2023
649. Expansion Of A Low-Cost, Open-Source, Saliva-Based PCR Test For The Detection Of Mpox Virus
Thomas R, Yolda-Carr D, Steel S, Tobik E, Zepeda T, Brownlee M, Saladi S, Parkin J, Fajardo K, Allicock O, Wyllie A. 649. Expansion Of A Low-Cost, Open-Source, Saliva-Based PCR Test For The Detection Of Mpox Virus. Open Forum Infectious Diseases 2023, 10: ofad500.712. PMCID: PMC10677374, DOI: 10.1093/ofid/ofad500.712.Peer-Reviewed Original Research881. Saliva-Based, Extraction-Free PCR Testing For The Detection Of Key Respiratory Pathogens
Allicock O, Lin T, Fajardo K, Yolda-Carr D, Hislop M, Wang J, Zuniga D, Platt W, Tuohy B, Peno C, Wyllie A. 881. Saliva-Based, Extraction-Free PCR Testing For The Detection Of Key Respiratory Pathogens. Open Forum Infectious Diseases 2023, 10: ofad500.926. PMCID: PMC10677551, DOI: 10.1093/ofid/ofad500.926.Peer-Reviewed Original ResearchSARS-CoV-2Saliva samplesRespiratory virusesRespiratory pathogensSARS-CoV-2 PCR testInfluenza A/BSARS-CoV-2 testingUpper respiratory tract pathogensAdditional respiratory virusesDetection of hMPVMass testing strategyPCR testCommon respiratory virusesCommon respiratory pathogensRespiratory tract pathogensKey respiratory pathogensYears of ageSARS-CoV-2 detectionGrant/research supportTransmissible infectious diseasesUse of salivaYale HealthRespiratory symptomsInfluenza B.Nasopharyngeal swabsBooster vaccination protection against SARS-CoV-2 infections in young adults during an Omicron BA.1-predominant period: A retrospective cohort study
Wan J, Cazer C, Clarkberg M, Henderson S, Lee S, Meredith G, Osman M, Shmoys D, Frazier P. Booster vaccination protection against SARS-CoV-2 infections in young adults during an Omicron BA.1-predominant period: A retrospective cohort study. PLOS Medicine 2023, 20: e1004153. PMID: 36626376, PMCID: PMC9876273, DOI: 10.1371/journal.pmed.1004153.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionInitial vaccination seriesPositive SARS-CoV-2 PCR testSARS-CoV-2 PCR testVaccination seriesBooster doseBooster vaccinationCohort studyStudy periodYoung adultsAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionSyndrome coronavirus 2 infectionSevere coronavirus disease 2019Polymerase chain reaction testingCoronavirus 2 infectionRetrospective cohort studyPCR testMultivariable Poisson regressionSARS-CoV-2 variantsStatistical analysis planCoronavirus disease 2019Active surveillance approachSARS-CoV-2World Health Organization
2022
Rapid emergence of SARS-CoV-2 Omicron variant is associated with an infection advantage over Delta in vaccinated persons
Chaguza C, Coppi A, Earnest R, Ferguson D, Kerantzas N, Warner F, Young HP, Breban MI, Billig K, Koch RT, Pham K, Kalinich CC, Ott IM, Fauver JR, Hahn AM, Tikhonova IR, Castaldi C, De Kumar B, Pettker CM, Warren JL, Weinberger DM, Landry ML, Peaper DR, Schulz W, Vogels CBF, Grubaugh ND. Rapid emergence of SARS-CoV-2 Omicron variant is associated with an infection advantage over Delta in vaccinated persons. Med 2022, 3: 325-334.e4. PMID: 35399324, PMCID: PMC8983481, DOI: 10.1016/j.medj.2022.03.010.Peer-Reviewed Original ResearchConceptsSpike gene target failureSARS-CoV-2 Omicron variantPositivity rateOmicron variantOmicron infectionVaccine dosesVaccine-induced immunityNumber of dosesTest positivity rateOdds of infectionSARS-CoV-2Significant reductionDominant Delta variantUnvaccinated personsVaccination statusHigher oddsDelta variantInfectionVaccine manufacturersDisease controlVirus copiesDosesPCR testOddsTarget failure
