2023
Prognostic significance of haemodynamic parameters in patients with cardiogenic shock
Berg D, Kaur G, Bohula E, Baird-Zars V, Alviar C, Barnett C, Barsness G, Burke J, Chaudhry S, Chonde M, Cooper H, Daniels L, Dodson M, Gerber D, Ghafghazi S, Gidwani U, Goldfarb M, Guo J, Hillerson D, Kenigsberg B, Kochar A, Kontos M, Kwon Y, Lopes M, Loriaux D, Miller P, O’Brien C, Papolos A, Patel S, Pisani B, Potter B, Prasad R, Roswell R, Shah K, Sinha S, Smith T, Solomon M, Teuteberg J, Thompson A, Zakaria S, Katz J, van Diepen S, Morrow D. Prognostic significance of haemodynamic parameters in patients with cardiogenic shock. European Heart Journal Acute Cardiovascular Care 2023, 12: 651-660. PMID: 37640029, PMCID: PMC10599641, DOI: 10.1093/ehjacc/zuad095.Peer-Reviewed Original ResearchConceptsCardiac intensive care unitInvasive haemodynamic assessmentRight atrial pressureCardiogenic shockHaemodynamic parametersHaemodynamic assessmentCICU admissionSerum lactateCritical Care Cardiology Trials NetworkLower pulmonary artery pulsatility indexPulmonary capillary wedge pressure ratioLow systemic vascular resistancePulmonary artery pulsatility indexLower systolic blood pressureTemporary mechanical circulatory supportMedian cardiac indexTIMI Study GroupVasoactive-inotropic scoreArtery pulsatility indexEnd-organ dysfunctionRight ventricular dysfunctionSystemic vascular resistancePulmonary artery catheterSystolic blood pressureManagement of patients
2019
Clinical impact of intraoperative hyperlactatemia during craniotomy
Romano D, Deiner S, Cherukuri A, Boateng B, Shrivastava R, Mocco J, Hadjipanayis C, Yong R, Kellner C, Yaeger K, Lin H, Brallier J. Clinical impact of intraoperative hyperlactatemia during craniotomy. PLOS ONE 2019, 14: e0224016. PMID: 31647826, PMCID: PMC6812741, DOI: 10.1371/journal.pone.0224016.Peer-Reviewed Original ResearchConceptsElevated lactateNeurological deficitsSerum lactateAssociated with new postoperative neurological deficitsCritically ill septic shock patientsCraniotomy patientsEarly due to futilityElevated serum lactate levelsAssociated with poor outcomesLactate levelsAssociated with neurological complicationsPostoperative neurological deficitsHospital length of staySeptic shock patientsSerum lactate levelsPostoperative myocardial infarctionDay of surgeryElevated lactate levelsArterial lactate valuesElective craniotomy patientsLength of stayCardiac surgeryTroponin valuesSystemic complicationsDay mortality463P Evaluation of pharmacodynamic (PD) biomarkers in advanced cancer patients treated with oxidative phosphorylation (OXPHOS) inhibitor, OPC-317 (OPC)
Eu J, Yadav K, Lim Y, Hirpara J, Kong L, Ng Z, Lee V, Lee S, Tan D, Soo R, Chee C, Yong W, Sundar R, Lim J, Wang L, Ohi N, Tsunoda T, Pervaiz S, Goh B, Wong A. 463P Evaluation of pharmacodynamic (PD) biomarkers in advanced cancer patients treated with oxidative phosphorylation (OXPHOS) inhibitor, OPC-317 (OPC). Annals Of Oncology 2019, 30: v174. DOI: 10.1093/annonc/mdz244.025.Peer-Reviewed Original ResearchMitochondrial membrane potentialSerum metabolomeHER2+ breast cancerOncogene-addicted tumorsDose-finding phaseClinically tolerable dosesCancer stem cellsNon-significant riseG3/4 toxicitiesOxidative phosphorylation inhibitionSignificantly with treatmentGIST patientsTolerated doseTumor biopsiesImmunohistochemistry expressionCopy numberOxidative phosphorylationSerum lactateBreast cancerClinical developmentDrug resistanceMerck SeronoDose levelsDay 1Pathway inhibitor
2017
Elevated Intraoperative Serum Lactate During Craniotomy Is Associated With New Neurological Deficit and Longer Length of Stay
