2025
Perfect health not so perfect after all – a methodological study on patient-reported outcome measures in 2574 patients following percutaneous coronary intervention
Norekvål T, Iversen M, Oterhals K, Allore H, Borregaard B, Pettersen T, Thompson D, Zwisler A, Breivik K. Perfect health not so perfect after all – a methodological study on patient-reported outcome measures in 2574 patients following percutaneous coronary intervention. Health And Quality Of Life Outcomes 2025, 23: 35. PMID: 40188074, PMCID: PMC11972467, DOI: 10.1186/s12955-025-02360-4.Peer-Reviewed Original ResearchConceptsMyocardial Infarction Dimensional Assessment ScaleEQ-5D-5L scoresPatient-reported outcome measuresEQ-5D-5LCeiling effectsOutcome measuresDaily life challengesPicture of patients' health statusHealth statusDisease-specific patient-reported outcome measuresPatient healthBackgroundPatient-reported outcome measuresLatent class analysisHealth utility instrumentsSelf-reported healthPercutaneous coronary interventionPercutaneous coronary intervention centreDisease-specific instrumentPatients' health statusSide effects of medicationsLife challengesEQ-5D-5L descriptive systemSymptoms of fatigueCoronary artery diseaseClass analysis
2024
Culturally adapted intervention regarding decision‐making on feeding options for Chinese American dementia caregivers: A human‐centered approach
Pei Y, Wang J, Schulman‐Green D, Fried T, Hanson L, Wu B. Culturally adapted intervention regarding decision‐making on feeding options for Chinese American dementia caregivers: A human‐centered approach. Alzheimer's & Dementia 2024, 20: e088317. PMCID: PMC11712302, DOI: 10.1002/alz.088317.Peer-Reviewed Original ResearchDementia caregiversFamily decision-makingFeeding optionsHealth statusEnd-of-life experiencesCultural adaptationDecision aid interventionTube feedingHealth care providersPatients' health statusDecision-making experiencesSemi-structured interviewsAdvanced dementiaHealthy eatingCare providersPLWDDecision-makingChinese versionDemographic questionnairePerception of comfortThematic analysisCaregiversCaregiving practicesAudio-recordedChinese AmericansEffect of Aficamten on Health Status Outcomes in Obstructive Hypertrophic Cardiomyopathy Results From SEQUOIA-HCM
Sherrod C, Saberi S, Nassif M, Claggett B, Coats C, Garcia-Pavia P, Januzzi J, Lewis G, Ma C, Maron M, Miao Z, Olivotto I, Veselka J, Butzner M, Jacoby D, Heitner S, Kupfer S, Malik F, Meng L, Wohltman A, Spertus J. Effect of Aficamten on Health Status Outcomes in Obstructive Hypertrophic Cardiomyopathy Results From SEQUOIA-HCM. Journal Of The American College Of Cardiology 2024, 84: 1773-1785. PMID: 39217569, PMCID: PMC11975529, DOI: 10.1016/j.jacc.2024.08.014.Peer-Reviewed Original ResearchKCCQ overall summary scoresKansas City Cardiomyopathy QuestionnaireObstructive hypertrophic cardiomyopathyHealth statusQuality of lifePatient-reported health statusParticipants' health statusHealth status outcomesHypertrophic cardiomyopathyHealth status benefitsHealth status improvementPatients' health statusClinically important changeProportion of participantsSymptoms of fatigueSymptomatic obstructive hypertrophic cardiomyopathyStatus outcomesSummary scoreImprove healthCardiac myosin inhibitorProportion of patientsBaseline scoresImportant changesShortness of breathStatus improvementImpact of early intervention on health status outcomes in peripheral artery disease patients with chronic total occlusion lesions using the PORTRAIT registry
Cerrud-Rodriguez R, Romain G, Hussain Y, Cleman J, Callegari S, Scierka L, Smolderen K, Mena-Hurtado C. Impact of early intervention on health status outcomes in peripheral artery disease patients with chronic total occlusion lesions using the PORTRAIT registry. Journal Of Vascular Surgery 2024, 80: 780-790.e10. PMID: 38735596, DOI: 10.1016/j.jvs.2024.04.061.Peer-Reviewed Original ResearchPeripheral Artery QuestionnairePeripheral arterial diseaseHealth statusChronic total occlusionChronic total occlusion lesionsPAD-specific health statusEarly invasive treatmentMultilevel generalized linear regression modelsPeripheral arterial disease symptomsLower extremity peripheral arterial diseaseBaseline health statusHealth status outcomesInvasive treatmentHealth status trajectoriesNon-invasive treatmentPatients' health statusImpact of early interventionHigh health statusFollow-upPeripheral arterial disease patientsSymptomatic peripheral arterial diseaseMonths of follow-upPresence of chronic total occlusionNon-invasive treatment strategyStatus outcomes
