Hamid Alemi, MD/MPH
Cards
About
Research
Publications
Featured Publications
The Neuropeptide α-Melanocyte–Stimulating Hormone Prevents Persistent Corneal Edema following Injury
Alemi H, Wang S, Blanco T, Kahale F, Singh R, Ortiz G, Musayeva A, Yuksel E, Pang K, Deshpande N, Dohlman T, Jurkunas U, Yin J, Dana R. The Neuropeptide α-Melanocyte–Stimulating Hormone Prevents Persistent Corneal Edema following Injury. American Journal Of Pathology 2023, 194: 150-164. PMID: 37827217, PMCID: PMC10768537, DOI: 10.1016/j.ajpath.2023.09.007.Peer-Reviewed Original ResearchConceptsCorneal edemaEndothelial functionΑ-MSHPersistent corneal edemaCorneal endothelial dysfunctionΑ-Melanocyte-Stimulating HormoneCorneal endothelial cellsNeuropeptide αEndothelial dysfunctionEndothelial decompensationOcular injuriesLeukocyte infiltrationPharmacologic interventionsCorneal transplantationStimulating hormoneMurine modelEndothelial regenerationInjuryCritical windowEndothelial cellsTranscorneal freezingCorneal hydrationRegenerative capacityEdemaCytoprotective functionInsights into mustard gas keratopathy- characterizing corneal layer-specific changes in mice exposed to nitrogen mustard
Alemi H, Dehghani S, Forouzanfar K, Surico P, Narimatsu A, Musayeva A, Sharifi S, Wang S, Dohlman T, Yin J, Chen Y, Dana R. Insights into mustard gas keratopathy- characterizing corneal layer-specific changes in mice exposed to nitrogen mustard. Experimental Eye Research 2023, 236: 109657. PMID: 37722586, DOI: 10.1016/j.exer.2023.109657.Peer-Reviewed Original ResearchConceptsMustard gas keratopathyHigh-dose groupDose groupMouse modelAnterior segment optical coherence tomographyPersistent corneal edemaOcular surface damageLow-dose groupSlit-lamp examinationNitrogen mustardNM exposureSulfur mustardCorneal epithelial erosionVivo confocal microscopyEndothelial cell densityLayer-specific changesOptical coherence tomographyBasal epithelial cellsSubbasal plexusCorneal edemaLamp examinationOcular injuriesEpithelial erosionsFluorescein stainingLimbal corneaPulse pressure and diabetes treatments
Alemi H, Khaloo P, Mansournia M, Rabizadeh S, Salehi S, Mirmiranpour H, Meftah N, Esteghamati A, Nakhjavani M. Pulse pressure and diabetes treatments. Medicine 2018, 97: e9791. PMID: 29419672, PMCID: PMC5944681, DOI: 10.1097/md.0000000000009791.Peer-Reviewed Original ResearchConceptsDiastolic blood pressureSystolic blood pressureType 2 diabetesBody mass indexBlood pressureHigher pulse pressurePulse pressureDiabetes treatmentStudied groupsNon-hypertensive patientsDuration of diabetesRetrospective cohort studyCohort studyDrug regimensMass indexConsecutive visitsDiabetesPatientsInteraction of timeSignificant differencesMetforminTreatmentRegression modelsSignificant changesGroupAssociation of extracellular heat shock protein 70 and insulin resistance in type 2 diabetes; independent of obesity and C-reactive protein
Alemi H, Khaloo P, Rabizadeh S, Mansournia M, Mirmiranpour H, Salehi S, Esteghamati A, Nakhjavani M. Association of extracellular heat shock protein 70 and insulin resistance in type 2 diabetes; independent of obesity and C-reactive protein. Cell Stress And Chaperones 2018, 24: 69-75. PMID: 30255491, PMCID: PMC6363625, DOI: 10.1007/s12192-018-0942-x.Peer-Reviewed Original ResearchConceptsHomeostatic model assessment-insulin resistanceC-reactive proteinHs-CRPType 2 diabetesWaist circumferenceHealthy controlsInsulin resistanceHeat shock protein70Extracellular HSP70High-sensitive C-reactive proteinExtracellular heat shock protein 70Model assessment-insulin resistanceAssessment-insulin resistancePathogenesis of T2DMShock protein70Heat shock protein 70Shock protein 70Central obesityClinical associationsEHSP70T2DMPatientsControl groupSignificant associationObesityDescemet Stripping Only Technique for Corneal Endothelial Damage in Mice
Nakagawa H, Alemi H, Wang S, Kahale F, Blanco T, Liu C, Yin J, Dohlman T, Dana R. Descemet Stripping Only Technique for Corneal Endothelial Damage in Mice. Cornea 2022, 42: 470-475. PMID: 36728991, PMCID: PMC10117527, DOI: 10.1097/ico.0000000000003223.Peer-Reviewed Original ResearchConceptsDescemet strippingCorneal endothelial cellsSurgical techniqueMurine modelDescemet's membraneEndothelial cellsCentral Descemet membraneDay 1 postinjurySignificant ocular complicationsCorneal endothelial damageCentral corneal thicknessCorneal endothelial diseaseBasic science investigationsOcular complicationsPostoperative outcomesWeeks postinjuryEndothelial damagePersistent edemaSlitlamp biomicroscopyCorneal thicknessEndothelial diseaseImmunohistochemical stainingSurgical proceduresZO-1Thickness assessmentAmbulatory blood pressure monitoring and diabetes complications
