About
Titles
Hospital Resident
Biography
I'm Marc, a PGY-1 in internal medicine who ultimately will be training in Heme/Onc as a part of the phsyician-scientist program. Originally an organic chemist in undergrad, I transitioned into cancer cell biology for my PhD. In Neil Ganem's lab we discovered that loss of the Hippo Pathway potently potentiates melanocyte transformation into melanoma even in the absence of oncogenic BRAF signaling as well as what miRNA permit whole-genome doubled cancer cells to escape arrest. Along the way I was fortunate enough to help out with multiple projects ranging from finding new kinases that mediate Hippo pathway signaling (Sanghee Lim's work), what controls cell fate following mitotic slippage (Amanda Bolgioni's work), and finding ways to selectively target whole-genome doubled cancer cells (Ryan Quinton's work).
Education & Training
- MD/PhD
- Boston University Chobanian & Avedisian School of Medicine (2023)
- BA
- New York University, Biochemistry (2014)
Research
Research at a Glance
Publications Timeline
A big-picture view of Marc Vittoria's research output by year.
8Publications
322Citations
Publications
Featured Publications
Inactivation of the Hippo tumor suppressor pathway promotes melanoma
Vittoria M, Kingston N, Kotynkova K, Xia E, Hong R, Huang L, McDonald S, Tilston-Lunel A, Darp R, Campbell J, Lang D, Xu X, Ceol C, Varelas X, Ganem N. Inactivation of the Hippo tumor suppressor pathway promotes melanoma. Nature Communications 2022, 13: 3732. PMID: 35768444, PMCID: PMC9243107, DOI: 10.1038/s41467-022-31399-w.Peer-Reviewed Original ResearchCitationsAltmetricA genome-wide microRNA screen identifies regulators of tetraploid cell proliferation
Vittoria M, Shenk E, O’Rourke K, Bolgioni A, Lim S, Kacprzak V, Quinton R, Ganem N. A genome-wide microRNA screen identifies regulators of tetraploid cell proliferation. Molecular Biology Of The Cell 2018, 29: 1682-1692. PMID: 29791254, PMCID: PMC6080710, DOI: 10.1091/mbc.e18-02-0141.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsTetraploid cellsGenome-wide screenRecent genomic studiesTumor suppressor pathwayP53 tumor suppressor pathwayProliferative capacityP53/p21 pathwayGenomic studiesHippo pathwayCell divisionMicroRNA screenGenetic routesSuppressor pathwaySingle miRNATumor suppressor gene NF2Nontransformed cellsHuman cancersP21 pathwayCell proliferationTumor developmentGene NF2PathwayMiRNAComprehensive gainProliferation
2023
Whole-genome doubling in tissues and tumors
Vittoria M, Quinton R, Ganem N. Whole-genome doubling in tissues and tumors. Trends In Genetics 2023, 39: 954-967. PMID: 37714734, PMCID: PMC10840902, DOI: 10.1016/j.tig.2023.08.004.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCell divisionTetraploid cellsSpecific cellular functionsSomatic human cellsWhole-genome doubling eventsWhole-genome doublingSuccessive cell divisionsCellular functionsGenomic stateTetraploid stateCell transitionWGDHuman cellsChromosomal contentTherapeutic avenuesCellsDivisionGeneticsPhysiology
2022
Oncogenic BRAF induces whole-genome doubling through suppression of cytokinesis
Darp R, Vittoria M, Ganem N, Ceol C. Oncogenic BRAF induces whole-genome doubling through suppression of cytokinesis. Nature Communications 2022, 13: 4109. PMID: 35840569, PMCID: PMC9287415, DOI: 10.1038/s41467-022-31899-9.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsWhole-genome doubling eventsWhole-genome doublingSuppression of cytokinesisOncogenic BRAFZebrafish melanoma modelLocalization of RhoAG1/S phaseG1/SMAPK pathway activityCytokinesis regulatorsInhibition of RhoACytokinesis failureGenomic configurationNascent tumor cellsCentriole amplificationDiploid cellsCell cycleCytokinesisSuch karyotypesS phaseTetraploid cellsNear-tetraploid karyotypePathway activityChromosomal gainsRhoA
2021
Whole-genome doubling confers unique genetic vulnerabilities on tumour cells
Quinton R, DiDomizio A, Vittoria M, Kotýnková K, Ticas C, Patel S, Koga Y, Vakhshoorzadeh J, Hermance N, Kuroda T, Parulekar N, Taylor A, Manning A, Campbell J, Ganem N. Whole-genome doubling confers unique genetic vulnerabilities on tumour cells. Nature 2021, 590: 492-497. PMID: 33505027, PMCID: PMC7889737, DOI: 10.1038/s41586-020-03133-3.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsWhole-genome doublingUnstable tetraploid cellsAccurate chromosome segregationDNA replication factorsSpindle assembly checkpointPrimary human cancer samplesHuman cancer samplesEssentiality dataChromosome segregationUnique genetic vulnerabilitiesTetraploid stateKinesin proteinsProteasome functionMitotic errorsGenetic traitsTetraploid cellsHuman cancersCancer cell linesCancer cellsCell linesKIF18ACell viabilityCancer samplesHuman tissuesCells
2019
Identification of the kinase STK25 as an upstream activator of LATS signaling
Lim S, Hermance N, Mudianto T, Mustaly H, Mauricio I, Vittoria M, Quinton R, Howell B, Cornils H, Manning A, Ganem N. Identification of the kinase STK25 as an upstream activator of LATS signaling. Nature Communications 2019, 10: 1547. PMID: 30948712, PMCID: PMC6449379, DOI: 10.1038/s41467-019-09597-w.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsHippo signalingHippo pathwayHippo tumor suppressor pathwayTranscriptional co-activator YAPActivation loop phosphorylationCo-activator YAPCore pathway componentsYAP/TAZ activationTumor suppressor pathwayKey unresolved questionLoop phosphorylationHippo activationPhosphorylation eventsHydrophobic motifTissue homeostasisTAZ activationUpstream activatorKinase activatorPathway componentsSuppressor pathwaySTK25Human cancersFunctional inactivationCellular proliferationSignaling
2018
Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel.
Bolgioni A, Vittoria M, Ganem N. Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel. Journal Of Visualized Experiments 2018 PMID: 29806834, PMCID: PMC6101178, DOI: 10.3791/57383.Peer-Reviewed Original ResearchCitationsAltmetric
2015
Aldehyde Capture Ligation for Synthesis of Native Peptide Bonds
Raj M, Wu H, Blosser S, Vittoria M, Arora P. Aldehyde Capture Ligation for Synthesis of Native Peptide Bonds. Journal Of The American Chemical Society 2015, 137: 6932-6940. PMID: 25966041, DOI: 10.1021/jacs.5b03538.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsBond formationAmide bond formationNative peptide bondChemoselective reactivityChemoselective reactionAmine terminusIntramolecular reactionSynthetic proteinsPeptide bondReactionAmino acid residuesBioconjugatesFormationAcid residuesAldehydesCarboxylBondsAminesSynthesisReactivityFragmentsPeptidesResidues