2020
Cutaneous and Pulmonary Mucormycosis in Rag1- and Il2rg-deficient Rats.
Sarfaty AE, Compton SR, Smith PC, Zeiss CJ. Cutaneous and Pulmonary Mucormycosis in Rag1- and Il2rg-deficient Rats. Journal Of The American Association For Laboratory Animal Science 2020, 70: 390-395. PMID: 32736665, PMCID: PMC7446636, DOI: 10.30802/aalas-cm-20-000015.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsFemaleHousing, AnimalImmunocompetenceMaleMucormycosisOpportunistic InfectionsRats
2018
Comprehensive long‐term safety of adalimumab from 18 clinical trials in adult patients with moderate‐to‐severe plaque psoriasis
Leonardi C, Papp K, Strober B, Thaçi D, Warren R, Tyring S, Arikan D, Karunaratne M, Valdecantos W. Comprehensive long‐term safety of adalimumab from 18 clinical trials in adult patients with moderate‐to‐severe plaque psoriasis. British Journal Of Dermatology 2018, 180: 76-85. PMID: 30169904, DOI: 10.1111/bjd.17084.Peer-Reviewed Original ResearchMeSH KeywordsAdalimumabAdultAnti-Inflammatory AgentsClinical Trials as TopicDatasets as TopicFemaleHeadacheHumansIncidenceInjections, SubcutaneousLong-Term CareMaleMiddle AgedNasopharyngitisNeoplasmsOpportunistic InfectionsPsoriasisSeverity of Illness IndexTime FactorsTuberculosisTumor Necrosis Factor-alphaConceptsNonmelanoma skin cancerStandardized incidence ratiosStandardized mortality ratioAdverse eventsLong-term safetyPlaque psoriasisClinical trialsIncidence rateIncidence of NMSCSevere chronic plaque psoriasisTreatment-emergent adverse eventsAE incidence ratesChronic plaque psoriasisCommon adverse eventsSevere plaque psoriasisNew safety signalsUpper respiratory infectionIncidence of malignancyAnalysis of patientsTumor necrosis factorHuman monoclonal antibodyAdalimumab doseAdalimumab exposureLast doseAdult patientsNecrotic cheek ulcer in a liver transplant patient
Coleman E, Levy L, Panse G, Leventhal JS. Necrotic cheek ulcer in a liver transplant patient. International Journal Of Dermatology 2018, 58: 285-287. PMID: 29926899, PMCID: PMC6309531, DOI: 10.1111/ijd.14101.Peer-Reviewed Original ResearchCase 1-2018: A 39-Year-Old Woman with Rapidly Progressive Respiratory Failure
Hibbert KA, Shepard JO, Lane RJ, Azar MM. Case 1-2018: A 39-Year-Old Woman with Rapidly Progressive Respiratory Failure. New England Journal Of Medicine 2018, 378: 182-190. PMID: 29320657, DOI: 10.1056/nejmcpc1712222.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsAdenoviridaeAdenoviridae InfectionsAdultAntiviral AgentsCidofovirCytosineDiagnosis, DifferentialFemaleHumansImmunocompromised HostLeukemia, Myeloid, AcuteLungNasopharynxOpportunistic InfectionsOrganophosphonatesRadiography, ThoracicRenal InsufficiencyRespiratory InsufficiencyStem Cell TransplantationTomography, X-Ray ComputedViral Load
2017
Progressive cutaneous Cryptococcosis complicated with meningitis in a myasthenia gravis patient on long-term immunosuppressive therapy – a case report
Huong N, Altibi A, Hoa N, Tuan L, Salman S, Morsy S, Lien N, Truong N, Mai N, Hoa P, Thang N, Trung V. Progressive cutaneous Cryptococcosis complicated with meningitis in a myasthenia gravis patient on long-term immunosuppressive therapy – a case report. BMC Infectious Diseases 2017, 17: 311. PMID: 28446137, PMCID: PMC5406963, DOI: 10.1186/s12879-017-2415-8.Peer-Reviewed Original ResearchConceptsLong-term immunosuppressive therapyImmunosuppressive therapyCutaneous cryptococcosisMyasthenia gravisCutaneous manifestations of cryptococcosisDifferential diagnosis of cutaneous lesionsAssociated with myasthenia gravisDiagnosis of cutaneous lesionsHIV-uninfected individualsManifestation of cryptococcosisChronic immunosuppressive therapyHIV-infected individualsProgressive skin lesionsDevelopment of cryptococcosisMyasthenia gravis patientsCD4 countCryptococcal meningitisDisseminated diseaseCase presentationWeOpportunistic infectionsMonth historyVietnamese male patientMale patientsCutaneous manifestationsDifferential diagnosisInflammation: A Double-Edged Sword in the Response to Pseudomonas aeruginosa Infection
