Edward Manning, MD, PhD
Assistant Professor of Medicine (Pulmonary)Cards
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About
Titles
Assistant Professor of Medicine (Pulmonary)
Biography
Ed is a native of Syracuse, NY. He attended the University of Albany where he majored in Physics and Russian. After his undergraduate education, he was commissioned in the United States Marine Corps. Ed served ten years in the Marine Corps, earned the rank of Major, then attended the Albert Einstein College of Medicine. At Einstein he earned his MD and PhD degrees under the supervision of Steven D. Schwartz PhD in collaboration with the laboratory of Jil Tardiff MD-PhD. He completed his internship and residency at the Hospital of the University of Pennsylvania. He then completed a clinical and research fellowship in pulmonary and critical care medicine at Yale School of Medicine in the Section of Pulmonary, Critical Care, and Sleep Medicine. He is currently an attending physician of pulmonary and critical care medicine at the West Haven VA and Yale-New Haven Hospitals. His current research focuses on the remodeling of the cardiopulmonary system with emphasis on the remodeling of the pulmonary vasculature in response to chronic hypoxia and aging and how this affects lung and right ventricular function.
Appointments
Pulmonary, Critical Care & Sleep Medicine
Assistant ProfessorPrimary
Other Departments & Organizations
- Internal Medicine
- Janeway Society
- Kaminski Lab
- Pulmonary Vascular Disease Program
- Pulmonary, Critical Care & Sleep Medicine
- Yale Medicine
Education & Training
- Pulmonary, Critical Care Fellowship
- Yale School of Medicine (2020)
- Residency
- Hospital of the University of Pennsylvania (2016)
- MD
- Albert Einstein College of Medicine of Yeshiva University (2014)
- PhD
- Albert Einstein College of Medicine of Yeshiva University, Biophysics (2014)
- MA
- Hunter College - City University of New York, Physics (2005)
- MPA
- Troy State University, Public Policy (2000)
- BS
- University of Albany - State University of New York, Physics/Russian (1994)
Research
Research at a Glance
Yale Co-Authors
Publications Timeline
Naftali Kaminski, MD
Inderjit Singh, MBChB, BMedSci, FRCP, FCCP
Lokesh Kumar Sharma, PhD
Maor Sauler, MD
George Tellides, MD, PhD
Jonas Christian Schupp, MD
Publications
2024
Stiffening of the human proximal pulmonary artery with increasing age
Manning E, Mishall P, Ramachandra A, Hassab A, Lamy J, Peters D, Murphy T, Heerdt P, Singh I, Downie S, Choudhary G, Tellides G, Humphrey J. Stiffening of the human proximal pulmonary artery with increasing age. Physiological Reports 2024, 12: e16090. PMID: 38884325, PMCID: PMC11181131, DOI: 10.14814/phy2.16090.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsProximal pulmonary arteriesPulmonary arteryAge-related stiffeningRight ventricular ejection fractionVentricular ejection fractionMean wall thicknessEjection fractionNo significant differenceSystemic circulationLuminal caliberDiffusing capacityArterial stiffeningIncreasing ageSignificant differenceDistensionArteryWall thicknessAdverse effectsWall strainVessel diameterCyclic biaxial strainOrgan donorsAgeMicrostructural remodelingProfibrotic Role of GPR87 in Pulmonary Fibrosis
Khoury J, Ahangari F, Manning E, Justet A, barnthaler T, Adams T, Necola F, Alysandratos K, Beermann M, Kotton D, Kaminski N. Profibrotic Role of GPR87 in Pulmonary Fibrosis. 2024, a5183-a5183. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5183.Peer-Reviewed Original ResearchEpidermal Growth Factor Receptor Regulates Beclin-1 in Hyperoxia-Induced Lung Injury
Harris Z, Sun Y, Korde A, Hu B, Sharma L, Manning E, Joerns J, Clark B, Stanley G, Shin H, Placek L, Unutmaz D, Chun H, Sauler M, Rajagopalan G, Zhang X, Wang H, Kang M, Koff J. Epidermal Growth Factor Receptor Regulates Beclin-1 in Hyperoxia-Induced Lung Injury. 2024, a6841-a6841. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a6841.Peer-Reviewed Original ResearchRemodeling of Murine Branch Pulmonary Arteries Under Chronic Hypoxia and Short-Term Normoxic Recovery.
