2024
Higher prevalence of kidney function impairment among older people living with HIV in Uganda
Ssemasaazi A, Kalyesubula R, Manabe Y, Mbabazi P, Naikooba S, Ssekindi F, Nasuuna E, Byakika-Kibwika P, Castelnuovo B. Higher prevalence of kidney function impairment among older people living with HIV in Uganda. BMC Nephrology 2024, 25: 321. PMID: 39334034, PMCID: PMC11428404, DOI: 10.1186/s12882-024-03761-1.Peer-Reviewed Original ResearchConceptsKidney function impairmentChronic kidney diseaseAntiretroviral therapyOlder PLWHFunctional impairmentKidney functionKidney diseaseHIV-related inflammationProgression of kidney diseasePrevalence of proteinuriaMultivariate logistic regression modelBurden of chronic kidney diseaseMeasures of kidney functionDiagnosis of hypertensionCross-sectional studyConclusionsHIV infectionHIV-related clinical characteristicsClinical characteristicsInstitution of measuresLogistic regression modelsDiabetes mellitusFemale sexHIVProteinuriaPLWH#822 Effect of renal Doppler ultrasound on the detection of nutcracker syndrome in children presenting orthostatic proteinuria
Lee K, Hwang E, Kim J, Park J, Shin J. #822 Effect of renal Doppler ultrasound on the detection of nutcracker syndrome in children presenting orthostatic proteinuria. Nephrology Dialysis Transplantation 2024, 39: gfae069-1321-822. DOI: 10.1093/ndt/gfae069.1321.Peer-Reviewed Original ResearchLeft renal veinOrthostatic proteinuriaRenal veinHilar portionRenal Doppler ultrasound examinationRenal Doppler ultrasoundPediatric nephrology clinicDoppler ultrasound examinationSuperior mesenteric arteryHealthy normal childrenPeak velocity ratioDoppler sonographic findingsNutcracker syndromeConsecutive childrenPeak velocitySonographic findingsMesenteric arteryProtein/creatinine ratioUltrasound examinationNephrology clinicMorning urineSeverance HospitalDoppler ultrasoundProteinuriaResults AgeTime-Varying Proteinuria and Progression of IgA Nephropathy: A Cohort Study
Tang C, Chen P, Si F, Lv J, Shi S, Zhou X, Liu L, Zhang H. Time-Varying Proteinuria and Progression of IgA Nephropathy: A Cohort Study. American Journal Of Kidney Diseases 2024, 84: 170-178.e1. PMID: 38364955, DOI: 10.1053/j.ajkd.2023.12.016.Peer-Reviewed Original ResearchComposite kidney outcomeProteinuria levelsKidney outcomesEnd-stage kidney diseaseFollow-upIgA nephropathyLong-term kidney outcomesHigh riskMonths of follow-upProgression of IgA nephropathyBaseline proteinuria levelsPeking University First HospitalMedian Follow-UpLevel of proteinuriaRisk of kidney failureTreatment of IgANProgression of IgANBaseline proteinuriaAbstractText Label="RATIONALECohort studyProteinuriaFirst HospitalKidney diseaseIgANSurrogate endpoints
2023
Relationships among Non-Neoplastic Histopathological Features, Kidney Function, Proteinuria, and Other Clinical Factors in Patients Undergoing Nephrectomy
