2020
Carbon monoxide: a critical physiological regulator sensitive to light
Oren DA, Sit DK, Goudarzi SH, Wisner KL. Carbon monoxide: a critical physiological regulator sensitive to light. Translational Psychiatry 2020, 10: 87. PMID: 32152296, PMCID: PMC7062897, DOI: 10.1038/s41398-020-0766-1.Peer-Reviewed Original ResearchConceptsHealthy female volunteersAntidepressant effectsPeripheral bloodBlood samplesFemale volunteersConfirmatory studiesPhysiological regulatorPeripheral blood samplesContinuous exposureBright light exposureCritical physiological regulatorHuman evidenceVivo modelNonseasonal depressionBlood carbon monoxideMean carbon monoxideBright white lightAdditional volunteersVolunteersPutative roleCircadian rhythmExposureBloodTherapeutic lightBright light
1996
Effects of Rapid Tryptophan Depletion in Patients With Seasonal Affective Disorder in Remission After Light Therapy
Lam RW, Zis AP, Grewal A, Delgado PL, Charney DS, Krystal JH. Effects of Rapid Tryptophan Depletion in Patients With Seasonal Affective Disorder in Remission After Light Therapy. JAMA Psychiatry 1996, 53: 41-44. PMID: 8540776, DOI: 10.1001/archpsyc.1996.01830010043007.Peer-Reviewed Original ResearchConceptsRapid tryptophan depletionSeasonal affective disorderTryptophan depletionLight therapyClinical remissionAffective disordersTryptophan levelsDouble-blind crossover studyRecurrent major depressive episodesMajor depressive episodeBright light therapyEffect of therapyFree tryptophan levelsAntidepressant effectsCrossover studySerotonergic mechanismsDepressive episodeAntidepressant drugsTherapeutic effectSignificant relapseDepression scoresPatientsTherapyRemissionNonseasonal depression
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