Ramachandra A, Jiang B, Jennings I, Manning E, Humphrey J. Remodeling of Murine Branch Pulmonary Arteries Under Chronic Hypoxia and Short-Term Normoxic Recovery. Journal Of Biomechanical Engineering 2024, 146 PMID: 38421341, DOI: 10.1115/1.4064967.Peer-Reviewed Original ResearchAltmetricConceptsWeeks of hypoxiaBranch pulmonary arteriesWeeks of normoxic recoveryPulmonary arteryEndothelial cell responsesSmooth muscleChronic hypoxiaNormoxic recoveryPulmonary arterial remodelingCell responsesProximal pulmonary arteriesLongitudinal changesHypoxia-induced changesC57BL/6J micePulmonary pathologyThin collagen fibersArterial remodelingBiaxial mechanicsCircumferential stressEnergy storageNormal valuesHypoxiaWeeksVascular adaptationFraction of cytoplasmGuillain-Barre in the long-term acute care hospital setting: Ventilation does not prolong stay
Weil K, Baumann V, Brown B, Nadeau R, Hrdlicka H, Gerstenhaber B, Rosenblum D, Manning E. Guillain-Barre in the long-term acute care hospital setting: Ventilation does not prolong stay. Journal Of Mechanical Ventilation 2024, 5: 13-19. DOI: 10.53097/jmv.10094.Peer-Reviewed Original ResearchConceptsGuillain-Barre syndrome patientsGuillain-Barre syndromeLong-term acute care hospitalProlonged mechanical ventilationGBS patientsMechanical ventilationLength of stayAcute inflammatory demyelinating polyneuropathyFunctional abilitySevere Guillain-Barre syndromeLong-term acute care hospital settingAcute care hospital settingInflammatory demyelinating polyneuropathyOutcomes of patientsAcute care hospitalsLoss of muscle functionRate of functional improvementTime of admissionMain Outcome MeasuresPoor functional statusDemyelinating polyneuropathyProlonged ventilationRespiratory failureNo significant differenceRetrospective studyDevelopmental changes in lung function of mice are independent of sex as a biological variable
Bärnthaler T, Ramachandra A, Ebanks S, Guerrera N, Sharma L, Dela Cruz C, Humphrey J, Manning E. Developmental changes in lung function of mice are independent of sex as a biological variable. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2024, 326: l627-l637. PMID: 38375577, PMCID: PMC11380952, DOI: 10.1152/ajplung.00120.2023.Peer-Reviewed Original ResearchCitationsAltmetricConceptsPulmonary function testsWeeks of ageStatic complianceMale miceInspiratory capacityLung functionBody weight-basedHuman lung pathologiesLung function of miceFemale C57BL/6J miceLung function parametersSex-dependent changesFunction of miceMeasures of lung functionIndependent of sexPreclinical modelsFemale miceC57BL/6J miceLung pathologyFunction testsMiceWeight-basedLungLung disease researchWeeks
2023
Alveolar Vascular Remodeling in Nonspecific Interstitial Pneumonia: Replacement of Normal Lung Capillaries with COL15A1-Positive Endothelial Cells.
Schupp J, Manning E, Chioccioli M, Kamp J, Christian L, Ryu C, Herzog E, Kühnel M, Prasse A, Kaminski N, Jonigk D, Homer R, Neubert L, Ius F, stringJustet A, Hariri L, Seeliger B, Welte T, Knipe R, Gottlieb J. Alveolar Vascular Remodeling in Nonspecific Interstitial Pneumonia: Replacement of Normal Lung Capillaries with COL15A1-Positive Endothelial Cells. American Journal Of Respiratory And Critical Care Medicine 2023, 208: 819-822. PMID: 37552025, PMCID: PMC10563189, DOI: 10.1164/rccm.202303-0544le.Peer-Reviewed Original ResearchCitationsAltmetricVISTA (PD-1H) Is a Crucial Immune Regulator to Limit Pulmonary Fibrosis.
