2010
Aplidin as a potential adjunct to radiation therapy: In vitro studies
Rockwell S, Liu Y. Aplidin as a potential adjunct to radiation therapy: In vitro studies. International Journal Of Radiation Biology 2010, 86: 63-70. PMID: 20070217, PMCID: PMC2837581, DOI: 10.3109/09553000903264531.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBystander EffectCell HypoxiaCell Line, TumorDepsipeptidesMiceNeoplasmsPeptides, CyclicRadiation ToleranceConceptsH drug treatmentDrug treatmentPhase II clinical trialEMT6 mouse mammary tumor cellsGy of radiationMouse mammary tumor cellsMammary tumor cellsBystander effectSupraadditive cytotoxicityTherapeutic regimensHematologic malignanciesClinical trialsRadiation therapyModerate hypoxiaActive metaboliteSevere hypoxiaTumor cellsUntreated cellsTreatmentCytotoxicityHypoxiaAplidinKV X-raysCellsMonolayer cultures
2009
Hypoxia and radiation therapy: past history, ongoing research, and future promise.
Rockwell S, Dobrucki IT, Kim EY, Marrison ST, Vu VT. Hypoxia and radiation therapy: past history, ongoing research, and future promise. 2009, 9: 442-58. PMID: 19519402, PMCID: PMC2752413, DOI: 10.2174/156652409788167087.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell HypoxiaClinical Trials as TopicHistory, 20th CenturyHumansNeoplasmsOxygenRadiotherapyResearch DesignConceptsClinical trialsSolid tumorsLarge bulky tumorsMicroscopic tumor involvementSmall primary tumorsSelection of patientsOutcome of treatmentNovel therapeutic approachesNew therapeutic targetsEffects of hypoxiaHypoxic tumor cellsTumor oxygen levelsSurgical marginsTumor involvementBulky tumorsTreatment regimensPrimary tumorVascular bedClinical studiesExtensive necrosisRadiation therapyTherapeutic approachesNew agentsTherapeutic targetTherapeutic resistance
1995
Cytotoxic potential of monoalkylation products between mitomycins and DNA: studies of decarbamoyl mitomycin C in wild-type and repair-deficient cell lines.
Rockwell S, Kim S. Cytotoxic potential of monoalkylation products between mitomycins and DNA: studies of decarbamoyl mitomycin C in wild-type and repair-deficient cell lines. Oncology Research Featuring Preclinical And Clinical Cancer Therapeutics 1995, 7: 39-47. PMID: 7549043.Peer-Reviewed Original Research
1991
Diarylsulfonylureas and Radiotherapy I. In Vitro Studies with N-(5-Indanylsulfonyl)-N′-(4-chlorophenyl)-urea (Sulofenur)
Rockwell S, Grindey G. Diarylsulfonylureas and Radiotherapy I. In Vitro Studies with N-(5-Indanylsulfonyl)-N′-(4-chlorophenyl)-urea (Sulofenur). Oncology Research Featuring Preclinical And Clinical Cancer Therapeutics 1991, 3: 103-108. PMID: 2025495, DOI: 10.3727/095535491820873434.Peer-Reviewed Original ResearchConceptsEMT6 mouse mammary tumor cellsMouse mammary tumor cellsMammary tumor cellsAcute hypoxiaSolid tumorsSulofenurTumor cellsCytotoxic effectsCulture mediumVitro studyPlateau-phase culturesDiarylsulfonylureasCytotoxicityDrugsFurther examinationProliferative stateMonolayer culturesQuiescent cellsTreatmentCritical determinantCellsRadiotherapy