2025
Ophthalmological Question Answering and Reasoning Using OpenAI o1 vs Other Large Language Models
Srinivasan S, Ai X, Zou M, Zou K, Kim H, Lo T, Pushpanathan K, Yang G, Goh J, Kong Y, Li A, Singer M, Jin K, Antaki F, Chen D, Liu D, Adelman R, Chen Q, Tham Y. Ophthalmological Question Answering and Reasoning Using OpenAI o1 vs Other Large Language Models. JAMA Ophthalmology 2025, 143: 740-748. PMID: 40742581, PMCID: PMC12314776, DOI: 10.1001/jamaophthalmol.2025.2413.Peer-Reviewed Original ResearchSensory and motor contents are prioritized dynamically in working memory
Echeverria-Altuna I, Boettcher S, van Ede F, Nobre A. Sensory and motor contents are prioritized dynamically in working memory. PLOS Biology 2025, 23: e3003273. PMID: 40658683, PMCID: PMC12258573, DOI: 10.1371/journal.pbio.3003273.Peer-Reviewed Original ResearchConceptsMotor contentWorking memoryAttention moduleItem locationsWorking-memory representationsWorking-memory contentsAttentional prioritizationAttentional functionsModulatory functionTemporal expectationsAdaptive behaviorProspective actionsPosterior alphaPattern of modulationHuman participantsSensory contentInternal representationResponse prioritizationDynamic alphaMemoryProspective behaviorRepresenting Visual Objects, Attention, and Load in Human Occipito-temporal and Posterior Parietal Cortices.
Xu Y, Chun M. Representing Visual Objects, Attention, and Load in Human Occipito-temporal and Posterior Parietal Cortices. Journal Of Cognitive Neuroscience 2025, 1-24. PMID: 40587619, DOI: 10.1162/jocn.a.64.Peer-Reviewed Original ResearchOccipito-temporal cortexPosterior parietal cortexParietal cortexHuman occipito-temporal cortexVisual representation spacesOccipito-temporalNeural separationTask demandsNeural mechanismsNeural responsesObject identityVisual processingRepresentation invarianceVisual objectsHuman participantsVisual processing centersCortexAdaptive naturePattern decodingRepresentation spaceVisual inputTask loadColored objectsEveryday visionRepresentationMental graphs structure the storage and retrieval of visuomotor associations
Trach J, McDougle S. Mental graphs structure the storage and retrieval of visuomotor associations. Nature Human Behaviour 2025, 9: 1898-1912. PMID: 40456940, PMCID: PMC12418510, DOI: 10.1038/s41562-025-02217-2.Peer-Reviewed Original ResearchMemory representationsVisuomotor mappingInfluence action selectionVisual stimulus featuresPreparation of movementDays of practiceVisuomotor associationsStimulus featuresAction selectionHuman memoryLatent structureHuman participantsMotor systemMemoryTransition response timeIndividual trialsParticipantsResponse timeMotorVisuomotorMultiple daysInternal computationsStructural memoryRepresentationRetrievalAdversarial testing of global neuronal workspace and integrated information theories of consciousness
Ferrante O, Gorska-Klimowska U, Henin S, Hirschhorn R, Khalaf A, Lepauvre A, Liu L, Richter D, Vidal Y, Bonacchi N, Brown T, Sripad P, Armendariz M, Bendtz K, Ghafari T, Hetenyi D, Jeschke J, Kozma C, Mazumder D, Montenegro S, Seedat A, Sharafeldin A, Yang S, Baillet S, Chalmers D, Cichy R, Fallon F, Panagiotaropoulos T, Blumenfeld H, de Lange F, Devore S, Jensen O, Kreiman G, Luo H, Boly M, Dehaene S, Koch C, Tononi G, Pitts M, Mudrik L, Melloni L. Adversarial testing of global neuronal workspace and integrated information theories of consciousness. Nature 2025, 642: 133-142. PMID: 40307561, PMCID: PMC12137136, DOI: 10.1038/s41586-025-08888-1.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingInferior frontal cortexLateral temporal cortexGlobal neuronal workspaceEarly visual areasPrefrontal cortexCognitive neuroscienceFrontal cortexTemporal cortexNeuronal workspaceConsciousness dimensionsTheory of consciousnessAdversarial collaborationConscious contentsNeural activityStimulus offsetCortexPosterior cortexStimulus durationHuman participantsVisual areasDivergent predictionsMagnetic resonance imagingTheory-DrivenStimuliCharacterizing Silence: Adolescents’ Nondisclosure of Their Suicidal Thoughts and Behaviors to Their Family and Peers
