2017
Dietary salt blunts vasodilation by stimulating epithelial sodium channels in endothelial cells from salt‐sensitive Dahl rats
Wang Z, Liu H, Sun Y, Hu Q, Li Y, Zheng W, Yu C, Li X, Wu M, Song B, Mu J, Yuan Z, Zhang Z, Ma H. Dietary salt blunts vasodilation by stimulating epithelial sodium channels in endothelial cells from salt‐sensitive Dahl rats. British Journal Of Pharmacology 2017, 175: 1305-1317. PMID: 28409833, PMCID: PMC5866993, DOI: 10.1111/bph.13817.Peer-Reviewed Original ResearchConceptsENaC activityEpithelial sodium channelDahl SS ratsArterial relaxationSS ratsEndothelial cellsHigh-salt (HS) dietActivity of epithelial sodium channelsCell-attached patch-clamp techniqueSodium channelsSalt-sensitive Dahl ratsEndothelium-dependent arterial relaxationBlocker of ENaCWire myograph assayActivation of ENaCMineralocorticoid receptor antagonistsPatch-clamp techniqueDahl salt-sensitiveLevels of aldosteroneSprague-Dawley ratsSalt sensitivityTail-cuff methodHS challengeLoss of vasorelaxationDahl rats
2015
Dietary salt regulates epithelial sodium channels in rat endothelial cells: adaptation of vasculature to salt
Liu H, Zhang J, Sun Y, Li X, Jiang S, Liu M, Shi J, Song B, Zhao D, Ma H, Zhang Z. Dietary salt regulates epithelial sodium channels in rat endothelial cells: adaptation of vasculature to salt. British Journal Of Pharmacology 2015, 172: 5634-5646. PMID: 25953733, PMCID: PMC4667865, DOI: 10.1111/bph.13185.Peer-Reviewed Original ResearchConceptsEndothelium-dependent relaxationWeeks of HS dietEpithelial sodium channelMesenteric arteryENaC activityEndothelial ENaCEndothelial cellsHS dietSprague-DawleyEnhancement of endothelium-dependent relaxationSodium channelsSecond-order mesenteric arteriesBlocker of ENaCWire myograph assayPatch-clamp techniquePlasma aldosterone levelsSalt-sensitive hypertensionResponse to AChNegative modulatorRat endothelial cellsModulation of vasodilationVascular endothelial cellsFunctional ENaCENaC expressionRelease of NO
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply