2025
Developmental Biology of the Placenta
Hui P. Developmental Biology of the Placenta. 2025, 15-30. DOI: 10.1007/978-3-031-83545-2_2.Peer-Reviewed Original ResearchUnique to eutherian mammalsParental gene expressionMammalian biologyPathogenesis of gestational trophoblastic diseasesEutherian mammalsGene expressionDevelopmental biologyGestational trophoblastic diseaseMaternal immunological rejectionTrophoblastic diseaseGas exchangeCell disordersMaternal uterusImmunological rejectionProliferative disordersPlacentaImplantation sitesImmunological characteristicsTissue remodelingHormone productionImmunological interactionsBiologyTransient organGenomeBiological changesGenetic Basis of Gestational Trophoblastic Disease
Hui P. Genetic Basis of Gestational Trophoblastic Disease. 2025, 31-45. DOI: 10.1007/978-3-031-83545-2_3.Peer-Reviewed Original ResearchPlacental site trophoblastic tumorEpithelioid trophoblastic tumorGestational trophoblastic diseaseIntermediate trophoblastTrophoblastic tumorTrophoblastic diseaseHydatidiform MoleEntities of gestational trophoblastic diseaseChorionic-type intermediate trophoblastNeoplastic cellsChorionic villous trophoblastPartial Hydatidiform MoleStage of placental formationTrophoblast cell typesMalignant human cancersGestational choriocarcinomaPlacental formationVillous trophoblastChorion laevePathway of differentiationTumor cellsHyperplastic proliferationCytologic featuresBiomarker expressionProliferative disordersOverview of Gestational Trophoblastic Disease
Hui P. Overview of Gestational Trophoblastic Disease. 2025, 1-14. DOI: 10.1007/978-3-031-83545-2_1.Peer-Reviewed Original ResearchGestational trophoblastic diseaseEpithelioid trophoblastic tumorMolecular genetic pathogenesisRare neoplastic conditionTrophoblastic tumorTrophoblastic diseaseHydatidiform MoleGenetic pathogenesisClinical managementBiological behaviorNeoplastic conditionsProliferative conditionsClinical settingDiagnostic entityAge groupsDiagnostic pathologyReproductive disordersGenetic compositionPathologyHuman pathologiesHuman medicineGeographical distributionHydatidiformTumorMorbidityMolecular Diagnosis of Gestational Trophoblastic Disease
Hui P. Molecular Diagnosis of Gestational Trophoblastic Disease. 2025, 217-251. DOI: 10.1007/978-3-031-83545-2_14.Peer-Reviewed Original ResearchGestational trophoblastic tumorsInternational Collaboration on Cancer ReportingGestational trophoblastic diseaseHydatidiform MoleDevelopment of gestational trophoblastic tumorsPolymerase chain reactionSTR genotypingSubtypes of hydatidiform moleShort tandem repeat (STRTrophoblastic tumorTrophoblastic diseaseDiagnostic workupPathological diagnosisPrognostic riskTumor developmentClinical sensitivityGerm cellsHydatidiformMolecular diagnosisAncillary toolSomatic originClinical practiceGenetic compositionSTR analysisCancer reportingClinical Aspects of Gestational Trophoblastic Disease
Clark M, Ratner E, Schwartz P. Clinical Aspects of Gestational Trophoblastic Disease. 2025, 253-260. DOI: 10.1007/978-3-031-83545-2_15.Peer-Reviewed Original ResearchMolar pregnancyRefractory to initial treatmentIntermediate trophoblastic tumorInvasive molar pregnancyGestational trophoblastic diseaseComplex clinical scenariosRate of regressionTrophoblastic tumorTrophoblastic diseasePrompt diagnosisInitial treatmentClinical entityClinical scenariosPregnancyCenters of excellenceDiseaseChoriocarcinomaImmunotherapySurgeryTumorDiagnosisPartial Hydatidiform Mole
Buza N. Partial Hydatidiform Mole. 2025, 83-96. DOI: 10.1007/978-3-031-83545-2_6.Peer-Reviewed Original ResearchPartial Hydatidiform MoleGestational trophoblastic neoplasiaGestational trophoblastic diseaseHydatidiform MoleComplete moleTrophoblastic hyperplasiaPersistent gestational trophoblastic diseaseNon-neoplastic proliferationTriploid gestationsTrophoblastic neoplasiaCytogenetic abnormalitiesTrophoblastic diseaseClinical presentationVillous trophoblastDiagnostic accuracyHydatidiformFlow cytometryTriploid karyotypeHyperplasiaFocal sparingVilliGestationFetusesEmbryo/fetusNeoplasiaGestational trophoblastic disease: STR genotyping for precision diagnosis
