2024
Distinguishing vulnerability and resilience to posttraumatic stress disorder evaluating traumatic experiences, genetic risk and electronic health records
Løkhammer S, Koller D, Wendt F, Choi K, He J, Friligkou E, Overstreet C, Gelernter J, Hellard S, Polimanti R. Distinguishing vulnerability and resilience to posttraumatic stress disorder evaluating traumatic experiences, genetic risk and electronic health records. Psychiatry Research 2024, 337: 115950. PMID: 38744179, PMCID: PMC11156529, DOI: 10.1016/j.psychres.2024.115950.Peer-Reviewed Original ResearchElectronic health recordsPosttraumatic stress disorderHealth recordsPTSD vulnerabilityUK Biobank (UKBPhenome-wide association studyRisk scorePhenotype risk scoreUs Research ProgramPolygenic risk scoresStress disorderAoU participantsUKB participantsPresence of posttraumatic stress disorderTrauma burdenGenetic riskPosttraumatic stress disorder symptomsAssociation studiesPheWASClinical comorbiditiesComorbid associationsEye conditionsAOUInverse relationshipMultiple phenotypes
2023
Insomnia and Early Incident Atrial Fibrillation: A 16‐Year Cohort Study of Younger Men and Women Veterans
Gaffey A, Rosman L, Lampert R, Yaggi H, Haskell S, Brandt C, Enriquez A, Mazzella A, Skanderson M, Burg M. Insomnia and Early Incident Atrial Fibrillation: A 16‐Year Cohort Study of Younger Men and Women Veterans. Journal Of The American Heart Association 2023, 12: e030331. PMID: 37791503, PMCID: PMC10757545, DOI: 10.1161/jaha.123.030331.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaIncident atrial fibrillationAtrial fibrillationHealth care utilizationSleep apneaAF onsetCohort studyCare utilizationAF riskMultivariate Cox proportional hazards modelVeterans Health Administration (VHA) careRisk of AFCox proportional hazards modelCases of AFEarly cardiovascular riskIncident AF riskAssociation of insomniaProportional hazards modelCommon sleep disorderPost-9/11 veteransElectronic health recordsAF incidenceCardiovascular riskClinical comorbiditiesLifestyle factorsMaternal and Pregnancy Outcomes Following Heart Transplantation in the United States
Craig A, Campbell A, Snow S, Spates T, Goldstein S, Denoble A, Meng M, Schroder J, Flores K, Agarwal R, Ward C, Federspiel J. Maternal and Pregnancy Outcomes Following Heart Transplantation in the United States. JACC Heart Failure 2023, 11: 1666-1674. PMID: 37804312, PMCID: PMC10841668, DOI: 10.1016/j.jchf.2023.08.018.Peer-Reviewed Original ResearchNontransfusion severe maternal morbiditySevere maternal morbidityHT recipientsHeart transplantationPreterm birthDelivery hospitalizationsGreater oddsPregnancy outcomesRate of SMMNationwide Readmissions DatabaseOutcome of pregnancyHigher readmission ratesProportional hazards regressionHigh morbidity rateMaternal morbidityReadmission ratesHospital readmissionAdjusted analysisComorbid conditionsClinical comorbiditiesHazards regressionMorbidity rateHigh riskHT historyDays postpartumAssociations between Anemia and Outcomes of Pregnant Patients with Pyelonephritis
Cunningham H, Knochenhauer H, Federspiel J, Wein L, Denoble A, Heine R, Dotters-Katz S. Associations between Anemia and Outcomes of Pregnant Patients with Pyelonephritis. American Journal Of Perinatology 2023, 41: e2403-e2409. PMID: 37339672, PMCID: PMC10799185, DOI: 10.1055/a-2113-2892.Peer-Reviewed Original ResearchSevere maternal morbidityNationwide Readmissions DatabaseMaternal morbidityPregnant patientsAcute respiratory distress syndromeAdverse maternal outcomesLonger hospital stayAcute renal failureDisease Control criteriaRetrospective cohort studyRespiratory distress syndromeWeighted national estimateComplex survey methodsMaternal comorbiditiesNonanemic patientsHospital stayMaternal outcomesBaseline characteristicsRenal failureCohort studyDistress syndromePrimary outcomeSepsis riskAnemic patientsClinical comorbidities
2021
Physiological Traits and Adherence to Sleep Apnea Therapy in Individuals with Coronary Artery Disease.