Lin CK, Kazmierczak BI. Inflammation: A Double-Edged Sword in the Response to Pseudomonas aeruginosa Infection. Journal Of Innate Immunity 2017, 9: 250-261. PMID: 28222444, PMCID: PMC5469373, DOI: 10.1159/000455857.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCytokinesHost-Pathogen InteractionsHumansImmunity, InnateInflammasomesInflammationOpportunistic InfectionsPseudomonas aeruginosaPseudomonas InfectionsConceptsP. aeruginosa pulmonary infectionInnate immune recognitionPseudomonas aeruginosa infectionInflamed airwaysPulmonary infectionAcute infectionAdjunct therapyChronic infectionBarrier defenseAeruginosa infectionAnatomic sitesPathogen clearanceBacterial productsImmune recognitionInnate immunityInfectionHost outcomesResistant pathogensP. aeruginosa adaptationInflammationP. aeruginosaPathogen persistenceDouble-edged swordPseudomonas aeruginosaDefense mechanisms
2016
Disseminated Mycobacterium tuberculosis following renal transplant with alemtuzumab induction
Baghban A, Azar MM, Bernardo RM, Malinis M. Disseminated Mycobacterium tuberculosis following renal transplant with alemtuzumab induction. BMJ Case Reports 2016, 2016: bcr2016217998. PMID: 27852682, PMCID: PMC5129162, DOI: 10.1136/bcr-2016-217998.Peer-Reviewed Case Reports and Technical NotesConceptsMycobacterium tuberculosisDisseminated Mycobacterium tuberculosisIsoniazid preventative therapyHigh-risk patientsSolid organ transplantsOngoing risk factorsAlemtuzumab inductionDisseminated tuberculosisInduction immunosuppressionPeritransplant periodRenal transplantRenal transplantationPulmonary tuberculosisTuberculosis infectionPreventative therapyRisk factorsOrgan transplantsTuberculosisPatientsTransplantAvailable literatureImmunosuppressionTransplantationUnique challengesTherapyIs There a Role for Opportunistic Infection Prophylaxis in Pemphigus? An Expert Survey
Leshem Y, Snast I, Friedland R, Atzmony L, Levi A, Hodak E, Mimouni D. Is There a Role for Opportunistic Infection Prophylaxis in Pemphigus? An Expert Survey. American Journal Of Clinical Dermatology 2016, 18: 127-132. PMID: 27826815, DOI: 10.1007/s40257-016-0233-1.Peer-Reviewed Original ResearchMeSH KeywordsHealth Care SurveysHumansImmunosuppressive AgentsMass ScreeningOpportunistic InfectionsPemphigusPractice Guidelines as TopicPractice Patterns, Physicians'ConceptsOpportunistic infection prophylaxisImmunosuppressive therapyInfection prophylaxisInitiation of immunosuppressive therapyEffects of immunosuppressive therapyAdverse effects of immunosuppressive therapyEmergence of resistant pathogensCessation of immunosuppressionHistory of OIInfectious disease specialistsDrug of choiceTertiary care settingBackgroundOpportunistic infectionsImmunosuppressive agentsImmunosuppressive conditionsRisk stratificationDisease specialistsFrequent drugsResistant pathogensSide effectsSevere diseaseHepatitis virusObjectiveOur objectivePatientsPemphigusHIV-Associated Neurologic Disorders and Central Nervous System Opportunistic Infections in HIV
Le LT, Spudich SS. HIV-Associated Neurologic Disorders and Central Nervous System Opportunistic Infections in HIV. Seminars In Neurology 2016, 36: 373-381. PMID: 27643907, DOI: 10.1055/s-0036-1585454.Peer-Reviewed Original ResearchMeSH KeywordsAIDS-Related Opportunistic InfectionsCD4-Positive T-LymphocytesHIV InfectionsHumansNervous System DiseasesOpportunistic InfectionsConceptsCombination antiretroviral therapyAsymptomatic neurocognitive impairmentPlasma viral loadViral loadMild neurocognitive disorderCerebral toxoplasmosisCryptococcal meningitisOpportunistic infectionsNeurocognitive disordersCentral nervous system opportunistic infectionsCNS immune reconstitution inflammatory syndromeDetectable plasma viral loadImmune reconstitution inflammatory syndromeCentral nervous system symptomsClassic opportunistic infectionsCSF viral loadProgressive neurologic symptomsReconstitution inflammatory syndromeT-cell countsProgressive multifocal leukoencephalopathyNervous system symptomsPresentation of infectionHigher mortality riskHigher CD4Immune recovery
2015
