exact testLower body weightOxidative stress-induced damagePercent body fatDNA damageBlinded histological analysisPartial hysterectomyWeight womenAnovulatory cyclesEndometrial glandsHyperinsulinemic miceCystic dilationObesity Induces Elevated Oxidative Stress in Uteri of Reproductive Age Mice
Huang J, Xiao E, Tal A, Kelly K, Kim J, Whirledge S, Flannery C. Obesity Induces Elevated Oxidative Stress in Uteri of Reproductive Age Mice. Journal Of The Endocrine Society 2021, 5: a752-a752. DOI: 10.1210/jendso/bvab048.1529.Peer-Reviewed Original ResearchConceptsWeeks of dietNC miceHF miceHigher body fatProtein carbonylsOxidative stressAge miceBody fatChronic diet-induced obesityDiet-induced obese miceObesity-related disruptionIndependent risk factorInsulin tolerance testingHigh-fat chowLong-term obesitySeverity of obesityC57BL/6 female miceDiet-induced obesityHigh fat consumptionUterine oxidative stressCYP enzymatic activitiesAge-dependent increaseElevated oxidative stressDNA damageCytochrome P450 expression
2019
SAT-LB041 Insulin and IGF-2 Equally Regulate Placental Triglyceride Content
Anam A, Cooke K, O'Bryan J, Flannery C. SAT-LB041 Insulin and IGF-2 Equally Regulate Placental Triglyceride Content. Journal Of The Endocrine Society 2019, 3: sat-lb041. PMCID: PMC6552031, DOI: 10.1210/js.2019-sat-lb041.Peer-Reviewed Original ResearchConceptsPlacental lipid metabolismLean womenIGF-2Triglyceride contentLipid metabolismIGF-1Maternal triglyceride levelsMean age 34.4Elective C-sectionTime of presentationInsulin receptor isoformsMultiple comparison testColorimetric spectrophotometerNeonatal complicationsPlacenta explantsMaternal obesityNeonatal adiposityPlacental lipid contentMaternal insulinObese womenPregnant womenTG levelsTriglyceride levelsEndocrine SocietyVillous explantsSUN-019 The Selective Progesterone Receptor Modulator Ulipristal Acetate Blocks Glucocorticoid Receptor Transactivation
Smalls B, Millard C, Kisanga E, Flannery C, Al-Hendy A, Whirledge S. SUN-019 The Selective Progesterone Receptor Modulator Ulipristal Acetate Blocks Glucocorticoid Receptor Transactivation. Journal Of The Endocrine Society 2019, 3: sun-019. PMCID: PMC6553416, DOI: 10.1210/js.2019-sun-019.Peer-Reviewed Original ResearchConceptsSelective progesterone receptor modulatorsAnti-glucocorticoid activityUlipristal acetateGlucocorticoid receptorEffect of UPAHuman uterine fibroid tissueLong-term therapeutic agentGR antagonist RU-486Progesterone receptor modulatorsAntagonist RU 486Post-marketing analysisGlucocorticoid-induced expressionLower glucocorticoid receptorUterine fibroid tissueEndogenous glucocorticoid receptorSynthetic glucocorticoid dexamethasoneCell linesUterine fibroid cellsHuman uterine fibroid cellsFemale reproductive systemUtLM cellsHepatic failureLiver injuryPR expressionTherapeutic options
2018
Postmenopausal Women with Endometrial Cancer Have Greater Metabolic Dysfunction and Higher BMI than Women with Benign Endometrium
COOKE K, DUN E, ANAM A, FLANNERY C. Postmenopausal Women with Endometrial Cancer Have Greater Metabolic Dysfunction and Higher BMI than Women with Benign Endometrium. Diabetes 2018, 67 DOI: 10.2337/db18-302-lb.Peer-Reviewed Original ResearchConceptsEndometrial adenocarcinomaType 2 diabetesBenign hyperplasiaPostmenopausal womenBMI distributionEC pathogenesisMore premenopausal womenRole of obesityIndependent risk factorWomen age 50T-testStudent's t-testBMI 25Premenopausal womenLow HDLObese womenEndometrial cancerHigh triglyceridesTotal cholesterolHigher BMIMetabolic abnormalitiesProspective studyBenign endometriumMedical recordsRisk factorsMitogenic Insulin Receptor A Increases in the Rodent Pituitary at the Onset of Puberty
SALEH F, TAYLOR H, FLANNERY C. Mitogenic Insulin Receptor A Increases in the Rodent Pituitary at the Onset of Puberty. Diabetes 2018, 67 DOI: 10.2337/db18-245-lb.Peer-Reviewed Original ResearchConceptsOnset of pubertyIGF-1RFVB/NJ miceIGF-1R levelsPhysiological insulin resistanceWeek old micePeri-pubertal girlsPituitary hormone productionT-testInitiation of pubertyStudent's t-testSteroid hormone synthesisActive folliculogenesisHPO axisOvarian axisInsulin resistanceRisk factorsReceptor expressionIGF-1Normal insulinOld miceVaginal openingPuberty developmentHormone productionSplice variant isoformsReducing severe hypoglycaemia in hospitalised patients with diabetes: Early outcomes of standardised reporting and management