Zinchuk AV, Chu JH, Liang J, Celik Y, Op de Beeck S, Redeker NS, Wellman A, Yaggi HK, Peker Y, Sands SA. Physiological Traits and Adherence to Sleep Apnea Therapy in Individuals with Coronary Artery Disease. American Journal Of Respiratory And Critical Care Medicine 2021, 204: 703-712. PMID: 34156917, PMCID: PMC8521693, DOI: 10.1164/rccm.202101-0055oc.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseObstructive sleep apneaLong-term CPAP adherenceContinuous positive airway pressureCPAP adherenceCPAP useLow ArTHArtery diseaseUntreated obstructive sleep apneaObjective CPAP adherencePositive airway pressureOSA characteristicsPharyngeal collapsibilityRICCADSA trialAirway pressureSleep apneaClinical comorbiditiesAdverse outcomesPoor adherenceClinical trialsAdherence determinantsLow adherenceCommon treatmentArousal thresholdApnea therapyDocumentation of Screening for Firearm Access by Healthcare Providers in the Veterans Healthcare System: A Retrospective Study
Brandt CA, Workman TE, Farmer MM, Akgün KM, Abel EA, Skanderson M, Bean-Mayberry B, Zeng-Treitler Q, Mason M, Bastian LA, Goulet JL, Post LA. Documentation of Screening for Firearm Access by Healthcare Providers in the Veterans Healthcare System: A Retrospective Study. Western Journal Of Emergency Medicine 2021, 22: 525-532. PMID: 34125022, PMCID: PMC8203018, DOI: 10.5811/westjem.2021.4.51203.Peer-Reviewed Original ResearchConceptsClinical notesPatient characteristicsHealthcare providersFirearm accessElectronic health record clinical notesProportion of patientsOutpatient care visitsVeterans Healthcare SystemCohort of veteransUnited States military veteransMilitary service characteristicsDocumentation of screeningDocumentation of accessFirst yearRace/ethnicityCare visitsOutpatient visitsClinical comorbiditiesRetrospective studyVHA careEmergency clinicHandling of firearmsDemographic dataSystemwide processRisk of violence
2020
Variation in Risk-standardized Rates and Causes of Unplanned Hospital Visits Within 7 Days of Hospital Outpatient Surgery
Desai MM, Zogg CK, Ranasinghe I, Parzynski CS, Lin Z, Gorbaty M, Merrill A, Krumholz HM, Drye EE. Variation in Risk-standardized Rates and Causes of Unplanned Hospital Visits Within 7 Days of Hospital Outpatient Surgery. Annals Of Surgery 2020, 276: e714-e720. PMID: 33214469, DOI: 10.1097/sla.0000000000004627.Peer-Reviewed Original ResearchConceptsUnplanned hospital visitsHospital outpatient surgeryHospital outpatient departmentsHospital visitsOutpatient surgeryShort-term safety outcomesFacility-level variationHierarchical logistic regression modelingPost-surgical visitSame-day surgeryHalf of proceduresLogistic regression modelingUrinary retentionStudy cohortUnplanned visitsClinical comorbiditiesOutpatient departmentOutpatient settingPreventable conditionPreventable reasonsBACKGROUND DATASafety outcomesMedicare feeSurgeryService beneficiaries
2019
Brief Report: Zinc Supplementation and Inflammation in Treated HIV.
Dirajlal-Fargo S, Yu J, Kulkarni M, Sattar A, Funderburg N, Barkoukis H, Mccomsey G. Brief Report: Zinc Supplementation and Inflammation in Treated HIV. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2019, 82: 275-280. PMID: 31609926, PMCID: PMC6812547, DOI: 10.1097/qai.0000000000002129.Peer-Reviewed Original ResearchConceptsZinc supplementationZinc levelsDouble-arm studyHigh-dose armLow-dose armMedian zinc levelStable antiretroviral therapyMarkers of inflammationYears old peopleTreated HIVAntiretroviral therapyHIV infectionMedian ageClinical comorbiditiesBiomarker levelsMonocyte activationLarge effect sizesHIVInflammationPilot studyPhase ISupplementationDlElemental zincAfrican AmericansAmyotrophic Lateral Sclerosis Among Veterans Deployed in Support of Post-9/11 U.S. Conflicts
Sagiraju HKR, Živković S, VanCott AC, Patwa H, Gimeno Ruiz de Porras D, Amuan ME, Pugh MJV. Amyotrophic Lateral Sclerosis Among Veterans Deployed in Support of Post-9/11 U.S. Conflicts. Military Medicine 2019, 185: e501-e509. PMID: 31642489, PMCID: PMC8921606, DOI: 10.1093/milmed/usz350.Peer-Reviewed Original ResearchConceptsAmyotrophic lateral sclerosisTraumatic brain injuryDefinite amyotrophic lateral sclerosisCumulative incidenceLateral sclerosisAssociation of TBIEarly-onset amyotrophic lateral sclerosisPrevalence of ALSPossible amyotrophic lateral sclerosisOnset amyotrophic lateral sclerosisObstructive sleep apneaCase-control study designHigh blood pressurePopulation of veteransVeterans Health AdministrationHealth care workersU.S. war veteransMilitary service membersALS prevalenceBlood pressureNeurodegenerative sequelaeService branchesSleep apneaCerebrovascular diseaseClinical comorbiditiesAssociations of Adverse Childhood Experiences with Past‐Year DSM‐5 Psychiatric and Substance Use Disorders in Older Adults