Becerra L, Betancourt J, Elfassy T, Iakymenko O, Thomas D, Isaac F, Fornoni A, Zuo Y, Barisoni L, Contreras G, Mendoza J. Relationships among Non-Neoplastic Histopathological Features, Kidney Function, Proteinuria, and Other Clinical Factors in Patients Undergoing Nephrectomy. Glomerular Diseases 2023, 3: 220-229. PMID: 37915860, PMCID: PMC10616670, DOI: 10.1159/000534339.Peer-Reviewed Original ResearchLower eGFRGlobal glomerulosclerosisInterstitial fibrosisCardiovascular diseaseClinical factorsHistopathological featuresSpecific histopathological featuresGlomerular filtration rateCross-sectional analysisDipstick proteinuriaKidney functionMultivariable analysisFiltration rateKidney parenchymaOutcome measuresProteinuriaRoutine examinationHypertensionPatientsArteriosclerosisEGFRNephrectomyObesityAssociationRegression modelsOnco-Nephrology Kidney Disease in the Cancer Patient
Yarandi N, Shirali A. Onco-Nephrology Kidney Disease in the Cancer Patient. 2023, 107: 749-762. PMID: 37258012, DOI: 10.1016/j.mcna.2023.03.007.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsKidney diseaseAcute kidney injuryChronic kidney diseaseDifferent clinical manifestationsSubspecialty of nephrologyOnco-NephrologyKidney injuryElectrolyte disturbancesClinical manifestationsCancer patientsGeneral internistsPatientsDiseaseCancerHypertensionProteinuriaInternistsInjuryNephrology
2022
Cell Cycle and Senescence Regulation by Podocyte Histone Deacetylase 1 and 2
Rangel P, Cross E, Liu C, Pedigo C, Tian X, Gutiérrez-Calabrés E, Nagata S, Priyadarshini A, Lerner G, Bunda P, Perincheri S, Gu J, Zhao H, Wang Y, Inoue K, Ishibe S. Cell Cycle and Senescence Regulation by Podocyte Histone Deacetylase 1 and 2. Journal Of The American Society Of Nephrology 2022, 34: 433-450. PMID: 36414418, PMCID: PMC10103311, DOI: 10.1681/asn.2022050598.Peer-Reviewed Original ResearchConceptsCell cycle entryDNA damageSenescence-associated β-galactosidase activityDouble knockout miceRole of HDACsNormal glomerular filtration barrierAssociated phenotypesP21-mediated cell cycle arrestOpen chromatin conformationGlomerular filtration barrierSevere proteinuriaKidney failureProinflammatory cytokinesCell cycle regulationHistone deacetylase 1Cell cycle arrestKi67 expressionSustained DNA damagePodocyte lossIntact expressionMice leadsPodocyte-specific lossMatrix metalloproteinasesPodocyte detachmentProteinuria
2020
Collagenofibrotic glomerulopathy in a kidney transplant recipient: A first report
Jdiaa SS, Moeckel GW, Kfoury H, Medawar WA, Abu-Alfa A. Collagenofibrotic glomerulopathy in a kidney transplant recipient: A first report. American Journal Of Transplantation 2020, 21: 1948-1952. PMID: 33206467, DOI: 10.1111/ajt.16399.Peer-Reviewed Case Reports and Technical NotesConceptsKidney transplant recipientsCollagenofibrotic glomerulopathyTransplant recipientsRenal dysfunctionType 3 fibresProgressive diseaseKidney diseaseDefinitive diagnosisUnknown causeRare diseaseDiseaseFirst caseRecipientsFirst reportHematuriaProteinuriaGlomerulopathyPatientsDysfunctionGlomeruliDiagnosisProgressionInhibiting calpain 1 and 2 in cyclin G associated kinase–knockout mice mitigates podocyte injury
Tian X, Inoue K, Zhang Y, Wang Y, Sperati CJ, Pedigo CE, Zhao T, Yan M, Groener M, Moledina DG, Ebenezer K, Li W, Zhang Z, Liebermann D, Greene L, Greer P, Parikh CR, Ishibe S. Inhibiting calpain 1 and 2 in cyclin G associated kinase–knockout mice mitigates podocyte injury. JCI Insight 2020, 5: e142740. PMID: 33208557, PMCID: PMC7710277, DOI: 10.1172/jci.insight.142740.Peer-Reviewed Original ResearchConceptsCalpain-1Chronic kidney diseaseDegree of proteinuriaCalpain inhibitor IIIGlomeruli of patientsProgressive proteinuriaCalpain protease activityGlobal glomerulosclerosisGlomerular injuryKidney functionKidney diseaseKidney failureCalcium dysregulationPodocyte injuryPodocyte-specific deletionPodocyte damageG associated kinaseProtective roleCalpain activationProteinuriaGlomerulosclerosisMiceReduced expressionStriking increaseInjuryRemission of Proteinuria May Protect against Progression to Chronic Kidney Disease in Pediatric-Onset IgA Nephropathy
