2022
Naive T-Cell Depletion to Prevent Chronic Graft-Versus-Host Disease
Bleakley M, Sehgal A, Seropian S, Biernacki MA, Krakow EF, Dahlberg A, Persinger H, Hilzinger B, Martin PJ, Carpenter PA, Flowers ME, Voutsinas J, Gooley TA, Loeb K, Wood BL, Heimfeld S, Riddell SR, Shlomchik WD. Naive T-Cell Depletion to Prevent Chronic Graft-Versus-Host Disease. Journal Of Clinical Oncology 2022, 40: 1174-1185. PMID: 35007144, PMCID: PMC8987226, DOI: 10.1200/jco.21.01755.Peer-Reviewed Original ResearchConceptsChronic GVHDAcute GVHDHost diseaseNonrelapse mortalityT cellsPeripheral blood stem cell graftsBlood stem cell graftsGrade II acute GVHDGrade III acute GVHDNaive T-cell depletionAllogeneic hematopoietic cell transplantationPhase II clinical trialChronic Graft-VersusUnrelated donor graftsT-cell depletionHematopoietic cell transplantationTotal body irradiationMemory T cellsRelapse-free survivalStem cell graftsNaive T cellsApparent excess riskCell transplantation approachesGastrointestinal GVHDGraft-Versus
2021
Optimal Biomechanical Parameters for Measuring Sclerotic Chronic Graft-Versus-Host Disease
Baker L, Chen F, Cronin A, Chen H, Vain A, Jagasia M, Tkaczyk E. Optimal Biomechanical Parameters for Measuring Sclerotic Chronic Graft-Versus-Host Disease. JID Innovations 2021, 1: 100037. PMID: 34790906, PMCID: PMC8594905, DOI: 10.1016/j.xjidi.2021.100037.Peer-Reviewed Original ResearchCGVHD patientsBiomechanical parametersChronic Graft-VersusSclerotic chronic graftHost disease patientsBackward stepwise selectionChronic graftGraft-VersusSclerotic cGvHDHost diseaseUnivariable analysisTransplant controlsDisease patientsAnatomic sitesPatientsDisease severityLogistic regressionSclerotic diseaseBiomechanical studyDiscriminatory abilityLASSO regressionCharacteristic curveMyotonometerStepwise selectionDisease
2019
Diagnostic Potential of Five Different Biomechanical Parameters to Detect Sclerotic Cutaneous Graft-Versus-Host Disease
Chen F, Wang L, Ssempijja Y, Vain A, Jagasia M, Tkaczyk E. Diagnostic Potential of Five Different Biomechanical Parameters to Detect Sclerotic Cutaneous Graft-Versus-Host Disease. Blood 2019, 134: 2002. DOI: 10.1182/blood-2019-129381.Peer-Reviewed Original ResearchCGVHD patientsBMT controlsCross-sectional studyHost diseaseSkin sclerosisSkin scoreBiomechanical parametersSclerotic patientsCutaneous Graft-VersusPost-BMT patientsMechanical stress relaxation timeHigh diagnostic yieldProspective longitudinal studyChronic graftGraft-VersusGVHD patientsSkin involvementUnaffected skinUnivariate analysisHealthy controlsMultivariate predictive modelClinician assessmentDiagnostic yieldTreatment responseResponse assessmentInterobserver Reproducibility of the Myoton and Durometer Devices to Measure Skin Stiffness and Hardness in Chronic Cutaneous Graft-Versus-Host Disease Patients
Chen F, Wang L, Vain A, Ssempijja Y, Dellalana L, Zhang K, Hood A, Chen H, Jagasia M, Tkaczyk E. Interobserver Reproducibility of the Myoton and Durometer Devices to Measure Skin Stiffness and Hardness in Chronic Cutaneous Graft-Versus-Host Disease Patients. Blood 2019, 134: 4515. DOI: 10.1182/blood-2019-129125.Peer-Reviewed Original ResearchIntraclass correlation coefficientCGVHD patientsInterobserver intraclass correlation coefficientSkin stiffness measurementsCutaneous cGVHDInterobserver reproducibilityChronic cutaneous graftCutaneous Graft-VersusHealth Chronic GraftSkin stiffnessHost disease patientsProgression of sclerosisStiffness measurementLongitudinal studyProspective longitudinal studyMinimal detectable changeTherapeutic response measuresDetectable changeChronic graftGraft-VersusHost diseaseSclerotic cGvHDSkin sclerosisCutaneous graftDisease patientsGraft-Versus-Host Disease After Pancreatic Transplantation