Pneumocystis jiroveci pneumonia (PCP) in patients receiving neoadjuvant and adjuvant anthracycline-based chemotherapy for breast cancer: incidence and risk factors
Waks AG, Tolaney SM, Galar A, Arnaout A, Porter JB, Marty FM, Winer EP, Hammond SP, Baden LR. Pneumocystis jiroveci pneumonia (PCP) in patients receiving neoadjuvant and adjuvant anthracycline-based chemotherapy for breast cancer: incidence and risk factors. Breast Cancer Research And Treatment 2015, 154: 359-367. PMID: 26420402, DOI: 10.1007/s10549-015-3573-2.Peer-Reviewed Original ResearchConceptsPneumocystis jiroveci pneumoniaCases of PCPEarly-stage breast cancerBreast cancerJiroveci pneumoniaAC chemotherapyRisk factorsDana-Farber Cancer Institute/BrighamNon-metastatic breast cancer patientsAdjuvant anthracycline-based chemotherapyEarly-stage breast cancer treatmentAdriamycin/cyclophosphamideDose-dense ACAnthracycline-based chemotherapyDose-dense scheduleBreast cancer patientsBreast cancer treatmentEquivalents/dayCalculate incidenceCorticosteroid doseNausea prophylaxisSame chemotherapyOpportunistic infectionsOverall incidencePCP incidence
2013
Opportunistic infections in a patient with HIV and thymoma
Leathers CA, Azar MM, Badve SS, Roth TD, Loehrer PJ, Nelson RP. Opportunistic infections in a patient with HIV and thymoma. The Journal Of Allergy And Clinical Immunology In Practice 2013, 1: 413-415. PMID: 24565551, DOI: 10.1016/j.jaip.2013.03.017.Peer-Reviewed Case Reports and Technical Notes
2011
Disseminated fusarium infection with muscle involvement
King BA, Seropian S, Fox LP. Disseminated fusarium infection with muscle involvement. Journal Of The American Academy Of Dermatology 2011, 65: 235-237. PMID: 21679835, DOI: 10.1016/j.jaad.2009.12.034.Peer-Reviewed Case Reports and Technical NotesHemolytic Phospholipase C Inhibition Protects Lung Function during Pseudomonas aeruginosa Infection
Wargo M, Gross M, Rajamani S, Allard J, Lundblad L, Allen G, Vasil M, Leclair L, Hogan D. Hemolytic Phospholipase C Inhibition Protects Lung Function during Pseudomonas aeruginosa Infection. American Journal Of Respiratory And Critical Care Medicine 2011, 184: 345-354. PMID: 21562128, PMCID: PMC3175536, DOI: 10.1164/rccm.201103-0374oc.Peer-Reviewed Original ResearchConceptsLung functionP. aeruginosa infectionAeruginosa infectionSignificant lung function impairmentLung function impairmentLung function declineBronchoalveolar lavage fluidPseudomonas aeruginosa infectionChronic lung infectionVirulence factorsP. aeruginosaP. aeruginosa virulence factorsPulmonary surfactant functionSingle virulence factorFunction declineMechanical ventilationFunction impairmentLavage fluidRespiratory endpointsSurfactant dysfunctionComputer-controlled ventilatorLung infectionAeruginosa virulence factorsStrain infectionLung physiology
2010
Cytomegalovirus Infection in Patients with Active Inflammatory Bowel Disease
Kim JJ, Simpson N, Klipfel N, DeBose R, Barr N, Laine L. Cytomegalovirus Infection in Patients with Active Inflammatory Bowel Disease. Digestive Diseases And Sciences 2010, 55: 1059-1065. PMID: 20112061, DOI: 10.1007/s10620-010-1126-4.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseActive inflammatory bowel diseaseActive ulcerative colitisUC patientsIndex flareCMV infectionUlcerative colitisCrohn's diseaseCytomegalovirus infectionBowel diseasePrevalence of CMVCourse of diseaseAcute exacerbationIBD colitisUC flareCMV antigensConclusionsThe prevalenceIndex endoscopyMethodsConsecutive patientsClinical courseSevere morbidityClinical featuresImmunohistochemistry stainingGeneral populationPatients
2009
Novel 2009 H1N1 influenza virus infection requiring extracorporeal membrane oxygenation in a pediatric heart transplant recipient