Suh J, Jang K, Hyun H, Cho M, Lee J, Park Y, Oh J, Kim J, Yoo K, Chung W, Kim S, Kim K, Lee D, Lee J, Cho M, Park H, Koo J, Han K, Yang E, Lee K, Shin J, Cho H, Kim K, Ha I, Park Y, Kang H. Remission of Proteinuria May Protect against Progression to Chronic Kidney Disease in Pediatric-Onset IgA Nephropathy. Journal Of Clinical Medicine 2020, 9: 2058. PMID: 32629965, PMCID: PMC7408672, DOI: 10.3390/jcm9072058.Peer-Reviewed Original ResearchChronic kidney diseaseRemission of proteinuriaAssociated with progression to chronic kidney diseaseKidney diseaseProgression to chronic kidney diseaseMedian Follow-UpTime of biopsyDecreased renal functionImmunoglobulin A nephropathyAsymptomatic hematuriaGross hematuriaRenal functionClinical featuresNephrotic syndromeAggressive managementFollow-upIgA nephropathyPrimary glomerulopathiesRemissionPediatric IgANMultivariate analysisSurvival rateProteinuriaIgANPatientsPD11-09 ELEVATED C-REACTIVE PROTEIN IS ASSOCIATED WITH POSTOPERATIVE DEVELOPMENT OF PROTEINURIA AND SUBSEQUENT RENAL FUNCTIONAL DECLINE AND MORTALITY
Meagher* M, Hamilton Z, Patil D, Saiko K, Bradshaw A, Patel S, Cotta B, Davaro-Comas F, Yasuda Y, Eldefrawy A, Ghali F, Nasseri R, Wan F, Fujii Y, Master V, Derweesh I. PD11-09 ELEVATED C-REACTIVE PROTEIN IS ASSOCIATED WITH POSTOPERATIVE DEVELOPMENT OF PROTEINURIA AND SUBSEQUENT RENAL FUNCTIONAL DECLINE AND MORTALITY. Journal Of Urology 2020, 203 DOI: 10.1097/ju.0000000000000845.09.Peer-Reviewed Original ResearchChapter 46 Approach to the Patient with Hypertensive Nephrosclerosis
Peixoto A, Bakris G. Chapter 46 Approach to the Patient with Hypertensive Nephrosclerosis. 2020, 737-752. DOI: 10.1016/b978-0-12-815876-0.00046-2.Peer-Reviewed Original ResearchHypertensive nephrosclerosisEnd-stage renal diseaseBlood pressure controlChronic kidney diseaseRenin-angiotensin systemMechanism of injuryArteriolar myogenic responseNonmalignant hypertensionTuft collapseBase therapyImpaired autoregulationUnderlying diseaseRenal diseaseInterstitial fibrosisKidney diseaseGlomerular hypertensionUrine sedimentMyogenic responsePressure controlHypertensionGene mutationsDiseaseNephrosclerosisPatientsProteinuria
2019
Medication-Associated Glomerular Disease
Tucker B, Luciano R. Medication-Associated Glomerular Disease. 2019, 735-772. DOI: 10.1007/978-3-319-49379-4_46.Peer-Reviewed Original ResearchGlomerular diseaseTubule-interstitial diseaseMinimal change diseaseFocal segmental glomerulosclerosisKidney injuryThrombotic microangiopathyAcute hemodynamicsCrystalline nephropathyChange diseaseHistologic patternSegmental glomerulosclerosisAdditional interventionsMedicationsDisease severitySpecific drugsDiseaseInjuryDrugsVasculitisHematuriaMicroangiopathyProteinuriaDiscontinuationGlomerulonephritisNephropathyPodocyte histone deacetylase activity regulates murine and human glomerular diseases