Saffo S, Peng C, Kibbi N, Patel N, Robert ME, Adekolu E, Asch WS, Sanchez M. Graft-Versus-Host Disease After Pancreatic Transplantation. ACG Case Reports Journal 2019, 6: e00214. PMID: 31750381, PMCID: PMC6831153, DOI: 10.14309/crj.0000000000000214.Peer-Reviewed Original ResearchHost diseasePancreatic transplantationHematopoietic stem cell transplantationSolid organ transplantsStem cell transplantationAggressive immunosuppressionDiabetic womenGraft-VersusLiver transplantMultiorgan failureBiopsy findingsCommon complicationEndoscopic confirmationSmall bowelCell transplantationOrgan transplantsBone marrowTransplantationMinimal responseGVHDTransplantDiseaseImmunosuppressionBowelComplications
2018
Hematopoietic Stem Cell Donor Selection and Graft-Versus-Host Disease
Siddon A, Tormey C. Hematopoietic Stem Cell Donor Selection and Graft-Versus-Host Disease. 2018, 105-117. DOI: 10.1007/978-3-319-89866-7_7.ChaptersCell transplantSide effectsHematopoietic progenitor cell transplantStem cell transplantMalignant hematological diseasesProgenitor cell transplantPotential side effectsStem cell sourceGraft-VersusHPC transplantHost diseaseABO compatibilityPotential complicationsDonor selectionHematological diseasesApheresis servicesPossible treatmentTransplantSevere disordersCell sourceDiseaseManagement optionsComplicationsPatientsTransplantation261 Sclerotic Chronic Graft-Versus-Host Disease Severity Can be Assessed via Biomechanical Properties of Skin
Chen F, Saknite I, Gandelman J, Vain A, Vaughan L, Clifton C, Logue M, Byrne M, Kassim A, Savani B, Jagasia M, Tkaczyk E. 261 Sclerotic Chronic Graft-Versus-Host Disease Severity Can be Assessed via Biomechanical Properties of Skin. Transplantation And Cellular Therapy 2018, 24: s198-s199. DOI: 10.1016/j.bbmt.2017.12.158.Peer-Reviewed Original Research
2015
Human Mesenchymal Stromal Cells Attenuate Graft‐Versus‐Host Disease and Maintain Graft‐Versus‐Leukemia Activity Following Experimental Allogeneic Bone Marrow Transplantation
Auletta J, Eid S, Wuttisarnwattana P, Silva I, Metheny L, Keller M, Guardia‐Wolff R, Liu C, Wang F, Bowen T, Lee Z, Solchaga L, Ganguly S, Tyler M, Wilson D, Cooke K. Human Mesenchymal Stromal Cells Attenuate Graft‐Versus‐Host Disease and Maintain Graft‐Versus‐Leukemia Activity Following Experimental Allogeneic Bone Marrow Transplantation. Stem Cells 2015, 33: 601-614. PMID: 25336340, PMCID: PMC4304927, DOI: 10.1002/stem.1867.Peer-Reviewed Original ResearchConceptsT cell expansionT cell proliferationGraft-VersusHost diseaseLeukemia activityExperimental allogeneic bone marrow transplantationDonor T cell expansionAllogeneic bone marrow transplantationCytotoxic T cell activityAlloreactive T cell proliferationPotent GVL effectCyclo-oxygenase inhibitionT cell activityT cell suppressionBone marrow transplantationMarrow-derived mesenchymal stromal cellsSecondary lymphoid organsSplenic T cellsSplenic marginal zoneMixed leukocyte cultureMesenchymal stromal cellsBMT miceEP2 agonismGVL activityGVL effect
2013
Graft-Versus-Host-Disease Recruits Both Monocyte and Pre-Conventional Dendritic Cell-Derived Tissue Antigen Presenting Cells Independent Of CCR2 and CCR6
