2021
A Review of Post-treatment Lyme Disease Syndrome and Chronic Lyme Disease for the Practicing Immunologist
Wong KH, Shapiro ED, Soffer GK. A Review of Post-treatment Lyme Disease Syndrome and Chronic Lyme Disease for the Practicing Immunologist. Clinical Reviews In Allergy & Immunology 2021, 62: 264-271. PMID: 34687445, DOI: 10.1007/s12016-021-08906-w.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPost-treatment Lyme disease syndromeChronic Lyme diseaseNon-specific symptomsLyme diseaseDisease syndromeBurgdorferi infectionCurrent Lyme diseaseUse of IVIGIntravenous immunoglobulin treatmentCompletion of therapyMajority of patientsMinority of patientsConstellation of symptomsBorrelia burgdorferi infectionB. burgdorferi infectionBorrelia burgdorferi sensu latoImmunoglobulin treatmentImmune dysregulationAntibiotic therapyMusculoskeletal painBurgdorferi sensu latoCognitive dysfunctionImmune systemInfected IxodesPatients
2020
A human secretome library screen reveals a role for Peptidoglycan Recognition Protein 1 in Lyme borreliosis
Gupta A, Arora G, Rosen CE, Kloos Z, Cao Y, Cerny J, Sajid A, Hoornstra D, Golovchenko M, Rudenko N, Munderloh U, Hovius JW, Booth CJ, Jacobs-Wagner C, Palm NW, Ring AM, Fikrig E. A human secretome library screen reveals a role for Peptidoglycan Recognition Protein 1 in Lyme borreliosis. PLOS Pathogens 2020, 16: e1009030. PMID: 33175909, PMCID: PMC7657531, DOI: 10.1371/journal.ppat.1009030.Peer-Reviewed Original ResearchConceptsPeptidoglycan recognition protein 1B. burgdorferi infectionB. burgdorferiBurgdorferi infectionHost responseLow serum IgG levelsCommon vector-borne illnessDiverse host responsesSerum IgG levelsProtein 1Vector-borne illnessImmune dysregulationIgG levelsBorreliacidal activityBurgdorferi sensu latoHuman extracellular proteinsSpirochete burdenTick biteB. burgdorferi sensu latoSpirochete Borrelia burgdorferiNervous systemLyme borreliosisLyme diseaseInfectionBorrelia burgdorferi
2019
Protective Immunity and New Vaccines for Lyme Disease
Gomes-Solecki M, Arnaboldi PM, Backenson PB, Benach JL, Cooper CL, Dattwyler RJ, Diuk-Wasser M, Fikrig E, Hovius JW, Laegreid W, Lundberg U, Marconi RT, Marques AR, Molloy P, Narasimhan S, Pal U, Pedra JHF, Plotkin S, Rock DL, Rosa P, Telford SR, Tsao J, Yang XF, Schutzer SE. Protective Immunity and New Vaccines for Lyme Disease. Clinical Infectious Diseases 2019, 70: 1768-1773. PMID: 31620776, PMCID: PMC7155782, DOI: 10.1093/cid/ciz872.Peer-Reviewed Original ResearchConceptsLyme diseaseCommon tick-borne illnessTick-borne illnessB. burgdorferi infectionBorrelia burgdorferi sensu latoMechanism of actionDirect vaccinationB. burgdorferi proteinsProtective immunityBurgdorferi sensu latoVaccination strategiesBurgdorferi infectionFirst vaccineImmune pathwaysNew vaccinesNumber of casesTick immunityDiseaseVaccineB. burgdorferiHuman hostTick proteinsInfectionImmunityPathogen transmissionThe role of Mannose Binding Lectin in the immune response against Borrelia burgdorferi sensu lato
Coumou J, Wagemakers A, Narasimhan S, Schuijt TJ, Ersoz JI, Oei A, de Boer OJ, Roelofs JJTH, Fikrig E, Hovius JW. The role of Mannose Binding Lectin in the immune response against Borrelia burgdorferi sensu lato. Scientific Reports 2019, 9: 1431. PMID: 30723261, PMCID: PMC6363739, DOI: 10.1038/s41598-018-37922-8.Peer-Reviewed Original ResearchConceptsMannose-binding lectinB. burgdorferiImmune responseComplement systemRole of MBLMBL-deficient miceWhole blood stimulationIgG serum antibodiesB. burgdorferi infectionB. burgdorferi numbersHost complement systemMechanism warrants further investigationSerum-sensitive isolatesBorrelia burgdorferi sensu lato groupWarrants further investigationBorrelia burgdorferi sensu latoLater time pointsBinding lectinsSevere courseBlood stimulationDetectable antibodiesBurgdorferi sensu latoSerum antibodiesMBL deficiencyDeficient mice