Flagg A, Danziger-Isakov L, Foster C, Nasman C, Smedira N, Carl J, Kwon C, Davis S, Boyle G. Novel 2009 H1N1 influenza virus infection requiring extracorporeal membrane oxygenation in a pediatric heart transplant recipient. The Journal Of Heart And Lung Transplantation 2009, 29: 582-584. PMID: 20044274, DOI: 10.1016/j.healun.2009.11.600.Peer-Reviewed Case Reports and Technical NotesConceptsExtracorporeal membrane oxygenationH1N1 influenza virusAcute respiratory distress syndromeCardiothoracic transplant recipientsTransplant recipientsInfluenza virusMembrane oxygenationSevere acute respiratory distress syndromeH1N1 influenza virus infectionPediatric heart transplant recipientsHeart transplant recipientsRespiratory distress syndromeInitiation of treatmentInfluenza virus infectionReal-time reverse transcriptase-polymerase chain reactionCongenital heart diseaseReverse transcriptase-polymerase chain reactionIncidence of infectionTranscriptase-polymerase chain reactionPediatric recipientsDistress syndromePediatric patientsLung diseaseHeart diseaseEarly suspicion
2008
Lymphopenia Associated with Adjuvant Anthracycline/Taxane Regimens
Tolaney SM, Najita J, Winer EP, Burstein HJ. Lymphopenia Associated with Adjuvant Anthracycline/Taxane Regimens. Clinical Breast Cancer 2008, 8: 352-356. PMID: 18757263, DOI: 10.3816/cbc.2008.n.041.Peer-Reviewed Original ResearchConceptsDose-dense ACPneumocystis carinii pneumoniaDose-dense chemotherapyCells/mm3Absolute lymphocyte countAbsolute neutrophil countAlbumin-bound paclitaxelLymphocyte countCohort 2Cohort 1Lymphocyte depletionOpportunistic infectionsCohort 3Day 1Cases of PCPLow absolute lymphocyte countDana-Farber Cancer InstitutePhase II clinical trialDoxorubicin/cyclophosphamideGrade 3/4 lymphopeniaGrade 4 lymphopeniaHIV-negative patientsMedian lymphocyte countPhase II studyCohort of patientsInjury Enhances Resistance to Escherichia coli Infection by Boosting Innate Immune System Function
Maung AA, Fujimi S, MacConmara MP, Tajima G, McKenna AM, Delisle AJ, Stallwood C, Onderdonk AB, Mannick JA, Lederer JA. Injury Enhances Resistance to Escherichia coli Infection by Boosting Innate Immune System Function. The Journal Of Immunology 2008, 180: 2450-2458. PMID: 18250454, DOI: 10.4049/jimmunol.180.4.2450.Peer-Reviewed Original ResearchConceptsBurn-injured miceSham miceCecal ligationEnhanced innate immune responseSystemic inflammatory response syndromeInnate immune system functionRelevant sepsis modelSham-injured miceInflammatory response syndromeMac-1 expressionEscherichia coli infectionInnate immune responseSite of infectionImmune system functionPolymicrobial sepsisResponse syndromeOpportunistic infectionsSepsis modelDays postinjuryInjury causesColi infectionImmune responseCommon pathogensMajor injuriesAnimal studies
1999
Subcutaneous Fusarium foot abscess in a renal transplant patient.
Girardi M, Glusac EJ, Imaeda S. Subcutaneous Fusarium foot abscess in a renal transplant patient. Cutis 1999, 63: 267-70. PMID: 10349541.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsAbscessCombined Modality TherapyFoot DermatosesFusariumHumansImmunocompromised HostKidney TransplantationMaleMiddle AgedOpportunistic Infections
1998
Pneumocystis carinii pneumonia complicating methotrexate treatment of pityriasis rubra pilaris
Duncan K, Imaeda S, Milstone L. Pneumocystis carinii pneumonia complicating methotrexate treatment of pityriasis rubra pilaris. Journal Of The American Academy Of Dermatology 1998, 39: 276-278. PMID: 9704846, DOI: 10.1016/s0190-9622(98)70088-x.Peer-Reviewed Case Reports and Technical NotesAgedDermatologic AgentsHumansMaleMethotrexateOpportunistic InfectionsPityriasis Rubra PilarisPneumonia, PneumocystisTHE COMPROMISED TRAVELER
Mileno M, Bia F. THE COMPROMISED TRAVELER. Infectious Disease Clinics Of North America 1998, 12: 369-412. PMID: 9658250, DOI: 10.1016/s0891-5520(05)70010-6.ChaptersConceptsSevere community-acquired pneumoniaAcquisition of tuberculosisCommunity-acquired pneumoniaSolid organ transplantationUrinary tract infectionTravel medicine specialistType of insulinTreatment of malignanciesImmunocompromised groupTract infectionsDiabetes mellitusHIV infectionCardiopulmonary compromiseMyocardial infarctionAdverse reactionsChronic infectionTropical infectionsOrgan transplantationMedicine specialistsGreater riskInfectious diseasesInfectionChallenging groupPatientsPopulation of travelers
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