2022
Compromised Cardiopulmonary Function in Fibulin-5 Deficient Mice.
Ramachandra AB, Mikush N, Sauler M, Humphrey JD, Manning EP. Compromised Cardiopulmonary Function in Fibulin-5 Deficient Mice. Journal Of Biomechanical Engineering 2022, 144 PMID: 35171214, PMCID: PMC8990734, DOI: 10.1115/1.4053873.Peer-Reviewed Original ResearchConceptsRight heart functionDeficient micePulmonary arteryHeart functionCompromised right ventricular functionFibulin-5 deficient micePulmonary arterial structureRight ventricular functionVentilation-perfusion relationshipsElastic fiber contentElastic fibersFiber dysfunctionLung compliancePulmonary healthVentricular functionCardiopulmonary functionAlveolar disruptionPulmonary pathologyLung parenchymaMurine modelMouse modelArterial structureHistological quantificationElastic laminaRight circulation
2020
Myoendothelial Junctions of Mature Coronary Vessels Express Notch Signaling Proteins
McCallinhart P, Biwer L, Clark O, Isakson B, Lilly B, Trask A. Myoendothelial Junctions of Mature Coronary Vessels Express Notch Signaling Proteins. Frontiers In Physiology 2020, 11: 29. PMID: 32116749, PMCID: PMC7010921, DOI: 10.3389/fphys.2020.00029.Peer-Reviewed Original ResearchInternal elastic laminaMyoendothelial junctionsCoronary circulationCoronary ECsBlood vesselsIntact blood vesselsNotch signalingSmooth muscleMature blood vesselsNotch3 expressionNotch inhibitorsNotch receptorsElastic laminaTranswell insertsCell phenotypeNormal vasculogenesisVSMCsCell contactReceptorsCritical determinantCell-cell contactSignalingVesselsNotch activityCritical sites
2017
Non–Endoplasmic Reticulum–Based Calr (Calreticulin) Can Coordinate Heterocellular Calcium Signaling and Vascular Function
Biwer L, Good M, Hong K, Patel R, Agrawal N, Looft-Wilson R, Sonkusare S, Isakson B. Non–Endoplasmic Reticulum–Based Calr (Calreticulin) Can Coordinate Heterocellular Calcium Signaling and Vascular Function. Arteriosclerosis Thrombosis And Vascular Biology 2017, 38: 120-130. PMID: 29122814, PMCID: PMC5746467, DOI: 10.1161/atvbaha.117.309886.Peer-Reviewed Original ResearchConceptsThird-order mesenteric arteriesBlood pressureMesenteric arteryVascular functionCalcium signalingIEL holesApplication of CChMyoendothelial junctionsCalcium eventsER calciumSmooth muscle cellsInternal elastic laminaVascular reactivityResistance arteriesSmall arteriesSame arteryKnockout miceArteryΔ miceElastic laminaMuscle cellsEndoplasmic reticulum calciumMiceCALRCalcium signals
2016
Endothelial calreticulin and its role in vascular function
Biwer L, Good M, Sonkusare S, Isakson B. Endothelial calreticulin and its role in vascular function. The FASEB Journal 2016, 30 DOI: 10.1096/fasebj.30.1_supplement.955.3.Peer-Reviewed Original ResearchBlood pressureResistance arteriesSmooth muscle cellsER calcium releaseEndothelial cellsMyoendothelial junctionsVascular toneCalcium releaseIntact resistance arteriesPercentage of CD31Microvascular endothelial cellsInternal elastic laminaKnockdown of calreticulinAcute injectionPressure myographyCalcium binding proteinControl miceTamoxifen injectionVascular functionCD31 antibodyKnockout miceCalcium transientsAnatomical hallmarksElastic laminaMuscle cells
2015
ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy
Albright RA, Stabach P, Cao W, Kavanagh D, Mullen I, Braddock AA, Covo MS, Tehan M, Yang G, Cheng Z, Bouchard K, Yu ZX, Thorn S, Wang X, Folta-Stogniew EJ, Negrete A, Sinusas AJ, Shiloach J, Zubal G, Madri JA, De La Cruz EM, Braddock DT. ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy. Nature Communications 2015, 6: 10006. PMID: 26624227, PMCID: PMC4686714, DOI: 10.1038/ncomms10006.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseVascular calcificationArterial calcificationOrphan diseaseCommon diseaseSequelae of diseaseEctopic vascular calcificationInternal elastic laminaPrevent mortalityRenal failureCardiac failureKidney diseaseSubcutaneous administrationRodent modelsAnimal modelsEctopic calcificationVascular wallLarge arteriesElastic laminaDiseaseCalcificationCalciphylaxisDecreased concentrationSclerosisArtery
1981
Ultrastructure of the Human Dermal Microcirculation. III. The Vessels in the Mid- and Lower Dermis and Subcutaneous Fat
Braverman I, Keh-Yen A. Ultrastructure of the Human Dermal Microcirculation. III. The Vessels in the Mid- and Lower Dermis and Subcutaneous Fat. Journal Of Investigative Dermatology 1981, 77: 297-304. PMID: 7264363, DOI: 10.1111/1523-1747.ep12482470.Peer-Reviewed Original ResearchConceptsElastic laminaSubcutaneous fatEndothelial cellsHuman Dermal MicrocirculationInternal elastic laminaLower dermisExamination of vesselsVeil cellsButtock skinDermal capillariesLarge arteriesArteriolesDermal microcirculationSweat glandsMicrocirculatory vesselsBlood vesselsVenous capillariesVessel wallUltrastructural featuresHair bulbDermisNormal thicknessElastic fibersFatVenules
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