2011
Population genetics, taxonomy, phylogeny and evolution of Borrelia burgdorferi sensu lato
Margos G, Vollmer S, Ogden N, Fish D. Population genetics, taxonomy, phylogeny and evolution of Borrelia burgdorferi sensu lato. Infection Genetics And Evolution 2011, 11: 1545-1563. PMID: 21843658, PMCID: PMC3214628, DOI: 10.1016/j.meegid.2011.07.022.Peer-Reviewed Original ResearchConceptsEvolutionary relationshipsSingle-locus approachesMultilocus sequence typing (MLST) schemeSequence typing schemePopulation geneticsPopulation structureBacterial speciesSensu latoLyme borreliosis spirochetesNovel insightsPhylogenyImportant groupLocus approachZoonotic bacteriaBacterial microorganismsBorrelia burgdorferi sensu latoTaxonomyTyping schemeBurgdorferi sensu latoGeneticsSpeciesLatoMicroorganismsBacteriaEvolution
2010
Infectivity of Borrelia burgdorferi sensu lato is unaltered in C3-deficient mice
van Burgel ND, Balmus NC, Fikrig E, van Dam AP. Infectivity of Borrelia burgdorferi sensu lato is unaltered in C3-deficient mice. Ticks And Tick-borne Diseases 2010, 2: 20-26. PMID: 21771533, DOI: 10.1016/j.ttbdis.2010.10.003.Peer-Reviewed Original ResearchConceptsWT miceAbsence of C3B. burgdorferiB. afzeliiQuantitative PCRDifferent Borrelia speciesC3 knockout miceC3-deficient miceComplement-deficient miceWild-type miceB. afzelii infectionBorrelia burgdorferi sensu latoHuman complementInflammation scoreBurgdorferi sensu latoB. bavariensisAfzelii infectionBorrelia speciesKnockout miceMiceHeart tissueWeeksB. gariniiBurgdorferiSignificant differences
2008
Preferential Protection of Borrelia burgdorferi Sensu Stricto by a Salp 15 Homologue in Ixodes ricinus Saliva
Hovius JW, Schuijt TJ, de Groot KA, Roelofs JJ, Oei GA, Marquart JA, de Beer R, Veer C, van der Poll T, Ramamoorthi N, Fikrig E, van Dam AP. Preferential Protection of Borrelia burgdorferi Sensu Stricto by a Salp 15 Homologue in Ixodes ricinus Saliva. The Journal Of Infectious Diseases 2008, 198: 1189-1197. PMID: 18752445, PMCID: PMC4317250, DOI: 10.1086/591917.Peer-Reviewed Original ResearchConceptsAntibody-mediated killingB. burgdorferiB. afzeliiB. gariniiEnzyme-linked immunosorbent assaySole causative agentBorrelia burgdorferi sensu latoBorrelia speciesSevere carditisOuter surface protein CImmune miceControl miceBorrelia burgdorferi sensu strictoBurgdorferi sensu latoSurface protein CSurvival advantageBurgdorferi sensu strictoSolid-phase overlayLyme borreliosisImmunosorbent assayProtein CCausative agentIxodes ticksBurgdorferiMicePrevalence of Borrelia burgdorferi sensu lato in Ixodes ricinus and I. lividus ticks collected from wild birds in the Republic of Moldova
Movila A, Gatewood A, Toderas I, Duca M, Papero M, Uspenskaia I, Conovalov J, Fish D. Prevalence of Borrelia burgdorferi sensu lato in Ixodes ricinus and I. lividus ticks collected from wild birds in the Republic of Moldova. International Journal Of Medical Microbiology 2008, 298: 149-153. DOI: 10.1016/j.ijmm.2007.12.009.Peer-Reviewed Original ResearchWild birdsI. lividusSensu latoB. burgdorferi s.I. ricinusLyme disease agentBurgdorferi s.Borrelia burgdorferi sensu latoBurgdorferi sensu latoIxodes ricinusBacterial speciesSequenced PCR productsForest ReserveFirst recordBirdsBorrelia sppLividusDisease agentsI. ricinus ticksImportant reservoirPCR productsLatoNorth AmericaRicinusS.The Tick Salivary Protein Salp15 Inhibits the Killing of Serum-Sensitive Borrelia burgdorferi Sensu Lato Isolates
Schuijt TJ, Hovius JW, van Burgel ND, Ramamoorthi N, Fikrig E, van Dam AP. The Tick Salivary Protein Salp15 Inhibits the Killing of Serum-Sensitive Borrelia burgdorferi Sensu Lato Isolates. Infection And Immunity 2008, 76: 2888-2894. PMID: 18426890, PMCID: PMC2446733, DOI: 10.1128/iai.00232-08.Peer-Reviewed Original ResearchConceptsComplement-mediated killingBurgdorferi-specific antibodiesBorrelia burgdorferiStrong protective effectSerum-sensitive isolatesNormal human serumBorrelia burgdorferi sensu latoBurgdorferi sensu latoProtective effectMembrane attack complexTick salivaLyme diseaseBorrelia burgdorferi sensu lato isolatesComplement complexI. scapularis Salp15B. burgdorferiSalp15Attack complexBurgdorferiHuman serumKillingSpirochetesIxodes scapularisIsolatesTicks