Inoue K, Gan G, Ciarleglio M, Zhang Y, Tian X, Pedigo CE, Cavanaugh C, Tate J, Wang Y, Cross E, Groener M, Chai N, Wang Z, Justice A, Zhang Z, Parikh CR, Wilson FP, Ishibe S. Podocyte histone deacetylase activity regulates murine and human glomerular diseases. Journal Of Clinical Investigation 2019, 129: 1295-1313. PMID: 30776024, PMCID: PMC6391095, DOI: 10.1172/jci124030.Peer-Reviewed Original ResearchConceptsEarly growth response 1Histone deacetylase 1Proteinuric patientsKidney diseaseHDAC2 activityValproic acidVeterans Aging Cohort StudyEnd-stage kidney diseaseDegree of proteinuriaGlomerular filtration rateAging Cohort StudyInhibition of HDAC1Proteinuric kidney diseaseHuman glomerular diseasesGlomerular disease modelsConnectivity Map databaseCohort studyFiltration rateGlomerular diseaseHistone deacetylase activityProteinuric kidneysHDAC inhibitorsProteinuriaMRNA expressionGenetic ablation
2018
Transgenic Expression of hCD47 Minimizes the Development of Proteinuria Following Pig-to-Baboon Kidney Transplantation and Reduces Phagocytosis of Porcine Endothelial Cells and Podocytes
Nomura S, Watanabe H, Ariyoshi Y, Pomposelli T, Garcia G, Sekijima M, Boyd L, Ekanayake-Alper D, Glor H, Tanabe T, Arn S, Hawley R, Sykes M, Sachs D, Richard J, Yamada K. Transgenic Expression of hCD47 Minimizes the Development of Proteinuria Following Pig-to-Baboon Kidney Transplantation and Reduces Phagocytosis of Porcine Endothelial Cells and Podocytes. Transplantation 2018, 102: s314-s315. DOI: 10.1097/01.tp.0000543036.39314.a6.Peer-Reviewed Original ResearchDevelopment of proteinuriaPorcine endothelial cellsEndothelial cellsGroup 2Development of massive proteinuriaGroup 1Glomerular cellsGlomerular endothelial damageExpression of hCD55Statistically significant reductionCo-culture assayIn vitro studiesCTLA-4IgImmunosuppressive regimensMinimal proteinuriaCTLA4-IgKidney transplantationMassive proteinuriaReduction of phagocytosisEndothelial damageInflammatory cascadeMediated cytotoxicityProteinuriaPromoting proteinuriaGroup 3SP415EMPAGLIFLOZIN AND PROGRESSION OF CHRONIC KIDNEY DISEASE IN TYPE 2 DIABETES COMPLICATED BY NEPHROTIC-RANGE PROTEINURIA: INSIGHTS FROM THE EMPA-REG OUTCOME® TRIAL
Ruggenenti P, Inzucchi S, Zinman B, Hantel S, Koitka-Weber A, von Eynatten M, Wanner C. SP415EMPAGLIFLOZIN AND PROGRESSION OF CHRONIC KIDNEY DISEASE IN TYPE 2 DIABETES COMPLICATED BY NEPHROTIC-RANGE PROTEINURIA: INSIGHTS FROM THE EMPA-REG OUTCOME® TRIAL. Nephrology Dialysis Transplantation 2018, 33: i487-i487. DOI: 10.1093/ndt/gfy104.sp415.Peer-Reviewed Original Research
2017
Medication-Associated Glomerular Disease
Tucker B, Luciano R. Medication-Associated Glomerular Disease. 2017, 1-36. DOI: 10.1007/978-3-319-27334-1_46-1.Peer-Reviewed Original ResearchGlomerular diseaseTubule-interstitial diseaseMinimal change diseaseFocal segmental glomerulosclerosisKidney injuryThrombotic microangiopathyAcute hemodynamicsCrystalline nephropathyChange diseaseHistologic patternSegmental glomerulosclerosisAdditional interventionsMedicationsDisease severitySpecific drugsDiseaseInjuryDrugsVasculitisHematuriaMicroangiopathyProteinuriaDiscontinuationGlomerulonephritisNephropathyLoss of the podocyte glucocorticoid receptor exacerbates proteinuria after injury