Kim S, Adams T, Hu Q, Shin H, Chae G, Lee S, Sharma L, Kwon H, Lee F, Park H, Huh W, Manning E, Kaminski N, Sauler M, Chen L, Song J, Kim T, Kang M. VISTA (PD-1H) Is a Crucial Immune Regulator to Limit Pulmonary Fibrosis. American Journal Of Respiratory Cell And Molecular Biology 2023, 69: 22-33. PMID: 36450109, PMCID: PMC10324045, DOI: 10.1165/rcmb.2022-0219oc.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsIdiopathic pulmonary fibrosisPulmonary fibrosisImmune regulatorsTherapeutic potentialHuman idiopathic pulmonary fibrosisCrucial immune regulatorsNovel immune regulatorPulmonary fibrosis micePulmonary fibrosis modelNovel therapeutic targetRole of VISTAWild-type littermatesMonocyte-derived macrophagesT lymphocyte lineageVISTA expressionIPF treatmentAntibody treatmentImmune landscapeFibrotic mediatorsLung fibrosisFibrosis miceInflammatory responseFibrosis modelMyeloid populationsTherapeutic targetThe Extracellular Matrix of the Human Proximal Pulmonary Artery Regulates Gene Expression of Resident Cells Responsible for Remodeling During Aging
Yuan Y, Khoury J, Ramachandra A, Singh I, Tellides G, Humphrey J, Kaminski N, Manning E. The Extracellular Matrix of the Human Proximal Pulmonary Artery Regulates Gene Expression of Resident Cells Responsible for Remodeling During Aging. 2023, a2680-a2680. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2680.Peer-Reviewed Original ResearchAge-related Changes in Structure, Function, and Transcriptomics of the Human Proximal Pulmonary Artery
Manning E, Ramachandra A, Cavinato C, Schupp J, Justet A, Lee P, Heerdt P, Singh I, Murphy T, Gill T, Tellides G, Kaminski N, Humphrey J. Age-related Changes in Structure, Function, and Transcriptomics of the Human Proximal Pulmonary Artery. 2023, a4656-a4656. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a4656.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
activity Myeloid Cell Senescence is Associated with Age-Related Stiffening of the Human Proximal Pulmonary Artery
Poster PresentationNational OAIC MeetingDetails04/27/2023 - 04/28/2023Arlington, VA, United StatesSponsored by OAIC Pepper Centers OAIC National Meetingactivity Clinician-Scientists Transdisciplinary Aging Research Coordinating Center
Meeting Planning and ParticipationCommittee MemberDetails2022 - 2023activity Functional Genetics Approach to Investigating Pulmonary Artery Remodeling
OtherVasculata - NAVBO 2022 (Duke University)Details07/15/2022 - 07/15/2022Durham, NC, United StatesSponsored by North American Vascular Biology Organizationactivity Age-Related Remodeling of the Human Proximal Pulmonary Artery
Oral PresentationMeasuring Biologic AgeDetails01/19/2022 - 01/20/2022 Sponsored by Research Centers Collaborative Network/National Institute on Aging, NIHhonor Butler-Williams Scholar
National AwardNational Institute on AgingDetails08/31/2021United States
Clinical Care
Overview
Clinical Specialties
Board Certifications
Adult Echocardiography
- Certification Organization
- National Board of Echocardiography
- Original Certification Date
- 2021
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News
- September 20, 2024
What Gets Lost When Autopsies Aren’t Done? Not Just Cause of Death
- May 22, 2020
Memorial Day Remembrance
- February 17, 2020Source: Annals of Internal Medicine
Annals On Call - Are VA Patients Different?
- October 30, 2019
Cultural Differences Between Veterans, Civilians Important For Physicians To Know, Understand
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Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.