Morin-Zorman S, Wysocki C, Matte-Martone C, Juchem K, Tan H, Venkatesan S, Rothstein D, Lakkis F, Shlomchik W. Graft-Versus-Host-Disease Recruits Both Monocyte and Pre-Conventional Dendritic Cell-Derived Tissue Antigen Presenting Cells Independent Of CCR2 and CCR6. Blood 2013, 122: 4463. DOI: 10.1182/blood.v122.21.4463.4463.Peer-Reviewed Original ResearchAntigen presenting cellsDonor T cellsDendritic cellsT cellsGVHD miceDC populationsBlood monocytesAllogeneic hematopoietic stem cell transplantationAlloreactive donor T cellsHematopoietic stem cell transplantationMyeloid hematopoiesisInitial T cell activationRole of CCR2Role of CCR6Role of CX3CR1Stem cell transplantationSecondary lymphoid organsModels of inflammationWild-type BMSuppressor of inflammationWT T cellsT cell activationGraft-VersusGVHD lesionsGVHD reactionsPhosphatidylinositol 3-Kinase–Independent Signaling Pathways Contribute to ICOS-Mediated T Cell Costimulation in Acute Graft-Versus-Host Disease in Mice
Li J, Heinrichs J, Leconte J, Haarberg K, Semple K, Liu C, Gigoux M, Kornete M, Piccirillo C, Suh W, Yu X. Phosphatidylinositol 3-Kinase–Independent Signaling Pathways Contribute to ICOS-Mediated T Cell Costimulation in Acute Graft-Versus-Host Disease in Mice. The Journal Of Immunology 2013, 191: 200-207. PMID: 23729441, PMCID: PMC4318500, DOI: 10.4049/jimmunol.1203485.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAnimalsDisease Models, AnimalGene Knock-In TechniquesGraft vs Host DiseaseInducible T-Cell Co-Stimulator ProteinLymphocyte ActivationMiceMice, 129 StrainMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutMice, TransgenicPhosphatidylinositol 3-KinaseSignal TransductionT-Lymphocyte SubsetsConceptsCD8 T cellsCD4 T cellsT cellsHost diseaseWild-type CD8 T cellsCD8 T cell compartmentAllogeneic bone marrow transplantationAcute Graft-VersusPathogenic potentialTotal T cellsAlloreactive T cellsBone marrow transplantationT cell compartmentWild-type T cellsIntracellular calcium mobilizationVivo pathogenic potentialT cell costimulationT cell activationKnockout T cellsAcute graftAcute GVHDGraft-VersusSevere GVHDGVHD modelMarrow transplantation
2012
CD24-Siglec-G Interaction Plays an Important in Reducing Experimental Graft-Versus-Host Disease (GVHD)
Toubai T, Evers R, Sun Y, Tawara I, Liu C, Tamaki H, Mathewson N, Nieves E, Bassetti M, Zheng P, Liu Y, Reddy P. CD24-Siglec-G Interaction Plays an Important in Reducing Experimental Graft-Versus-Host Disease (GVHD). Blood 2012, 120: 453. DOI: 10.1182/blood.v120.21.453.453.Peer-Reviewed Original ResearchHost antigen presenting cellsAntigen presenting cellsBALB/c donorsT cellsWT B6Allogeneic BMTImmunoreceptor tyrosine-based inhibitory motifWorse survivalSerum levelsImmune activationBM chimerasDonor T cell expansionAllogeneic T-cell responsesT cell responsesBALB/c T cellsPro-inflammatory cytokinesT cell expansionRelevant murine modelRole of SiglecsC donorsIg-like lectinsIntensity of conditioningGraft-VersusGVHD mortalityHigher GVHD
2011
Cross-Presentation by Host CD8α+dendritic Cells Augments Graft-Versus-Tumor Effect without Aggravating Graft-Versus-Host Disease After Allogeneic BMT
Toubai T, Sun Y, Tawara I, Liu C, Reddy P. Cross-Presentation by Host CD8α+dendritic Cells Augments Graft-Versus-Tumor Effect without Aggravating Graft-Versus-Host Disease After Allogeneic BMT. Blood 2011, 118: 310. DOI: 10.1182/blood.v118.21.310.310.Peer-Reviewed Original ResearchAntigen presenting cellsTumor-specific antigensProfessional antigen presenting cellsGVT responseAllogeneic animalsGraft-VersusSyngeneic B6APC subsetsTumor cellsPoly IToll-like receptor 3Induction of GVHDGVHD target organsWild-type B6Acute GVHDAllo-BMTCD8α- DCsAllogeneic BMTGVHD modelGVHD severityGVT effectHost diseaseTumor effectTLR-3Allo-antigenProspective Evaluation of Acute Graft-Versus-Host Disease
