2025
Geographic patterns in wildland fire exposures and county-level lung cancer mortality in the United States
Remigio R, Buller I, Bogle M, Kamenetsky M, Ammons S, Bell J, Fisher J, Freedman N, Jones R. Geographic patterns in wildland fire exposures and county-level lung cancer mortality in the United States. International Journal Of Health Geographics 2025, 24: 8. PMID: 40217528, PMCID: PMC11992742, DOI: 10.1186/s12942-025-00394-x.Peer-Reviewed Original ResearchConceptsLung cancer mortality ratesLung cancer mortalityCigarette smoking prevalenceCancer mortalityWestern USSmoking prevalenceBurned land areasNational Center for Health StatisticsCenter for Health StatisticsLand areaExposure-response assessmentLee's L statisticGeographic patternsMid‐Appalachian regionCombustion by-productsConterminous United StatesSex-SpecificUnited StatesHealth StatisticsEvaluate geographic patternsWildland firesPoisson regressionMultiple comparisonsUS countiesBivariate associationsPredictors and Uptake of Lung Cancer Screening in the US: An Integrative Literature Review
Sarkar S, Choa E, Manzo L, Richman I, Batten J, Raziani Y, Poghosyan H. Predictors and Uptake of Lung Cancer Screening in the US: An Integrative Literature Review. Lung Cancer 2025, 203: 108529. PMID: 40253942, DOI: 10.1016/j.lungcan.2025.108529.Peer-Reviewed Original ResearchConceptsLung cancer screeningCancer screeningUptake of lung cancer screeningLung cancer screening utilizationLung cancer mortalityOrganizational-level policiesIntegrative literature reviewUS-based studiesCancer mortalityUninsured individualsDecision-making resourcesOvid MEDLINEInclusion criteriaOvid EmbaseMedical librariansExclusion criteriaDisparitiesOvidEarly detectionLiterature reviewCINAHLScreeningLung cancerMEDLINEEMBASEDeveloping a digital video to support lung cancer screening in diverse populations
Lindsay M, Odole I, Belliveau O, Abujarad F, Gross C, Richman I. Developing a digital video to support lung cancer screening in diverse populations. PEC Innovation 2025, 6: 100388. PMID: 40212805, PMCID: PMC11982046, DOI: 10.1016/j.pecinn.2025.100388.Peer-Reviewed Original ResearchLung cancer screeningKnowledge of lung cancer screeningCancer screeningLevels of educational attainmentEducational attainmentKnowledge scoresDiverse populationsPrimary care clinicsLung cancer mortalityParticipants' knowledge scoresLower educational attainmentOpen-ended feedbackScreening behaviorLow dose computed tomographyPatient engagementCare clinicsCancer mortalityAssess knowledgeParticipant feedbackIncreased knowledgeParticipantsAdultsScreeningAttainmentScores
2024
Inverse probability weighting to estimate impacts of hypothetical occupational limits on radon exposure to reduce lung cancer
Keil A, Li Y, Lan Q, Bertke S, Daniels R, Edwards J, Kelly-Reif K. Inverse probability weighting to estimate impacts of hypothetical occupational limits on radon exposure to reduce lung cancer. American Journal Of Epidemiology 2024, 194: 1295-1303. PMID: 39168837, PMCID: PMC11973934, DOI: 10.1093/aje/kwae299.Peer-Reviewed Original ResearchHealthy worker survivor biasInverse probability weightingCumulative risk of lung cancerReduce lung cancer mortalitySurvivor biasRisk of lung cancerLung cancer mortalityReduce lung cancerRadon exposureProbability weightingWorking level monthsHealth effectsHealth outcomesCancer mortalityOccupational cohortOccupational limitsCumulative riskLung cancerHealthInverse probabilityUS Mine SafetyWorkersCancerAnnual standardEstimated impactDigital Interventions to Support Lung Cancer Screening: A Systematic Review
Odole I, Andersen M, Richman I. Digital Interventions to Support Lung Cancer Screening: A Systematic Review. American Journal Of Preventive Medicine 2024, 66: 899-908. PMID: 38246408, PMCID: PMC11451259, DOI: 10.1016/j.amepre.2024.01.007.Peer-Reviewed Original ResearchLung cancer screeningMulti-level interventionsJoanna Briggs InstituteDigital interventionsLow-dose computed tomographyDecision aidCancer screeningElectronic health record (EHR)-based interventionsUptake of lung cancer screeningPromote lung cancer screeningEffectiveness of digital interventionsSystematic review INTRODUCTIONImprove knowledgeDiverse healthcare settingsReduce decisional conflictLung cancer mortalityEvaluate implementation strategiesRelated to knowledgeScreening behaviorEngaging patientsDecisional conflictAppraisal toolCancer mortalityScreen useHealthcare settings
2022
Cancer of the Lung
Morgensztern D, Boffa D, Chen A, Dhanasopon A, Goldberg S, Decker R, Devarakonda S, Ko J, Soto L, Waqar S, Wistuba I, Herbst R. Cancer of the Lung. 2022, 1-29. DOI: 10.1002/9781119000822.hfcm085.pub2.Peer-Reviewed Original ResearchThe role of lung cancer risk and comorbidity in lung cancer screening use
Richman IB, Long JB, Poghosyan H, Sather P, Gross CP. The role of lung cancer risk and comorbidity in lung cancer screening use. Preventive Medicine Reports 2022, 30: 102006. PMID: 36203942, PMCID: PMC9530957, DOI: 10.1016/j.pmedr.2022.102006.Peer-Reviewed Original ResearchLung cancer screeningLung cancer riskDiagnostic chest CTCancer riskLow comorbidityCancer screeningChest CTGreater lung cancer riskHigher lung cancer riskLow-dose computed tomographyCancer screening useLung cancer mortalityDose computed tomographyElectronic health recordsLCS useCohort studyPatient characteristicsEligible adultsCancer mortalityScreening useComorbiditiesComputed tomographyDiagnostic CTDiagnostic imagingPatientsEvidence of Racial Disparities in the Lung Cancer Screening Process: a Systematic Review and Meta-Analysis
Kunitomo Y, Bade B, Gunderson CG, Akgün KM, Brackett A, Tanoue L, Bastian LA. Evidence of Racial Disparities in the Lung Cancer Screening Process: a Systematic Review and Meta-Analysis. Journal Of General Internal Medicine 2022, 37: 3731-3738. PMID: 35838866, PMCID: PMC9585128, DOI: 10.1007/s11606-022-07613-2.Peer-Reviewed Original ResearchConceptsLung cancer screeningLCS participationLung cancer mortalityScreening ratesWhite patientsSystematic reviewCancer mortalityPatient populationRacial disparitiesPatient studiesLung cancer screening processAllied Health Literature databasesLow-dose chestHigh-risk individualsMethodsA systematic reviewCancer screening processFull-text reviewTitles/abstractsWeb of ScienceBlack patientsDatabase inceptionCancer screeningClinical trialsInclusion criteriaProvider awareness
2021
Racial Differences in Adherence to Lung Cancer Screening Follow-up A Systematic Review and Meta-analysis
Kunitomo Y, Bade B, Gunderson CG, Akgün KM, Brackett A, Cain H, Tanoue L, Bastian LA. Racial Differences in Adherence to Lung Cancer Screening Follow-up A Systematic Review and Meta-analysis. CHEST Journal 2021, 161: 266-275. PMID: 34390706, DOI: 10.1016/j.chest.2021.07.2172.Peer-Reviewed Original ResearchConceptsLung cancer screeningLung cancer mortalityCancer mortalityCancer screeningLow adherenceSystematic reviewAnnual lung cancer screeningLung cancer mortality benefitLow-dose chest CTEligible black patientsAllied Health Literature databasesA Systematic ReviewRate of adherenceHigh-risk individualsUnited States Preventive Services TaskforceFull-text reviewHealth Literature databasesWeb of ScienceLCS adherenceLCS participationBlack populationMortality benefitWhite patientsBlack patientsInitial screening results
2020
Publisher Correction: A clonal expression biomarker associates with lung cancer mortality
Biswas D, Birkbak N, Rosenthal R, Hiley C, Lim E, Papp K, Boeing S, Krzystanek M, Djureinovic D, La Fleur L, Greco M, Döme B, Fillinger J, Brunnström H, Wu Y, Moore D, Skrzypski M, Abbosh C, Litchfield K, Al Bakir M, Watkins T, Veeriah S, Wilson G, Jamal-Hanjani M, Moldvay J, Botling J, Chinnaiyan A, Micke P, Hackshaw A, Bartek J, Csabai I, Szallasi Z, Herrero J, McGranahan N, Swanton C. Publisher Correction: A clonal expression biomarker associates with lung cancer mortality. Nature Medicine 2020, 26: 1148-1148. PMID: 32494065, DOI: 10.1038/s41591-020-0899-z.Peer-Reviewed Original ResearchLung cancer mortalityCancer mortality
2019
A clonal expression biomarker associates with lung cancer mortality
Biswas D, Birkbak N, Rosenthal R, Hiley C, Lim E, Papp K, Boeing S, Krzystanek M, Djureinovic D, La Fleur L, Greco M, Döme B, Fillinger J, Brunnström H, Wu Y, Moore D, Skrzypski M, Abbosh C, Litchfield K, Al Bakir M, Watkins T, Veeriah S, Wilson G, Jamal-Hanjani M, Moldvay J, Botling J, Chinnaiyan A, Micke P, Hackshaw A, Bartek J, Csabai I, Szallasi Z, Herrero J, McGranahan N, Swanton C. A clonal expression biomarker associates with lung cancer mortality. Nature Medicine 2019, 25: 1540-1548. PMID: 31591602, PMCID: PMC6984959, DOI: 10.1038/s41591-019-0595-z.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerClinicopathological risk factorsCell lung cancerLung cancer mortalityPrognostic gene expression signaturesCancer cell proliferationGene expression signaturesCancer mortalityLung cancerRisk factorsExpression-based biomarkersCopy number gainsDisease subtypesClinical descriptorsTranscriptomic biomarkersIndividual tumorsCancer typesDiagnostic precisionMolecular biomarkersExpression signaturesCell proliferationDNA copy number gainsBiomarkersPatientsIntratumor heterogeneity
2018
Smoking and Lung Cancer Mortality in the United States From 2015 to 2065: A Comparative Modeling Approach.
Jeon J, Holford TR, Levy DT, Feuer EJ, Cao P, Tam J, Clarke L, Clarke J, Kong CY, Meza R. Smoking and Lung Cancer Mortality in the United States From 2015 to 2065: A Comparative Modeling Approach. Annals Of Internal Medicine 2018, 169: 684-693. PMID: 30304504, PMCID: PMC6242740, DOI: 10.7326/m18-1250.Peer-Reviewed Original ResearchConceptsLung cancer mortalityTobacco control effortsCancer mortalityLung cancer ratesLung cancerCancer ratesLung cancer burdenLung cancer deathsLung cancer screeningSmoking-related diseasesU.S. populationNational Cancer InstituteLonger life expectancyCancer burdenSmoking patternsCancer deathCessation effortsCancer screeningTobacco useCancer InstituteSmokingAdditional preventionNatural historyMortalityCancerBenefits and harms of lung cancer screening in HIV-infected individuals with CD4+ cell count at least 500 cells/&mgr;l
Kong CY, Sigel K, Criss SD, Sheehan DF, Triplette M, Silverberg MJ, Henschke CI, Justice A, Braithwaite RS, Wisnivesky J, Crothers K. Benefits and harms of lung cancer screening in HIV-infected individuals with CD4+ cell count at least 500 cells/&mgr;l. AIDS 2018, 32: 1333-1342. PMID: 29683843, PMCID: PMC5991188, DOI: 10.1097/qad.0000000000001818.Peer-Reviewed Original ResearchConceptsLow-dose computed tomographyLung cancer screeningCD4 cell countMedicaid Services criteriaCancer screeningLung cancerMortality reductionCell countLDCT examinationsAnnual low-dose computed tomographyUninfected individualsLung cancer mortality reductionVeterans Aging Cohort StudyCancer mortality reductionAntiretroviral therapy adherenceAging Cohort StudyLung cancer mortalityCells/Lung Cancer Policy ModelMultiple national organizationsAlternative screening strategiesBase-case analysisHIV cohortCohort studyFormer smokersMultifactorial Analysis of Mortality in Screening Detected Lung Cancer
Digumarthy SR, De Man R, Canellas R, Otrakji A, Wang G, Kalra MK. Multifactorial Analysis of Mortality in Screening Detected Lung Cancer. Journal Of Oncology 2018, 2018: 1296246. PMID: 29861726, PMCID: PMC5976935, DOI: 10.1155/2018/1296246.Peer-Reviewed Original ResearchCoronary artery calcificationNational Lung Screening TrialLow-dose CTBody mass indexLung cancerFat attenuationMuscle massLow-dose chest CTLung cancer mortalitySeverity of emphysemaLung cancer stageNLST trialNonsurvivor groupArtery calcificationSmoking historyMass indexCancer mortalityChest CTCancer stageSurvivor groupScreening TrialSurvival timeEmphysemaPatientsCancer
2017
Lung Cancer Mortality Associated With Smoking and Smoking Cessation Among People Living With HIV in the United States
