Ilias Nikolakopoulos, MD
About
Titles
Hospital Resident
Biography
Ilias is a resident at the Internal Medicine Program at Yale. Prior to residency, he was a research fellow at the Minneapolis Heart Institute Center for Coronary Artery and worked on multicenter registries and randomized controlled trials on topics spanning complex high-risk indicated cardiac procedures, myocardial infarction, and stress cardiomyopathy. Several of his projects used imaging to guide procedures, and that is what made him interested in cardiac imaging as well. During this time, he also grew an interest in methodology and data analysis, incorporating methods such as Bayesian statistics into his projects.
During residency, he continues to work on noninvasive imaging for cardiac risk stratification and risk stratification before percutaneous coronary interventions. He continues to expand on his interests in observational data analysis, currently focusing on machine learning clustering models as well as the assessment of the predictive ability of time-to-event models. He also gained experience in the regulatory side of research, serving at the Yale IRB. Ilias is interested in applying methods for observational causal inference and prediction to data derived from EHR and noninvasive cardiac imaging with the goal of personalizing the diagnosis and treatment of coronary artery disease.
His work has been published in several peer-reviewed journals, including Circulation, JACC Cardiovascular Interventions, Circulation Cardiovascular Interventions, Catheterization and Cardiovascular Interventions, International Journal of Cardiology, American Journal of Cardiology, Eurointervention.
Education & Training
- Research Fellow/Scholar
- Minneapolis Heart Institute Foundation (2021)
- Stavros Niarchos Foundation RTP-CEM Clinical and Research Scholar
- Feinstein Institute for Medical Research, Zucker School of Medicine, Hofstra/Northwell (2018)
- MD
- National and Kapodistrian University of Athens (2017)
Research
Overview
Medical Subject Headings (MeSH)
ORCID
0000-0002-7408-8653
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Evangelia (Evi) Vemmou, MD
Brian Cambi, MD, FACC, FSCAI
Michael Nanna, MD, MHS, FSCAI, FACC
Sukrit Narula, MD
Coronary Artery Disease
Publications
2024
Temporal change in PET myocardial flow reserve is predictive of cardiovascular outcomes
Nikolakopoulos I, Liu Y, Sinusas A, Miller E, Feher A. Temporal change in PET myocardial flow reserve is predictive of cardiovascular outcomes. European Heart Journal - Cardiovascular Imaging 2024, 25: jeae142.099. DOI: 10.1093/ehjci/jeae142.099.Peer-Reviewed Original ResearchConceptsPositron emission tomographyMyocardial flow reserveCoronary artery diseaseCardiovascular outcomesArtery diseaseFlow reserveEvaluation of coronary artery diseaseHistory of heart transplantationMedian interval timeKaplan-Meier methodPredictive of cardiovascular outcomesLong-term outcomesPerioperative risk stratificationCoronary bloodChest painHeart transplantationRisk stratificationSerial examsCox regressionMyocardial infarctionInterquartile rangeC-statisticEmission tomographyPatientsContinuous variables
2023
Protean Electrocardiographic Patterns of ST-Segment Elevation in Patients With Takotsubo Syndrome
Xenogiannis I, Nikolakopoulos I, Vemmou E, Brilakis E, Herman R, Sharkey S. Protean Electrocardiographic Patterns of ST-Segment Elevation in Patients With Takotsubo Syndrome. The American Journal Of Cardiology 2023, 206: 292-294. PMID: 37722226, DOI: 10.1016/j.amjcard.2023.08.149.Peer-Reviewed Original ResearchContemporary In-Hospital Outcomes of Chronic Total Occlusion Percutaneous Coronary Interventions: Insights from the MENATA (Middle East, North Africa, Turkey, and Asia) Chapter of the PROGRESS-CTO Registry