Rozenova K, Buza N, Hui P. Gestational trophoblastic disease: STR genotyping for precision diagnosis. Expert Review Of Molecular Diagnostics 2025, 25: 1-19. PMID: 39801212, DOI: 10.1080/14737159.2025.2453506.Peer-Reviewed Original ResearchConceptsShort tandem repeatsGestational trophoblastic diseaseShort tandem repeat genotypingDiagnosis of gestational trophoblastic diseaseGestational trophoblastic tumorsHydatidiform MoleSTR genotypingTrophoblastic tumorDifferential diagnosis of gestational trophoblastic diseaseRepetitive DNA sequencesManagement of gestational trophoblastic diseaseSubclassification of hydatidiform molesGestational trophoblastic neoplasmsPrognostication of patientsPaternity testingNon-neoplastic natureHuman genomeTandem repeatsDNA sequencesForensic identityTrophoblastic diseaseTrophoblastic neoplasmsGynecologic conditionsDiagnostic workupClinical outcomes
2023
MR“I”: An “eye” for the preoperative diagnosis of ectopic molar pregnancy, a case report
Swamy S, Swamy M, Samanvitha H, Elsayed S. MR“I”: An “eye” for the preoperative diagnosis of ectopic molar pregnancy, a case report. Journal Of Family Medicine And Primary Care 2023, 12: 581-585. PMID: 37122670, PMCID: PMC10131974, DOI: 10.4103/jfmpc.jfmpc_1770_22.Peer-Reviewed Original ResearchPlacental site trophoblastic diseaseEctopic molar pregnancyEpithelioid trophoblastic tumorMolar pregnancyEctopic gestationEctopic pregnancyInvasive moleTrophoblastic tumorTrophoblastic diseasePreoperative diagnosisDiagnosis of ectopic pregnancySuperiority of magnetic resonance imagingGestational trophoblastic neoplasiaMagnetic resonance imagingMolar gestationsMolar tissueTrophoblastic neoplasiaAnalysis of clinical signsGestational massHydatidiform MoleBeta-hCGMaternal deathsSonographic identificationCase reportMaternal mortality
2021
Genotyping diagnosis of gestational trophoblastic disease: frontiers in precision medicine
Buza N, Hui P. Genotyping diagnosis of gestational trophoblastic disease: frontiers in precision medicine. Modern Pathology 2021, 34: 1658-1672. PMID: 34088998, DOI: 10.1038/s41379-021-00831-9.Peer-Reviewed Original ResearchConceptsGestational trophoblastic diseaseTrophoblastic diseaseGestational trophoblastic tumorsGestational trophoblastic neoplasiaRoutine diagnostic workupDNA genotypingSignificant clinical relevancePowerful ancillary toolFIGO/Genetic zygosityGestational eventIndex gestationTrophoblastic tumorTrophoblastic neoplasiaGestational choriocarcinomaPrognostic stratificationDiagnostic workupPrognostic assessmentClinical relevanceClinical practiceGestational originMolecular diagnostic capabilitiesPatient careSporadic hydatidiformCopy number alterationsMolecular Diagnosis
Weisman P, Wei J, Hui P. Molecular Diagnosis. Practical Anatomic Pathology 2021, 417-431. DOI: 10.1007/978-3-030-68608-6_16.Peer-Reviewed Original ResearchGynecologic pathologyMolecular diagnostic techniquesGynecologic tumorsCell tumorsTherapeutic implicationsOvarian sex cord-stromal tumorsHigh-grade endometrial stromal sarcomaSertoli-Leydig cell tumorSex cord-stromal tumorsJuvenile granulosa cell tumorMolecular diagnostic findingsSpindle cell leiomyosarcomaEndometrial stromal sarcomaGranulosa cell tumorsGestational trophoblastic diseaseLow mitotic ratePeutz-Jeghers syndromeDiagnostic techniquesFibrosarcoma-like tumorsStromal sarcomaOvarian neoplasiaSporadic settingHistological featuresTrophoblastic diseaseDiagnostic findings
2020
Heterozygous/dispermic complete mole confers a significantly higher risk for post-molar gestational trophoblastic disease
Zheng XZ, Qin XY, Chen SW, Wang P, Zhan Y, Zhong PP, Buza N, Jin YL, Wu BQ, Hui P. Heterozygous/dispermic complete mole confers a significantly higher risk for post-molar gestational trophoblastic disease. Modern Pathology 2020, 33: 1979-1988. PMID: 32404958, DOI: 10.1038/s41379-020-0566-4.Peer-Reviewed Original ResearchConceptsNon-molar gestationsGestational trophoblastic diseaseTrophoblastic diseaseHigh riskGestational trophoblastic neoplasiaProducts of conceptionPatient demographicsClinical followClinical outcomesGynecology HospitalTrophoblastic neoplasiaBeijing ObstetricsFIGO criteriaChinese patientsClinical prognosisPatient managementLarge cohortGestationMolar gestationDiseaseGenetic abnormalitiesChromosomal monosomyChromosomal aneuploidyHydatidiformUniparental disomy
2019
Gestational Trophoblastic Neoplasia, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology.