2018
1988. Development of a Laboratory Stewardship Algorithm for Anaplasma phagocytophilum Polymerase Chain Reaction Testing
Anahtar M, Pattanayak V, Branda J, Azar M, Coffey K, Eng G, Rudolf J, Baron J, Lewandrowski K, Turbett S. 1988. Development of a Laboratory Stewardship Algorithm for Anaplasma phagocytophilum Polymerase Chain Reaction Testing. Open Forum Infectious Diseases 2018, 5: s578-s578. PMCID: PMC6253421, DOI: 10.1093/ofid/ofy210.1644.Peer-Reviewed Original ResearchWhite blood cellsPolymerase chain reactionClinical criteriaPCR testMedian white blood cellPolymerase chain reaction testingComplete blood count valuesBlood count valuesLow positivity ratePreferred diagnostic methodAnaplasma infectionMann-Whitney testChart reviewLaboratory abnormalitiesUnstable patientsClinical parametersPositivity ratePCR testingPLT countReaction testingTypical laboratory abnormalitiesPatientsNegative casesRoche Diagnostics
2017
Duration of viral shedding and factors associated with prolonged shedding among inpatients with influenza treated with oseltamivir: a prospective cohort study
Khoury J, Szwarcwort M, Kra-oz Z, Saffuri M, Seh K, Yahalomi T, Braun E, Azzam Z, Paul M, Neuberger A. Duration of viral shedding and factors associated with prolonged shedding among inpatients with influenza treated with oseltamivir: a prospective cohort study. European Journal Of Clinical Microbiology & Infectious Diseases 2017, 37: 319-323. PMID: 29143145, DOI: 10.1007/s10096-017-3135-0.Peer-Reviewed Original ResearchConceptsRisk factorsBlood pressureDiagnostic yieldDay 2Lower diastolic blood pressureNegative PCR testIndependent risk factorProspective cohort studyProspective observational studyDiastolic blood pressureLower blood pressurePCR testInitiation of treatmentLow diagnostic yieldFirst positive testEvaluable patientsInfluenza PCROseltamivir administrationOseltamivir treatmentCohort studyMedian ageAdult inpatientsViral sheddingPositive PCRPCR positivityImpact of Enteroviral Polymerase Chain Reaction Testing on Length of Stay for Infants 60 Days Old or Younger
Aronson PL, Lyons TW, Cruz AT, Freedman SB, Okada PJ, Fleming AH, Arms JL, Thompson AD, Schmidt SM, Louie J, Alfonzo MJ, Monuteaux MC, Nigrovic LE, Group P, Alpern E, Balamuth F, Bradin S, Curtis S, Garro A, Grether-Jones K, Ishimine P, Kulik D, Mahajan P, Miller A, Mistry R, Pruitt C, Schnadower D, Shah S, Thomson J, Uspal N. Impact of Enteroviral Polymerase Chain Reaction Testing on Length of Stay for Infants 60 Days Old or Younger. The Journal Of Pediatrics 2017, 189: 169-174.e2. PMID: 28705656, PMCID: PMC5870831, DOI: 10.1016/j.jpeds.2017.06.021.Peer-Reviewed Original ResearchConceptsPCR testShorter LOSCentral nervous system infectionPolymerase chain reaction testingCerebrospinal fluid culturesNervous system infectionPlanned secondary analysisLarge multicenter cohortCerebrospinal fluid evaluationLength of stayPositive test resultsNegative test resultsDays of ageHospital lengthHospital LOSRetrospective cohortSystem infectionBacterial meningitisMulticenter cohortPatient ageFluid cultureHospital CenterPCR testingReaction testingInfantsCost-Effectiveness Study of Criteria for Screening Cerebrospinal Fluid To Determine the Need for Herpes Simplex Virus PCR Testing
Hauser RG, Campbell SM, Brandt CA, Wang S. Cost-Effectiveness Study of Criteria for Screening Cerebrospinal Fluid To Determine the Need for Herpes Simplex Virus PCR Testing. Journal Of Clinical Microbiology 2017, 55: 1566-1575. PMID: 28298450, PMCID: PMC5405275, DOI: 10.1128/jcm.00119-17.Peer-Reviewed Original ResearchConceptsCerebrospinal fluidHerpes simplex virus (HSV) central nervous system (CNS) infectionPCR testingCentral nervous system infectionCSF white blood cellsHSV PCR testingNervous system infectionLarge health care systemWhite blood cellsCost-effectiveness studiesHealth care systemDecision analysis modelHSV encephalitisCNS infectionSystem infectionHSV infectionAbsence of markersImmunocompetent hostsNecessary diagnostic testsOrgan transplantsPatient careDiagnostic testsBlood cellsCare systemPCR test
2001
The Effectiveness of the Varicella Vaccine in Clinical Practice
Vázquez M, LaRussa P, Gershon A, Steinberg S, Freudigman K, Shapiro E. The Effectiveness of the Varicella Vaccine in Clinical Practice. New England Journal Of Medicine 2001, 344: 955-960. PMID: 11274621, DOI: 10.1056/nejm200103293441302.Peer-Reviewed Original ResearchConceptsVaricella-zoster virusVaricella vaccinePolymerase chain reactionMild diseasePediatric practiceClinical practicePositive PCR testCase-control studyConditional logistic regressionPotential casesUnvaccinated childrenPotential confoundersActive surveillanceSevere diseaseChickenpoxDay 3VaccineLogistic regressionPCR testDiseaseChain reactionChildrenResearch assistantsIllnessVirusHow Reliable is Sputum PCR Test in the Diagnosis of Pulmonary Tuberculosis When Sputum Smear is Negative?
Baek S, Lee J, Kang M, Son J, Lee S, Kim D, Lee M, Hyun I, Jung K, Lee K, Joe H. How Reliable is Sputum PCR Test in the Diagnosis of Pulmonary Tuberculosis When Sputum Smear is Negative? Tuberculosis And Respiratory Diseases 2001, 50: 222-228. DOI: 10.4046/trd.2001.50.2.222.Peer-Reviewed Original ResearchDirect amplification testsAcid-fast bacilliPulmonary tuberculosisPositive predictive valueAFB smearPredictive valueM. tuberculosis complex DNASputum acid-fast bacilliSputum AFB stainActive pulmonary tuberculosisPulmonary tuberculosis patientsSputum AFB smearValuable diagnostic methodClinical tuberculosisTuberculosis patientsAFB stainRespiratory specimensSputum smearM. tuberculosis complexClinical utilityAmplification testsTuberculosisPatientsPCR testDiagnostic reliabilityClinical Significance of PCR-Based Rapid Detection of Mycobacterium tuberculosis DNA in Peripheral Blood
Kim G, Lee J, Kang M, Son J, Lee S, Kim D, Lee M, Hyun I, Jung K, Lee Y, Lee K. Clinical Significance of PCR-Based Rapid Detection of Mycobacterium tuberculosis DNA in Peripheral Blood. Tuberculosis And Respiratory Diseases 2001, 50: 599-606. DOI: 10.4046/trd.2001.50.5.599.Peer-Reviewed Original ResearchMycobacterium tuberculosis DNAPulmonary tuberculosisActive tuberculosisPositive predictive valueBlood PCRPredictive valueTuberculosis DNAPeripheral bloodMajor public health problemBlood PCR testsEarly diagnostic ratePeripheral blood PCRActive pulmonary tuberculosisHigh positive predictive valuePCR testPositive tuberculosis patientsSimple chest radiographPublic health problemNegative predictive valuePresumed tuberculosisExtrapulmonary tuberculosisPositive tuberculosisTuberculosis patientsMedication useAFB stain
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