2025
Association of dilated aortic root on point-of-care ultrasound with aortic aneurysm and dissection
Hesami M, Denkewicz R, Boivin Z, Bhalodkar S, Li J, Moore C. Association of dilated aortic root on point-of-care ultrasound with aortic aneurysm and dissection. The American Journal Of Emergency Medicine 2025, 95: 89-94. PMID: 40440820, DOI: 10.1016/j.ajem.2025.05.039.Peer-Reviewed Original ResearchThoracic aortic aneurysmThoracic aortic dissectionPoint-of-care ultrasound measurementsPoint-of-care ultrasoundPositive predictive valueAortic aneurysmEfficacy of point-of-care ultrasoundAccuracy of point-of-care ultrasoundDiagnostic accuracy of point-of-care ultrasoundCardiac point-of-care ultrasoundAssociated with thoracic aortic dissectionPredictive valueDilated aortic rootAssociated with thoracic aortic aneurysmAortic root measurementsLife-threatening conditionBland-Altman plotsChest CTAortic measurementsPrompt diagnosisAortic dissectionAortic rootDiagnostic accuracyPatientsMedical records
2024
Thoracic aortic aneurysm in an adolescent with intraoperative discovery of contained rupture: a case report
Lee M, Boules H, Steele J, Asnes J, Assi R. Thoracic aortic aneurysm in an adolescent with intraoperative discovery of contained rupture: a case report. AME Case Reports 2024, 0: 0-0. PMID: 38711883, PMCID: PMC11070988, DOI: 10.21037/acr-23-163.Peer-Reviewed Original ResearchSurgical interventionAortic aneurysmAortic root replacementCoronary artery reimplantationThoracic aortic dilatationAssociated with aortopathyPost-operative complicationsThoracic aortic aneurysmThoracic aortic dissectionValved composite graftAssociated with Noonan syndromeRisk of ruptureHemiarch replacementRoot replacementAortic dilatationArtery reimplantationAortic pathologyIntraoperative findingsIntraoperative discoveryAortic dissectionAortic ruptureRisk-stratifiedAdolescent patientsAscending aortaCase report
2023
Genetic Overlap of Spontaneous Dissection of Either the Thoracic Aorta or the Coronary Arteries
Jeoffrey S, Kalyanasundaram A, Zafar M, Ziganshin B, Elefteriades J. Genetic Overlap of Spontaneous Dissection of Either the Thoracic Aorta or the Coronary Arteries. The American Journal Of Cardiology 2023, 205: 69-74. PMID: 37591066, DOI: 10.1016/j.amjcard.2023.07.046.Peer-Reviewed Original ResearchConceptsCorresponding molecular pathwaysSpontaneous coronary artery dissectionGenetic overlapMolecular pathwaysGenome-wide association studiesGenetic commonalityGenetic variantsThoracic aortic dissectionIndependent genesGenetic pathwaysSmooth muscle cell functionGenetic methodsAortic dissectionMuscle cell functionAssociation studiesGenetic studiesSudden deathConnective tissue genesGenesTGFβ pathwayCausative genesCoronary artery dissectionTissue genesEarly-onset myocardial infarctionBiologic processesManagement of Thoracic Aortic Dissection
Hameed I, Cifu A, Vallabhajosyula P. Management of Thoracic Aortic Dissection. JAMA 2023, 329: 756-757. PMID: 36795378, DOI: 10.1001/jama.2023.0265.Peer-Reviewed Original ResearchKIF6 Trp719Arg Genetic Variant Increases Risk for Thoracic Aortic Dissection
Velasco J, Li Y, Ziganshin B, Zafar M, Rizzo J, Ma D, Zang H, Kalyanasundaram A, Elefteriades J. KIF6 Trp719Arg Genetic Variant Increases Risk for Thoracic Aortic Dissection. Genes 2023, 14: 252. PMID: 36833179, PMCID: PMC9956195, DOI: 10.3390/genes14020252.Peer-Reviewed Original ResearchConceptsThoracic aortic aneurysmAortic dissectionOdds ratioVariant statusArg allele carriersThoracic aortic dissectionOccurrence of ADAortic sizeArg alleleMarked adverse impactTAA patientsAortic aneurysmClinical assessmentSurgical decisionAllele carriersIncrease riskVariant patientsArg carriersPilot studyDissectionImportant intracellular functionsConfirmatory findingsPatientsAneurysmsPresent study
2022
Ultimate tensile strength and biaxial stress–strain responses of aortic tissues—A clinical-engineering correlation
Dong H, Liu M, Lou X, Leshnower B, Sun W, Ziganshin B, Zafar M, Elefteriades J. Ultimate tensile strength and biaxial stress–strain responses of aortic tissues—A clinical-engineering correlation. Applications In Engineering Science 2022, 10: 100101. DOI: 10.1016/j.apples.2022.100101.Peer-Reviewed Original ResearchThoracic aortic dissectionAortic dissectionAortic tissueDissection eventsBicuspid aortic valveUnderlying genetic abnormalitiesHuman aortic tissueHypertensive episodesAortic arch morphologyAortic valveAdvanced ageTissue injuryConnective tissue ingrowthAged animalsAortic wallInciting factorsGenetic abnormalitiesClinical contextArch morphologyDissectionDissected tissuesTissueResponseTissue ingrowthInjury
2021
Adventitial remodeling protects against aortic rupture following late smooth muscle-specific disruption of TGFβ signaling
Kawamura Y, Murtada S, Gao F, Liu X, Tellides G, Humphrey J. Adventitial remodeling protects against aortic rupture following late smooth muscle-specific disruption of TGFβ signaling. Journal Of The Mechanical Behavior Of Biomedical Materials 2021, 116: 104264. PMID: 33508556, PMCID: PMC7959590, DOI: 10.1016/j.jmbbm.2020.104264.Peer-Reviewed Original ResearchConceptsAortic dissectionMouse modelAortic wallCompensatory changesThoracic aortic dissectionMuscle-specific disruptionSmooth muscle cellsLoss of TGFβMedial integrityAortic ruptureClinical presentationMuscle cellsQuantitative histologyMatrix turnoverTGFβ receptorsDissectionWall stressTGFβType IIndividual subjectsSpecific disruptionVivo valuesExaminationRupture
2020
Polycystin-1 Downregulation Induced Vascular Smooth Muscle Cells Phenotypic Alteration and Extracellular Matrix Remodeling in Thoracic Aortic Dissection
Zhang J, Liu F, He Y, Zhang W, Ma W, Xing J, Wang L. Polycystin-1 Downregulation Induced Vascular Smooth Muscle Cells Phenotypic Alteration and Extracellular Matrix Remodeling in Thoracic Aortic Dissection. Frontiers In Physiology 2020, 11: 548055. PMID: 33071810, PMCID: PMC7541897, DOI: 10.3389/fphys.2020.548055.Peer-Reviewed Original ResearchAortic vascular smooth muscle cellsVascular smooth muscle cellsThoracic aortic dissectionMarkers of vascular smooth muscle cellsPolycystic kidney disease-1Polycystin-1TAD groupProgression of thoracic aortic dissectionAortic dissectionExtracellular matrix remodelingPrimary aortic vascular smooth muscle cellsPhosphorylation of mTORCollagen IIIS6KExpression of polycystin-1Extracellular matrixControl groupMatrix metalloproteinase (MMP)-2Phenotypic alterationsCell phenotypic alterationsSmooth muscle cellsCollagen IExpression of mRNAMetalloproteinase (MMP)-2Synthetic markers
2017
Point‐of‐Care Ultrasonography of the Thoracic Aorta
Taylor R, Moore C. Point‐of‐Care Ultrasonography of the Thoracic Aorta. 2017, 32-38. DOI: 10.1002/9781119072874.ch3.Peer-Reviewed Original ResearchThoracic aortaAortic dissectionComputed tomographyThoracic aortic pathologyHours of diagnosisThoracic aortic aneurysmThoracic aortic dissectionAortic pathologyIntravenous contrastThoracic aneurysmAbdominal aneurysmAortic aneurysmThoracicAortaAneurysmGold standardMortality rateDissectionDiagnosisMortalityUltrasound imagingEchocardiographyAngiographyUltrasonographyCumulative mortality
2016
Do Familial Aortic Dissections Tend to Occur at the Same Age?