Abu-Rustum NR, Yashar CM, Bean S, Bradley K, Campos SM, Chon HS, Chu C, Cohn D, Crispens MA, Damast S, Dorigo O, Eifel PJ, Fisher CM, Frederick P, Gaffney DK, Han E, Huh WK, Lurain JR, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Fader AN, Remmenga SW, Reynolds RK, Sisodia R, Tillmanns T, Ueda S, Wyse E, McMillian NR, Scavone J. Gestational Trophoblastic Neoplasia, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology. Journal Of The National Comprehensive Cancer Network 2019, 17: 1374-1391. PMID: 31693991, DOI: 10.6004/jnccn.2019.0053.Peer-Reviewed Original ResearchConceptsGestational trophoblastic neoplasiaGestational trophoblastic diseaseTrophoblastic neoplasiaHigh-risk gestational trophoblastic neoplasiaTypes of GTDLow-risk gestational trophoblastic neoplasiaNCCN Clinical Practice GuidelinesPost-molar gestational trophoblastic neoplasiaIntermediate trophoblastic tumorClinical practice guidelinesNCCN guidelinesTrophoblastic tumorTreatment recommendationsTrophoblastic diseasePractice guidelinesNeoplasiaTumorsGuidelinesPregnancyPlacentaDiseaseOncologyHydatidiform
2011
Partial Hydatidiform Mole
Buza N. Partial Hydatidiform Mole. Current Clinical Pathology 2011, 77-90. DOI: 10.1007/978-1-61779-394-3_5.Peer-Reviewed Original ResearchGestational trophoblastic neoplasiaGestational trophoblastic diseasePersistent gestational trophoblastic diseasePartial Hydatidiform MoleClinical presentationTrophoblastic neoplasiaSubsequent riskTrophoblastic diseaseNonneoplastic proliferationTriploid gestationsVillous trophoblastDistinct subtypesTrophoblastic hyperplasiaHydatidiform MolePartial hydatidiformChorionic villiSignificant differencesHydatidiformGestationHyperplasiaNeoplasiaSubtypesDiseaseTrophoblastHistomorphologyMolecular Diagnosis of Gestational Trophoblastic Disease
Hui P. Molecular Diagnosis of Gestational Trophoblastic Disease. Current Clinical Pathology 2011, 161-178. DOI: 10.1007/978-1-61779-394-3_11.Peer-Reviewed Original ResearchMinimal histological abnormalitiesGestational trophoblastic diseaseAvailable ancillary studiesGestational trophoblastic disordersNormal pregnancyHistological diagnosisTrophoblastic diseaseGynecological pathologyHistological abnormalitiesAncillary studiesTrophoblastic disordersComplete hydatidiformPartial hydatidiformDaily practiceDiagnosisHydatidiformMolecular diagnosisSignificant percentagePathologistsHydropic abortusGenetic Basis of Gestational Trophoblastic Disease
Hui P. Genetic Basis of Gestational Trophoblastic Disease. Current Clinical Pathology 2011, 41-55. DOI: 10.1007/978-1-61779-394-3_3.Peer-Reviewed Original ResearchGestational trophoblastic diseasePlacental site trophoblastic tumorEpithelioid trophoblastic tumorTrophoblastic tumorIntermediate trophoblastTrophoblastic diseaseExaggerated placental site reactionChorionic villous trophoblastPlacental site noduleUnique clinical settingGestational choriocarcinomaSite reactionsMalignant tumorsLesional cellsProliferative lesionsProliferative disordersTrophoblastic cellsVillous trophoblastBiomarker expressionClinical settingImplantation sitesTumorsUnique genetic factorsRecent linkage studiesComplete hydatidiformGestational Choriocarcinoma