Spears A, Shin K, B. C. Characterizing Silence: Adolescents’ Nondisclosure of Their Suicidal Thoughts and Behaviors to Their Family and Peers. JAACAP Open 2025, 3: 496-505. PMID: 40922770, PMCID: PMC12414306, DOI: 10.1016/j.jaacop.2024.12.005.Peer-Reviewed Original ResearchPaper self-identifiesLifetime historyRecruitment of human participantsAbstractText Label="RESULTS"AbstractText Label="MethodsClinical assessmentSuicidal thoughtsSuicide-related experiencesFrequent suicidal thoughtsLifetime history of suicidal thoughtsHistory of suicidal thoughtsEthnic groupsSelf-identifyStudy questionnaireFear of negative reactionsAdolescentsPrimary confidantsAnonymous surveySelf-consentGroupSense of self-relianceAdolescent self-consentHuman participantsN-methyl-d-aspartate receptor hypofunction causes recurrent and transient failures of perceptual inference
Weilnhammer V, Rothkirch M, Yilmaz D, Fritsch M, Ptasczynski L, Reichenbach K, Roediger L, Corlett P, Sterzer P. N-methyl-d-aspartate receptor hypofunction causes recurrent and transient failures of perceptual inference. Brain 2025, 148: 1531-1539. PMID: 39821016, PMCID: PMC12073972, DOI: 10.1093/brain/awaf011.Peer-Reviewed Original ResearchN-methyl-D-aspartate receptorsN-methyl-D-aspartateN-methyl-D-aspartate receptor hypofunctionS-ketamineSymptoms of schizophreniaDissociation of perceptionsHealthy human participantsExternal sensory signalsReceptor hypofunctionSensory signalsNMDAR hypofunctionPerceptual inferenceCase-control studyInternal predictionsHuman participantsPlacebo-ControlledDouble-blindCross-over experimentHypofunctionSchizophreniaParanoidPerceptionSCZ
2024
Collaborative Outcomes Study on Health and Functioning During Infection Times (COH-FIT): Global and Risk-Group Stratified Course of Well-Being and Mental Health During the COVID-19 Pandemic in Adolescents
Solmi M, Thompson T, Cortese S, Estradé A, Agorastos A, Radua J, Dragioti E, Vancampfort D, Thygesen L, Aschauer H, Schlögelhofer M, Aschauer E, Schneeberger A, Huber C, Hasler G, Conus P, Do Cuénod K, von Känel R, Arrondo G, Fusar-Poli P, Gorwood P, Llorca P, Krebs M, Scanferla E, Kishimoto T, Rabbani G, Skonieczna-Żydecka K, Brambilla P, Favaro A, Takamiya A, Zoccante L, Colizzi M, Bourgin J, Kamiński K, Moghadasin M, Seedat S, Matthews E, Wells J, Vassilopoulou E, Gadelha A, Su K, Kwon J, Kim M, Lee T, Papsuev O, Manková D, Boscutti A, Gerunda C, Saccon D, Righi E, Monaco F, Croatto G, Cereda G, Demurtas J, Brondino N, Veronese N, Enrico P, Politi P, Ciappolino V, Pfennig A, Bechdolf A, Meyer-Lindenberg A, Kahl K, Domschke K, Bauer M, Koutsouleris N, Winter S, Borgwardt S, Bitter I, Balazs J, Czobor P, Unoka Z, Mavridis D, Tsamakis K, Bozikas V, Tunvirachaisakul C, Maes M, Rungnirundorn T, Supasitthumrong T, Haque A, Brunoni A, Costardi C, Schuch F, Polanczyk G, Luiz J, Fonseca L, Aparicio L, Valvassori S, Nordentoft M, Vendsborg P, Hoffmann S, Sehli J, Sartorius N, Heuss S, Guinart D, Hamilton J, Kane J, Rubio J, Sand M, Koyanagi A, Solanes A, Andreu-Bernabeu A, San José Cáceres A, Arango C, Díaz-Caneja C, Hidalgo-Mazzei D, Vieta E, Gonzalez-Peñas J, Fortea L, Parellada M, Fullana M, Verdolini N, Andrlíková E, Janků K, Millan M, Honciuc M, Moniuszko-Malinowska A, Łoniewski I, Samochowiec J, Kiszkiel Ł, Marlicz M, Sowa P, Marlicz W, Spies G, Stubbs B, Firth J, Sullivan S, Darcin A, Aksu H, Dilbaz N, Noyan O, Kitazawa