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Evangelos K. Oikonomou, MD, DPhil

Clinical Fellow; Cardiovascular Medicine, Yale School of Medicine

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Evangelos K. Oikonomou, MD, DPhil


Evangelos (Evan) Oikonomou is a clinical fellow in cardiovascular medicine, a post-doctoral research fellow in the Cardiovascular Data Science (CarDS) lab, and a member of the ABIM Physician-Scientist Research Pathway at Yale. His work focuses on the intersection of applied computer vision and statistical machine learning, with a specific focus on developing tools for the improved phenotyping of cardiovascular disease using scalable approaches that can be deployed at minimal cost using existing care pathways. He graduated as valedictorian of his class from the University of Athens Medical School in Greece, before pursuing a Ph.D. (D.Phil.) degree at the University of Oxford, where he was recognized with the Radcliffe Department of Medicine Graduate Prize for his scientific work. In 2019 he joined the Physician-Scientist Training Program at the Yale School of Medicine, and he has since completed his internal medicine residency and his core clinical fellowship in cardiology.

He is a recipient of an F32 NRSA fellowship award from NHLBI (National Institutes of Health), and his work has been recognized through numerous Young Investigator Awards sponsored by the American Heart Association, American College of Cardiology, Northwestern Cardiovascular Young Investigator Forum, the European Society of Cardiology and European Association of Preventive Cardiology.

He has led a broad portfolio in applied artificial intelligence in cardiovascular and cardiometabolic medicine. First, he has defined and translated a key interplay between the perivascular adipose tissue and vascular inflammation in humans into a clinically actionable algorithmic tool that can refine cardiovascular risk on routine cardiac CT scans. Second, he has developed and validated deep learning algorithms for the efficient diagnosis of common and rare cardiomyopathies specifically adapted for point-of-care echocardiography. Finally, he has led an extensive body of work on defining treatment effect heterogeneity across clinical trials, with direct implications for evidence translation and the design of new adaptive trials with data-driven predictive enrichment.

His work has been published in several peer-reviewed journals, including the Lancet, Lancet Digital Health, European Heart Journal, JACC, Circulation, JAMA Cardiology, Diabetes Care.

Education & Training

  • Clinical fellow
    Yale School of Medicine (2023)
  • Resident
    Yale School of Medicine (2021)
  • Intern
    Yale School of Medicine (2020)
  • DPhil
    University of Oxford (2019)
  • MD
    University of Athens School of Health Sciences (2015)


  • Board Certification
    ABIM, Internal Medicine (2022)

Honors & Recognition

AwardAwarding OrganizationDate
Heart Tank For the Cardiovascular Investigator - Imaging (Winner)American College of Cardiology (ACC)2024
Trainee Poster Award WinnerCERSI Summit 20242024
Elizabeth Barrett-Connor Research Award in Epidemiology and Prevention (Winner)American Heart Association2023
Ruth L. Kirschstein Postdoctoral Individual National Research Service Award (F32)National Heart, Lung, and Blood Institute (NIH)2023
Yale/Mayo CERSI scholar 2022-2023Yale University & Mayo Clinic Center for Excellence in Regulatory Science and Innovation (CERSI)2022
Council on Lifestyle and Cardiometabolic Health Early Career Investigator AwardAmerican Heart Association2021
First Place Award (Clinical Fellows)Northwestern Cardiovascular Young Investigators' Forum2021
Young Investigator Award in Population Science (Winner)European Association of Preventive Cardiology2021
Young Investigator Award in Clinical Science (Winner)European Society of Cardiology Congress 20192019
Radcliffe Department of Medicine Graduate PrizeUniversity of Oxford2018
Young Investigator Award in Clinical Science (Winner)European Society of Cardiology Congress 20182018
Paul Dudley White international ScholarAmerican Heart Association2017
Toshiba Young Investigator Award (Winner)Society of Cardiovascular Computed Tomography2017
Class ValedictorianUniversity of Athens2015

Professional Service

JAMAReviewer2023 - Present
European Heart JournalReviewer2020 - Present
CirculationReviewer2020 - Present
JACC: Cardiovascular ImagingReviewer2020 - Present
JACC: Journal of the American College of CardiologyReviewer2020 - Present
Cardiovascular ResearchReviewer2018 - Present
American Journal of CardiologyReviewer2017 - Present

Departments & Organizations