Najafi MT, Khaloo P, Alemi H, Jaafarinia A, Blaha MJ, Mirbolouk M, Mansournia MA, Afarideh M, Esteghamati S, Nakhjavani M, Esteghamati A. Ambulatory blood pressure monitoring and diabetes complications. Medicine 2018, 97: e12185. PMID: 30235664, PMCID: PMC6160188, DOI: 10.1097/md.0000000000012185.Peer-Reviewed Original ResearchMeSH KeywordsAgedBlood GlucoseBlood PressureBlood Pressure Monitoring, AmbulatoryBody Mass IndexBody Weights and MeasuresCircadian RhythmCross-Sectional StudiesDiabetes Mellitus, Type 2Diabetic NeuropathiesFemaleGlycated HemoglobinHumansHypertensionIranLipidsLogistic ModelsMaleMiddle AgedPhenotypeRisk FactorsTime FactorsConceptsMorning blood pressure surgeAmbulatory blood pressure monitoringBlood pressureBlood pressure monitoringCardiovascular diseaseLipoprotein cholesterolPressure monitoringHigh-density lipoprotein cholesterolLow-density lipoprotein cholesterolMultiple logistic regression modelAmbulatory BP monitoringBlood pressure surgeClinic blood pressureNocturnal blood pressureNocturnal BP dippingBody mass indexCircadian blood pressurePrevalence of daytimeType 2 diabetesCross-sectional associationsLogistic regression modelsDifferent BP phenotypesAntihypertensive therapyClinic hypertensionMacrovascular complications
2024
Effector T Cells Promote Fibrosis in Corneal Transplantation Failure
Wang S, Mittal S, Lee S, Herrera A, Krauthammer M, Elbasiony E, Blanco T, Alemi H, Nakagawa H, Chauhan S, Dana R, Dohlman T. Effector T Cells Promote Fibrosis in Corneal Transplantation Failure. Investigative Ophthalmology & Visual Science 2024, 65: 40. PMID: 38261311, PMCID: PMC10810018, DOI: 10.1167/iovs.65.1.40.Peer-Reviewed Original ResearchConceptsCD4+ T cellsEffector T cellsCD4+CD25- effector T cellsCorneal transplant failureT cellsA-SMA expressionFailed graftsIFN-gCorneal transplantationGraft opacityCorneal fibroblastsTransplant failureReal-time PCREffector CD4+ T cellsIn vivo confocal microscopyExpression of alpha-smooth muscle actinAllogeneic corneal transplantationTransplant recipient miceSlit-lamp biomicroscopyA-SMAAlpha-smooth muscle actinCorneal transplant rejectionExpression of a-SMACo-cultureSigns of fibrosis
2023
The impact of donor diabetes on corneal transplant immunity
Blanco T, Musayeva A, Singh R, Nakagawa H, Lee S, Alemi H, Gonzalez-Nolasco B, Ortiz G, Wang S, Kahale F, Dohlman T, Chen Y, Dana R. The impact of donor diabetes on corneal transplant immunity. American Journal Of Transplantation 2023, 23: 1345-1358. PMID: 37245642, PMCID: PMC10527508, DOI: 10.1016/j.ajt.2023.05.027.Peer-Reviewed Original ResearchConceptsAntigen-presenting cellsFunctional regulatory T cellsRegulatory T cellsDiabetes mellitusGraft survivalT cellsCorneal antigen-presenting cellsType 1 diabetes mellitusHigher suppressive capacityDiabetic murine modelSuccess rateBALB/cDonor diabetesTolerogenic profileImmunopathologic processGraft failureGraft rejectionTransplant immunityAlloreactive cellsDiabetic miceCorneal transplantationSuppressive capacityImmunostimulatory phenotypeInsulin treatmentAPC migrationEight Weeks of Vitamin C Supplementation Restores the Lost Correlation between Serum Leptin and C-reactive Protein (CRP) in Patients with Type 2 Diabetes; A Randomized, Double-blind, Parallel-group, Placebo-controlled Clinical Trial
Mohammadi A, Rabizadeh S, Mirmoosavi S, Alemi H, Mirmiranpoor H, Bagheri S, Moradi K, Esteghamati A, Nakhjavani M. Eight Weeks of Vitamin C Supplementation Restores the Lost Correlation between Serum Leptin and C-reactive Protein (CRP) in Patients with Type 2 Diabetes; A Randomized, Double-blind, Parallel-group, Placebo-controlled Clinical Trial. Current Pharmaceutical Design 2023, 29: 3497-3503. PMID: 37612864, DOI: 10.2174/1381612829666230823091226.Peer-Reviewed Original ResearchType 2 diabetes mellitusC-reactive proteinVitamin C groupType 2 diabetesDiabetes mellitusLeptin levelsPlacebo groupBlood pressureC groupVitamin CPlacebo-controlled clinical trialSerum C-reactive proteinSerum leptin levelsVitamin C supplementationDiabetic medicationsBaseline characteristicsC-reactiveSerum leptinSerum levelsC supplementationPlasma glucoseClinical trialsPatientsLeptinTriglycerides
2022
A Novel Murine Model of Endothelial Keratoplasty
Nakagawa H, Blanco T, Kahale F, Wang S, Musayeva A, Alemi H, Dohlman T, Dana R. A Novel Murine Model of Endothelial Keratoplasty. Cornea 2022, 42: 224-231. PMID: 36582035, PMCID: PMC9805546, DOI: 10.1097/ico.0000000000003047.Peer-Reviewed Original ResearchConceptsNovel murine modelEndothelial keratoplastyMurine modelRecipient corneaBALB/c recipient miceCentral corneal thicknessC57BL/6 donorsGraft survivalDonor graftsCorneal edemaSlitlamp microscopyAnterior chamberRecipient miceDonor endotheliumCorneal thicknessCentral endotheliumGraft adherenceDay 1Endothelial cell morphologyGraft orientationDescemet's membraneKeratoplastyGraftCorneaHistology