Aslanian H, Chander B, Robert M, Cooper D, Proctor D, Seropian S, Jain D. Prospective Evaluation of Acute Graft-Versus-Host Disease. Digestive Diseases And Sciences 2011, 57: 720-725. PMID: 22011927, DOI: 10.1007/s10620-011-1938-x.Peer-Reviewed Original ResearchConceptsAcute GVHDHost diseaseLower endoscopyRectal biopsyDiagnostic yieldGastrointestinal tractAllogeneic bone marrow transplantationAcute Graft-VersusCases of GVHDLower gastrointestinal involvementOptimal endoscopic approachDiagnosis of GVHDNon-specific symptomsStem cell transplantationBone marrow transplantationUpper gastrointestinal tractLower gastrointestinal tractUpper intestinal tractMajority of casesColonic GVHDGastrointestinal GVHDGastrointestinal involvementGraft-VersusGVHD casesIntestinal GVHDA Pilot Study of Pharmacokinetics-Based Mycophenolate Mofetil Dosing for Acute Graft-Versus-Host-Disease Prophylaxis
Windreich R, Venkataramanan R, Howrie D, Krishnamurti L, Goyal R. A Pilot Study of Pharmacokinetics-Based Mycophenolate Mofetil Dosing for Acute Graft-Versus-Host-Disease Prophylaxis. Transplantation And Cellular Therapy 2011, 17: s344-s345. DOI: 10.1016/j.bbmt.2010.12.570.Peer-Reviewed Original ResearchManipulating the Bioenergetics of Alloreactive T Cells Causes Their Selective Apoptosis and Arrests Graft-Versus-Host Disease
Gatza E, Wahl D, Opipari A, Sundberg T, Reddy P, Liu C, Glick G, Ferrara J. Manipulating the Bioenergetics of Alloreactive T Cells Causes Their Selective Apoptosis and Arrests Graft-Versus-Host Disease. Science Translational Medicine 2011, 3: 67ra8. PMID: 21270339, PMCID: PMC3364290, DOI: 10.1126/scitranslmed.3001975.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBenzodiazepinesBone Marrow CellsBone Marrow TransplantationFemaleGraft vs Host DiseaseIsoantigensLactatesLymphocyte ActivationMetabolomeMiceMice, Inbred BALB CMice, Inbred C57BLMitochondrial Proton-Translocating ATPasesOxidative PhosphorylationOxygen ConsumptionReactive Oxygen SpeciesT-LymphocytesConceptsAlloreactive T cellsT cellsHost diseaseBM transplantationAerobic glycolysisAdenosine triphosphateAccumulation of acylcarnitinesBone marrow cellsFatty acid oxidationGraft-VersusLymphocyte reconstitutionImmune activationBMT modelBM cellsImmune disordersHematopoietic engraftmentTherapeutic strategiesOxidative phosphorylationSmall molecule inhibitorsMarrow cellsSuperoxide productionSufficient adenosine triphosphateMitochondrial membrane potentialMetabolic adaptationAcid oxidation
2010
Recipient B Cells Are Not Required for Graft-Versus-Host Disease Induction
Matte-Martone C, Wang X, Anderson B, Jain D, Demetris AJ, McNiff J, Shlomchik MJ, Shlomchik WD. Recipient B Cells Are Not Required for Graft-Versus-Host Disease Induction. Transplantation And Cellular Therapy 2010, 16: 1222-1230. PMID: 20338255, PMCID: PMC3135976, DOI: 10.1016/j.bbmt.2010.03.015.Peer-Reviewed Original ResearchConceptsRecipient B cellsAntigen presenting cellsB cellsAllogeneic hematopoietic stem cell transplantationB cell-deficient recipientsImportant antigen presenting cellsRecipient antigen presenting cellsAllogeneic bone marrow transplantationHematopoietic stem cell transplantationCD8-mediated GVHDHost disease inductionB-cell depletionAntibody-mediated depletionHost B cellsCD20 monoclonal antibodyStem cell transplantationT cell responsesBone marrow transplantationGraft-VersusAPC subsetsHost diseaseMarrow transplantationCell depletionCell transplantationPresenting cells
2009
Memory CD8. + T Cells Specific for Minor Histocompatibility Antigen H60 Can Mediate the Graft-Versus-Leukemia Effect.
