2025
A mixed-methods study assessing the performance of a clinical decision support tool for Clostridioides difficile testing for patients receiving laxatives
Peaper D, Rathod S, Sussman L, Azar M, Murdzek C, Roberts S, Tichy E, Topal J, Kashyap N, McManus D, Martinello R. A mixed-methods study assessing the performance of a clinical decision support tool for Clostridioides difficile testing for patients receiving laxatives. Infection Control And Hospital Epidemiology 2025, 46: 497-503. PMID: 40079209, PMCID: PMC12034449, DOI: 10.1017/ice.2025.30.Peer-Reviewed Original ResearchClinical decision supportAdvanced practice providersClinical decision support alertsClinical decision support toolMixed-methods studyPractice providersClinician interactionClinician concernsPhysician's instructionsTest orderingAttending physiciansMixed-methodsDoses of laxativesPatient riskLaxative useClinicians' rationaleCliniciansDecision support toolHospitalized patientsStudy periodDecision supportAttendanceCase seriesAntibiotic exposureResidents
2024
Decision Support Tool to Improve Decision-Making for HIV Pre-Exposure Prophylaxis (PrEP): Development Process and Alpha Testing
Ajiboye W, Yusuf A, Pedersen C, Brown R, Dzonsons K, Nelson L. Decision Support Tool to Improve Decision-Making for HIV Pre-Exposure Prophylaxis (PrEP): Development Process and Alpha Testing. JMIR Formative Research 2024, 8: e57348. PMID: 39393055, PMCID: PMC11512116, DOI: 10.2196/57348.Peer-Reviewed Original ResearchDecision support toolEarly Warning Scores With and Without Artificial Intelligence
Edelson D, Churpek M, Carey K, Lin Z, Huang C, Siner J, Johnson J, Krumholz H, Rhodes D. Early Warning Scores With and Without Artificial Intelligence. JAMA Network Open 2024, 7: e2438986. PMID: 39405061, PMCID: PMC11544488, DOI: 10.1001/jamanetworkopen.2024.38986.Peer-Reviewed Original ResearchConceptsEarly Warning ScoreWarning ScoreCohort studyYale New Haven Health SystemClinical deterioration eventsHigh-risk thresholdHealth systemRetrospective cohort studyPatient encountersDeteriorating patientsOverall PPVMain OutcomesInpatient encountersEDI scoresHospital encountersDeterioration eventsClinical deteriorationIntensive care unitEarly warning toolCare unitDecision support toolArtificial intelligenceScoresReceiver operating characteristic curveNEWS2SMART Medical Review: Acute Pancreatitis Assessment and Management in the First 24 Hours
Lee P, Bishu S, Breze C, Chak A, Gardner T, Guda N, Kaul V, Muniraj T, Papachristou G, Schrope B, Spagnolo D, Strand D, Tarnasky P, Taylor J, Wilcox C, Whitcomb D. SMART Medical Review: Acute Pancreatitis Assessment and Management in the First 24 Hours. SMART-MD Journal Of Precision Medicine 2024, 1: e19-e48. DOI: 10.69734/7dcnna53.Peer-Reviewed Original ResearchPoint of careManagement of APClinical decision support toolQuality of careQuality improvement recommendationsGroup of clinical expertsAcute pancreatitisInnate inflammatory responseCareClinical expertsExpert recommendationsLife-threatening consequencesDecision support toolEarly treatmentPhysical examinationInflammatory responseInflammatory reactionRecommendationsSeveral determinantsIndividualized treatmentImprovement recommendationsSupport toolDiagnosisLaboratory testsTreatment229TiP A phase II trial of a neural network-based treatment decision support tool in patients (pts) with refractory solid organ malignancies
Walsh R, Jayagopal A, Tan T, Pitt J, Sundar R, Lee S, Goh B, Rajan V, Tan D, Jeyasekharan A. 229TiP A phase II trial of a neural network-based treatment decision support tool in patients (pts) with refractory solid organ malignancies. Annals Of Oncology 2024, 35: s307-s308. DOI: 10.1016/j.annonc.2024.08.2233.Peer-Reviewed Original ResearchExploring Factors That Influence Postexercise Glycemia in Youth With Type 1 Diabetes in the Real World: The Type 1 Diabetes Exercise Initiative Pediatric (T1DEXIP) Study.
