Zhiyuan Zhang
BiostatisticianCards
About
Research
Publications
2024
Mechanical loading on cell-free polymer composite scaffold enhances in situ regeneration of fully functional Achilles tendon in a rabbit model
Wang W, Lin X, Tu T, Guo Z, Song Z, Jiang Y, Zhou B, Lei D, Wang X, Zhang W, Zhou G, Yi B, Zhang P, Liu W. Mechanical loading on cell-free polymer composite scaffold enhances in situ regeneration of fully functional Achilles tendon in a rabbit model. Biomaterials Advances 2024, 163: 213950. PMID: 38972278, DOI: 10.1016/j.bioadv.2024.213950.Peer-Reviewed Original ResearchMechanical loadingComposite scaffoldsMechanical propertiesIn situ tendon regenerationTendon regenerationPorous composite scaffoldsCell-loaded scaffoldsEnhanced mechanical propertiesInduce tenogenic differentiationAchilles tendon regenerationHybrid yarnsPGA fibersScaffold productionTendon engineeringHost cell infiltrationTransmission electron microscopePolylactic acidFilament fibersMelt spinningNative tendonLoadElectron microscopeMatrix modificationApplication potentialPolyglycolic acidAnnexin-A5 monomer as a membrane repair agent for the treatment of renal ischemia-reperfusion injury
Dong Y, Jia Z, Kang B, Zhang W. Annexin-A5 monomer as a membrane repair agent for the treatment of renal ischemia-reperfusion injury. Molecular Biology Reports 2024, 51: 679. PMID: 38796668, DOI: 10.1007/s11033-024-09606-2.Peer-Reviewed Original ResearchConceptsRenal ischemia-reperfusion injuryIschemia-reperfusion injuryEffect of anxA5Bilateral renal IRIBackgroundRenal ischemia-reperfusion injuryProtective effectTreatment of renal ischemia-reperfusion injuryAcute kidney injurySimulated ischemia-reperfusion injuryEpithelial cell membranesHK-2 cellsMechanism of actionKidney injurySD ratsIn vitro experimentsTherapeutic effectPrevent cell deathMeasure cellular activityKidney structureAnnexin A5HK-2AnxA5In vitroCell deathCell membrane integrityRecombinant human annexin A5 accelerates diabetic wounds healing by regulating skin inflammation
Kang B, Jia Z, Dong Y, Li W, Zhang W. Recombinant human annexin A5 accelerates diabetic wounds healing by regulating skin inflammation. Regenerative Therapy 2024, 27: 342-353. PMID: 38645281, PMCID: PMC11031805, DOI: 10.1016/j.reth.2024.03.013.Peer-Reviewed Original ResearchCell-free fat extractAnnexin A5Regulator of macrophage inflammationEpithelial cellsDiabetic wound healingHealing of diabetic woundsPromotion of epithelializationDiabetic woundsHuman annexin A5Anti-CD68 stainingWound healingAnti-inflammatory proteinReduced pro-inflammatory factorsRegulating skin inflammationMigration of epithelial cellsAnti-CD86Pro-inflammatory factorsPolarization of macrophagesQRT-PCRCell migration assayM1 to M2 phenotypeActive inflammationEpithelial regulationSkin inflammationTransition of macrophagesCell-free fat extract promotes axon regeneration and retinal ganglion cells survival in traumatic optic neuropathy
Sun Y, Chen D, Dai T, Yu Z, Xie H, Wang X, Zhang W. Cell-free fat extract promotes axon regeneration and retinal ganglion cells survival in traumatic optic neuropathy. Frontiers In Cellular Neuroscience 2024, 18: 1344853. PMID: 38515790, PMCID: PMC10954833, DOI: 10.3389/fncel.2024.1344853.Peer-Reviewed Original ResearchCell-free fat extractRate of retinal ganglion cellsEnzyme-linked immunosorbent assayCentral nervous systemOptic nerve crushSurvival rate of retinal ganglion cellsTherapeutic effectRetinal ganglion cell survivalInflammatory factorsAxonal regenerationTraumatic optic neuropathyGanglion cell survivalWestern blottingStaining of microgliaGene OntologyCentral nervous system injuryLevels of inflammatory factorsRetinal ganglion cellsOptic neuropathyWeeks post-injuryComprehensive gene ontologyOptic nerveNerve crushRetinal tissueClinical challengePro-vasculogenic Fibers by PDA-Mediated Surface Functionalization Using Cell-Free Fat Extract (CEFFE)
Li D, Li Q, Xu T, Guo X, Tang H, Wang W, Zhang W, Zhang Y. Pro-vasculogenic Fibers by PDA-Mediated Surface Functionalization Using Cell-Free Fat Extract (CEFFE). Biomacromolecules 2024, 25: 1550-1562. PMID: 38411008, DOI: 10.1021/acs.biomac.3c01124.Peer-Reviewed Original ResearchConceptsFunctional biomaterial scaffoldsFunctional electrospun fibersFunctional tissue regenerationEngineered three-dimensionalTissue regenerationFibrous scaffoldsElectrospun fibersBiomaterial scaffoldsFiber surfaceBiomaterial constructsSurface functionalizationPCL/GTThree-dimensionalAdequate vascular networkPolydopamineFibersScaffoldsSustained mannerBioactive agentsCytocompatibilityVascular networkCell-free fat extract
2023
Type I collagen and fibromodulin enhance the tenogenic phenotype of hASCs and their potential for tendon regeneration
Tu T, Shi Y, Zhou B, Wang X, Zhang W, Zhou G, Mo X, Wang W, Wu J, Liu W. Type I collagen and fibromodulin enhance the tenogenic phenotype of hASCs and their potential for tendon regeneration. Npj Regenerative Medicine 2023, 8: 67. PMID: 38092758, PMCID: PMC10719373, DOI: 10.1038/s41536-023-00341-z.Peer-Reviewed Original ResearchHuman adipose-derived stem cellsExtracellular matrixTenogenic phenotypeCell-substrate adhesionStem cellsTenogenic differentiationCytoskeletal organizationMajor bioactive moleculesPositive regulationRNA sequencingBiological processesMesenchymal stem cellsECM moleculesSpecific differentiationRegulation axisAdipose-derived stem cellsKey moleculesPeptidase activityExpression levelsTendon extracellular matrixInductive mechanismDifferentiationRegulationVital nicheType I collagenIntradermal Local Injection of Autologous Cell-Free Fat Extract for the Treatment of Refractory Postinflammatory Hyperpigmentation
Cai Y, Jia Z, Gu J, Kang B, Zheng H, Li W, Zhang W. Intradermal Local Injection of Autologous Cell-Free Fat Extract for the Treatment of Refractory Postinflammatory Hyperpigmentation. Dermatologic Therapy 2023, 2023 DOI: 10.1155/2023/9561809.Peer-Reviewed Original ResearchCell-free fat extractTreatment of PIHPostinflammatory hyperpigmentationTreatment-related adverse eventsMonths of treatmentCurrent treatment modalitiesTransepidermal water lossAdverse eventsSerious complicationsTreatment modalitiesIntradermal injectionLocal injectionEfficacy assessmentFat extractTwo-week intervalsPatientsLesion colorSubjective parametersTreatmentSignificant reductionHyperpigmentationInjectionBS indexSkin lightnessSignificant improvement