Hui P. Gestational Choriocarcinoma. Current Clinical Pathology 2011, 127-137. DOI: 10.1007/978-1-61779-394-3_8.Peer-Reviewed Original ResearchGestational choriocarcinomaMalignant tumorsMethotrexate-based chemotherapyMortality of patientsDecidua of pregnancyHematogenous spreadCure rateFatal malignancyTrophoblastic diseaseChemotherapy managementAggressive formChoriocarcinomaChorial villiTumorsTumor cellsSarcomaDiseaseChemotherapyPatientsPregnancyDramatic decreaseMalignancyMortalityPlacentaDeciduaUrinary hCG Screening in the Gynecologic Oncology Population
Richter C, Buza N, Hui P, Silasi D, Azodi M, Santin A, Rutherford T, Schwartz P. Urinary hCG Screening in the Gynecologic Oncology Population. Journal Of Gynecologic Surgery 2011, 27: 143-146. DOI: 10.1089/gyn.2010.0048.Peer-Reviewed Original ResearchGestational trophoblastic diseasePositive urine pregnancy testUrine pregnancy testGynecologic malignanciesUrinary hCGTrophoblastic diseasePregnancy testHuman chorionic gonadotropin testingClear cell ovarian carcinomaGynecologic oncology clinicGynecologic oncology populationRetrospective chart reviewHCG testingChart reviewNonpregnant patientsConsecutive patientsOncology populationPrimary peritonealOncology clinicVaginal carcinomaNongynecologic malignanciesUterine cancerFallopian tubeOvarian carcinomaOvarian cancer
2010
Gestational trophoblastic disease: histopathological diagnosis in the molecular era
Buza N, Hui P. Gestational trophoblastic disease: histopathological diagnosis in the molecular era. Diagnostic Histopathology 2010, 16: 526-537. DOI: 10.1016/j.mpdhp.2010.08.002.Peer-Reviewed Original ResearchGestational trophoblastic diseaseTrophoblastic diseaseTrophoblastic tumorCharacteristic histological featuresExaggerated placental sitePlacental site noduleEpithelioid trophoblastic tumorTumor-like conditionsFuture diagnostic algorithmsDiagnosis of hydatidiformUnique neoplasmGestational choriocarcinomaPlacental siteHistological featuresHistopathological diagnosisDifferential diagnosisDiagnostic criteriaMolecular testingPlacental trophoblastsProliferative disordersDiagnostic algorithmDiagnosisPartial hydatidiformHeterogeneous groupDiagnostic problemsGestational Trophoblastic Disease
Chhieng D, Hui P. Gestational Trophoblastic Disease. Current Clinical Pathology 2010, 131-138. DOI: 10.1007/978-1-60761-164-6_8.Peer-Reviewed Original ResearchExpression of glypican 3 in placental site trophoblastic tumor
Ou-Yang RJ, Hui P, Yang XJ, Zynger DL. Expression of glypican 3 in placental site trophoblastic tumor. Diagnostic Pathology 2010, 5: 64. PMID: 20868507, PMCID: PMC2954974, DOI: 10.1186/1746-1596-5-64.Peer-Reviewed Original ResearchConceptsPlacental site trophoblastic tumorPlacental site noduleInvasive cervical squamous cell carcinomaCervical squamous cell carcinomaNon-trophoblastic tumorsSquamous cell carcinomaTrophoblastic tumorCell carcinomaCytoplasmic stainingRare gestational trophoblastic neoplasmDiagnostic markerGestational trophoblastic neoplasmsGestational trophoblastic diseaseUseful diagnostic markerNon-neoplastic tissuesMembrane-bound heparan sulfate proteoglycanEndometrial adenocarcinomaUterine tumorsIntermediate trophoblastTrophoblastic diseaseTrophoblastic neoplasmsImmunohistochemical expressionHepatocellular carcinomaImmunohistochemical markersResultsEighty percent
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