Sherr J, Bergford S, Gal R, Clements M, Patton S, Calhoun P, Beaulieu L, Riddell M. Exploring Factors That Influence Postexercise Glycemia in Youth With Type 1 Diabetes in the Real World: The Type 1 Diabetes Exercise Initiative Pediatric (T1DEXIP) Study. Diabetes Care 2024, 47: 849-857. PMID: 38412033, DOI: 10.2337/dc23-2212.Peer-Reviewed Original ResearchParticipants self-reported physical activitySelf-reported physical activityPostexercise recovery periodEvent-level factorsExercise sessionsPhysical activitySedentary dayExercise studiesSupport exerciseExerciseDelivery modalitiesSD ageType 1 diabetesHemoglobin A1cPostexercisePump useShorter disease durationDecision support toolGlucose dataRecovery periodHbA1cDisease durationHypoglycemia riskInsulin delivery modalityHypoglycemia ratesDevelopment of a Prototype Clinical Decision Support Tool for a Machine Learning Based Individualized Prediction of Outcomes of Hematopoietic Cell Transplantation for Sickle Cell Disease
Subramaniam R, Kane M, Krishnamurti L. Development of a Prototype Clinical Decision Support Tool for a Machine Learning Based Individualized Prediction of Outcomes of Hematopoietic Cell Transplantation for Sickle Cell Disease. Transplantation And Cellular Therapy 2024, 30: s65-s66. DOI: 10.1016/j.jtct.2023.12.104.Peer-Reviewed Original ResearchHematopoietic cell transplantationOutcomes of hematopoietic cell transplantationSickle cell diseasePositive predictive valueDecision support toolMachine-learningClinical decision support toolCell transplantationBalanced accuracyGraft failureSupport toolFold cross validationDecision-making methodPositive outcomesPredictive valueGVHD prophylaxis regimensEvent-free survivalBinary classifierUser inputRelevant clinical parametersReceiver operating characteristic curvePrototype decision support toolTraining datasetOperating characteristics curveTest dataset
2023
Paths Forward for Clinicians Amidst the Rise of Unregulated Clinical Decision Support Software: Our Perspective on NarxCare
Buonora M, Axson S, Cohen S, Becker W. Paths Forward for Clinicians Amidst the Rise of Unregulated Clinical Decision Support Software: Our Perspective on NarxCare. Journal Of General Internal Medicine 2023, 39: 858-862. PMID: 37962733, PMCID: PMC11043299, DOI: 10.1007/s11606-023-08528-2.Peer-Reviewed Original ResearchClinical decision support toolClinical decision support softwareHealthcare institutionsOpioid prescribingOverdose epidemicPatient encountersIndividual cliniciansPatient careProprietary formulaRigorous external validationCliniciansWider implementationExternal validationPrescribingPotential harmSufficient evidencePublic healthDecision support softwareDecision support toolSpecific actionsMortalityCareA Novel Approach to Delivering Evidence-based, High-quality Care in Psychiatry Through an Electronic Integrated Care Pathway (eICP) Pilot
Li L, Kruger M, Kim N, Ong S, Riley S, Cameron K, Koslosky K, Rhodes D. A Novel Approach to Delivering Evidence-based, High-quality Care in Psychiatry Through an Electronic Integrated Care Pathway (eICP) Pilot. Psychiatric Quarterly 2023, 94: 103-111. PMID: 36840898, PMCID: PMC9959944, DOI: 10.1007/s11126-023-10016-z.Peer-Reviewed Original ResearchConceptsElectronic health recordsUser-friendly experienceEvidence-based decision support toolUsage trackingDecision support toolSupport toolHealth recordsIntegrated care pathwayNovel approachService areaTeam structureImplementationEarly adoptionAdoptionTechnology columnHealth service areasAcademic medical centerQuality of careHigh-quality careTrackingAdoption resultsCare pathwayFuture directionsMedical CenterTechnology
2022
Artificial intelligence in liver diseases: Improving diagnostics, prognostics and response prediction
Nam D, Chapiro J, Paradis V, Seraphin TP, Kather JN. Artificial intelligence in liver diseases: Improving diagnostics, prognostics and response prediction. JHEP Reports 2022, 4: 100443. PMID: 35243281, PMCID: PMC8867112, DOI: 10.1016/j.jhepr.2022.100443.Peer-Reviewed Original ResearchArtificial intelligenceSuch AI systemsDiverse clinical datasetsDeep learningAI systemsMultiple data sourcesDecision support toolImage dataLarge-scale clinical validationSupport toolRadiology dataClinical datasetsData sourcesRelevant informationIntelligenceClinical routineDisease courseLiver diseaseInformationNovel biomarkersNeoplastic diseaseHepatologyClinical validationCritical obstacleDataset
2019
Seeking compromise across competing goals in conservation translocations: The case of the ‘extinct’ Floreana Island Galapagos giant tortoise
Hunter E, Gibbs J, Cayot L, Tapia W, Quinzin M, Miller J, Caccone A, Shoemaker K. Seeking compromise across competing goals in conservation translocations: The case of the ‘extinct’ Floreana Island Galapagos giant tortoise. Journal Of Applied Ecology 2019, 57: 136-148. DOI: 10.1111/1365-2664.13516.Peer-Reviewed Original ResearchConservation translocationsSingle-objective solutionsDecision support toolGiant tortoisesIndividual-based simulation modelGalapagos giant tortoisesGeneralized Additive ModelsEcosystem servicesTranslocation projectsFloreana IslandIsland speciesManagement objectivesSevere declineSupport toolNumber of individualsModel-based decision support toolSource populationGalapagos IslandsStakeholder valuesManagement strategiesMulti-objective solutionsOptimal management strategyAdditive modelTortoisesCost constraintsAccuracy of Risk Estimates from the iPrevent Breast Cancer Risk Assessment and Management Tool
