Predictors of response to intra-arterial vasodilatory therapy of non-occlusive mesenteric ischemia in patients with severe shock: results from a prospective observational study
Rittgerodt N, Pape T, Busch M, Becker L, Schneider A, Wedemeyer H, Seeliger B, Schmidt J, Hunkemöller A, Fuge J, Knitsch W, Fegbeutel C, Gillmann H, Meyer B, Hoeper M, Hinrichs J, David S, Stahl K. Predictors of response to intra-arterial vasodilatory therapy of non-occlusive mesenteric ischemia in patients with severe shock: results from a prospective observational study. Critical Care 2022, 26: 92. PMID: 35379286, PMCID: PMC8981621, DOI: 10.1186/s13054-022-03962-w.Peer-Reviewed Original ResearchConceptsMulti-organ failureVasodilatory therapyMesenteric ischemiaPredictors of response to therapyBackgroundNon-occlusive mesenteric ischemiaBiomarkers of intestinal injuryNon-occlusive mesenteric ischemiaLocal intra-arterial infusionIntra-arterial therapyDoses of norepinephrineResponse to therapyRetrospective case seriesIntra-arterial infusionSevere shockLife-threatening conditionImprovement of ischemiaProstaglandin infusionSecondary endpointsClinical parametersElevated lactate concentrationsCase seriesTherapeutic optionsMesenteric arteryReduction of lactateIntestinal ischemia
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