2023
Studies in humans and mice reveal a critical role for CCR2 in trafficking of pDCs during infection with SARS-CoV-2
Zhang H, Lu X, Garner D, Parween F, Singh S, Majumdar S, Weaver J, Stein S, Lesho P, Damcott C, Lutfi F, Petrick K, Rock P, Chertow D, Kelsall B, Murphy P, Dahiya S, Hardy N, Farber J. Studies in humans and mice reveal a critical role for CCR2 in trafficking of pDCs during infection with SARS-CoV-2. The Journal Of Immunology 2023, 210: 143.04-143.04. DOI: 10.4049/jimmunol.210.supp.143.04.Peer-Reviewed Original ResearchMAIT cellsSARS-CoV-2Chemokine receptorsCCR2-deficient miceHospitalized COVID-19 patientsCOVID-19 pathogenesisBlood pDCCOVID-19 patientsReporter miceAffecting disease severityCCR2 ligandsCCR2III interferonsBlood leukocytesType 1ChemokinesDisease severityIncreased MortalityBlood cellsReceptorsAbsolute numberLeukocyte extravasationLungTransendothelial migrationBlood
2014
CCR2+ monocytes contribute to hematoma clearance and long-term functional recovery after experimental intracerebral hemorrhage (HUM1P.324)
Hammond M, Taylor R, Ai Y, Sansing L. CCR2+ monocytes contribute to hematoma clearance and long-term functional recovery after experimental intracerebral hemorrhage (HUM1P.324). The Journal Of Immunology 2014, 192: 52.24-52.24. DOI: 10.4049/jimmunol.192.supp.52.24.Peer-Reviewed Original ResearchIntracerebral hemorrhageHematoma clearanceFunctional recoveryBlood injection ICH modelLong-term functional recoveryExperimental intracerebral hemorrhageSevere motor deficitsEarly neurological injuryResident microgliaInflammatory monocytesMotor deficitsNeurological injuryICH modelMouse modelInjected bloodMotor coordinationCCR2Day 1Normal microgliaMinimal deficitsBrain regionsMonocytesBrainClearancePotential role
2003
Experimental Autoimmune Encephalomyelitis (EAE) in CCR2−/− Mice Susceptibility in Multiple Strains
Gaupp S, Pitt D, Kuziel WA, Cannella B, Raine CS. Experimental Autoimmune Encephalomyelitis (EAE) in CCR2−/− Mice Susceptibility in Multiple Strains. American Journal Of Pathology 2003, 162: 139-150. PMID: 12507897, PMCID: PMC1851120, DOI: 10.1016/s0002-9440(10)63805-9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DivisionCrosses, GeneticDisease Models, AnimalEncephalomyelitis, Autoimmune, ExperimentalGenetic Predisposition to DiseaseGlycoproteinsImmunity, InnateImmunohistochemistryIn Situ HybridizationLymphocytesMiceMice, Inbred BALB CMice, Inbred C57BLMice, Inbred StrainsMice, KnockoutMyelin SheathMyelin-Oligodendrocyte GlycoproteinNuclease Protection AssaysPeptide FragmentsReceptors, CCR2Receptors, ChemokineRNA, MessengerSpecies SpecificityConceptsExperimental autoimmune encephalomyelitisCentral nervous systemAutoimmune encephalomyelitisLow molecular weight cytokinesLack of CCR2Deletion of CCR2Sites of inflammationWild-type animalsDifferent mouse strainsCCR2 deletionCNS lesionsMultiple sclerosisWeight cytokinesAutoimmune diseasesMouse susceptibilityNervous systemImmune systemCompensatory mechanismsBalb CCCR2Mouse strainsChemokinesMonocytesEncephalomyelitisAppropriate receptors
2001
CCR2 and CCR5 receptor‐binding properties of herpesvirus‐8 vMIP‐II based on sequence analysis and its solution structure
Shao W, Fernandez E, Sachpatzidis A, Wilken J, Thompson D, Schweitzer B, Lolis E. CCR2 and CCR5 receptor‐binding properties of herpesvirus‐8 vMIP‐II based on sequence analysis and its solution structure. The FEBS Journal 2001, 268: 2948-2959. PMID: 11358512, DOI: 10.1046/j.1432-1327.2001.02184.x.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBinding SitesChemokinesChemokines, CCDimerizationEpitopesMagnetic Resonance SpectroscopyModels, ChemicalModels, MolecularMolecular Sequence DataPeptide BiosynthesisProtein BindingProtein ConformationProtein FoldingProtein Structure, SecondaryReceptors, CCR2Receptors, CCR5Receptors, ChemokineSequence Analysis, ProteinSequence Homology, Amino AcidConceptsHuman herpesvirus 8VMIP-IIChemokine receptorsCC chemokinesReceptor-binding propertiesNumerous chemokine receptorsPresence of epitopesHIV-1 viral entryHuman CC chemokineReceptor CCR2Kaposi's sarcomaHerpesvirus 8Infectious agentsCCR2Viral entryReceptor bindingReceptor specificityCCR5ChemokinesSarcomaReceptorsReceptor subfamiliesMagnetic resonanceBroad receptor specificityProtein II
2000
Influence of CCR5 promoter haplotypes on AIDS progression in African–Americans
An P, Martin M, Nelson G, Carrington M, Smith M, Gong K, Vlahov D, O'Brien S, Winkler C. Influence of CCR5 promoter haplotypes on AIDS progression in African–Americans. AIDS 2000, 14: 2117-2122. PMID: 11061652, DOI: 10.1097/00002030-200009290-00007.Peer-Reviewed Original ResearchConceptsCCR5 promoter haplotypesAIDS progressionSurvival analysisAfrican AmericansNatural history cohort studyPromoter haplotypesRate of progressionPromoter variantsCohort studyCCR5 alleleRapid progressionCaucasian cohortProgressionCaucasiansComplete linkage disequilibriumCCR2AIDSUnidentified polymorphismsRacial groupsLinkage disequilibriumSeroconvertersCCR5CohortHaplotypes
1997
Contrasting Genetic Influence of CCR2 and CCR5 Variants on HIV-1 Infection and Disease Progression
Smith M, Dean M, Carrington M, Winkler C, Huttley G, Lomb D, Goedert J, O'Brien T, Jacobson L, Kaslow R, Buchbinder S, Vittinghoff E, Vlahov D, Hoots K, Hilgartner M, Study H, San Francisco City Cohort ALIVE Study M, O'Brien S. Contrasting Genetic Influence of CCR2 and CCR5 Variants on HIV-1 Infection and Disease Progression. Science 1997, 277: 959-965. PMID: 9252328, DOI: 10.1126/science.277.5328.959.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeBlack PeopleCohort StudiesDisease ProgressionGenotypeHaplotypesHeterozygoteHIV InfectionsHIV-1HumansMutationPolymerase Chain ReactionPolymorphism, Restriction Fragment LengthPolymorphism, Single-Stranded ConformationalProportional Hazards ModelsReceptors, CCR2Receptors, CCR5Receptors, ChemokineReceptors, CytokineReceptors, HIVSurvival AnalysisWhite PeopleConceptsHIV-1 infectionCCR2-64IDisease progressionHIV-1 disease progressionHIV-1-infected individualsLong-term survivorsCCR2-64I alleleReceptor geneChemokine receptor genesAIDS 2CCR2 chemokineSyndrome cohortAIDS patientsCCR5-Delta32Human immunodeficiencyChemokine receptorsCCR5 variantsCCR2CCR5InfectionIndependent effectsAfrican AmericansMutant genotypesProgressionGenetic association analysis
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