Xuefei Tian, MD
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WIP1-mediated regulation of p38 MAPK signaling attenuates pyroptosis in sepsis-associated acute kidney injury
Wang Y, Cui C, Zhao W, Tian X, Liu P, Wei L, Zhu Z, Liu M, Fu R, Jia L. WIP1-mediated regulation of p38 MAPK signaling attenuates pyroptosis in sepsis-associated acute kidney injury. Immunobiology 2024, 229: 152832. PMID: 38943814, DOI: 10.1016/j.imbio.2024.152832.Peer-Reviewed Original ResearchAcute kidney injuryAcute tubular injuryLPS-induced acute kidney injuryHuman kidney 2Wip1 activityKidney injuryRenal tubulesUnilateral ischemia-reperfusion injurySepsis-associated acute kidney injuryRenal tubules of patientsHK2 cellsProtein levelsInduce acute injuryProximal renal tubulesWild-type p53-induced phosphatase 1Ischemia-reperfusion injuryPhosphorylation of p38 MAPKGSDMD-NHuman kidney-2 cellsSingle-cell sequencingPPM1D mRNAPhospho-p38 MAPKTubular injuryWip1 inhibitorScRNA-seqClinical Characteristics of 427 Unvaccinated Chinese Adult Patients with Maintenance Hemodialysis Infected with the SARS-CoV-2 Omicron Variant: A Retrospective Study
Ha X, Zhao Z, Zhao T, Muhetaer G, Wang X, Bao A, Duan Y, Zhuang J, Song X, Zhou Y, Zhang Q, Wu J, Fan M, Zhang L, Tian X, Jiang H. Clinical Characteristics of 427 Unvaccinated Chinese Adult Patients with Maintenance Hemodialysis Infected with the SARS-CoV-2 Omicron Variant: A Retrospective Study. Integrative Medicine In Nephrology And Andrology 2024, 11: e23-00018. DOI: 10.1097/imna-d-23-00018.Peer-Reviewed Original ResearchSARS-CoV-2 Omicron infectionMaintenance hemodialysisClinical characteristicsMHD patientsSARS-CoV-2 Omicron variantSARS-CoV-2Disease severityFollow-upSerum C-reactive protein levelsOmicron infectionRisk factorsC-reactive protein levelsFollow-up assessmentIndependent risk factorSpectrum of disease severityChinese adult patientsTailored treatment strategiesNegative nucleic acidAdult MHD patientsMaintenance hemodialysis patientsHigh-risk populationArterial oxygen partial pressureOmicron variantProcalcitonin levelsPrognostic factorsZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging
Jiang Q, Song G, He L, Li X, Jiang B, Wang Q, Wang S, Kim C, Barkestani M, Lopez R, Fan M, Wanniarachchi K, Quaranta M, Tian X, Mani A, Gonzalez A, Goodwin J, Sessa W, Ishibe S, Jane-Wit D. ZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging. Kidney International 2024 PMID: 38797325, DOI: 10.1016/j.kint.2024.05.007.Peer-Reviewed Original ResearchVascular barrier functionEndothelial cellsReduced endothelial nitric oxideRegulator of vascular barrier functionEndothelial nitric oxide signalingENOS activityEndosome-associated proteinsBarrier functionKidney organ culturesEndothelial nitric oxideAkt-dependent mannerNitric oxide donorGTPase Rab5Nitric oxide signalingZFYVE21Live cell imagingKidney insufficiencyReporter miceTrafficking mechanismsAccelerated aging phenotypeKnockout miceInterstitial edemaKidney functionVesicular populationOxide donorMediating role of social support in dysphoria, despondency, and quality of life in patients undergoing maintenance hemodialysis
Zhou X, Jiang H, Zhou Y, Wang X, Ren H, Tian X, Zhang Q. Mediating role of social support in dysphoria, despondency, and quality of life in patients undergoing maintenance hemodialysis. World Journal Of Psychiatry 2024, 14: 409-420. PMID: 38617988, PMCID: PMC11008395, DOI: 10.5498/wjp.v14.i3.409.Peer-Reviewed Original ResearchQuality of lifeSocial supportSocial Support Rating ScaleMental well-being of patientsLevels of social supportOveral quality of lifeImpact of social supportSelf-Rating Anxiety ScaleQuality of Life ScaleSelf-Rating Depression ScaleWell-being of patientsSelf-ratingsMental well-beingQuality of life of patientsDepression ScaleEffects of dysphoriaPsychological issuesAnxiety ScaleRating ScaleDysphoriaMaintenance hemodialysisMediation roleRandom sampling approachSupportDespondencyDPP8/9 inhibition attenuates the TGF-β1-induced excessive deposition of extracellular matrix (ECM) in human mesangial cells via Smad and Akt signaling pathways
Li K, Zhang Y, Zhao W, Wang R, Li Y, Wei L, Wang L, Chen X, Chen Z, Liu P, Nie N, Tian X, Fu R. DPP8/9 inhibition attenuates the TGF-β1-induced excessive deposition of extracellular matrix (ECM) in human mesangial cells via Smad and Akt signaling pathways. Toxicology Letters 2024, 395: 1-10. PMID: 38458339, DOI: 10.1016/j.toxlet.2024.03.001.Peer-Reviewed Original ResearchHuman mesangial cellsAkt signaling pathwayExtracellular matrixSignaling pathwayDipeptidyl peptidase IVMesangial cellsExpression of ECM-related proteinsPhosphorylation of AktECM-related proteinsAbnormal extracellular matrixECM depositionExcessive deposition of extracellular matrixPhosphorylation of Smad2DPP8/9 inhibitionDeposition of extracellular matrixGlomerular mesangial cellsDPP9Collagen IVDPP8AktMultiple diseasesDPP8/9SiRNAPathogenesis of glomerular diseaseCellsA comparison of chemiluminescent immunoassay and enzyme-linked immunosorbent assay for detecting phospholipase A2 receptor antibody in primary membranous nephropathy
