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Petr Protiva, MD, MPH

Associate Professor of Medicine (Digestive Diseases)
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Additional Titles

Adjunct Faculty at Breslow Lab, Rockefeller University, New York, NY

Contact Info

Yale School of Medicine

Department of Medicine (Digestive Diseases), PO Box 208019

New Haven, CT 06520-8019

United States

About

Titles

Associate Professor of Medicine (Digestive Diseases)

Adjunct Faculty at Breslow Lab, Rockefeller University, New York, NY

Biography

Dr Protiva is a clinician scientist with focus on colon cancer biology, screening and prevention. Main goal of his research is to identify the biological pathways and interventions that modulate the risk of cancer with special focus on colon cancer and nutrition. His laboratory focuses on cancer prevention and investigates the molecular events underlying preventive interventions using translational approach in a highly controlled settings. His group elucidated molecular events underlying the effects of estrogen, folic acid, vitamin D, calcium and Western style diet in human colorectal tissue.

Dr Protiva’s additional cancer research project involve clinical research. He serves as a local site investigator for the largest interventional VA study – CSP#577 – investigating the effect of colonoscopy vs FIT on mortality from colon cancer (50,000 subjects randomized).

In addition, Dr Protiva conducts epidemiology research using healthcare databases, exploring large patient datasets and generating hypotheses for future cancer research.

Other focus of his laboratory is the analysis and systems approach to basic and translational research questions using genome wide gene expression analysis. He collaborates with other researchers that show overlap with his interest in colon cancer biology or interpretation of large-scale gene expression data.

He serves as an Associate Editor for the BMJ Open Gastroenterology where he manages manuscripts related to luminal GI research.

Appointments

Other Departments & Organizations

Education & Training

MPH
Yale University, Applied Biostatistics and Epidemiology (2017)
Research Associate
Rockefeller University, New York, NY (2006)
MD
Charles University (1993)
BA
Masaryk University (1987)

Board Certifications

  • Gastroenterology

    Certification Organization
    AB of Internal Medicine
    Latest Certification Date
    2023
    Original Certification Date
    2003

Research

Overview

Colonoscopy Versus Fecal Immunochemical Test in Reducing Mortality From Colorectal Cancer (CONFIRM)

This is a VA Multisite Study. The purpose of this study is to compare two types of colon cancer screening tests and determine which is more effective in preventing death from colon and rectal cancer. These tests have not been compared in a large study and it is not clear which test is more effective Role: Site Principal Investigator/Local Site Investigator

Effect of Dietary Folate Supplementation and Depletion on Human Colonic Mucosa

Adequate folate status is important for optimal one carbon metabolic processes including the synthesis and methylation of DNA and genomic stability. This may impact the risk of cancer. The purpose of this study was to examine the effect of folate depletion-repletion and supplementation on gene expression and genomic stability in human colorectal mucosa. Multiple additional biomarkers were measured.

Calcium and 1,25-dihydroxyvitamin D3 modulate genes of immune and inflammatory pathways in the human colon: a human crossover trial

Inadequate calcium and vitamin D levels/intake are implicated in colorectal carcinogenesis. The purpose of this study was to examine the effect of Western style diet +/- calcium and/or vitamin D on gene expression in human colorectal mucosa.

Medical Subject Headings (MeSH)

Colorectal Neoplasms; Endpoint Determination; Molecular Epidemiology; Nontherapeutic Human Experimentation; Therapeutic Human Experimentation

Research at a Glance

Yale Co-Authors

Frequent collaborators of Petr Protiva's published research.

Publications

2024

2023

Academic Achievements & Community Involvement

  • activity

    AGA

Get In Touch

Contacts

Mailing Address

Yale School of Medicine

Department of Medicine (Digestive Diseases), PO Box 208019

New Haven, CT 06520-8019

United States

Administrative Support