Jay Humphrey, PhD
John C. Malone Professor of Biomedical EngineeringCards
About
Research
Publications
2025
Mechanisms of aortic dissection: From pathological changes to experimental and in silico models
Rolf-Pissarczyk M, Schussnig R, Fries T, Fleischmann D, Elefteriades J, Humphrey J, Holzapfel G. Mechanisms of aortic dissection: From pathological changes to experimental and in silico models. Progress In Materials Science 2025, 150: 101363. DOI: 10.1016/j.pmatsci.2024.101363.Peer-Reviewed Original Research
2024
Transcriptional regulation of postnatal aortic development
Weiss D, Yeung N, Ramachandra A, Humphrey J. Transcriptional regulation of postnatal aortic development. Cells And Development 2024, 180: 203971. PMID: 39426523, PMCID: PMC11634634, DOI: 10.1016/j.cdev.2024.203971.Peer-Reviewed Original ResearchMultiscale homogenized constrained mixture model of the bio-chemo-mechanics of soft tissue growth and remodeling
Paukner D, Humphrey J, Cyron C. Multiscale homogenized constrained mixture model of the bio-chemo-mechanics of soft tissue growth and remodeling. Biomechanics And Modeling In Mechanobiology 2024, 23: 2115-2136. PMID: 39419845, PMCID: PMC11554721, DOI: 10.1007/s10237-024-01884-w.Peer-Reviewed Original ResearchConstrained mixture modelsNonlinear continuum mechanicsSoft biological tissuesChemo-mechanical interactionsSolid mechanicsChemo-mechanical couplingContinuum mechanicsOrdinary differential equationsSignal processingBiological tissuesMixture modelDifferential equationsEquationsSimulate many casesTissue growthOrgan-scaleComputational analysis of heart valve growth and remodeling after the Ross procedure
Middendorp E, Braeu F, Baaijens F, Humphrey J, Cyron C, Loerakker S. Computational analysis of heart valve growth and remodeling after the Ross procedure. Biomechanics And Modeling In Mechanobiology 2024, 23: 1889-1907. PMID: 39269523, PMCID: PMC11554944, DOI: 10.1007/s10237-024-01874-y.Peer-Reviewed Original ResearchRoss procedureBlood pressure controlRoot dilatationHomogeneous mixture modelPatient's own pulmonary valveMechanical homeostasisPressure controlAortic heart valvesPublished clinical studiesConstrained mixture modelsHemodynamic environmentPulmonary autograftPulmonary valveLeaflet elongationPressure conditionsClinical studiesG&RHemodynamic loadTissue compositionValve growthTissue depositionMixture modelDilatationHeart valvesAutograftAT1b receptors contribute to regional disparities in angiotensin II mediated aortic remodelling in mice
Cavinato C, Spronck B, Caulk A, Murtada S, Humphrey J. AT1b receptors contribute to regional disparities in angiotensin II mediated aortic remodelling in mice. Journal Of The Royal Society Interface 2024, 21: 20240110. PMID: 39192727, PMCID: PMC11350382, DOI: 10.1098/rsif.2024.0110.Peer-Reviewed Original ResearchConceptsAngiotensin II infusionAT1B receptorsII infusionAngiotensin IIChronic angiotensin II infusionDays of angiotensin II infusionWild-typeAortas of WTSmooth muscle contractilityDescending thoracic aortaAngiotensin II signalingInflammatory cell responseRenin-angiotensin systemRegulating blood pressureAngII infusionAortic remodelingCell biological changesImmunohistological changesIndependent of sexMuscle contractilityMale miceMouse modelAbdominal aortaArterial remodelingBlood pressureCellular stiffness sensing through talin 1 in tissue mechanical homeostasis