Ma X, Wang R, Wei L, Liu P, Jing L, Wang J, Dong W, Tian X, Fu R. A comparison of chemiluminescent immunoassay and enzyme-linked immunosorbent assay for detecting phospholipase A2 receptor antibody in primary membranous nephropathy. Practical Laboratory Medicine 2024, 39: e00385. PMID: 38495349, PMCID: PMC10940994, DOI: 10.1016/j.plabm.2024.e00385.Peer-Reviewed Original ResearchAnti-PLA2R antibodiesEnzyme-linked immunosorbent assayNegative predictive valuePositive predictive valueAnti-PLA2RMembranous nephropathyChemiluminescence immunoassayLevels of anti-PLA2R antibodiesPhospholipase A2 receptor antibodyPredictive valuePrimary membranous nephropathyPhospholipase A2 receptorImmunosorbent assayResults Serum levelsStatistical analysis of sensitivityROC curve analysisNon-membranous nephropathyStatistically significant differencePMN groupReceptor antibodiesSerum levelsA2 receptorsSpearman correlation analysisDiagnostic valueNephropathyClinical Characteristics and Outcomes of Unvaccinated Kidney Transplant Recipients Infected with the SARS-CoV-2 Omicron Variant: A Case Series
Qu Y, Zhuang J, Duan Y, Baibutihan A, Maimaiti Z, Zhang C, Niu J, Teng W, Ailimu M, Wei X, Qi B, Li J, Du S, Wang D, Cao K, Wang J, Lu C, Tian X, Jiang H. Clinical Characteristics and Outcomes of Unvaccinated Kidney Transplant Recipients Infected with the SARS-CoV-2 Omicron Variant: A Case Series. Integrative Medicine In Nephrology And Andrology 2024, 11: e00019. DOI: 10.1097/imna-d-23-00019.Peer-Reviewed Original ResearchKidney transplant recipientsKT recipientsClinical characteristicsKidney transplantationTransplant recipientsElevated serum D-dimerIncidence of severe infectionsOmicron infectionSevere/critical illnessOutcomes of severe acute respiratory syndrome coronavirus 2Calcineurin inhibitor drugsSerum D-dimerSerum albumin levelSARS-CoV-2Acute kidney injuryFollow-up periodC-reactive proteinSARS-CoV-2 Omicron infectionSARS-CoV-2 Omicron variantReverse transcription polymerase chain reactionImmunocompromised statusFerritin levelsTranscription polymerase chain reactionSevere/critical groupAntiviral therapyEditorial: Association between diabetic nephropathy and diabetic retinopathy or non-diabetic nephropathy
Chen H, Tian X, Yu X. Editorial: Association between diabetic nephropathy and diabetic retinopathy or non-diabetic nephropathy. Frontiers In Endocrinology 2024, 15: 1359011. PMID: 38332890, PMCID: PMC10852059, DOI: 10.3389/fendo.2024.1359011.Commentaries, Editorials and LettersCharacteristics of renal pathology and coagulation function in IgA nephropathy and IgA vasculitis associated nephritis
Wang Y, Wang H, Ma X, Zhu Z, Tian X, Fu R, Jia L. Characteristics of renal pathology and coagulation function in IgA nephropathy and IgA vasculitis associated nephritis. BMC Nephrology 2024, 25: 35. PMID: 38273279, PMCID: PMC10811929, DOI: 10.1186/s12882-024-03465-6.Peer-Reviewed Original ResearchConceptsIgAN patientsFibrinogen degradation productsIgA nephropathyIgAVN patientsLevels of plasma D-dimerLevels of serum creatininePartial remission rateSevere coagulation abnormalitiesPlasma D-dimerPoor renal functionChronic kidney injuryRemission ratePathological resultsSerum creatinineAbdominal symptomsRenal functionCoagulation abnormalitiesDeposition of fibrinogenKidney biopsyD-dimerKidney injuryCoagulation functionIgAVNIgAN groupMethodsA totalUnderstanding the podocyte immune responses in proteinuric kidney diseases: from pathogenesis to therapy
Jiang H, Shen Z, Zhuang J, Lu C, Qu Y, Xu C, Yang S, Tian X. Understanding the podocyte immune responses in proteinuric kidney diseases: from pathogenesis to therapy. Frontiers In Immunology 2024, 14: 1335936. PMID: 38288116, PMCID: PMC10822972, DOI: 10.3389/fimmu.2023.1335936.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsChronic kidney diseaseGlomerular filtration barrierProteinuric glomerular diseasesKidney diseaseGlomerular diseaseImmune responseFiltration barrierTherapeutic targetCell-like characteristicsFocal segmental glomerulosclerosisProteinuric kidney diseaseTargets of immune responsesDamage to podocytesLupus nephritisPotential therapeutic targetGlomerular basement membraneImmune injuryGlomerular injuryMembranous nephropathyFenestrated endothelial cellsKidney functionSegmental glomerulosclerosisAdaptive immunityEpithelial cellsPathogenic mechanisms
Academic Achievements and Community Involvement
Links & Media
News
- January 11, 2023
Discoveries & Impact (January 2023)
- November 02, 2022
ASN Kidney Week 2022: Presentations from Yale Nephrology
- February 16, 2022
Discoveries & Impact (February 2022)