2006
Fundamental processes in the evolutionary ecology of Lyme borreliosis
Kurtenbach K, Hanincová K, Tsao J, Margos G, Fish D, Ogden N. Fundamental processes in the evolutionary ecology of Lyme borreliosis. Nature Reviews Microbiology 2006, 4: 660-669. PMID: 16894341, DOI: 10.1038/nrmicro1475.Peer-Reviewed Original ResearchConceptsEvolutionary ecologyGenetic changesMultiple-niche polymorphismVector-borne zoonosesB. burgdorferi s.Natural transmission cycleEvolutionary relationshipsEcological parallelsEvolutionary biologyVector-Borne PathogensBurgdorferi s.Population fluctuationsProcess-based modelEcologySensu latoDifferent membersFundamental processesVector-borne diseasesPathogensTransmission cycleSpeciesBorrelia burgdorferi sensu latoSame fundamental questionsKey processesBurgdorferi sensu lato
2003
Adaptation of Borrelia burgdorferi in the vector and vertebrate host
Pal U, Fikrig E. Adaptation of Borrelia burgdorferi in the vector and vertebrate host. Microbes And Infection 2003, 5: 659-666. PMID: 12787742, DOI: 10.1016/s1286-4579(03)00097-2.Peer-Reviewed Original ResearchConceptsComplex enzootic cycleUnique adaptive featuresDifferent host environmentsAdaptation of BorreliaMolecular adaptationsRegulatory mechanismsB. burgdorferiHost environmentSensu latoEnzootic cycleExtracellular pathogensDomestic animalsAdaptive featuresBorrelia burgdorferi sensu latoHostBurgdorferi sensu latoCausative agentDiverse rangeArthropodsAdaptationLatoBurgdorferiPathogensLyme diseaseBorrelia
2001
Prospective Assessment of the Etiology of Acute Febrile Illness after a Tick Bite in Slovenia
Lotrič-Furlan S, Petrovec M, Avsic-Zupanc T, Nicholson W, Sumner J, Childs J, Strle F. Prospective Assessment of the Etiology of Acute Febrile Illness after a Tick Bite in Slovenia. Clinical Infectious Diseases 2001, 33: 503-510. PMID: 11462187, DOI: 10.1086/322586.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAnimalsBites and StingsBorrelia burgdorferi GroupCohort StudiesEhrlichiaEhrlichia chaffeensisEhrlichiosisEncephalitis Viruses, Tick-BorneEncephalitis, Tick-BorneFemaleFeverHumansLyme DiseaseMaleMiddle AgedProspective StudiesSloveniaTick-Borne DiseasesTicksConceptsFebrile illnessTick biteEhrlichia phagocytophila infectionAcute febrile illnessTickborne diseasesEvidence of infectionBorrelia burgdorferi sensu latoMeningeal involvementProspective studyClinical criteriaBurgdorferi sensu latoTickborne encephalitisProspective assessmentPatientsLaboratory evidenceImportant causeBacterial infectionsIllnessLyme borreliosisInfectionDiseaseResidents of SloveniaEtiologyBiteEncephalitis
1995
Vaccination against Lyme disease caused by diverse Borrelia burgdorferi.
Fikrig E, Telford SR, Wallich R, Chen M, Lobet Y, Matuschka FR, Kimsey RB, Kantor FS, Barthold SW, Spielman A, Flavell RA. Vaccination against Lyme disease caused by diverse Borrelia burgdorferi. Journal Of Experimental Medicine 1995, 181: 215-221. PMID: 7807004, PMCID: PMC2191810, DOI: 10.1084/jem.181.1.215.Peer-Reviewed Original ResearchConceptsLyme diseaseB. burgdorferiVivo protection studiesBorrelia burgdorferi sensu latoSurface protein AOuter surface protein AVector-borne infectionsVaccine efficacyBurgdorferi sensu latoChallenge inoculumSpirochetal agentInfectionBorrelia burgdorferiDiseaseBurgdorferiOspAClassification systemProtection studiesProtein ADifferent geographic regionsSyringe injectionGeographic regionsVaccinationImmunizationVaccine
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