M, Kurokawa S, Tazawa Y, Anselmi A, Cracco C, Machado A, Estrade N, De Leo D, Curtis J, Berk M, Carvalho A, Ward P, Teasdale S, Rosenbaum S, Marx W, Horodnic A, Oprea L, Alexinschi O, Ifteni P, Turliuc S, Ciuhodaru T, Bolos A, Matei V, Nieman D, Sommer I, van Os J, van Amelsvoort T, Sun C, Guu T, Jiao C, Zhang J, Fan J, Zou L, Yu X, Chi X, de Timary P, van Winkel R, Ng B, Pena E, Arellano R, Roman R, Sanchez T, Movina L, Morgado P, Brissos S, Aizberg O, Mosina A, Krinitski D, Mugisha J, Sadeghi-Bahmani D, Sheybani F, Sadeghi M, Hadi S, Brand S, Errazuriz A, Crossley N, Ristic D, López-Jaramillo C, Efthymiou D, Kuttichira P, Kallivayalil R, Javed A, Afridi M, James B, Seb-Akahomen O, Fiedorowicz J, Daskalakis J, Yatham L, Yang L, Okasha T, Dahdouh A, Tiihonen J, Shin J, Lee J, Mhalla A, Gaha L, Brahim T, Altynbekov K, Negay N, Nurmagambetova S, Jamei Y, Weiser M, Correll C. Collaborative Outcomes Study on Health and Functioning During Infection Times (COH-FIT): Global and Risk-Group Stratified Course of Well-Being and Mental Health During the COVID-19 Pandemic in Adolescents. Journal Of The American Academy Of Child & Adolescent Psychiatry 2024, 64: 499-519. PMID: 39581373, DOI: 10.1016/j.jaac.2024.07.932.Peer-Reviewed Original ResearchConceptsWHO-5Effective coping strategiesRecruitment of human participantsCoping strategiesCollaborative outcome studiesMental health impact of COVID-19Global public health strategyHealth and FunctioningHealth impact of COVID-19Mental health of childrenIdentified at-risk groupsWHO-5 scoreMental health conditionsImpact of COVID-19Public health focusPublic health strategiesCOVID-19 pandemicMental health impactsRisk factorsHealth of childrenOutcome studiesProportion of adolescentsAt-risk groupsHuman participantsSocial contactPositive affect modulates memory by regulating the influence of reward prediction errors
Qasim S, Deswal A, Saez I, Gu X. Positive affect modulates memory by regulating the influence of reward prediction errors. Communications Psychology 2024, 2: 52. PMID: 39242805, PMCID: PMC11332028, DOI: 10.1038/s44271-024-00106-4.Peer-Reviewed Original ResearchReward prediction errorMood disordersPositive affectInfluence of reward prediction errorsPositive reward prediction errorAccuracy of memoryDecision-making taskProbabilistic rewardsMemorized stimuliMemory searchBiased memoriesRecognition testCohort of human participantsPerceptual informationHuman participantsRewardMemoryMoodTemporal efficiencyAffectPrediction errorDisordersStimuliComputational mechanicsPerceptuallyRacial Implicit Associations in Child Psychiatry
Malison K, Avila-Quintero V, Al-Mateen C, Flores J, Landeros-Weisenberger A, Njoroge W, Novins D, Robles-Ramamurthy B, Taylor J, Bloch M, Tobón A. Racial Implicit Associations in Child Psychiatry. Journal Of The American Academy Of Child & Adolescent Psychiatry 2024, 64: 734-744. PMID: 38823476, DOI: 10.1016/j.jaac.2024.04.013.Peer-Reviewed Original ResearchImplicit Association TestRace Implicit Association TestRecruitment of human participantsExternalizing behavior problemsPaper self-identifiesImplicit associationsChildren faceBehavior problemsChild psychiatryAbstractText Label="DIVERSITY &Negatively valenced wordsExternal wordHuman participantsValenced wordsExternalizing disordersParticipating psychiatristsPsychiatric cliniciansNegative valenceNegative wordsPsychiatristsAssociation TestPsychiatryInvestigate psychiatristsReduce racial inequalityDemographic predictorsTime for What? Dissociating Explicit Timing Tasks through Electrophysiological Signatures