Gorgulu S, Kostantinis S, ElGuindy A, Abi Rafeh N, Simsek B, Rempakos A, Karacsonyi J, Kalay N, Samir A, Jaoudeh F, Maalouf A, Soylu K, Yildirim U, Tigen M, Cincin A, Kalyanasundaram A, Aygul N, Altunkeser B, El Sayed A, Sadek Y, Shelton C, Jbara K, Vemmou E, Nikolakopoulos I, Mastrodemos O, Rangan B, Allana S, Sandoval Y, Burke M, Brilakis E, Goktekin O. Contemporary In-Hospital Outcomes of Chronic Total Occlusion Percutaneous Coronary Interventions: Insights from the MENATA (Middle East, North Africa, Turkey, and Asia) Chapter of the PROGRESS-CTO Registry. The American Journal Of Cardiology 2023, 206: 221-229. PMID: 37717475, DOI: 10.1016/j.amjcard.2023.08.103.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPercutaneous coronary interventionChronic total occlusion (CTO) percutaneous coronary interventionCoronary interventionConsecutive CTO percutaneous coronary interventionsHospital major adverse cardiac eventsAir kerma radiation dosePrevious percutaneous coronary interventionMajor adverse cardiac eventsCTO percutaneous coronary interventionCommon target vesselJapanese CTO scoreMedian contrast volumePROGRESS-CTO RegistryAdverse cardiac eventsIn-Hospital OutcomesAcceptable complication rateProcedural success ratePrevalence of diabetesRight coronary arteryIncidence of perforationPROGRESS CTO scoresAntegrade wire escalationAngiographic characteristicsCardiac eventsExperienced centersUnderstanding the Facets of Emulating Randomized Clinical Trials
Narula S, Nikolakopoulos I. Understanding the Facets of Emulating Randomized Clinical Trials. JAMA 2023, 330: 769-770. PMID: 37606679, DOI: 10.1001/jama.2023.11532.Peer-Reviewed Original ResearchAltmetricMeSH KeywordsCONTEMPORARY IN-HOSPITAL OUTCOMES OF CHRONIC TOTAL OCCLUSION INTERVENTIONS: UPDATE FROM MENATA (MIDDLE EAST, NORTH AFRICA, TURKEY AND ASIA) CHAPTER OF THE PROGRESS-CTO (PROSPECTIVE GLOBAL REGISTRY FOR THE STUDY OF CHRONIC TOTAL OCCLUSION INTERVENTION) REGISTRY
Kostantinis S, ElGuindy A, Goktekin O, Simsek B, Karacsonyi J, kalay N, Samir A, Maalouf A, soylu K, Yildirim U, Tigen K, cincin A, Kalyanasundaram A, Aygul N, sayed A, Jbara K, Shelton C, Vemmou E, Nikolakopoulos I, Allana S, Mastrodemos O, Rempakos A, Rangan B, Brilakis E, Rafeh N. CONTEMPORARY IN-HOSPITAL OUTCOMES OF CHRONIC TOTAL OCCLUSION INTERVENTIONS: UPDATE FROM MENATA (MIDDLE EAST, NORTH AFRICA, TURKEY AND ASIA) CHAPTER OF THE PROGRESS-CTO (PROSPECTIVE GLOBAL REGISTRY FOR THE STUDY OF CHRONIC TOTAL OCCLUSION INTERVENTION) REGISTRY. Journal Of The American College Of Cardiology 2023, 81: 937. DOI: 10.1016/s0735-1097(23)01381-5.Peer-Reviewed Original ResearchVALIDATION OF THE OPEN-CLEAN CHRONIC TOTAL OCCLUSION PERCUTANEOUS CORONARY INTERVENTION PERFORATION SCORE IN A MULTICENTER REGISTRY
Simsek B, Carlino M, Pan M, Vemmou E, Nikolakopoulos I, Kostantinis S, Karacsonyi J, Agostoni P, Alexandre A, Knaapen P, La Manna A, Spratt J, Tanabe M, Walsh S, Goktekin O, Allana S, Rangan B, Rempakos A, Choi J, Kearney K, Lombardi W, Grantham J, Hirai T, Brilakis E, Azzalini L. VALIDATION OF THE OPEN-CLEAN CHRONIC TOTAL OCCLUSION PERCUTANEOUS CORONARY INTERVENTION PERFORATION SCORE IN A MULTICENTER REGISTRY. Journal Of The American College Of Cardiology 2023, 81: 774. DOI: 10.1016/s0735-1097(23)01218-4.Peer-Reviewed Original ResearchEXTERNAL VALIDATION OF THE PROGRESS-CTO COMPLICATION RISK SCORES: INDIVIDUAL PATIENT DATA POOLED ANALYSIS OF 3 REGISTRIES