Brallier J, Dalal P, McCormick P, Lin H, Deiner S. Elevated Intraoperative Serum Lactate During Craniotomy Is Associated With New Neurological Deficit and Longer Length of Stay. Journal Of Neurosurgical Anesthesiology 2017, 29: 388-392. PMID: 27438799, DOI: 10.1097/ana.0000000000000332.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAdultAgedCerebrovascular CirculationCohort StudiesCraniotomyFemaleHumansIntraoperative ComplicationsLactic AcidLength of StayMaleMiddle AgedMyocardial InfarctionNervous System DiseasesNeurosurgical ProceduresPerfusionPostoperative ComplicationsRetrospective StudiesRisk FactorsSurvival AnalysisTreatment OutcomeConceptsAssociated with new neurological deficitsNew neurological deficitsSerum lactateNeurological deficitsAssociated with systemic complicationsElevated serum lactateSerum lactate levelsRetrospective cohort studySurgical decision-makingAssociated with hypoperfusionLonger length of stayLength of stayInadequate blood supplySystemic complicationsSystemic hypoperfusionFluid resuscitationElevated lactateProspective studyClinical impactCraniotomy casesLonger lengthGlobal hypoperfusionSurgical retractionCohort studyCraniotomy patientsEvaluation of a novel 5-group classification system of sepsis by vasopressor use and initial serum lactate in the emergency department
Swenson KE, Dziura JD, Aydin A, Reynolds J, Wira CR. Evaluation of a novel 5-group classification system of sepsis by vasopressor use and initial serum lactate in the emergency department. Internal And Emergency Medicine 2017, 13: 257-268. PMID: 28132131, DOI: 10.1007/s11739-017-1607-y.Peer-Reviewed Original ResearchConceptsInitial serum lactate levelSerum lactate levelsEmergency departmentLactate elevationVasoplegic shockLactate levelsCryptic shockVasopressor useInfected patientsShock mortalityHigh-risk ED patientsGroup mortality rateInitial serum lactateVasopressor-dependent patientsIdentifiable risk factorsSepsis-3 definitionRisk-stratify patientsHigh-risk subgroupsInitial lactate levelProximal phaseVasopressor dependenceVasopressor requirementHospital outcomesED patientsSerum lactate
2012
Acute superior mesenteric artery embolism: reperfusion with AngioJet hydrodynamic suction thrombectomy and pharmacologic thrombolysis with the EKOS catheter
Ballehaninna U, Hingorani A, Ascher E, Shiferson A, Marks N, Aboian E, Jimenez R, Jacob T, McIntyre T. Acute superior mesenteric artery embolism: reperfusion with AngioJet hydrodynamic suction thrombectomy and pharmacologic thrombolysis with the EKOS catheter. Vascular 2012, 20: 166-169. PMID: 22442382, DOI: 10.1258/vasc.2011.cr0311.Peer-Reviewed Original ResearchConceptsSuperior mesenteric arterySuction thrombectomyEKOS catheterPharmacological thrombolysisContinuous thrombolysisNew-onset atrial fibrillationAcute SMA embolismOnset atrial fibrillationPharmaco-mechanical thrombolysisAcute mesenteric ischemiaOpen thrombectomySMA embolismSurgical thrombectomyAbdominal painMesenteric ischemiaMechanical thrombectomyRepeat angiogramPharmacologic thrombolysisSurgical explorationMesenteric arterySerum lactateAtrial fibrillationMesenteric embolismAcute embolusFilling defect
2011
Frequency and Outcomes of Hyperlactatemia After Neurosurgery
Kohli-Seth R, Mukkera S, Leibowitz A, Nemani N, Oropello J, Manasia A, Bassily-Marcus A, Benjamin E. Frequency and Outcomes of Hyperlactatemia After Neurosurgery. ICU Director 2011, 2: 211-214. DOI: 10.1177/1944451611424486.Peer-Reviewed Original ResearchSerum lactate levelsSurgery groupSerum lactateIntracranial vascular surgeryLactate levelsSpinal surgery groupElevated serum lactateNeurosurgical intensive care unitIncidence of hyperlactatemiaAssociated with survivalTertiary care hospitalIntensive care unitBrain tumor groupVascular surgery groupPatients admitted to neurosurgical intensive care unitLength of stayPostoperative hyperlactatemiaSpinal surgeryTumor groupRetrospective analysisVascular surgeryCare unitBrain tumorsNeurosurgical patientsPatients
2009
Prolonged Propofol Anesthesia Is Not Associated with an Increase in Blood Lactate
Rozet I, Tontisirin N, Vavilala MS, Treggiari MM, Lee LA, Lam AM. Prolonged Propofol Anesthesia Is Not Associated with an Increase in Blood Lactate. Anesthesia & Analgesia 2009, 109: 1105-1110. PMID: 19641048, DOI: 10.1213/ane.0b013e3181b5a220.Peer-Reviewed Original ResearchConceptsPropofol groupVolatile anesthesiaBlood lossAnesthesia timeSpine surgeryElective spine surgeryHigh serum lactateIntraoperative hemodynamic variablesProlonged spine surgeryPropofol infusion syndromeUse of vasopressorsPropofol patientsVA casesASA gradeInfusion syndromeSerum lactateArterial lactatePropofol infusionProspective studyHemodynamic variablesVA patientsPropofol anesthesiaIntraoperative dataLactic acidosisBlood lactate
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