2019
Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments
Duman RS, Sanacora G, Krystal JH. Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments. Neuron 2019, 102: 75-90. PMID: 30946828, PMCID: PMC6450409, DOI: 10.1016/j.neuron.2019.03.013.Peer-Reviewed Original ResearchConceptsAltered connectivityDepressed patientsExcitatory glutamate neuronsMajor neuronal typesRapid-acting agentsAtrophy of neuronsTreatment of depressionLimbic brain regionsChronic stress exposureStress-related disordersBrain imaging studiesImportant sex differencesNeurotransmitter deficitsGABA interneuronsImmunologic mechanismsGlutamate neuronsCurrent antidepressantsExcitotoxic effectsNeurochemical deficitsGlutamate dysfunctionPathophysiological mechanismsGABA systemInflammatory cytokinesAdrenal glucocorticoidsHippocampal region
2018
Positron emission tomography imaging of the γ-aminobutyric acid system
Andersson JD, Matuskey D, Finnema SJ. Positron emission tomography imaging of the γ-aminobutyric acid system. Neuroscience Letters 2018, 691: 35-43. PMID: 30102960, DOI: 10.1016/j.neulet.2018.08.010.Peer-Reviewed Original ResearchConceptsPositron emission tomographyGABA levelsΓ-aminobutyric acid A (GABAA) receptorsGABA sensitivityEmission tomographyImportance of GABACentral nervous systemAminobutyric acid systemBenzodiazepine binding siteEndogenous GABA levelsGABA releaseGABA transmissionGABA systemNervous systemGABA concentrationPET tracersPET imagingAgonist GABAA receptorsBasic physiologyGABARadioligandReceptorsTomographyTranslational applications
2017
Brain circuits and neurochemical systems in essential tremor: insights into current and future pharmacotherapeutic approaches
Schaefer SM, Rodriguez A, Louis ED. Brain circuits and neurochemical systems in essential tremor: insights into current and future pharmacotherapeutic approaches. Expert Review Of Neurotherapeutics 2017, 18: 101-110. PMID: 29206482, DOI: 10.1080/14737175.2018.1413353.Peer-Reviewed Original ResearchConceptsEssential tremorGABA systemReceptor subtypesΓ-aminobutyric acid (GABA) neurotransmissionT-type calcium channelsHuman data pointUnderlying biochemical dysfunctionGABA-ergic neuronsRole of GABAInferior olivary nucleusPurkinje cell outputCertain GABANumerous medicationsClinical guidelinesPharmacotherapeutic approachesOlivary nucleusGABA receptorsPubMed searchCalcium channelsBiochemical dysfunctionNeurochemical systemsBrain circuitsMedicationsDegeneration modelGABA
2015
How Imaging Glutamate, γ‐Aminobutyric Acid, and Dopamine Can Inform the Clinical Treatment of Alcohol Dependence and Withdrawal
Hillmer AT, Mason GF, Fucito LM, O'Malley SS, Cosgrove KP. How Imaging Glutamate, γ‐Aminobutyric Acid, and Dopamine Can Inform the Clinical Treatment of Alcohol Dependence and Withdrawal. Alcohol Clinical And Experimental Research 2015, 39: 2268-2282. PMID: 26510169, PMCID: PMC4712074, DOI: 10.1111/acer.12893.Peer-Reviewed Original ResearchConceptsAlcohol dependenceΓ-aminobutyric acidClinical treatmentMajor public health issuePublic health issuePositron emission tomographyRelapse prevention strategiesSingle photon emissionSpecific imaging modalityAlcohol withdrawalTobacco smokingGABA systemNeurotransmitter systemsNeurochemical basisPrevention strategiesDopaminergic functioningEmission tomographyHealth issuesImaging modalitiesWithdrawalSex differencesImaging literatureDopamineTomographyGlutamate
2012
GABAA receptors in visual and auditory cortex and neural activity changes during basic visual stimulation
Qin P, Duncan N, Wiebking C, Gravel P, Lyttelton O, Hayes D, Verhaeghe J, Kostikov A, Schirrmacher R, Reader A, Northoff G. GABAA receptors in visual and auditory cortex and neural activity changes during basic visual stimulation. Frontiers In Human Neuroscience 2012, 6: 337. PMID: 23293594, PMCID: PMC3533380, DOI: 10.3389/fnhum.2012.00337.Peer-Reviewed Original ResearchAuditory cortexFunctional connectivityVisual cortexInter-regional functional connectivityNeural activityNeural activity changesBrain activityLocal brain activityStimulus-induced activityVisual stimuliRecent imaging studiesEyes-open stateHaemodynamic responseGABA systemΓ-aminobutyric acidGABAA receptorsReceptor levelsGABA concentrationImaging studiesCortexVisual stimulationReceptorsSimple visual stimuliDiscrete visual stimulusClosed eyes
2011
Neuroimaging insights into the role of cortical GABA systems and the influence of nicotine on the recovery from alcohol dependence
Cosgrove KP, Esterlis I, Mason GF, Bois F, O’Malley S, Krystal JH. Neuroimaging insights into the role of cortical GABA systems and the influence of nicotine on the recovery from alcohol dependence. Neuropharmacology 2011, 60: 1318-1325. PMID: 21276806, PMCID: PMC3078950, DOI: 10.1016/j.neuropharm.2011.01.020.Peer-Reviewed Original ResearchConceptsAlcohol withdrawalTobacco smokingGABA levelsNeuronal functionNeuronal nicotinic acetylcholine receptorsAlcohol-dependent smokersCortical GABA systemGABA neuronal functionProlonged alcohol withdrawalInfluence of nicotineNicotinic acetylcholine receptorsAlcohol-dependent individualsEffects of alcoholPreclinical evidenceRole of alcoholGABA systemPreclinical modelsTobacco smokeErminio CostaBenzodiazepine receptorsAcetylcholine receptorsAlcohol dependenceSmokingPrimary actionClinical experiments