Li N, Matte-Martone C, Venkatesan S, Shlomchik W. Memory CD8. + T Cells Specific for Minor Histocompatibility Antigen H60 Can Mediate the Graft-Versus-Leukemia Effect. Blood 2009, 114: 1332. DOI: 10.1182/blood.v114.22.1332.1332.Peer-Reviewed Original ResearchMemory T cellsCD8 cellsT cellsLess GVHDCP-CMLImmune reconstitutionVaccinated miceMouse modelAntigen distributionAllogeneic hematopoietic stem cell transplantationBC-CMLCentral memory T cellsStrong anti-tumor responsesHematopoietic stem cell transplantationHuman memory T cellsRecipient B6 miceDonor T cellsAnti-tumor responseCentral memory phenotypeStem cell transplantationMemory CD8 cellsNaïve T cellsT Cells SpecificChronic myelogenous leukemiaGraft-VersusT helper17 Cells Are Sufficient But Not Necessary to Induce Acute Graft-Versus-Host Disease
Iclozan C, Yu Y, Liu C, Liang Y, Yi T, Anasetti C, Yu X. T helper17 Cells Are Sufficient But Not Necessary to Induce Acute Graft-Versus-Host Disease. Transplantation And Cellular Therapy 2009, 16: 170-178. PMID: 19804837, PMCID: PMC3876952, DOI: 10.1016/j.bbmt.2009.09.023.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalBody WeightBone Marrow TransplantationCD3 ComplexCells, CulturedGraft vs Host DiseaseGraft vs Host ReactionInterferon-gammaInterleukin-17MiceMice, Inbred StrainsMice, TransgenicNuclear Receptor Subfamily 1, Group F, Member 3Severity of Illness IndexSurvival AnalysisT-Lymphocyte SubsetsT-Lymphocytes, Helper-InducerTh1 CellsTime FactorsTumor Necrosis Factor-alphaWhole Body ImagingConceptsHost diseaseBALB/c recipientsBone marrow transplantation settingAcute Graft-VersusT helper17 cellsGVHD target organsInduction of graftPathogenesis of GVHDCD4 T cellsGraft-VersusGVHD developmentC recipientsT helperTh17 cellsAllogeneic recipientsAutoimmune diseasesC57BL/6 miceSyngeneic recipientsTransplantation settingGVHDT cellsIFN-gammaTarget organsSuperior expansionDisease
2008
350: Macrophage Migration Inhibitory Factor as a New Target in Graft-Versus-Host Disease after Allogeneic Stem Cell Transplantation
Chang Y, Miklos S, Mueller G, Holler E, Lindner P, Leng L, Schubert T, Bucala R, Hildebrandt G. 350: Macrophage Migration Inhibitory Factor as a New Target in Graft-Versus-Host Disease after Allogeneic Stem Cell Transplantation. Transplantation And Cellular Therapy 2008, 14: 128. DOI: 10.1016/j.bbmt.2007.12.360.Peer-Reviewed Original Research
2005
CD8+ Central Memory T Cells Mediate Graft-Versus-Host Disease Although Retain Graft-Versus-Leukemia Effect.
Zheng H, Matte C, Anderson B, Venkatesan S, Jain D, Shlomchik M, Shlomchik W. CD8+ Central Memory T Cells Mediate Graft-Versus-Host Disease Although Retain Graft-Versus-Leukemia Effect. Blood 2005, 106: 1312. DOI: 10.1182/blood.v106.11.1312.1312.Peer-Reviewed Original ResearchCD8 cellsMemory T cellsMore weight lossCell recipientsT cellsCM cellsWeight lossGraft-VersusHistologic GVHDLess weight lossEffector functionsBALB/c recipientsEffector memory T cellsCentral memory T cellsDay 16Central memory TClear histologic evidencePeriportal inflammatory infiltrationReconstitution of immunityDonor T cellsTime pointsMost time pointsDonor BMEarly time pointsEffective GVL
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