2009
Melanin-concentrating hormone directly inhibits GnRH neurons and blocks kisspeptin activation, linking energy balance to reproduction
Wu M, Dumalska I, Morozova E, van den Pol A, Alreja M. Melanin-concentrating hormone directly inhibits GnRH neurons and blocks kisspeptin activation, linking energy balance to reproduction. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 17217-17222. PMID: 19805188, PMCID: PMC2761345, DOI: 10.1073/pnas.0908200106.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainEnergy MetabolismFemaleGonadotropin-Releasing HormoneGreen Fluorescent ProteinsHypothalamic HormonesImmunohistochemistryKisspeptinsMaleMelaninsMembrane PotentialsMiceMice, TransgenicMicroscopy, FluorescenceNeuronsPatch-Clamp TechniquesPeptide FragmentsPituitary HormonesReceptors, SomatostatinReproductionTime FactorsTumor Suppressor ProteinsVesicular Glutamate Transport Protein 2ConceptsInhibitory effectDirect postsynaptic effectGnRH-GFP neuronsMCH knockout miceMCH-immunoreactive fibersRole of MCHMelanin-concentrating hormone (MCH) systemMCH receptor antagonistsPatch-clamp recordingsMelanin-concentrating hormoneNegative energy balanceKisspeptin activationDrug abuse behaviorGnRH neuronsPostsynaptic effectsExcitatory effectsGABAergic neuronsTransgenic GFP miceImmunoreactive fibersReceptor antagonistCNS neuronsAntidepressant drugsBrain slicesFood restrictionKnockout mice
2001
Pyramidal cell axons show a local specialization for GABA and 5‐HT inputs in monkey and human cerebral cortex
DeFelipe J, Arellano J, Gómez A, Azmitia E, Muñoz A. Pyramidal cell axons show a local specialization for GABA and 5‐HT inputs in monkey and human cerebral cortex. The Journal Of Comparative Neurology 2001, 433: 148-155. PMID: 11283956, DOI: 10.1002/cne.1132.Peer-Reviewed Original ResearchConceptsChandelier cell axon terminalsGamma-aminobutyric acidPyramidal cell axonsCerebral cortexPyramidal cellsAxon terminalsCell axonsHuman cerebral cortexDouble-labeling experimentsPowerful inhibitory mechanismChandelier cellsMonkey neocortexGABAergic interneuronsImmunoreactive fibersSerotonin receptorsSerotonin afferentsAxonal specializationsParacrine mannerLayers IISynaptic connectionsImmunocytochemical methodsProximal portionInhibitory mechanismClose appositionConfocal laser microscopy
1996
Transient compartmental expression of a family of protein tyrosine phosphatases in the developing striatum
Raghunathan A, Matthews G, Lombroso P, Naegele J. Transient compartmental expression of a family of protein tyrosine phosphatases in the developing striatum. Brain Research 1996, 91: 190-199. PMID: 8852369, DOI: 10.1016/0165-3806(95)00176-x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, NorthernBlotting, WesternCalbindinsCell CountDopamine and cAMP-Regulated Phosphoprotein 32Enzyme InhibitorsFemaleGene Expression Regulation, DevelopmentalIsoenzymesNeostriatumNerve Tissue ProteinsNeuronsPhosphoproteinsPostpartum PeriodPregnancyProtein Tyrosine PhosphatasesRatsRats, Inbred StrainsS100 Calcium Binding Protein GSubstance PSubstantia NigraTime FactorsTranscription, GeneticConceptsPatch neuronsPostnatal weekTwo-color immunofluorescent stainingTyrosine hydroxylase-immunoreactive fibersDopaminoceptive brain regionsCalbindin-positive neuronsHydroxylase-immunoreactive fibersStriatum of ratsDopamine islandsPostnatal day 1Most striatal neuronsFirst postnatal weekEarly postnatal developmentMatrix neuronsStriatal afferentsStriatal neuronsImmunoreactive fibersSubstance PLateral striatumDay 1StriatumPostnatal developmentBrain regionsNeuronsCompartmental expression
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