Bueno F, Nobre A, Cravo A. Time for What? Dissociating Explicit Timing Tasks through Electrophysiological Signatures. ENeuro 2024, 11: eneuro.0351-23.2023. PMID: 38272676, PMCID: PMC10884563, DOI: 10.1523/eneuro.0351-23.2023.Peer-Reviewed Original ResearchConceptsExplicit timing tasksTime taskMultivariate pattern analysisReference stimulusNeural timing mechanismTask-dependent processingTiming mechanismNeural processesTask contextElectrophysiological signaturesExperimental blocksStimulus durationHuman participantsTask requirementsStimuliTaskPattern analysisParticipantsComparing intervalsElectroencephalogram
2023
Youth Screen Media Activity Patterns and Associations With Behavioral Developmental Measures and Resting-state Brain Functional Connectivity
Song K, Zhang J, Zhou N, Fu Y, Zou B, Xu L, Wang Z, Li X, Zhao Y, Potenza M, Fang X, Zhang J. Youth Screen Media Activity Patterns and Associations With Behavioral Developmental Measures and Resting-state Brain Functional Connectivity. Journal Of The American Academy Of Child & Adolescent Psychiatry 2023, 62: 1051-1063. PMID: 36963562, PMCID: PMC10509312, DOI: 10.1016/j.jaac.2023.02.014.Peer-Reviewed Original ResearchConceptsBrain functional connectivityResting-state brain functional connectivityDevelopmental measuresFunctional connectivityHuman participantsTotal behavioral problemsPsychotic-like experiencesPoorer neurocognitive performanceHuman Connectome ProjectCognitive processesAdolescent brainYouth developmentABCD dataHigh impulsivityNeurocognitive performanceBrain measuresPunishment/Behavioral problemsConnectome ProjectLate childhoodLinear mixed effectsBrain areasYouth lifeIndependent samplesParticipants
2022
Motor learning without movement
Kim OA, Forrence AD, McDougle SD. Motor learning without movement. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2204379119. PMID: 35858450, PMCID: PMC9335319, DOI: 10.1073/pnas.2204379119.Peer-Reviewed Original ResearchConceptsImplicit motor adaptationSensory prediction errorsMotor adaptationSingle-trial adaptationSubset of trialsForms of learningImplicit adaptationSensory predictionsMotor planningVisuomotor taskPrediction errorHuman participantsTeaching signalMovement executionMotor imageryOvert movementMotor commandsSensory feedbackMovement trialsDirection of movementAdaptationTaskBrainParticipantsRecent workTransient beta activity and cortico-muscular connectivity during sustained motor behaviour
Echeverria-Altuna I, Quinn A, Zokaei N, Woolrich M, Nobre A, van Ede F. Transient beta activity and cortico-muscular connectivity during sustained motor behaviour. Progress In Neurobiology 2022, 214: 102281. PMID: 35550908, PMCID: PMC9742854, DOI: 10.1016/j.pneurobio.2022.102281.Peer-Reviewed Original ResearchConceptsMotor behaviorMeasured magnetoencephalographyIsometric contractionBeta activitySingle-trial levelSustained isometric contractionCortico-muscular connectivityTask demandsMotor demandsMotor stateMotor requirementsDistant neural populationsFrequency-specific connectivityNeural oscillationsBeta connectivityHuman participantsContralateral musclesMotor cortexNeural populationsNeural synchronisationDownstream musclesComputational mechanisms underlying illusion of control in delusional individuals
Na S, Blackmore S, Chung D, O'Brien M, Banker S, Heflin M, Fiore V, Gu X. Computational mechanisms underlying illusion of control in delusional individuals. Schizophrenia Research 2022, 245: 50-58. PMID: 35177284, PMCID: PMC9232936, DOI: 10.1016/j.schres.2022.01.054.Peer-Reviewed Original ResearchConceptsIllusion of controlDelusions groupDelusional ideationDelusional individualsAssociated with delusional ideationStronger sense of controlComputational psychiatry approachPoor mental health outcomesMental health outcomesSelf-reported beliefsMaladaptive behaviorsPsychiatry approachMonetary offersAberrant computationsSimulated partnerDelusionsSense of controlHuman participantsStronger senseControl conditionIdeationComputational mechanicsParticipantsHealth outcomesIndividualsIncreasing stimulus similarity drives nonmonotonic representational change in hippocampus
