Jennifer VanOudenhove, PhD
Associate Research Scientist
Research & Publications
Biography
News
Coauthors
Selected Publications
- Open-label, single-arm phase Ib/II study of immune combination therapy with elotuzumab and belantamab mafodotin in patients with relapsed refractory multiple myeloma.Browning S, Li F, Parker T, Bar N, Anderson T, Stevens E, VanOudenhove J, Matthews M, Gorshein E, Talsania A, Sabbath K, Seropian S, Halene S, Neparidze N. Open-label, single-arm phase Ib/II study of immune combination therapy with elotuzumab and belantamab mafodotin in patients with relapsed refractory multiple myeloma. Journal Of Clinical Oncology 2024, 42: 7559-7559. DOI: 10.1200/jco.2024.42.16_suppl.7559.
- CLONAL HEMATOPOIESIS OF INDETERMINATE POTENTIAL (CHIP) IS AN INDEPENDENT RISK FACTOR FOR IMMUNE CHECKPOINT INHIBITOR MYOCARDITISChen N, Martinez C, Jayakrishnan R, Jiang M, Guajardo A, Vanoudenhove J, Im Y, Hwa J, Halene S, Kwan J. CLONAL HEMATOPOIESIS OF INDETERMINATE POTENTIAL (CHIP) IS AN INDEPENDENT RISK FACTOR FOR IMMUNE CHECKPOINT INHIBITOR MYOCARDITIS. Journal Of The American College Of Cardiology 2024, 83: 2492. DOI: 10.1016/s0735-1097(24)04482-6.
- Abstract 3632: Cytokine profiles associated with ICI myocarditis using machine learning approaches identifies novel cytokines and implicated pathwaysChehayeb R, Hong D, Chen N, Martinez C, Jayakrishnan R, Guajardo A, Lin D, Im Y, Halene S, VanOudenhove J, Hwa J, Jha A, Kwan J. Abstract 3632: Cytokine profiles associated with ICI myocarditis using machine learning approaches identifies novel cytokines and implicated pathways. Cancer Research 2024, 84: 3632-3632. DOI: 10.1158/1538-7445.am2024-3632.
- Abstract 7123: Biomarker-targeted alkylator and DNA damage repair inhibitor combination for refractory and relapsed acute myeloid leukemia (AML)Bhardwaj P, Sundaram R, Baassiri A, Matthews M, VanOudenhove J, Gueble S, Halene S, Bindra R. Abstract 7123: Biomarker-targeted alkylator and DNA damage repair inhibitor combination for refractory and relapsed acute myeloid leukemia (AML). Cancer Research 2024, 84: 7123-7123. DOI: 10.1158/1538-7445.am2024-7123.
- Abstract P03: Splicing factor mutations induce stress granule upregulation in myeloid malignanciesBiancon G, Busarello E, Cheng M, Baccon D, VanOudenhove J, Ciceri F, Tebaldi T, Halene S. Abstract P03: Splicing factor mutations induce stress granule upregulation in myeloid malignancies. Blood Cancer Discovery 2024, 5: p03-p03. DOI: 10.1158/2643-3249.bcdsymp24-p03.
- Abstract 17607: Clonal Hematopoiesis of Indeterminate Potential (CHIP) is an Independent Risk Factor for Cardiomyopathy in Patients With Solid MalignancyMartinez C, Jayakrishnan R, Guajardo A, Leveille E, Lin D, Im Y, Christofides A, Chen N, Baldassarre L, VanOudenhove J, Halene S, Hwa J, Kwan J. Abstract 17607: Clonal Hematopoiesis of Indeterminate Potential (CHIP) is an Independent Risk Factor for Cardiomyopathy in Patients With Solid Malignancy. Circulation 2023, 148: a17607-a17607. DOI: 10.1161/circ.148.suppl_1.17607.
- Abstract 17610: A Novel Approach Using Deep Neural Networks on Clinical Cardiac MRIs Can Identify Patients With Clonal Hematopoiesis of Indeterminate Potential With High AccuracyRyu A, Christofides A, Martinez C, Jayakrishnan R, Ahn S, Guajardo A, Espinoza J, Chen N, Jha A, Im Y, Halene S, VanOudenhove J, MOJIBIAN H, Duncan J, Dvornek N, Kwan J. Abstract 17610: A Novel Approach Using Deep Neural Networks on Clinical Cardiac MRIs Can Identify Patients With Clonal Hematopoiesis of Indeterminate Potential With High Accuracy. Circulation 2023, 148: a17610-a17610. DOI: 10.1161/circ.148.suppl_1.17610.
- Abstract 17603: Novel Cardiac Dynamics Modeling of Clinical Cardiac MRIs Can Identify Who Has Clonal Hematopoiesis of Indeterminate Potential With High AccuracyZappala E, Cross J, Christofides A, Martinez C, Jayakrishnan R, Im Y, Guajardo A, Ahn S, Jha A, Halene S, VanOudenhove J, Van Dijk D, Kwan J. Abstract 17603: Novel Cardiac Dynamics Modeling of Clinical Cardiac MRIs Can Identify Who Has Clonal Hematopoiesis of Indeterminate Potential With High Accuracy. Circulation 2023, 148: a17603-a17603. DOI: 10.1161/circ.148.suppl_1.17603.
- CAR T-Related Toxicities Based on Dynamic Proteomic Profiles Identifies Risk Factors for Cytokine Release Syndrome (CRS) and Immune Effector Cell -Associated Neurotoxicity Syndrome (ICANS)Kewan T, Mirza S, Pine A, Rasheed Y, Hamouche R, Leveille E, Goshua G, Gu S, Liu Y, Vanoudenhove J, Bar N, Neparidze N, Foss F, Gowda L, Isufi I, Halene S, Lee A, Seropian S. CAR T-Related Toxicities Based on Dynamic Proteomic Profiles Identifies Risk Factors for Cytokine Release Syndrome (CRS) and Immune Effector Cell -Associated Neurotoxicity Syndrome (ICANS). Blood 2023, 142: 2132. DOI: 10.1182/blood-2023-187295.
- Can Emergency Hematopoiesis Due to Sepsis Lead to Clonal Hematopoiesis? Implications for Understanding the Pathogenesis of Clonal EvolutionOgbue O, Kewan T, Mehkri O, Fadell F, Nautiyal I, Reynold M, Durmaz A, VanOudenhove J, Awada H, Unlu S, Singh A, Visconte V, Mendez L, Bosler D, Duggal A, Halene S, Maciejewski J, Al-Jaghbeer M, Gurnari C. Can Emergency Hematopoiesis Due to Sepsis Lead to Clonal Hematopoiesis? Implications for Understanding the Pathogenesis of Clonal Evolution. Blood 2023, 142: 2691. DOI: 10.1182/blood-2023-187424.
- Impact of Memory T Cells on SARS-COV-2 Vaccine Response in Hematopoietic Stem Cell Transplant.VanOudenhove J, Liu Y, Nelakanti R, Kim D, Busarello E, Ovalle NT, Qi Z, Mamillapalli P, Siddon A, Bai Z, Axtmayer A, Corso C, Kothari S, Foss F, Isufi I, Tebaldi T, Gowda L, Fan R, Seropian S, Halene S. Impact of Memory T Cells on SARS-COV-2 Vaccine Response in Hematopoietic Stem Cell Transplant. BioRxiv 2023 PMID: 37961434, DOI: 10.1101/2023.10.26.564259.
- Microfluidic Immuno‐Serolomic Assay Reveals Systems Level Association with COVID‐19 Pathology and Vaccine Protection (Small Methods 10/2023)Kim D, Biancon G, Bai Z, VanOudenhove J, Liu Y, Kothari S, Gowda L, Kwan J, Buitrago‐Pocasangre N, Lele N, Asashima H, Racke M, Wilson J, Givens T, Tomayko M, Schulz W, Longbrake E, Hafler D, Halene S, Fan R. Microfluidic Immuno‐Serolomic Assay Reveals Systems Level Association with COVID‐19 Pathology and Vaccine Protection (Small Methods 10/2023). Small Methods 2023, 7 DOI: 10.1002/smtd.202370057.
- Integrative analysis of transcriptome dynamics during human craniofacial development identifies candidate disease genesYankee T, Oh S, Winchester E, Wilderman A, Robinson K, Gordon T, Rosenfeld J, VanOudenhove J, Scott D, Leslie E, Cotney J. Integrative analysis of transcriptome dynamics during human craniofacial development identifies candidate disease genes. Nature Communications 2023, 14: 4623. PMID: 37532691, PMCID: PMC10397224, DOI: 10.1038/s41467-023-40363-1.
- Is it the time to integrate novel sequencing technologies into clinical practice?VanOudenhove J, Halene S, Mendez L. Is it the time to integrate novel sequencing technologies into clinical practice? Current Opinion In Hematology 2022, 30: 70-77. PMID: 36602939, DOI: 10.1097/moh.0000000000000754.
- NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological healthLee P, Benz C, Blood P, Börner K, Campisi J, Chen F, Daldrup-Link H, De Jager P, Ding L, Duncan F, Eickelberg O, Fan R, Finkel T, Furman D, Garovic V, Gehlenborg N, Glass C, Heckenbach I, Joseph Z, Katiyar P, Kim S, Königshoff M, Kuchel G, Lee H, Lee J, Ma J, Ma Q, Melov S, Metis K, Mora A, Musi N, Neretti N, Passos J, Rahman I, Rivera-Mulia J, Robson P, Rojas M, Roy A, Scheibye-Knudsen M, Schilling B, Shi P, Silverstein J, Suryadevara V, Xie J, Wang J, Wong A, Niedernhofer L, Wang S, Anvari H, Balough J, Benz C, Bons J, Brenerman B, Evans W, Gerencser A, Gregory H, Hansen M, Justice J, Kapahi P, Murad N, O’Broin A, Pavone M, Powell M, Scott G, Shanes E, Shankaran M, Verdin E, Winer D, Wu F, Adams A, Blood P, Bueckle A, Cao-Berg I, Chen H, Davis M, Filus S, Hao Y, Hartman A, Hasanaj E, Helfer J, Herr B, Joseph Z, Molla G, Mou G, Puerto J, Quardokus E, Ropelewski A, Ruffalo M, Satija R, Schwenk M, Scibek R, Shirey W, Sibilla M, Welling J, Yuan Z, Bonneau R, Christiano A, Izar B, Menon V, Owens D, Phatnani H, Smith C, Suh Y, Teich A, Bekker V, Chan C, Coutavas E, Hartwig M, Ji Z, Nixon A, Dou Z, Rajagopal J, Slavov N, Holmes D, Jurk D, Kirkland J, Lagnado A, Tchkonia T, Abraham K, Dibattista A, Fridell Y, Howcroft T, Jhappan C, Montes V, Prabhudas M, Resat H, Taylor V, Kumar M, Suryadevara V, Cigarroa F, Cohn R, Cortes T, Courtois E, Chuang J, Davé M, Domanskyi S, Enninga E, Eryilmaz G, Espinoza S, Gelfond J, Kirkland J, Kuchel G, Kuo C, Lehman J, Aguayo-Mazzucato C, Meves A, Rani M, Sanders S, Thibodeau A, Tullius S, Ucar D, White B, Wu Q, Xu M, Yamaguchi S, Assarzadegan N, Cho C, Hwang I, Hwang Y, Xi J, Adeyi O, Aliferis C, Bartolomucci A, Dong X, DuFresne-To M, Ikramuddin S, Johnson S, Nelson A, Niedernhofer L, Revelo X, Trevilla-Garcia C, Sedivy J, Thompson E, Robbins P, Wang J, Aird K, Alder J, Beaulieu D, Bueno M, Calyeca J, Chamucero-Millaris J, Chan S, Chung D, Corbett A, Gorbunova V, Gowdy K, Gurkar A, Horowitz J, Hu Q, Kaur G, Khaliullin T, Lafyatis R, Lanna S, Li D, Ma A, Morris A, Muthumalage T, Peters V, Pryhuber G, Reader B, Rosas L, Sembrat J, Shaikh S, Shi H, Stacey S, Croix C, Wang C, Wang Q, Watts A, Gu L, Lin Y, Rabinovitch P, Sweetwyne M, Artyomov M, Ballentine S, Chheda M, Davies S, DiPersio J, Fields R, Fitzpatrick J, Fulton R, Imai S, Jain S, Ju T, Kushnir V, Link D, Ben Major M, Oh S, Rapp D, Rettig M, Stewart S, Veis D, Vij K, Wendl M, Wyczalkowski M, Craft J, Enninful A, Farzad N, Gershkovich P, Halene S, Kluger Y, VanOudenhove J, Xu M, Yang J, Yang M. NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health. Nature Aging 2022, 2: 1090-1100. PMID: 36936385, PMCID: PMC10019484, DOI: 10.1038/s43587-022-00326-5.
- Zebrafish models of Alx-linked frontonasal dysplasia reveal a role for Alx1 and Alx3 in the anterior segment and vasculature of the developing eyeYoon B, Yeung P, Santistevan N, Bluhm L, Kawasaki K, Kueper J, Dubielzig R, Vanoudenhove J, Cotney J, Liao E, Grinblat Y. Zebrafish models of Alx-linked frontonasal dysplasia reveal a role for Alx1 and Alx3 in the anterior segment and vasculature of the developing eye. Biology Open 2022, 11: bio059189. PMID: 35142342, PMCID: PMC9167625, DOI: 10.1242/bio.059189.
- Mission, Organization, and Future Direction of the Serological Sciences Network for COVID-19 (SeroNet) Epidemiologic Cohort StudiesFigueiredo JC, Hirsch FR, Kushi LH, Nembhard WN, Crawford JM, Mantis N, Finster L, Merin NM, Merchant A, Reckamp KL, Melmed GY, Braun J, McGovern D, Parekh S, Corley DA, Zohoori N, Amick BC, Du R, Gregersen PK, Diamond B, Taioli E, Sariol C, Espino A, Weiskopf D, Gifoni A, Brien J, Hanege W, Lipsitch M, Zidar DA, McAlearney A, Wajnberg A, LaBaer J, Lewis E, Binder RA, Moormann AM, Forconi C, Forrester S, Batista J, Schieffelin J, Kim D, Biancon G, VanOudenhove J, Halene S, Fan R, Barouch DH, Alter G, Pinninti S, Boppana SB, Pati SK, Latting M, Karaba AH, Roback J, Sekaly R, Neish A, Brincks AM, Granger DA, Karger AB, Thyagarajan B, Thomas SN, Klein SL, Cox AL, Lucas T, Furr-Holden D, Key K, Jones N, Wrammerr J, Suthar M, Wong S, Bowman NM, Simon V, Richardson LD, McBride R, Krammer F, Rana M, Kennedy J, Boehme K, Forrest C, Granger SW, Heaney CD, Lapinski M, Wallet S, Baric RS, Schifanella L, Lopez M, Fernández S, Kenah E, Panchal AR, Britt WJ, Sanz I, Dhodapkar M, Ahmed R, Bartelt LA, Markmann AJ, Lin JT, Hagan RS, Wolfgang MC, Skarbinski J. Mission, Organization, and Future Direction of the Serological Sciences Network for COVID-19 (SeroNet) Epidemiologic Cohort Studies. Open Forum Infectious Diseases 2022, 9: ofac171. PMID: 35765315, PMCID: PMC9129196, DOI: 10.1093/ofid/ofac171.
- Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftmentPettinato A, Yoo D, VanOudenhove J, Chen Y, Cohn R, Ladha F, Yang X, Thakar K, Romano R, Legere N, Meredith E, Robson P, Regnier M, Cotney J, Murry C, Hinson J. Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment. Cell Reports 2021, 35: 109088. PMID: 33951429, PMCID: PMC8161465, DOI: 10.1016/j.celrep.2021.109088.
- Epigenomic and Transcriptomic Dynamics During Human Heart OrganogenesisVanOudenhove J, Yankee T, Wilderman A, Cotney J. Epigenomic and Transcriptomic Dynamics During Human Heart Organogenesis. Circulation Research 2020, 127: e184-e209. PMID: 32772801, PMCID: PMC7554226, DOI: 10.1161/circresaha.120.316704.
- High-Resolution Epigenomic Atlas of Human Embryonic Craniofacial DevelopmentWilderman A, VanOudenhove J, Kron J, Noonan JP, Cotney J. High-Resolution Epigenomic Atlas of Human Embryonic Craniofacial Development. Cell Reports 2018, 23: 1581-1597. PMID: 29719267, PMCID: PMC5965702, DOI: 10.1016/j.celrep.2018.03.129.
