Tse-Yu Chen
Postdoctoral AssociateAbout
Titles
Postdoctoral Associate
Education & Training
- PhD
- University of Florida, Entomology (2021)
- MS
- National Yang-Ming University, Biochemistry and Molecular Biology (2012)
- BS
- National Chung-Hsing University, Entomology (2010)
Research
Publications
2024
Zika virus exists in enterocytes and enteroendocrine cells of the Aedes aegypti midgut
Chen T, Raduwan H, Marín-López A, Cui Y, Fikrig E. Zika virus exists in enterocytes and enteroendocrine cells of the Aedes aegypti midgut. IScience 2024, 27: 110353. DOI: 10.1016/j.isci.2024.110353.Peer-Reviewed Original ResearchAedes aegypti midgutEnteroendocrine cellsSingle-cell RNA sequencingIntestinal stem cellsVirus infectionPathogen interactionsExpressed genesRNA sequencingCopy numberTranscriptomic changesFunctional studiesInfected cellsZika virus infectionEnteroendocrineBlood digestionRNA copy numberCellular levelCell processesGenesMidgutPotential targetCell clustersCellsEnterocytesViral infection
2023
Immune-related transcripts, microbiota and vector competence differ in dengue-2 virus-infected geographically distinct Aedes aegypti populations
Chen T, Bozic J, Mathias D, Smartt C. Immune-related transcripts, microbiota and vector competence differ in dengue-2 virus-infected geographically distinct Aedes aegypti populations. Parasites & Vectors 2023, 16: 166. PMID: 37208697, PMCID: PMC10199558, DOI: 10.1186/s13071-023-05784-3.Peer-Reviewed Original ResearchConceptsRefractory populationVector competenceMosquito interactionsDengue virus serotype 2Immune-related transcriptsVirus serotype 2Presence of microbiotaDengue 2Aegypti populationsDistinct AeSerotype 2Susceptible populationExpression levelsCompetence studiesBlood mealMicrobiotaConclusionsThe resultsPresent studyPotential factorsVirusGene involvementPopulationAedes aegypti populationsAedes aegyptiInvolvementMosquito Salivary Proteins and Arbovirus Infection: From Viral Enhancers to Potential Targets for Vaccines
Marín-López A, Raduwan H, Chen T, Utrilla-Trigo S, Wolfhard D, Fikrig E. Mosquito Salivary Proteins and Arbovirus Infection: From Viral Enhancers to Potential Targets for Vaccines. Pathogens 2023, 12: 371. PMID: 36986293, PMCID: PMC10054260, DOI: 10.3390/pathogens12030371.Peer-Reviewed Original ResearchMosquito salivary proteinsImmune responseImportant public health challengeAdaptive immune responsesHost immune responsePublic health challengeNon-endemic areasSalivary proteinsSerious complicationsLicensed vaccineNeurological alterationsMosquito salivaClinical signsMosquito bitesHemorrhagic feverInfection outcomesRapid onsetArbovirus infectionExplosive outbreaksHealth challengesVaccineDifferent arbovirusesArboviral diseasesArthropod salivaPotential target
2022
TWO NOVEL SINGLE NUCLEOTIDE POLYMORPHISMS IN THE VOLTAGE-GATED SODIUM CHANNEL GENE IDENTIFIED IN AEDES AEGYPTI MOSQUITOES FROM FLORIDA
Kosinski K, Lee Y, Romero-Weaver A, Chen T, Collier T, Wang X, Mathias D, Buckner E. TWO NOVEL SINGLE NUCLEOTIDE POLYMORPHISMS IN THE VOLTAGE-GATED SODIUM CHANNEL GENE IDENTIFIED IN AEDES AEGYPTI MOSQUITOES FROM FLORIDA. Journal Of The Florida Mosquito Control Association 2022, 69 DOI: 10.32473/jfmca.v69i1.130622.Peer-Reviewed Original ResearchSingle nucleotide polymorphismsVoltage-gated sodium channelsYellow fever virusTime of survivalNucleotide polymorphismsAegypti individualsResistance genesVoltage-gated sodium channel geneInsecticide resistance genesSodium channelsFever virusNovel nonsynonymous single nucleotide polymorphismsNonsynonymous single nucleotide polymorphismsNovel single nucleotide polymorphismsFurther studiesKnockdown resistance (kdr) geneSodium channel geneResistant phenotypeWhole-genome sequencing
2021
Activation of the autophagy pathway decreases dengue virus infection in Aedes aegypti cells