2023
A state-of-the-art review of quality-of-life assessment in venous disease
Cleman J, Xia K, Haider M, Nikooie R, Scierka L, Romain G, Attaran R, Grimshaw A, Mena-Hurtado C, Smolderen K. A state-of-the-art review of quality-of-life assessment in venous disease. Journal Of Vascular Surgery Venous And Lymphatic Disorders 2023, 12: 101725. PMID: 38128828, PMCID: PMC11523418, DOI: 10.1016/j.jvsv.2023.101725.Peer-Reviewed Original ResearchDisease-specific patient-reported outcome measurePatient-reported outcome measuresChronic venous diseaseCharing Cross Venous Ulcer QuestionnaireChronic Venous Insufficiency QuestionnaireVenous diseaseHealth statusVenous ulcersEvidence baseRelevant English-language studiesPatients' health statusContent validityEnglish-language studiesFull-text articlesManifestations of diseaseC6 diseaseOvid EmbaseInclusion criteriaOutcome measuresCommon conditionClinical settingDiseaseLiterature searchPatientsUlcers
2021
Environmental emissions reduction of a preoperative evaluation center utilizing telehealth screening and standardized preoperative testing guidelines
Wang E, Zafar J, Lawrence C, Gavin L, Mishra S, Boateng A, Thiel C, Dubrow R, Sherman J. Environmental emissions reduction of a preoperative evaluation center utilizing telehealth screening and standardized preoperative testing guidelines. Resources Conservation And Recycling 2021, 171: 105652. DOI: 10.1016/j.resconrec.2021.105652.Peer-Reviewed Original ResearchClinic visitsPreoperative testingRetrospective cross-sectional analysisTesting guidelinesYale-New Haven HospitalElective spine surgeryPreoperative evaluation centerPreoperative evaluation processUnnecessary preoperative testsAnesthesiologists class IUnnecessary preoperative testingNew Haven HospitalPatients' health statusCross-sectional analysisElectronic health recordsPreoperative clinicPreoperative testsClinic evaluationSpine surgeryAnnual surgeriesUnnecessary testingHealthcare resourcesHealth statusPatient travelUrgent reductionMavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): health status analysis of a randomised, double-blind, placebo-controlled, phase 3 trial
Spertus JA, Fine JT, Elliott P, Ho CY, Olivotto I, Saberi S, Li W, Dolan C, Reaney M, Sehnert AJ, Jacoby D. Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): health status analysis of a randomised, double-blind, placebo-controlled, phase 3 trial. The Lancet 2021, 397: 2467-2475. PMID: 34004177, DOI: 10.1016/s0140-6736(21)00763-7.Peer-Reviewed Original ResearchConceptsKansas City Cardiomyopathy QuestionnaireSymptomatic obstructive hypertrophic cardiomyopathyObstructive hypertrophic cardiomyopathyHypertrophic cardiomyopathyPatients' health statusQuality of lifeHealth statusWeek 30KCCQ overall summary scoreAvailable pharmacological optionsKCCQ-OS scorePlacebo-controlled trialPhase 3 trialProportion of patientsPrimary treatment goalOverall summary scoreDisease-specific measuresEffect of mavacamtenHealth status analysisNew potential strategyEXPLORER-HCMPlacebo groupAdult patientsBristol-Myers Squibb CompanyPharmacological options
2018
PORTRAIT (Patient-Centered Outcomes Related to Treatment Practices in Peripheral Arterial Disease
