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Petr Protiva, MD, MPH

Associate Professor of Medicine (Digestive Diseases); Adjunct Faculty at Breslow Lab, Rockefeller University, New York, NY

Contact Information

Petr Protiva, MD, MPH

Mailing Address

  • Yale School of Medicine

    Department of Medicine (Digestive Diseases), PO Box 208019

    New Haven, CT 06520-8019

    United States

Research Summary

Major goal of our research is to identify molecular pathways that modulate the risk of colon cancer.

Extensive Research Description

Colonoscopy Versus Fecal Immunochemical Test in Reducing Mortality From Colorectal Cancer (CONFIRM)

This is a VA Multisite Study. The purpose of this study is to compare two types of colon cancer screening tests and determine which is more effective in preventing death from colon and rectal cancer. These tests have not been compared in a large study and it is not clear which test is more effective Role: Site Principal Investigator/Local Site Investigator

Effect of Dietary Folate Supplementation and Depletion on Human Colonic Mucosa

Adequate folate status is important for optimal one carbon metabolic processes including the synthesis and methylation of DNA and genomic stability. This may impact the risk of cancer. The purpose of this study was to examine the effect of folate depletion-repletion and supplementation on gene expression and genomic stability in human colorectal mucosa. Multiple additional biomarkers were measured.

Calcium and 1,25-dihydroxyvitamin D3 modulate genes of immune and inflammatory pathways in the human colon: a human crossover trial

Inadequate calcium and vitamin D levels/intake are implicated in colorectal carcinogenesis. The purpose of this study was to examine the effect of Western style diet +/- calcium and/or vitamin D on gene expression in human colorectal mucosa.


Research Interests

Colorectal Neoplasms; Molecular Epidemiology; Endpoint Determination; Nontherapeutic Human Experimentation; Therapeutic Human Experimentation

Public Health Interests

Biomarkers; Cancer; Clinical Trials; Genetics, Genomics, Epigenetics; Nutrition

Selected Publications