2022
Hippocampal acetylcholine modulates stress-related behaviors independent of specific cholinergic inputs
Mineur YS, Mose TN, Vanopdenbosch L, Etherington IM, Ogbejesi C, Islam A, Pineda CM, Crouse RB, Zhou W, Thompson DC, Bentham MP, Picciotto MR. Hippocampal acetylcholine modulates stress-related behaviors independent of specific cholinergic inputs. Molecular Psychiatry 2022, 27: 1829-1838. PMID: 34997190, PMCID: PMC9106825, DOI: 10.1038/s41380-021-01404-7.Peer-Reviewed Original ResearchConceptsStress-related behaviorsCholinergic inputMedial septum/diagonal bandBehavioral effectsBrain ACh levelsChAT-positive neuronsSelective chemogenetic activationMuscarinic ACh receptorsDepression-like symptomsSignificant behavioral effectsHippocampal acetylcholineMaladaptive behavioral responsesAntidepressant effectsCholinergic neuronsACh releaseChemogenetic activationChemogenetic inhibitionCholinergic antagonistsLocal infusionAcetylcholine levelsACh levelsDiagonal bandACh receptorsHippocampal neuronsPharmacological approaches
2020
Implications of Oligomeric Amyloid-Beta (oAβ42) Signaling through α7β2-Nicotinic Acetylcholine Receptors (nAChRs) on Basal Forebrain Cholinergic Neuronal Intrinsic Excitability and Cognitive Decline
George AA, Vieira JM, Xavier-Jackson C, Gee MT, Cirrito JR, Bimonte-Nelson HA, Picciotto MR, Lukas RJ, Whiteaker P. Implications of Oligomeric Amyloid-Beta (oAβ42) Signaling through α7β2-Nicotinic Acetylcholine Receptors (nAChRs) on Basal Forebrain Cholinergic Neuronal Intrinsic Excitability and Cognitive Decline. Journal Of Neuroscience 2020, 41: 555-575. PMID: 33239400, PMCID: PMC7821864, DOI: 10.1523/jneurosci.0876-20.2020.Peer-Reviewed Original ResearchMeSH Keywordsalpha7 Nicotinic Acetylcholine ReceptorAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsBasal ForebrainCell LineCognitive DysfunctionElectrophysiological PhenomenaFemaleGenotypeHumansMaleMaze LearningMiceMice, TransgenicNeuronsParasympathetic Nervous SystemPeptide FragmentsSignal TransductionConceptsBasal forebrain cholinergic neuronsNeuronal intrinsic excitabilityAlzheimer's diseaseCholinergic neuronsDiagonal bandIntrinsic excitabilityAPP/PS1 transgenic miceCognitive declineCharacteristics of ADMedial septum-diagonal bandNicotinic acetylcholine receptor subtypesOligomeric amyloid betaAction potential firing rateForebrain cholinergic neuronsPS1 transgenic miceHorizontal diagonal bandLevels of amyloidSeptum-diagonal bandCurrent-clamp recordingsAcetylcholine receptor subtypesAction potential afterhyperpolarizationAge-matched littermatesOrganotypic slice culturesSpatial reference memoryHomomeric α7
2015
Chapter 19 Organization of the Basal Forebrain Cholinergic Projection System Specific or Diffuse?