Chanduri M, Kumar A, Weiss D, Emuna N, Barsukov I, Shi M, Tanaka K, Wang X, Datye A, Kanyo J, Collin F, Lam T, Schwarz U, Bai S, Nottoli T, Goult B, Humphrey J, Schwartz M. Cellular stiffness sensing through talin 1 in tissue mechanical homeostasis. Science Advances 2024, 10: eadi6286. PMID: 39167642, PMCID: PMC11338229, DOI: 10.1126/sciadv.adi6286.Peer-Reviewed Original ResearchConceptsTissue mechanical homeostasisStiffness sensingExtracellular matrixTalin-1Mechanical homeostasisExtracellular matrix mechanicsIncreased cell spreadingCell spreadingTalinMutationsCellular sensingFibrillar collagenReduced axial stiffnessTissue mechanical propertiesMechanical propertiesAxial stiffnessCompliant substratesHomeostasisRupture pressureArp2/3ARPC5LStiffnessHomeostasis hypothesisResident cellsTissue stiffnessFSGe: A fast and strongly-coupled 3D fluid–solid-growth interaction method
Pfaller M, Latorre M, Schwarz E, Gerosa F, Szafron J, Humphrey J, Marsden A. FSGe: A fast and strongly-coupled 3D fluid–solid-growth interaction method. Computer Methods In Applied Mechanics And Engineering 2024, 431: 117259. PMID: 39430055, PMCID: PMC11484312, DOI: 10.1016/j.cma.2024.117259.Peer-Reviewed Original ResearchWall shear stressG&R modelIntramural stressVariation of wall shear stressHyperelastic material modelNavier-Stokes equationsFluid-solid-growthMaterial modelMaterial propertiesShear stressSimulation resultsThree-dimensionalComputational examplesComputational costEvolving geometryG&RWall adaptationLocal variationsFluid solutionStressMechanics and mechanobiology of intracranial aneurysms
Humphrey J. Mechanics and mechanobiology of intracranial aneurysms. Mathematics And Mechanics Of Solids 2024 DOI: 10.1177/10812865231219163.Peer-Reviewed Original ResearchDynamic biaxial loading of vascular smooth muscle cell seeded tissue equivalents
Paukner D, Jennings I, Cyron C, Humphrey J. Dynamic biaxial loading of vascular smooth muscle cell seeded tissue equivalents. Journal Of The Mechanical Behavior Of Biomedical Materials 2024, 157: 106639. PMID: 38970943, DOI: 10.1016/j.jmbbm.2024.106639.Peer-Reviewed Original ResearchCyclic loadingBiaxial loading conditionsPeriod of cyclic loadingStudy cell-matrix interactionsLoad amplitudeUniaxial experimentsDynamic loadingBiaxial forceCruciform samplesLoading conditionsExternal loadMechanical stateBoundary conditionsLoadExtracellular matrixInfluence cell phenotypeMechanical constraintsRange of forcesCell-matrix interactionsCollagen gelsTissue equivalentsForceSynthetic cellsLoad in vivoVascular smooth muscle cellsStiffening of the human proximal pulmonary artery with increasing age
Manning E, Mishall P, Ramachandra A, Hassab A, Lamy J, Peters D, Murphy T, Heerdt P, Singh I, Downie S, Choudhary G, Tellides G, Humphrey J. Stiffening of the human proximal pulmonary artery with increasing age. Physiological Reports 2024, 12: e16090. PMID: 38884325, PMCID: PMC11181131, DOI: 10.14814/phy2.16090.Peer-Reviewed Original ResearchConceptsProximal pulmonary arteriesPulmonary arteryAge-related stiffeningRight ventricular ejection fractionVentricular ejection fractionMean wall thicknessEjection fractionNo significant differenceSystemic circulationLuminal caliberDiffusing capacityArterial stiffeningIncreasing ageSignificant differenceDistensionArteryWall thicknessAdverse effectsWall strainVessel diameterCyclic biaxial strainOrgan donorsAgeMicrostructural remodeling
Academic Achievements & Community Involvement
News
News
- May 12, 2023
Targeting Fibronectin-integrin α5 Signaling in Marfan Syndrome
- April 02, 2020
Why do aortic aneurysms form? Yale-led team finds the reason
- June 14, 2018
New university report recommends science priorities for the decade ahead
- February 12, 2013
Jay Humphrey named to the inaugural John C. Malone Professorship