Chen T, Smartt C. Activation of the autophagy pathway decreases dengue virus infection in Aedes aegypti cells. Parasites & Vectors 2021, 14: 551. PMID: 34702321, PMCID: PMC8549150, DOI: 10.1186/s13071-021-05066-w.Peer-Reviewed Original ResearchConceptsAag-2 cellsDengue virusImmune responseAntiviral mechanismAutophagy pathwayMicrotubule-associated protein light chainDengue virus infectionRapamycin treatmentMosquito immune responsePossible antiviral mechanismPotential antiviral targetsProtein light chainAedes aegypti cellsMosquito vector Aedes aegyptiDENV diseaseDENV titersDENV infectionVirus infectionAntiviral targetConclusionsOur studyVirus replicationVirus titersMosquito physiologyInfectionProtein 1Profiling Transcriptional Response of Dengue-2 Virus Infection in Midgut Tissue of Aedes aegypti
Chen T, Lee Y, Wang X, Mathias D, Caragata E, Smartt C. Profiling Transcriptional Response of Dengue-2 Virus Infection in Midgut Tissue of Aedes aegypti. Frontiers In Tropical Diseases 2021, 2: 708817. DOI: 10.3389/fitd.2021.708817.Peer-Reviewed Original ResearchDengue-2 virus infectionVirus infectionImmune responseAntiviral responseMosquito antiviral responseVirus-infected groupMosquito immune responsePaucity of dataDengue control strategiesExpression levelsReplication stageGene expression levelsInfectionTarget pathwaysCurrent literatureInhibition experimentsOxidative stress responseMidgut tissueAedes aegyptiTissueGene expression patternsExpression patternsFurther researchResponseCandidate genesMosquito Control Priorities in Florida—Survey Results from Florida Mosquito Control Districts
Kondapaneni R, Malcolm A, Vazquez B, Zeng E, Chen T, Kosinski K, Romero-Weaver A, Giordano B, Allen B, Riles M, Killingsworth D, Campbell L, Caragata E, Lee Y. Mosquito Control Priorities in Florida—Survey Results from Florida Mosquito Control Districts. Pathogens 2021, 10: 947. PMID: 34451411, PMCID: PMC8401384, DOI: 10.3390/pathogens10080947.Peer-Reviewed Original ResearchEvidence of Local Extinction and Reintroduction of Aedes aegypti in Exeter, California
Kelly E, Mack L, Campos M, Grippin C, Chen T, Romero-Weaver A, Kosinski K, Brisco K, Collier T, Buckner E, Campbell L, Cornel A, Lanzaro G, Rosario-Cruz R, Smith K, Attardo G, Lee Y. Evidence of Local Extinction and Reintroduction of Aedes aegypti in Exeter, California. Frontiers In Tropical Diseases 2021, 2: 703873. DOI: 10.3389/fitd.2021.703873.Peer-Reviewed Original ResearchThe Population Genomics of Anopheles gambiae Species Complex: Progress and Prospects
Schmidt H, Kirstein O, Chen T, Campbell L, Collier T, Lee Y. The Population Genomics of Anopheles gambiae Species Complex: Progress and Prospects. Population Genomics 2021, 1-21. DOI: 10.1007/13836_2021_92.Peer-Reviewed Original ResearchPopulation genomicsSpecies groupsAnopheles gambiae species complexInsecticide resistanceIslands of speciationDiverged populationsAdaptive introgressionAsymmetric introgressionGenomic resourcesGenomic divergenceSpecies hybridizationGenomic toolsSpecies complexNatural populationsPrincipal malaria vectorGenomic databasesPopulation originGambiae sensu strictoVector biologySensu strictoSensu latoAnopheles gambiae sensu latoGambiae sensu latoGambiaeRapid evolutionThe Population Genomics of Aedes aegypti: Progress and Prospects
Lee Y, Saavedra-Rodriguez K, Chen T, Campbell L, Smartt C. The Population Genomics of Aedes aegypti: Progress and Prospects. Population Genomics 2021, 1-19. DOI: 10.1007/13836_2021_93.Peer-Reviewed Original ResearchPopulation genomicsLarge genome sizePopulation genomic dataPopulation genomic studiesSequence-based studiesCost of sequencingAedes aegyptiGenome sizeGenomic approachesReference assemblyGenomic studiesPopulation structureGenomic dataGenetic controlAnopheles gambiaeExome captureField populationsInsecticide resistancePopulation sizeMosquito control methodsGenomic markersAdditional collectionsGenomicsAegyptiRecent advances