Reddy KP, Kong CY, Hyle EP, Baggett TP, Huang M, Parker RA, Paltiel AD, Losina E, Weinstein MC, Freedberg KA, Walensky RP. Lung Cancer Mortality Associated With Smoking and Smoking Cessation Among People Living With HIV in the United States. JAMA Internal Medicine 2017, 177: 1613-1621. PMID: 28975270, PMCID: PMC5675744, DOI: 10.1001/jamainternmed.2017.4349.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusLung cancer mortalityAge 40 yearsAntiretroviral therapyLung cancerCancer mortalityLower lung cancer mortalityIncomplete ART adherenceLung cancer deathsAge 80 yearsRisk of deathMortality risk ratioHigher overall mortalityStandard demographic dataGreater AIDSLight smokersSmoking exposureCurrent smokersFormer smokersART adherenceModerate smokersOverall mortalitySmoking habitsSmoking statusImmunodeficiency virusCancer of the Lung
Lu C, Morgensztern D, Chiang A, Onn A, Sepesi B, Vaporciyan A, Chang J, Komaki R, Wistuba I, Herbst R. Cancer of the Lung. 2017, 1-30. DOI: 10.1002/9781119000822.hfcm085.Peer-Reviewed Original ResearchLung cancerLung cancer mortalityStandard therapy optionsCancer-related deathNovel therapeutic strategiesCancer mortalityTherapy optionsHeterogeneous diseaseTherapeutic strategiesTobacco consumptionCancerMolecular pathwaysCurrent standardImmunotherapyChemotherapySurgeryRadiotherapyLungTherapyMortalityDiseaseSignificant excitementCare
2016
Survival analysis with measurement error in a cumulative exposure variable: radon progeny in relation to lung cancer mortality
Spiegelman* D, Khudyakov P, Samet J, Wiggins C, Liao X, Meisner A. Survival analysis with measurement error in a cumulative exposure variable: radon progeny in relation to lung cancer mortality. ISEE Conference Abstracts 2016, 2016 DOI: 10.1289/isee.2016.2988.Peer-Reviewed Original ResearchLung cancer screening
Tanoue LT. Lung cancer screening. Current Opinion In Pulmonary Medicine 2016, 22: 327-335. PMID: 27159896, DOI: 10.1097/mcp.0000000000000287.Peer-Reviewed Original ResearchConceptsLung cancer screeningLow-dose chestCancer screeningUS Preventive Services Task ForceNational Lung Screening TrialFuture screening practicesLung cancer mortalityHigh-risk individualsIndividualized risk assessmentTobacco treatmentCancer mortalityFalse-positive resultsLung cancerPositive screenChest radiographyScreening practicesInvasive testingScreening TrialLung cancer biomarkersMultidisciplinary programHigh false positive ratePotential harmOngoing studiesChestRelative reduction
2015
Oxidative burden of fine particulate air pollution and risk of cause-specific mortality in the Canadian Census Health and Environment Cohort (CanCHEC)
Weichenthal S, Crouse DL, Pinault L, Godri-Pollitt K, Lavigne E, Evans G, van Donkelaar A, Martin RV, Burnett RT. Oxidative burden of fine particulate air pollution and risk of cause-specific mortality in the Canadian Census Health and Environment Cohort (CanCHEC). Environmental Research 2015, 146: 92-99. PMID: 26745732, DOI: 10.1016/j.envres.2015.12.013.Peer-Reviewed Original ResearchConceptsCause-specific mortalityFine particulate air pollutionOxidative burdenParticulate air pollutionHazard ratioLung cancer hazard ratiosLong-term mortality riskCox proportional hazards modelCanadian Census HealthCancer hazard ratioLung cancer mortalityRisk of mortalityProportional hazards modelRespiratory tract lining fluidCanadian Long Form CensusEnvironment CohortSynthetic respiratory tract lining fluidCancer mortalityLung cancerLining fluidMortality riskHazards modelIndividual-level covariatesInterquartile changeLong-form censusIntegrating Palliative Care Into the Care of Patients With Advanced Lung Cancer
Kapo JM, Akgün KM. Integrating Palliative Care Into the Care of Patients With Advanced Lung Cancer. The Cancer Journal 2015, 21: 434-439. PMID: 26389769, DOI: 10.1097/ppo.0000000000000149.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAdvanced lung cancerLung cancerPalliative careMedian survivalAdvanced non-small cell lung cancerNon-small cell lung cancerBurden of symptomsRegional lymph nodesCell lung cancerLung cancer mortalityTreatment of painTreatment of patientsCare of patientsCause of deathSupport of caregiversMetastatic diseaseLymph nodesCancer mortalityCancer deathPatientsHigh mortalityCancerNeed of supportCareDyspnea
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