Rhee TG, Barry LC, Kuchel GA, Steffens DC, Wilkinson ST. Associations of Adverse Childhood Experiences with Past‐Year DSM‐5 Psychiatric and Substance Use Disorders in Older Adults. Journal Of The American Geriatrics Society 2019, 67: 2085-2093. PMID: 31206597, PMCID: PMC10666528, DOI: 10.1111/jgs.16032.Peer-Reviewed Original ResearchConceptsSubstance use disordersAdverse childhood experiencesPast-year psychiatric disordersUse disordersOlder adultsPsychiatric disordersForms of ACEsMultivariable-adjusted logistic regression analysesAssociation of ACEsRelated Conditions Wave IIIHealth Interview SurveyLogistic regression analysisNational Epidemiological SurveyCross-sectional analysisChildhood experiencesPublic mental healthClinical comorbiditiesNational prevalenceHigher oddsLong-term effectsWave IIIEpidemiological surveyMental disordersOlder ageMental health
2018
Utilization, In-Hospital Mortality, and 30-Day Readmission After Percutaneous Mitral Valve Repair in the United States Shortly After Device Approval
Faridi KF, Popma JJ, Strom JB, Shen C, Choi E, Yeh RW. Utilization, In-Hospital Mortality, and 30-Day Readmission After Percutaneous Mitral Valve Repair in the United States Shortly After Device Approval. The American Journal Of Cardiology 2018, 121: 1365-1372. PMID: 29627105, DOI: 10.1016/j.amjcard.2018.02.016.Peer-Reviewed Original ResearchConceptsPercutaneous mitral valve repairMitral valve repairValve repairHospital volumeClinical comorbiditiesReduced hospital readmissionsHospital mortality rateDays of dischargeIn-Hospital MortalityNationwide Readmissions DatabaseAdministrative claims databaseHospital readmission ratesRoutine clinical practiceDevice approvalCause mortalityHospital deathMultivariable adjustmentPatient demographicsReadmission ratesHospital readmissionMitraClip deviceClaims databaseHospital characteristicsRisk factorsProcedural volume
2017
Fixed and variable cost of carotid endarterectomy and stenting in the United States: A comparative study
Obeid T, Alshaikh H, Nejim B, Arhuidese I, Locham S, Malas M. Fixed and variable cost of carotid endarterectomy and stenting in the United States: A comparative study. Journal Of Vascular Surgery 2017, 65: 1398-1406.e1. PMID: 28216356, DOI: 10.1016/j.jvs.2016.11.062.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAngioplastyAsymptomatic DiseasesCarotid StenosisChi-Square DistributionDatabases, FactualDecision Support TechniquesEndarterectomy, CarotidFemaleHospital CostsHumansMaleMiddle AgedModels, EconomicPatient SelectionProcess Assessment, Health CarePropensity ScoreRetrospective StudiesStentsTime FactorsTreatment OutcomeUnited StatesConceptsCost of carotid artery stentingSymptomatic patientsHospital costsPropensity score matchingSymptomatic statusScore matchingPremier Perspective databaseCarotid artery stentingComorbidities of patientsStudent's t-testIn-hospital costsActual hospital costsAsymptomatic patientsSurgeon specialtyHospital characteristicsMale patientsCosts of carotid endarterectomyAsymptomatic cohortPerspective databaseArtery stentingPrimary outcomeCarotid endarterectomyPatientsClinical comorbiditiesHospital discharge
2014
A meta-analysis of computerized cognitive-behavioral therapy for the treatment of DSM-5 anxiety disorders.
Adelman CB, Panza KE, Bartley CA, Bontempo A, Bloch MH. A meta-analysis of computerized cognitive-behavioral therapy for the treatment of DSM-5 anxiety disorders. The Journal Of Clinical Psychiatry 2014, 75: e695-704. PMID: 25093485, DOI: 10.4088/jcp.13r08894.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyPerson cognitive-behavioural therapyComputerized cognitive behavioral therapyAnxiety disordersComputerized CBTNon-PTSD anxiety disordersCompletion of treatmentTreatment gainsStandardized mean differenceDSM-5 anxiety disordersGreater symptom reductionWait-list controlSpecific anxiety disordersFixed-effects modelClinical outcomesClinical comorbiditiesEfficacious interventionsSymptom reductionReal-world settingGreater efficacyMeta-analysisCBT treatmentMean differenceDisordersAnxiety symptoms
2013
National Trends in Heart Failure Hospitalization After Acute Myocardial Infarction for Medicare Beneficiaries
Chen J, Hsieh AF, Dharmarajan K, Masoudi FA, Krumholz HM. National Trends in Heart Failure Hospitalization After Acute Myocardial Infarction for Medicare Beneficiaries. Circulation 2013, 128: 2577-2584. PMID: 24190958, PMCID: PMC4415510, DOI: 10.1161/circulationaha.113.003668.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionHF hospitalizationHeart failureMyocardial infarctionMedicare beneficiariesManagement of AMIHeart failure hospitalizationSubsequent HF hospitalizationNumber of patientsNational trendsHigh-risk conditionsContemporary national trendsRelative annual increaseDemographic factorsFailure hospitalizationPerson yearsClinical comorbiditiesNational sampleComplete national sampleHospitalizationMedicare feeAMI hospitalizationService beneficiariesAnnual declineStudy period
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