2010
Contributions of Glutamate and GABA Systems to the Neurobiology and Treatment of Schizophrenia
Krystal J, Moghaddam B. Contributions of Glutamate and GABA Systems to the Neurobiology and Treatment of Schizophrenia. 2010, 433-461. DOI: 10.1002/9781444327298.ch21.Peer-Reviewed Original Research
2006
γ-Aminobutyric Acid Type A Receptors and Alcoholism: Intoxication, Dependence, Vulnerability, and Treatment
Krystal JH, Staley J, Mason G, Petrakis IL, Kaufman J, Harris RA, Gelernter J, Lappalainen J. γ-Aminobutyric Acid Type A Receptors and Alcoholism: Intoxication, Dependence, Vulnerability, and Treatment. JAMA Psychiatry 2006, 63: 957-968. PMID: 16952998, DOI: 10.1001/archpsyc.63.9.957.Peer-Reviewed Original ResearchConceptsBrain GABA systemsGABA systemAlcohol dependenceWithdrawal symptomsGABA functionGamma-aminobutyric acid (GABA) functionCortical GABA levelsAlcohol withdrawal symptomsΓ-Aminobutyric Acid Type A ReceptorsEnvironmental risk factorsLong-term alcohol effectsType A ReceptorsAlcohol-dependent individualsLong-term sobrietyGABA releaseNeurosteroid levelsAcute withdrawalAlcoholism vulnerabilityGABA neurotransmissionRisk factorsGABA levelsExtrasynaptic locationsLow chloride conductanceReceptor densityTonic component
2005
Cortical Gamma-Aminobutyric Acid Levels and the Recovery from Ethanol Dependence: Preliminary Evidence of Modification by Cigarette Smoking
Mason GF, Petrakis IL, de Graaf RA, Gueorguieva R, Guidone E, Coric V, Epperson CN, Rothman DL, Krystal JH. Cortical Gamma-Aminobutyric Acid Levels and the Recovery from Ethanol Dependence: Preliminary Evidence of Modification by Cigarette Smoking. Biological Psychiatry 2005, 59: 85-93. PMID: 16289397, DOI: 10.1016/j.biopsych.2005.06.009.Peer-Reviewed Original ResearchConceptsEthanol-dependent patientsTobacco smokingEthanol dependenceHealthy subjectsN-acetylaspartateCortical gamma-aminobutyric acid (GABA) levelsGamma-aminobutyric acid (GABA) levelsCortical GABA levelsCortical GABA systemAlcohol withdrawal symptomsAcute ethanol withdrawalComorbidity of alcoholismProton magnetic resonance spectroscopyGamma-aminobutyric acidCortical GABASmoking patientsEthanol withdrawalCigarette smokingGABA systemHealthy menWithdrawal symptomsGABA levelsClinical dataNAA levelsWithdrawal severity
2002
Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments
Krystal JH, Sanacora G, Blumberg H, Anand A, Charney DS, Marek G, Epperson CN, Goddard A, Mason GF. Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments. Molecular Psychiatry 2002, 7: s71-s80. PMID: 11986998, DOI: 10.1038/sj.mp.4001021.Peer-Reviewed Original ResearchConceptsCortical GABA levelsMood-stabilizing treatmentMood disordersGABA levelsΓ-amino-butyric acid (GABA) systemMood-stabilizing agentsGlutamate receptor functionDevelopment of medicationsGABA deficitAvailable antidepressantsGABAergic modulationAntimanic effectsGlutamatergic activityClinical evidenceNovel antidepressantsGABA systemAntidepressant drugsNew agentsReceptor functionAvailable evidenceReceptor targetsAntidepressantsDisordersGlutamateTreatment
1996
GABA Levels in the Brain: A Target for New Antiepileptic Drugs
Kocsis J, Mattson R. GABA Levels in the Brain: A Target for New Antiepileptic Drugs. The Neuroscientist 1996, 2: 326-334. DOI: 10.1177/107385849600200610.Peer-Reviewed Original ResearchAntiepileptic drugsGABA levelsBrain GABA systemsBrain GABA levelsSeverity of seizuresNew antiepileptic drugsAbundant inhibitory neurotransmitterGABA receptor sitesNormal electrical activityMinimal side effectsPrecise cellular mechanismsAntiepileptic actionGABA releaseSeizure dischargesGABA systemPharmacological treatmentInhibitory neurotransmitterCNS neuronsEffective antiepilepticSide effectsElectrophysiological studiesMetabolic modulatorsClinical useSodium channelsDrugs
1988
Schizophrenia: Instability in Norepinephrine, Serotonin, and γ-Aminobutyric Acid Systems
Gelernter J, van Kammen D. Schizophrenia: Instability in Norepinephrine, Serotonin, and γ-Aminobutyric Acid Systems. International Review Of Neurobiology 1988, 29: 309-347. PMID: 3042667, DOI: 10.1016/s0074-7742(08)60091-4.Peer-Reviewed Original ResearchConceptsGABA systemΓ-aminobutyric acid (GABA) systemPathophysiology of schizophreniaClinical instabilitySymptomatic periodClinical syndromeDA dysregulationNeurotransmitter systemsSystem disordersState-dependent changesClinical pathologyConflicting dataSchizophrenia researchSchizophreniaDopamineGenetic vulnerabilitySchizophrenic individualsMost evidenceNorepinephrineSerotoninNE systemDisordersEvidenceRelapsePathophysiology
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply