David Geller, MD/PhD
Research & Publications
Biography
News
Research Summary
We are interested in using insights gained from the study of human genetic disease to gain a better understanding of molecular mechanisms underlying hypertension and cardiovascular disease. We previously identified a novel Mendelian form of human hypertension exacerbated by pregnancy, and we demonstrated that this disorder is caused by a gain of function mutation in the mineralocorticoid receptor. We have used these findings as a springboard to move our research in two complementary directions. In the first, we are seeking to use information gained from the study of this mutant receptor to improve our understanding of molecular mechanisms of steroid hormone receptor function, and we believe we have uncovered an intramolecular interaction critical to the activity of steroid hormone receptors. We are also pursuing physiologic studies to examine the links between steroid hormones and cardiovascular disease on a tissue–specific level in in vivo models. Finally, we are collaborating with other investigators at Yale to clarify the function of a novel group of renal potassium channels.
Specialized Terms: Hypertension; Cardiovascular disease
Research Interests
Cardiovascular Diseases; Hypertension; Nephrology; Receptors, Mineralocorticoid
Selected Publications
- Chapter 8 Familial hyperaldosteronismPappachan J, Fernandez C, Geller D. Chapter 8 Familial hyperaldosteronism. 2023, 105-112. DOI: 10.1016/b978-0-323-96120-2.00016-9.
- Erratum: Corrigendum: Epigenetic modulation of the renal β-adrenergic–WNK4 pathway in salt-sensitive hypertensionMu S, Shimosawa T, Ogura S, Wang H, Uetake Y, Kawakami-Mori F, Marumo T, Yatomi Y, Geller D, Tanaka H, Fujita T. Erratum: Corrigendum: Epigenetic modulation of the renal β-adrenergic–WNK4 pathway in salt-sensitive hypertension. Nature Medicine 2012, 18: 630-630. DOI: 10.1038/nm0412-630b.
- Erratum: Corrigendum: Epigenetic modulation of the renal β-adrenergic–WNK4 pathway in salt-sensitive hypertensionMu S, Shimosawa T, Ogura S, Wang H, Uetake Y, Kawakami-Mori F, Marumo T, Yatomi Y, Geller D, Tanaka H, Fujita T. Erratum: Corrigendum: Epigenetic modulation of the renal β-adrenergic–WNK4 pathway in salt-sensitive hypertension. Nature Medicine 2011, 17: 1220-1020. DOI: 10.1038/nm0811-1020.
- Chapter 18 Pseudohypaldosteronism Type 1 and Hypertension Exacerbated in PregnancyGeller D. Chapter 18 Pseudohypaldosteronism Type 1 and Hypertension Exacerbated in Pregnancy. 2009, 301-312. DOI: 10.1016/b978-0-12-449851-8.00018-8.
- Activating and inactivating mutations of the human mineralocorticoid receptorGeller D. Activating and inactivating mutations of the human mineralocorticoid receptor. Current Opinion In Endocrinology Diabetes And Obesity 2003, 10: 186-190. DOI: 10.1097/00060793-200306000-00005.
- A mineralocorticoid receptor mutation causing human hypertensionGeller D. A mineralocorticoid receptor mutation causing human hypertension. Current Opinion In Nephrology & Hypertension 2001, 10: 661-665. PMID: 11496062, DOI: 10.1097/00041552-200109000-00018.
- Molecular Mechanisms of Human HypertensionLifton R, Gharavi A, Geller D. Molecular Mechanisms of Human Hypertension. Cell 2001, 104: 545-556. PMID: 11239411, DOI: 10.1016/s0092-8674(01)00241-0.
- Activating Mineralocorticoid Receptor Mutation in Hypertension Exacerbated by PregnancyGeller D, Farhi A, Pinkerton N, Fradley M, Moritz M, Spitzer A, Meinke G, Tsai F, Sigler P, Lifton R. Activating Mineralocorticoid Receptor Mutation in Hypertension Exacerbated by Pregnancy. Science 2000, 289: 119-123. PMID: 10884226, DOI: 10.1126/science.289.5476.119.
- Mutations in the mineralocorticoid receptor gene cause autosomal dominant pseudohypoaldosteronism type IGeller D, Rodriguez-Soriano J, Boado A, Schifter S, Bayer M, Chang S, Lifton R. Mutations in the mineralocorticoid receptor gene cause autosomal dominant pseudohypoaldosteronism type I. Nature Genetics 1998, 19: 279-281. PMID: 9662404, DOI: 10.1038/966.