Zhou H, Tian X, Tufro A, Moeckel G, Ishibe S, Goodwin J. Loss of the podocyte glucocorticoid receptor exacerbates proteinuria after injury. Scientific Reports 2017, 7: 9833. PMID: 28852159, PMCID: PMC5575043, DOI: 10.1038/s41598-017-10490-z.Peer-Reviewed Original ResearchConceptsKnockout miceGlucocorticoid receptorNephrotic syndromeSimilar renal functionMainstay of therapyReceptor knockout miceTreatment of proteinuriaFoot process effacementMechanism of actionImmunomodulatory therapyRenal functionGlomerular injuryProtein excretionKO miceCommon disorderNephrotoxic serumPodocyte injuryPodocyte-specific deletionMouse modelSlit diaphragm proteinsWild-type podocytesProcess effacementProteinuriaUnstimulated conditionsKnockout animalsA case of severe nephrotoxicity associated with long-term dietary supplement use
Koraishy FM, Moeckel GW, Geller DS. A case of severe nephrotoxicity associated with long-term dietary supplement use. Clinical Nephrology - Case Studies 2017, 5: 42-47. PMID: 28766491, PMCID: PMC5642467, DOI: 10.5414/cncs109180.BooksDietary supplement useDietary supplementsSupplement useNew-onset renal failureNon-steroidal anti-inflammatory drugsAcute interstitial nephritisCourse of prednisoneAcute kidney injuryAcute tubular necrosisNephrotic range proteinuriaAnti-inflammatory drugsCherry extractKidney injuryRenal failureSerum creatinineTubular necrosisInterstitial nephritisRenal biopsyKidney diseaseSevere nephrotoxicityCyclooxygenase inhibitorSide effectsProteinuriaDaily intakeHealth benefitsHepatic vein pressure predicts GFR in cirrhotic patients with hemodynamic kidney dysfunction
Desai N, Neugarten J, Dominguez M, Golestaneh L. Hepatic vein pressure predicts GFR in cirrhotic patients with hemodynamic kidney dysfunction. Physiological Reports 2017, 5: e13301. PMID: 28611152, PMCID: PMC5471440, DOI: 10.14814/phy2.13301.Peer-Reviewed Original ResearchConceptsHepatic vein pressureTransjugular intrahepatic portosystemic shuntEnd-stage renal diseaseParenchymal kidney diseaseChronic kidney diseaseVein pressureRenal diseaseKidney diseaseCirrhotic patientsUltrasound evidenceCohort of cirrhotic patientsLiver diseaseIntrahepatic portosystemic shuntIntra-abdominal hypertensionPercentage of patientsAssociated with eGFRIntra-abdominal pressureChart reviewLiver failureKidney dysfunctionPortosystemic shuntMultivariate linear regressionEGFRPatientsProteinuria
2016
The risk of death associated with proteinuria in heart failure is restricted to patients with an elevated blood urea nitrogen to creatinine ratio
Brisco MA, Zile MR, Maaten J, Hanberg JS, Wilson FP, Parikh C, Testani JM. The risk of death associated with proteinuria in heart failure is restricted to patients with an elevated blood urea nitrogen to creatinine ratio. International Journal Of Cardiology 2016, 215: 521-526. PMID: 27153048, PMCID: PMC4986924, DOI: 10.1016/j.ijcard.2016.04.100.Peer-Reviewed Original ResearchConceptsElevated blood urea nitrogenBUN/CrRenal dysfunctionBlood urea nitrogenCreatinine ratioUrea nitrogenLeft Ventricular Dysfunction (SOLVD) trialVentricular Dysfunction trialsGlomerular filtration rateRisk of deathBaseline characteristicsWorsened survivalAdverse eventsHeart failureTop tertileFiltration rateBottom tertileProteinuriaSurvival disadvantagePatientsMortalityTertileDysfunctionSurvivalSurvival models
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