Smolderen KG, Gosch K, Patel M, Jones WS, Hirsch AT, Beltrame J, Fitridge R, Shishehbor MH, Denollet J, Vriens P, Heyligers J, Stone MEd N, Aronow H, Abbott JD, Labrosciano C, Tutein-Nolthenius R, A Spertus J. PORTRAIT (Patient-Centered Outcomes Related to Treatment Practices in Peripheral Arterial Disease. Circulation Cardiovascular Quality And Outcomes 2018, 11: e003860. PMID: 29440123, DOI: 10.1161/circoutcomes.117.003860.Peer-Reviewed Original ResearchMeSH KeywordsAgedAustraliaCardiovascular AgentsExercise TherapyFemaleHealth StatusHealth Status IndicatorsHealthcare DisparitiesHumansIntermittent ClaudicationLife StyleMaleMiddle AgedMulticenter Studies as TopicNetherlandsPatient Outcome AssessmentPeripheral Arterial DiseaseProspective StudiesQuality of LifeRegistriesResearch DesignRisk FactorsSurveys and QuestionnairesTime FactorsTreatment OutcomeUnited StatesVascular Surgical ProceduresConceptsHealth status outcomesHealth statusMedical historyMedical recordsStatus outcomesAbnormal ankle-brachial indexPAD-related hospitalizationAnkle-brachial indexCardiovascular risk factorsMajor cardiovascular eventsPatients' medical recordsComparative effectiveness studiesHealth status dataPatient's medical historyPatients' health statusQuality of lifeClaudication symptomsEligible patientsCardiovascular eventsPAD symptomsPatient characteristicsClinician adherenceRisk stratificationLifestyle factorsFunctional statusAssociation between health status and sociodemographic, clinical and treatment disparities in the Patient-centered Outcomes Related to TReatment Practices in Peripheral Arterial Disease: Investigating Trajectories (PORTRAIT) registry
Noyes AM, Abbott JD, Gosch K, Smolderen K, Spertus JA, Hyder O, Soukas P, Shishehbor MH, Aronow HD. Association between health status and sociodemographic, clinical and treatment disparities in the Patient-centered Outcomes Related to TReatment Practices in Peripheral Arterial Disease: Investigating Trajectories (PORTRAIT) registry. Vascular Medicine 2018, 23: 32-38. PMID: 29338591, DOI: 10.1177/1358863x17747047.Peer-Reviewed Original ResearchConceptsPeripheral artery diseasePoor health statusIntermittent claudicationHealth statusPatient characteristicsDisease-specific health status measuresNon-vascular factorsPeripheral arterial diseaseChronic lung diseaseSpecialty care visitsTime of presentationHealth status measuresMultivariable linear regressionPatients' health statusQuality of lifeCare visitsArtery diseaseInitial presentationArterial diseaseBack painExercise programTreatment disparitiesLung diseaseFemale sexFunctional status
2017
Preinfarct Health Status and the Use of Early Invasive Versus Ischemia-Guided Management in Non–ST-Elevation Acute Coronary Syndrome
Qintar M, Smolderen KG, Chan PS, Gosch KL, Jones PG, Buchanan DM, Girotra S, Spertus JA. Preinfarct Health Status and the Use of Early Invasive Versus Ischemia-Guided Management in Non–ST-Elevation Acute Coronary Syndrome. The American Journal Of Cardiology 2017, 120: 1062-1069. PMID: 28797471, PMCID: PMC5766265, DOI: 10.1016/j.amjcard.2017.06.045.Peer-Reviewed Original ResearchConceptsEarly invasive managementEarly invasive treatmentInvasive managementHealth statusMyocardial infarctionInvasive treatmentAcute Myocardial Infarction Patients' Health StatusAcute Coronary Events (GRACE) risk scoreElevation acute coronary syndromeProspective Registry Evaluating OutcomesHighest risk decileHospital treatment strategiesPoor baseline qualityAcute coronary syndromeElevation myocardial infarctionWorse health statusHigher mortality riskPatients' health statusQuality of lifeAngina frequencyNSTEMI cohortCoronary syndromeGRACE scoreMulticenter registryNon–ST
2014
Personal Health Record Reach in the Veterans Health Administration: A Cross-Sectional Analysis
Shimada SL, Brandt CA, Feng H, McInnes DK, Rao SR, Rothendler JA, Haggstrom DA, Abel EA, Cioffari LS, Houston TK. Personal Health Record Reach in the Veterans Health Administration: A Cross-Sectional Analysis. Journal Of Medical Internet Research 2014, 16: e272. PMID: 25498515, PMCID: PMC4275468, DOI: 10.2196/jmir.3751.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationSchizophrenia/schizoaffective disorderPersonal health recordsCross-sectional analysisHealth recordsClinical conditionsSchizoaffective disorderHealth AdministrationHealth statusSociodemographic characteristicsUnited States Veterans Health AdministrationMultivariable logistic regression modelFacility-level differencesPatients' sociodemographic characteristicsTethered personal health recordClustering of patientsSpinal cord injurySpecific clinical conditionsTraumatic brain injuryPatients' health statusSpecific medical conditionsLogistic regression modelsOutpatient visitsCord injuryInpatient admissionsDeterminants of invasive treatment in lower extremity peripheral arterial disease
van Zitteren M, Vriens PW, Burger DH, de Fijter WM, Gerritsen GP, Heyligers JM, Nooren MJ, Smolderen KG. Determinants of invasive treatment in lower extremity peripheral arterial disease. Journal Of Vascular Surgery 2014, 59: 400-408.e2. PMID: 24461863, DOI: 10.1016/j.jvs.2013.08.045.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnkle Brachial IndexChi-Square DistributionDecision Support TechniquesEndovascular ProceduresFemaleHealth StatusHumansLower ExtremityMaleMiddle AgedNetherlandsOdds RatioPatient SelectionPeripheral Arterial DiseasePredictive Value of TestsProspective StudiesReferral and ConsultationRisk FactorsTreatment OutcomeUltrasonography, Doppler, DuplexVascular Surgical ProceduresConceptsPeripheral arterial diseaseLower extremity peripheral arterial diseasePhysical component scaleInvasive treatmentLesion locationHealth statusArterial diseaseTreatment referralSymptomatic lower extremity peripheral arterial diseaseProspective observational cohort studyVascular surgery outpatient clinicProximal lesion locationAnkle-brachial indexObservational cohort studySurgery outpatient clinicShort Form-12Poor health statusPatients' health statusPoisson regression analysisPAD diagnosisCohort studyPAD symptomsIndependent predictorsAmbulatory patientsForm-12
2012
Deferasirox Is Associated with Reduced Mortality Risk in a Medicare Population with Myelodysplastic Syndromes
Zeidan A, Hendrick F, Friedmann E, Gore S, Baer M, Sasane M, Paley C, McNally D, Davidoff A. Deferasirox Is Associated with Reduced Mortality Risk in a Medicare Population with Myelodysplastic Syndromes. Blood 2012, 120: 426. DOI: 10.1182/blood.v120.21.426.426.Peer-Reviewed Original ResearchIron chelation therapyErythropoiesis-stimulating agentsMarginal structural modelsRisk of deathMyelodysplastic syndromeRenal diseaseTransfusion thresholdThyroid diseaseIron overloadChelation therapyObservation periodHealth statusOral iron chelation therapyICD-9-CM diagnosisICD-9-CM codesOlder MDS patientsSolid tumor diagnosisDuration of therapyCo-morbid conditionsOnset of diabetesEnd of studyOverall survival analysisPatients' health statusReduced mortality riskDrug side effectsPhysical function and independence 1 year after myocardial infarction: Observations from the Translational Research Investigating Underlying disparities in recovery from acute Myocardial infarction: Patients' Health status registry
Dodson JA, Arnold SV, Reid KJ, Gill TM, Rich MW, Masoudi FA, Spertus JA, Krumholz HM, Alexander KP. Physical function and independence 1 year after myocardial infarction: Observations from the Translational Research Investigating Underlying disparities in recovery from acute Myocardial infarction: Patients' Health status registry. American Heart Journal 2012, 163: 790-796. PMID: 22607856, PMCID: PMC3359897, DOI: 10.1016/j.ahj.2012.02.024.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAge FactorsAgedAngioplasty, Balloon, CoronaryAttitude to HealthCardiac CatheterizationCoronary AngiographyDepressionElectrocardiographyFemaleFollow-Up StudiesHealth SurveysHumansIncidenceIndependent LivingMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionPhysical FitnessPoisson DistributionPredictive Value of TestsQuality of LifeRegistriesRisk AssessmentSickness Impact ProfileSurveys and QuestionnairesSurvivorsTime FactorsTranslational Research, BiomedicalConceptsAcute myocardial infarctionPhysical function declineFunction declinePhysical functionMyocardial infarctionHealth statusEuroQol-5DUninsured statusTime of AMIShort Form-12 Physical Component ScoreIndependence lossEnd-stage renal diseasePost-acute myocardial infarctionCardiac rehabilitation referralPhysical component scorePatients' health statusQuality of lifePoisson regression modelsTRIUMPH registryRehabilitation referralRenal diseaseNonwhite raceFemale sexRisk factorsUnmarried status
2011
Translational Research Investigating Underlying Disparities in Acute Myocardial Infarction Patients' Health Status (TRIUMPH)
Arnold SV, Chan PS, Jones PG, Decker C, Buchanan DM, Krumholz HM, Ho PM, Spertus JA. Translational Research Investigating Underlying Disparities in Acute Myocardial Infarction Patients' Health Status (TRIUMPH). Circulation Cardiovascular Quality And Outcomes 2011, 4: 467-476. PMID: 21772003, PMCID: PMC3376532, DOI: 10.1161/circoutcomes.110.960468.Peer-Reviewed Original ResearchConceptsHealth status studiesMyocardial infarctionHealth statusPostdischarge careAcute Myocardial Infarction Patients' Health StatusSubset of patientsTranslational researchPost-MI outcomesRacial differencesHigh mortality ratePatients' health statusMI registryChart abstractionHospital dischargeWhite patientsBlack patientsVital statusMedical historyWorse outcomesTreatment characteristicsInpatient careBaseline interviewUS CentersBlood samplesPatients
2008
Further Validation of the Peripheral Artery Questionnaire: Results from a Peripheral Vascular Surgery Survey in the Netherlands
Smolderen KG, Hoeks SE, Aquarius AE, Reimer W, Spertus JA, van Urk H, Denollet J, Poldermans D. Further Validation of the Peripheral Artery Questionnaire: Results from a Peripheral Vascular Surgery Survey in the Netherlands. European Journal Of Vascular And Endovascular Surgery 2008, 36: 582-591. PMID: 18804390, DOI: 10.1016/j.ejvs.2008.07.015.Peer-Reviewed Original ResearchMeSH KeywordsAgedCross-Sectional StudiesDisability EvaluationFemaleHealth Care SurveysHealth Status IndicatorsHumansLanguageMaleMiddle AgedNetherlandsPatient SatisfactionPerceptionPeripheral Vascular DiseasesPrincipal Component AnalysisQuality of LifeRecovery of FunctionReproducibility of ResultsSurveys and QuestionnairesTreatment OutcomeVascular Surgical ProceduresConceptsPeripheral Artery QuestionnairePeripheral arterial diseaseEQ-5D scalePAD patientsPatients' health statusHealth statusPerceived DisabilityTreatment satisfactionPhysical functionEuro Heart Survey ProgrammeDisease-specific health statusAdverse cardiovascular eventsCross-sectional studyCardiovascular eventsArterial diseaseTreatment optionsPatientsAlpha valuesClinical researchCronbach's alpha valuesDutch versionConvergent validityDisabilityStatusQuestionnaire
2004
Prognostic Value of Health Status in Patients With Heart Failure After Acute Myocardial Infarction
Soto GE, Jones P, Weintraub WS, Krumholz HM, Spertus JA. Prognostic Value of Health Status in Patients With Heart Failure After Acute Myocardial Infarction. Circulation 2004, 110: 546-551. PMID: 15262843, DOI: 10.1161/01.cir.0000136991.85540.a9.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAmericasCardiovascular DiseasesCohort StudiesComorbidityDisease-Free SurvivalEplerenoneEuropeFemaleHealth Status IndicatorsHeart FailureHospitalizationHumansMaleMiddle AgedMineralocorticoid Receptor AntagonistsMyocardial InfarctionPrognosisProspective StudiesRisk FactorsSeverity of Illness IndexSpironolactoneConceptsKansas City Cardiomyopathy QuestionnaireAcute myocardial infarctionHeart failureKCCQ-OSMyocardial infarctionHealth statusKCCQ scoresCardiovascular mortalityPrognostic valueDisease-specific health status instrumentRecent acute myocardial infarctionSubsequent cardiovascular eventsEvent-free survivalOutpatient clinical practiceFirst outpatient visitHealth status instrumentsPatients' health statusQuality of lifeCardiovascular eventsClinical characteristicsOutpatient visitsMultivariable modelInternational cohortFunctional limitationsClinical practice
2003
Understanding racial disparities in HIV using data from the veterans aging cohort 3-site study and VA administrative data.