Simsek B, Tajti P, Carlino M, Rinfret S, Vemmou E, Kostantinis S, Nikolakopoulos I, Karacsonyi J, Agostoni P, Alaswad K, Megaly M, Avran A, Choi J, Khatri J, Knaapen P, La Manna A, Spratt J, Rangan B, Goktekin O, Kearney K, Lombardi W, Grantham J, Mashayekhi K, Brilakis E, Azzalini L. EXTERNAL VALIDATION OF THE PROGRESS-CTO COMPLICATION RISK SCORES: INDIVIDUAL PATIENT DATA POOLED ANALYSIS OF 3 REGISTRIES. Journal Of The American College Of Cardiology 2023, 81: 777. DOI: 10.1016/s0735-1097(23)01221-4.Peer-Reviewed Original ResearchTRENDS AND IMPACT OF INTRAVASCULAR ULTRASOUND AND OPTICAL COHERENCE TOMOGRAPHY ON PERCUTANEOUS CORONARY INTERVENTION FOR MYOCARDIAL INFARCTION
Vemmou E, Park D, An S, Nikolakopoulos I, Regan C, Cambi B, Frampton J, Vij A, Brilakis E, Nanna M. TRENDS AND IMPACT OF INTRAVASCULAR ULTRASOUND AND OPTICAL COHERENCE TOMOGRAPHY ON PERCUTANEOUS CORONARY INTERVENTION FOR MYOCARDIAL INFARCTION. Journal Of The American College Of Cardiology 2023, 81: 1013. DOI: 10.1016/s0735-1097(23)01457-2.Peer-Reviewed Original ResearchTrends and impact of intravascular ultrasound and optical coherence tomography on percutaneous coronary intervention for myocardial infarction
Park D, Vemmou E, An S, Nikolakopoulos I, Regan C, Cambi B, Frampton J, Vij A, Brilakis E, Nanna M. Trends and impact of intravascular ultrasound and optical coherence tomography on percutaneous coronary intervention for myocardial infarction. IJC Heart & Vasculature 2023, 45: 101186. PMID: 36852085, PMCID: PMC9957744, DOI: 10.1016/j.ijcha.2023.101186.Peer-Reviewed Original ResearchCitationsAltmetricConceptsIntravascular imaging-guided percutaneous coronary interventionImaging-guided percutaneous coronary interventionPercutaneous coronary interventionOptical coherence tomographyMyocardial infarctionIntravascular ultrasoundCoronary interventionIntravascular imagingIVUS-guided percutaneous coronary interventionCoherence tomographyNumber of PCIsNational Inpatient SampleMultivariable logistic regressionCochran-Armitage trend testIVUS useHospital mortalityClinical outcomesOCT guidanceInpatient SampleImproved outcomesLower oddsLower mortalityLogistic regressionContinuous outcomesOutcomesSingle vs. multiple operators for chronic total occlusion percutaneous coronary interventions: From the PROGRESS‐CTO Registry
Karacsonyi J, Alaswad K, Krestyaninov O, Karmpaliotis D, Kirtane A, Ali Z, McEntegart M, Masoumi A, Poomipanit P, Jaffer F, Khatri J, Choi J, Patel M, Koutouzis M, Tsiafoutis I, Gorgulu S, Sheikh A, Elbarouni B, Jaber W, ElGuindy A, Yeh R, Kostantinis S, Simsek B, Rangan B, Mastrodemos O, Vemmou E, Nikolakopoulos I, Ungi I, Rafeh N, Goktekin O, Burke M, Brilakis E, Sandoval Y. Single vs. multiple operators for chronic total occlusion percutaneous coronary interventions: From the PROGRESS‐CTO Registry. Catheterization And Cardiovascular Interventions 2023, 101: 543-552. PMID: 36695421, DOI: 10.1002/ccd.30564.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCTO-PCIChronic total occlusion (CTO) percutaneous coronary interventionAir kerma radiation dosePercutaneous coronary intervention outcomesChronic total occlusion interventionLow MACE ratePROGRESS-CTO RegistryProspective global registryProcedural success ratePercutaneous coronary interventionHigh technical successRisk of complicationsMO casesCTO PCI casesMACE rateCoronary interventionMulticenter registryPatient ageMultivariable analysisProcedural successContrast volumeGlobal RegistryTechnical successProcedural outcomesPCI cases
Academic Achievements and Community Involvement
activity Associate Editor
Journal ServiceBMJ HeartDetails04/05/2024 - Presentactivity Reviewer
Journal ServiceExpert Review of Cardiovascular TherapyDetails2020 - Presentactivity Reviewer
Journal ServiceCirculationDetails2021 - Presentactivity Board Member, Semantic Scholar Advisory Board
Advisory BoardsSemantic ScholarDetails2021 - 2022honor Roy and Diana Vagelos Fellowship
International AwardWorld Hellenic Biomedical AssociationDetails07/21/2017Greece