Dietary salt regulates epithelial sodium channels in rat endothelial cells: adaptation of vasculature to salt
Liu H, Zhang J, Sun Y, Li X, Jiang S, Liu M, Shi J, Song B, Zhao D, Ma H, Zhang Z. Dietary salt regulates epithelial sodium channels in rat endothelial cells: adaptation of vasculature to salt. British Journal Of Pharmacology 2015, 172: 5634-5646. PMID: 25953733, PMCID: PMC4667865, DOI: 10.1111/bph.13185.Peer-Reviewed Original ResearchConceptsEndothelium-dependent relaxationWeeks of HS dietEpithelial sodium channelMesenteric arteryENaC activityEndothelial ENaCEndothelial cellsHS dietSprague-DawleyEnhancement of endothelium-dependent relaxationSodium channelsSecond-order mesenteric arteriesBlocker of ENaCWire myograph assayPatch-clamp techniquePlasma aldosterone levelsSalt-sensitive hypertensionResponse to AChNegative modulatorRat endothelial cellsModulation of vasodilationVascular endothelial cellsFunctional ENaCENaC expressionRelease of NO
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