McGinnis KA, Fine MJ, Sharma RK, Skanderson M, Wagner JH, Rodriguez-Barradas MC, Rabeneck L, Justice AC. Understanding racial disparities in HIV using data from the veterans aging cohort 3-site study and VA administrative data. American Journal Of Public Health 2003, 93: 1728-33. PMID: 14534229, PMCID: PMC1448041, DOI: 10.2105/ajph.93.10.1728.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntiretroviral Therapy, Highly ActiveBlack or African AmericanCohort StudiesDisease ManagementFemaleHispanic or LatinoHIV SeropositivityHumansMaleMiddle AgedPatient Acceptance of Health CarePatient ComplianceProportional Hazards ModelsSocioeconomic FactorsSurvival AnalysisUnited StatesUnited States Department of Veterans AffairsVeteransWhite PeopleConceptsWhite veteransClinical managementMinority veteransHealth statusVeterans Aging CohortSeverity of illnessVA administrative dataRace-associated differencesHigh mortality ratePatients' health statusNational administrative dataAdministrative dataPossible etiologiesUS veteransPoor survivalMortality rateAging CohortHIVPoor healthRacial disparitiesVeteransSignificant differencesSurvivalCohortAdherence
2000
Primary Care Outcomes in Patients Treated by Nurse Practitioners or Physicians: A Randomized Trial
Mundinger M, Kane R, Lenz E, Totten A, Tsai W, Cleary P, Friedewald W, Siu A, Shelanski M. Primary Care Outcomes in Patients Treated by Nurse Practitioners or Physicians: A Randomized Trial. JAMA 2000, 283: 59-68. PMID: 10632281, DOI: 10.1001/jama.283.1.59.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmbulatory CareCommunity Health CentersContinuity of Patient CareEmergenciesFemaleHealth Services ResearchHealth StatusHumansMaleMiddle AgedNew York CityNurse PractitionersOutcome Assessment, Health CarePatient SatisfactionPhysicians, FamilyPrimary Health CareProfessional AutonomyRegression AnalysisConceptsPrimary care clinicsNurse practitionersInitial appointmentHealth statusCare clinicsPrimary careService utilizationCommunity-based primary care clinicsHealth service utilization dataUrban academic medical centerUrgent care visitsHealth service utilizationPrimary care outcomesPrimary care physiciansPrimary care appointmentsService utilization dataNurse practitioner practicePatients' health statusAcademic medical centerSignificant differencesType of providerSatisfaction ratingsCare visitsPractitioners' patientsCare appointments
1999
Carepartner Experiences With Hospital Care
vom Eigen K, Walker J, Edgman-Levitan S, Cleary P, Delbanco T. Carepartner Experiences With Hospital Care. Medical Care 1999, 37: 33-38. PMID: 10413390, DOI: 10.1097/00005650-199901000-00006.Peer-Reviewed Original ResearchConceptsIndependent predictorsRegular doctorHospital experienceMultivariable regression analysisSupport of patientsDomains of carePatients' health statusNonsurgical admissionsDischarge planningPatient satisfactionEmergency hospitalizationHospital careCarepartnersNationwide telephone surveyHealth statusPatient careHospitalizationPatientsCareTelephone surveyRegression analysisFamily participationBetter awarenessFamily membersEmotional support
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