Chou AS, Ma WG, Mok SC, Ziganshin BA, Peterss S, Rizzo JA, Tranquilli M, Elefteriades JA. Do Familial Aortic Dissections Tend to Occur at the Same Age? The Annals Of Thoracic Surgery 2016, 103: 546-550. PMID: 27570161, DOI: 10.1016/j.athoracsur.2016.06.007.Peer-Reviewed Original Research
2013
A decision analysis to determine a testing threshold for computed tomographic angiography and d-dimer in the evaluation of aortic dissection
Taylor RA, Iyer NS. A decision analysis to determine a testing threshold for computed tomographic angiography and d-dimer in the evaluation of aortic dissection. The American Journal Of Emergency Medicine 2013, 31: 1047-1055. PMID: 23702073, DOI: 10.1016/j.ajem.2013.03.039.Peer-Reviewed Original ResearchConceptsThoracic aortic dissectionD-dimerTesting thresholdAortic dissectionTomographic angiographyAcute renal failureHigh-risk featuresRenal replacement therapyClinical decision ruleD-dimer testingD-dimer sensitivityD-dimer testLarge mortality benefitMortality benefitPatient ageRenal failureReplacement therapyPretest probabilityLow prevalenceCTA testSmall riskDecision analysis softwareDisease probabilityCTAAngiography
1999
PATHOLOGIC VARIANTS OF THORACIC AORTIC DISSECTIONS Penetrating Atherosclerotic Ulcers and Intramural Hematomas
Coady M, Rizzo J, Elefteriades J. PATHOLOGIC VARIANTS OF THORACIC AORTIC DISSECTIONS Penetrating Atherosclerotic Ulcers and Intramural Hematomas. Cardiology Clinics 1999, 17: 637-657. PMID: 10589337, DOI: 10.1016/s0733-8651(05)70106-5.Peer-Reviewed Original ResearchConceptsClassic aortic dissectionAcute aortic pathologyIntramural hematomaAortic dissectionAortic lumenAtherosclerotic ulcerAortic lesionsIMH patientsAortic pathologyClassic dissectionRupture rateType B aortic dissectionTypical aortic dissectionB aortic dissectionDistinct clinical entityThoracic aortic dissectionTypical patient profileMore superficial locationHigher rupture rateBranch-vessel compromiseLarger aortasMinimal arteriosclerosisTypical dissectionIschemic manifestationsThoracoabdominal aorta
1993
Painless aortic dissection presenting as a progressive myelopathy
Holloway S, Fayad P, Kalb R, Guarnaccia J, Waxman S. Painless aortic dissection presenting as a progressive myelopathy. Journal Of The Neurological Sciences 1993, 120: 141-144. PMID: 8138802, DOI: 10.1016/0022-510x(93)90265-z.Peer-Reviewed Original ResearchConceptsPainless aortic dissectionAortic dissectionProgressive myelopathyCentral nervous system ischemiaSpinal cord syndromeThoracic aortic dissectionAbsence of painThoracic vertebral bodyMagnetic resonance imagingTransverse myelopathyCord syndromeNeurologic deficitsNeurologic symptomsIschemic changesEarly recognitionSpinal cordDifferential diagnosisNew therapiesVertebral bodyResonance imagingMyelopathyThoracic vertebraeDissectionPainIschemia
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