Phillips K, Liao Y, Milne R, MacInnis R, Collins I, Buchsbaum R, Weideman P, Bickerstaffe A, Nesci S, Chung W, Southey M, Knight J, Whittemore A, Dite G, Goldgar D, Giles G, Glendon G, Thorne H, Niedermayr E, Stanhope L, O’Connor S, Picken S, Cuzick J, Antoniou A, Andrulis I, John E, Daly M, Buys S, Hopper J, Terry M. Accuracy of Risk Estimates from the iPrevent Breast Cancer Risk Assessment and Management Tool. JNCI Cancer Spectrum 2019, 3: pkz066. PMID: 31853515, PMCID: PMC6901082, DOI: 10.1093/jncics/pkz066.Peer-Reviewed Original ResearchInternational Breast Cancer Intervention StudyBC riskDiscriminatory accuracyOvarian Analysis of Disease IncidenceProspective Family Study CohortRisk management decision support toolBreast cancerBreast cancer risk assessmentAnalysis of Disease IncidenceRisk estimatesAbsolute BC riskRisk factor dataCancer risk assessmentAccuracy of risk estimatesYears of follow-upOvarian AnalysisIntervention studiesCalibration overallC-statisticRisk management informationProspective dataStudy cohortFactor dataIPreventDecision support tool
2016
Discharge decision-making after complex surgery: Surgeon behaviors compared to predictive modeling to reduce surgical readmissions
Leeds IL, Sadiraj V, Cox JC, Gao XS, Pawlik TM, Schnier KE, Sweeney JF. Discharge decision-making after complex surgery: Surgeon behaviors compared to predictive modeling to reduce surgical readmissions. The American Journal Of Surgery 2016, 213: 112-119. PMID: 28029373, PMCID: PMC5362294, DOI: 10.1016/j.amjsurg.2016.03.010.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAdultAgedAged, 80 and overAlgorithmsAttitude of Health PersonnelCohort StudiesDatabases, FactualDecision Making, Computer-AssistedDecision Support TechniquesFemaleHumansIncidenceLogistic ModelsMaleMiddle AgedPatient ReadmissionPredictive Value of TestsRetrospective StudiesRisk AssessmentSurgeonsSurgical Procedures, OperativeTertiary Care CentersUnited StatesYoung Adult
2012
A multimedia comprehensive informatics system with decision support tools for a multi-site collaboration research of stroke rehabilitation
Wang X, Documet J, Garrison K, Winstein C, Liu B. A multimedia comprehensive informatics system with decision support tools for a multi-site collaboration research of stroke rehabilitation. Proceedings Of SPIE--the International Society For Optical Engineering 2012, 8319: 83190u-83190u-11. DOI: 10.1117/12.910971.Peer-Reviewed Original Research
2011
A multi-layered framework for disseminating knowledge for computer-based decision support
Boxwala A, Rocha B, Maviglia S, Kashyap V, Meltzer S, Kim J, Tsurikova R, Wright A, Paterno M, Fairbanks A, Middleton B. A multi-layered framework for disseminating knowledge for computer-based decision support. Journal Of The American Medical Informatics Association 2011, 18: i132-i139. PMID: 22052898, PMCID: PMC3241169, DOI: 10.1136/amiajnl-2011-000334.Peer-Reviewed Original ResearchConceptsCDS systemsComputer-based decision supportPatient data representationKnowledge representation frameworkMulti-layered frameworkData representationDecision support toolStructured knowledgeClinical decision support toolCDS servicesText recommendationDecision supportRepresentation frameworkSupport toolPreliminary evaluationFrameworkDifferent clinical sitesGuideline knowledgeWorkflowSystemImplementationServicesImplementabilityKnowledgeRepresentation
2010
Automating pressure ulcer risk assessment using documented patient data
Kim H, Choi J, Thompson S, Meeker L, Dykes P, Goldsmith D, Ohno-Machado L. Automating pressure ulcer risk assessment using documented patient data. International Journal Of Medical Informatics 2010, 79: 840-848. PMID: 20869303, DOI: 10.1016/j.ijmedinf.2010.08.005.Peer-Reviewed Original Research
1991
The prospect of expert system—Based cognitive support as a by-product of image acquisition and reporting
Mutalik P, Weltin G, Fisher P, Swett H. The prospect of expert system—Based cognitive support as a by-product of image acquisition and reporting. Journal Of Imaging Informatics In Medicine 1991, 4: 233-240. PMID: 1772916, DOI: 10.1007/bf03173905.Peer-Reviewed Original ResearchConceptsDecision supportComputer-based decision support toolDomain of mammographyImage acquisitionComputer interactionUser interfaceDecision support toolExpert systemAutomatic fashionKnowledge contentCognitive supportContent-related questionsInformal evaluationClinical radiologyCase informationInterfaceUsersComputerInterface modelSystemAcquisitionWork patternsInformationSupportTool
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