Wammes J, Norman KA, Turk-Browne N. Increasing stimulus similarity drives nonmonotonic representational change in hippocampus. ELife 2022, 11: e68344. PMID: 34989336, PMCID: PMC8735866, DOI: 10.7554/elife.68344.Peer-Reviewed Original ResearchConceptsRepresentational changeHigh-level visual regionsShaped functionPairs of stimuliHigh-resolution fMRIStimulus similarityVisual regionsHuman participantsHippocampal learningMemoryPlasticity hypothesisCoactivationFMRIHippocampusGyrusStimuliWide enough rangeContradictory resultsParticipantsImage similarityLearningHypothesisU-shapeSimilar imagesEnough range
2021
Saracatinib Fails to Reduce Alcohol-Seeking and Consumption in Mice and Human Participants
Thompson SL, Gianessi CA, O'Malley SS, Cavallo DA, Shi JM, Tetrault JM, DeMartini KS, Gueorguieva R, Pittman B, Krystal JH, Taylor JR, Krishnan-Sarin S. Saracatinib Fails to Reduce Alcohol-Seeking and Consumption in Mice and Human Participants. Frontiers In Psychiatry 2021, 12: 709559. PMID: 34531767, PMCID: PMC8438169, DOI: 10.3389/fpsyt.2021.709559.Peer-Reviewed Original ResearchNMDA receptorsSrc/FynAlcohol consumptionEffect of saracatinibVehicle 2 hChronic alcohol useDays of treatmentDSM-IV criteriaMore effective treatmentsNumber of drinksGlutamatergic systemAdditional drinkAlcohol drinkingAdditional dosesEthanol exposureEffective treatmentNR2B subunitAlcohol abuseHuman studiesPriming drinkAlcohol cravingSaracatinibDrinking paradigmNovel pharmacotherapeuticsHuman participants
2020
Sustained and transient gray matter volume changes after n-back training: A VBM study
Miró-Padilla A, Bueichekú E, Adrián-Ventura J, Costumero V, Palomar-García M, Villar-Rodríguez E, Marin-Marin L, Aguirre N, Ávila C. Sustained and transient gray matter volume changes after n-back training: A VBM study. Neurobiology Of Learning And Memory 2020, 178: 107368. PMID: 33348048, DOI: 10.1016/j.nlm.2020.107368.Peer-Reviewed Original ResearchConceptsWorking Memory TrainingRight superior parietal cortexN-back trainingSuperior parietal cortexMemory trainingN-backParietal cortexVoxel-based morphometry techniqueGray matter volume changesInvestigate gray matterGray matterPassive control groupRight putamenGM decreaseVBM studiesFunctional connectivityBrain adaptationMorphometry techniqueBrain plasticityGM changesTraining tasksEffect of trainingHuman participantsBrainCortexFinding the Pattern: On-Line Extraction of Spatial Structure During Virtual Navigation
Graves KN, Antony JW, Turk-Browne NB. Finding the Pattern: On-Line Extraction of Spatial Structure During Virtual Navigation. Psychological Science 2020, 31: 1183-1190. PMID: 32853531, PMCID: PMC7542246, DOI: 10.1177/0956797620948828.Peer-Reviewed Original ResearchAAN position statement: Ethical issues in clinical research in neurology
Tolchin B, Conwit R, Epstein LG, Russell JA, Law A. AAN position statement: Ethical issues in clinical research in neurology. Neurology 2020, 94: 661-669. PMID: 32179700, PMCID: PMC7251519, DOI: 10.1212/wnl.0000000000009241.Peer-Reviewed Original ResearchConceptsEthical issuesInstitutional review board oversightWorld Medical Association DeclarationImportant ethical issuesPrinciple-based frameworkCommon rulesModern bioethicsEthical frameworkNuremberg CodeBelmont ReportEthical conductFoundational documentsResearch participantsClinical researchReplication crisisBoard oversightParticipant inclusionHuman participantsDeclarationNeurologic researchPosition statementBioethicsIssuesConductGenetic testing
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