2022
Pharmacokinetics and Tolerability of Intraperitoneal Chloroprocaine After Fetal Extraction in Women Undergoing Cesarean Delivery
Togioka BM, Zarnegarnia Y, Bleyle LA, Koop D, Brookfield K, Yanez ND, Treggiari MM. Pharmacokinetics and Tolerability of Intraperitoneal Chloroprocaine After Fetal Extraction in Women Undergoing Cesarean Delivery. Anesthesia & Analgesia 2022, 135: 777-786. PMID: 35544759, DOI: 10.1213/ane.0000000000006064.Peer-Reviewed Original ResearchConceptsLocal anesthetic systemic toxicityPeak plasma concentrationCesarean deliveryPlasma concentrationsSystemic toxicityIntraperitoneal administrationFetal extractionMultiple-dose escalation studyPatient drug exposureMaternal blood samplesMaximum plasma concentrationRoute of administrationYears of ageClinical tolerabilityEscalation studySpinal anesthesiaUterine closureNeuraxial anesthesiaClinical symptomsDrug exposureClinical signsWomen 18Prospective assessmentBlood samplesPharmacokinetic profile
2020
Extragonadal Yolk Sac Tumor Limited to the Myometrium: Report of a Case With Potential Fertility Preservation and Molecular Analysis Suggesting Germ Cell Origin
Simpson S, Simoni M, Hui P, Taylor H, Buza N. Extragonadal Yolk Sac Tumor Limited to the Myometrium: Report of a Case With Potential Fertility Preservation and Molecular Analysis Suggesting Germ Cell Origin. International Journal Of Gynecological Pathology 2020, 39: 247-253. PMID: 31033797, DOI: 10.1097/pgp.0000000000000601.Peer-Reviewed Original ResearchConceptsYolk sac tumorExtragonadal yolk sac tumorGerm cell originFuture fertilityIntraoperative frozen section evaluationCell originPatient's strong desirePostpubertal female patientsEvidence of diseaseFrozen section evaluationMarked nuclear atypiaClear treatment algorithmRare malignant neoplasmHigh-grade malignancyEosinophilic hyaline globulesNext-generation sequencing resultsAdjuvant chemotherapySurgical stagingAbdominal myomectomyNulligravid womenIrregular bleedingUterine closureWedge resectionYounger patientsFemale patients
2018
The Effect of Adding Subarachnoid Epinephrine to Hyperbaric Bupivacaine and Morphine for Repeat Cesarean Delivery
Katz D, Hamburger J, Gutman D, Wang R, Lin H, Marotta M, Zahn J, Beilin Y. The Effect of Adding Subarachnoid Epinephrine to Hyperbaric Bupivacaine and Morphine for Repeat Cesarean Delivery. Anesthesia & Analgesia 2018, 127: 171-178. PMID: 29077615, DOI: 10.1213/ane.0000000000002542.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalgesia, ObstetricalAnalgesics, OpioidAnesthesia, ObstetricalAnesthesia, SpinalAnesthetics, LocalBupivacaineCesarean Section, RepeatDouble-Blind MethodEpinephrineFemaleHumansLabor PainMorphineMotor ActivityNerve BlockNew York CityPain MeasurementPain ThresholdPain, PostoperativePregnancyProspective StudiesRecovery of FunctionSubarachnoid SpaceTime FactorsTreatment OutcomeConceptsCesarean deliveryHyperbaric bupivacaineHD groupSpinal anesthesiaNE groupRepeat cesarean deliveryMedian differencePreservative-free morphineSixty-five patientsIncidence of hypotensionModified Bromage scaleBlock onset timeDuration of actionVital sign changesRandomized Controlled TrialsUterine closurePostoperative regressionDouble-blindEpidural catheterPain scoresProlonged surgeryDermatome levelPinprick sensationSensory blockadeBromage scale
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