Araque KA, Kadayakkara DK, Gigauri N, Sheehan D, Majumdar S, Buller G, Flannery CA. Reducing severe hypoglycaemia in hospitalised patients with diabetes: Early outcomes of standardised reporting and management. BMJ Open Quality 2018, 7: e000120. PMID: 29756070, PMCID: PMC5942454, DOI: 10.1136/bmjoq-2017-000120.Peer-Reviewed Original ResearchConceptsSystems-based interventionsGeneral medical wardsHypoglycaemic eventsMedian timeHospitalised adultsMedical wardsBasal-bolus insulin regimenRecurrent hypoglycaemic eventsSevere hypoglycaemic eventsFS testingHypoglycemia protocolInsulin regimenSevere hypoglycaemiaAdult patientsCumulative incidenceRecurrent hypoglycemiaSecondary outcomesAcute managementPrimary outcomeProlonged hospitalizationEndocrine consultationPhysician notificationEarly outcomesPoor outcomeMin postintervention
Clinical Trials
Current Trials
Endometrium and Metabolism
HIC ID2000020045RolePrincipal InvestigatorPrimary Completion Date11/30/2026Recruiting ParticipantsPrevalence of Carbohydrate Intolerance in Lean and Obese Children
HIC ID9909011190RoleSub InvestigatorPrimary Completion Date09/30/2025Recruiting ParticipantsGenderBothAge8 years - 18 years
Academic Achievements & Community Involvement
honor Women's Health at Yale
Yale School of Medicine AwardDetails07/01/2020United Stateshonor Harold Behrman Award for Mentorship
Yale School of Medicine AwardYale Obstetrics, Gynecology, & Reproductive SciencesDetails05/29/2020United Stateshonor R01
National AwardNIH-NICHDDetails02/01/2019United Stateshonor Albert McKern Scholar Award
Yale School of Medicine AwardDetails07/01/2017United Stateshonor Yale Discovery to Cure Grant
Yale School of Medicine AwardDetails04/04/2016United States
Clinical Care
Overview
Clare Flannery, MD, is an expert on type 2 diabetes and reproductive endocrinology. She has a special interest in working with women who have polycystic ovary syndrome (PCOS), a common endocrine system disorder. She also provides hormone therapy for menopause and gender transition.
“We now have so many great options for the prevention and treatment of diabetes,” Dr. Flannery says. “I wish to prevent complications and improve the reproductive health in women with diabetes, obesity, or PCOS.” She advises her patients to help them make informed decisions based on the most up-to-date knowledge in the field.
Dr. Flannery is an associate professor of Obstetrics, Gynecology and Reproductive sciences, and of Medicine (Endocrinology) at Yale School of Medicine. Her NIH-funded research focuses on understanding how diabetes and obesity affect the uterus, with a special interest in endometrial cancer.
Clinical Specialties
Fact Sheets
Reproductive Options for Transgender Individuals
Learn More on Yale MedicineAmenorrhea
Learn More on Yale MedicineHyperglycemia: Symptoms, Causes, and Treatments
Learn More on Yale MedicineOvulation Induction and Intrauterine Insemination
Learn More on Yale Medicine
Board Certifications
Endocrinology Diabetes & Metabolism
- Certification Organization
- AB of Internal Medicine
- Latest Certification Date
- 2022
- Original Certification Date
- 2008
Yale Medicine News
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Media
- Photo by Robert A. Lisak
- Photo by Robert A. Lisak
News
- November 07, 2024
Yale Ob/Gyn Faculty Present the Latest in Gynecologic Oncology at Memorial Conference
- July 17, 2023
Women’s Health 2023: What We Know and Why it Matters
- December 15, 2022
WHRY’S Undergraduate Fellows Focus on the Future
- October 05, 2020
WHRY Launches Studies on Endometrial Cancer, Addiction to Opioids, and Stroke
Get In Touch
Contacts
Obstetrics, Gynecology & Reproductive Sciences
PO Box 208020
New Haven, CT 06520-8020
United States
Locations
Yale Reproductive Endocrinology
Academic Office
Laboratory for Surgery, Obsterics & Gynecology
375 Congress Avenue, Ste Suite 304A
New Haven, CT 06519
Patient Care Locations
Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.