- Unique Regulatory Mechanisms for the Human Embryonic Stem Cell CycleVanOudenhove J, Grandy R, Ghule P, Lian J, Stein J, Zaidi S, Stein G. Unique Regulatory Mechanisms for the Human Embryonic Stem Cell Cycle. Journal Of Cellular Physiology 2017, 232: 1254-1257. PMID: 27532275, PMCID: PMC5315681, DOI: 10.1002/jcp.25567.
- Precocious Phenotypic Transcription‐Factor Expression During Early DevelopmentVanOudenhove J, Medina R, Ghule P, Lian J, Stein J, Zaidi S, Stein G. Precocious Phenotypic Transcription‐Factor Expression During Early Development. Journal Of Cellular Biochemistry 2017, 118: 953-958. PMID: 27591551, PMCID: PMC5336526, DOI: 10.1002/jcb.25723.
- Transient RUNX1 Expression during Early Mesendodermal Differentiation of hESCs Promotes Epithelial to Mesenchymal Transition through TGFB2 SignalingVanOudenhove J, Medina R, Ghule P, Lian J, Stein J, Zaidi S, Stein G. Transient RUNX1 Expression during Early Mesendodermal Differentiation of hESCs Promotes Epithelial to Mesenchymal Transition through TGFB2 Signaling. Stem Cell Reports 2016, 7: 884-896. PMID: 27720906, PMCID: PMC5106514, DOI: 10.1016/j.stemcr.2016.09.006.
- Lineage-Specific Early Differentiation of Human Embryonic Stem Cells Requires a G2 Cell Cycle Pause.Van Oudenhove JJ, Grandy RA, Ghule PN, Del Rio R, Lian JB, Stein JL, Zaidi SK, Stein GS. Lineage-Specific Early Differentiation of Human Embryonic Stem Cells Requires a G2 Cell Cycle Pause. Stem Cells 2016, 34: 1765-75. PMID: 26946228, DOI: 10.1002/stem.2352.
- Genome-Wide Studies Reveal that H3K4me3 Modification in Bivalent Genes Is Dynamically Regulated during the Pluripotent Cell Cycle and Stabilized upon DifferentiationGrandy R, Whitfield T, Wu H, Fitzgerald M, VanOudenhove J, Zaidi S, Montecino M, Lian J, van Wijnen A, Stein J, Stein G. Genome-Wide Studies Reveal that H3K4me3 Modification in Bivalent Genes Is Dynamically Regulated during the Pluripotent Cell Cycle and Stabilized upon Differentiation. Molecular And Cellular Biology 2016, 36: 615-627. PMID: 26644406, PMCID: PMC4751694, DOI: 10.1128/mcb.00877-15.
- MicroRNA-378-mediated suppression of Runx1 alleviates the aggressive phenotype of triple-negative MDA-MB-231 human breast cancer cellsBrowne G, Dragon J, Hong D, Messier T, Gordon J, Farina N, Boyd J, VanOudenhove J, Perez A, Zaidi S, Stein J, Stein G, Lian J. MicroRNA-378-mediated suppression of Runx1 alleviates the aggressive phenotype of triple-negative MDA-MB-231 human breast cancer cells. Tumor Biology 2016, 37: 8825-8839. PMID: 26749280, PMCID: PMC4939137, DOI: 10.1007/s13277-015-4710-6.
- PSA regulates androgen receptor expression in prostate cancer cellsSaxena P, Trerotola M, Wang T, Li J, Sayeed A, VanOudenhove J, Adams D, FitzGerald T, Altieri D, Languino L. PSA regulates androgen receptor expression in prostate cancer cells. The Prostate 2011, 72: 769-776. PMID: 21956655, PMCID: PMC3404455, DOI: 10.1002/pros.21482.
- Analysis of PKR Structure by Small-Angle ScatteringVanOudenhove J, Anderson E, Krueger S, Cole J. Analysis of PKR Structure by Small-Angle Scattering. Journal Of Molecular Biology 2009, 387: 910-920. PMID: 19232355, PMCID: PMC2663012, DOI: 10.1016/j.jmb.2009.02.019.