Zaborszky L, Duque A, Gielow M, Gombkoto P, Nadasdy Z, Somogyi J. Chapter 19 Organization of the Basal Forebrain Cholinergic Projection System Specific or Diffuse? 2015, 491-507. DOI: 10.1016/b978-0-12-374245-2.00019-x.ChaptersCholinergic neuronsDendritic fieldsDendritic arborsCholinergic cell populationParent cell bodiesCell populationsCholinergic cellsClassical anatomical studiesProximal dendritesInternal capsuleAxonal inputsHorizontal limbDiagonal bandDendritic organizationDendritic treeCell bodiesDendritic orientationCoronal planeAnatomical studyOblique axisNeuronsConnectivity patternsArborsCellsPopulation
2007
Neurokinins robustly activate the majority of septohippocampal cholinergic neurons
Morozova E, Wu M, Dumalska I, Alreja M. Neurokinins robustly activate the majority of septohippocampal cholinergic neurons. European Journal Of Neuroscience 2007, 27: 114-122. PMID: 18184316, DOI: 10.1111/j.1460-9568.2007.05993.x.Peer-Reviewed Original ResearchConceptsSeptohippocampal cholinergic neuronsHippocampal acetylcholine releaseCholinergic neuronsNK3 receptorsHemokinin-1Acetylcholine releaseNK2 receptorsElectrophysiological effectsRat brain slice preparationWhole-cell patch-clamp recordingsMedial septum/diagonal bandDiagonal band neuronsNK3 receptor agonistPost-synaptic mechanismsStress-related affective disordersBrain slice preparationPatch-clamp recordingsEffect of NKCholinergic cellsNK receptorsReceptor agonistSlice preparationDiagonal bandNeurokinin receptorsBrain neuronsExtrinsic afferent systems to the dentate gyrus
Leranth C, Hajszan T. Extrinsic afferent systems to the dentate gyrus. Progress In Brain Research 2007, 163: 63-799. PMID: 17765712, PMCID: PMC1989689, DOI: 10.1016/s0079-6123(07)63004-0.Peer-Reviewed Original ResearchConceptsDentate gyrusAfferent systemsMedial septum/diagonal bandExtrinsic afferent systemsVentral tegmental areaGranule cell dendritesPopulations of neuronsExtrinsic afferentsNoradrenergic afferentsCholinergic neuronsGlutamatergic innervationLocus ceruleusSerotonergic fibersCommissural afferentsGABAergic interneuronsPostsynaptic targetsEntorhinal afferentsTegmental areaCell dendritesDiagonal bandMedian rapheSupramammillary areaPontine nucleiHippocampal formationAfferents
2006
Muscarine activates the sodium–calcium exchanger via M3 receptors in basal forebrain neurons
Xu C, Wu M, Morozova E, Alreja M. Muscarine activates the sodium–calcium exchanger via M3 receptors in basal forebrain neurons. European Journal Of Neuroscience 2006, 24: 2309-2313. PMID: 17074051, DOI: 10.1111/j.1460-9568.2006.05118.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBasal GangliaBiotransformationDiagonal Band of BrocaDiphenylacetic AcidsElectrophysiologyIn Vitro TechniquesIon ChannelsIonsLithium ChlorideMaleMuscarineMuscarinic AgonistsPatch-Clamp TechniquesPiperidinesProsencephalonRatsRats, Sprague-DawleyReceptor, Muscarinic M3Sodium-Calcium ExchangerThioureaConceptsMuscarinic activationWhole-cell patch-clamp recording techniqueMedial septum/diagonal bandPatch-clamp recording techniquesSeptohippocampal GABAergic neuronsBasal forebrain neuronsMuscarinic cholinergic mechanismsRat brain slicesHippocampus-dependent learningHippocampal theta rhythmSodium-calcium exchangerIntraseptal carbacholMSDB neuronsCholinergic neuronsExcitatory actionGABAergic neuronsCholinergic mechanismsKB-R7943M3 receptorsForebrain neuronsDiagonal bandPrimary involvementBrain slicesHippocampal functionPotent modulator
2004
Histamine innervation and activation of septohippocampal GABAergic neurones: involvement of local ACh release
Xu C, Michelsen KA, Wu M, Morozova E, Panula P, Alreja M. Histamine innervation and activation of septohippocampal GABAergic neurones: involvement of local ACh release. The Journal Of Physiology 2004, 561: 657-670. PMID: 15486020, PMCID: PMC1665378, DOI: 10.1113/jphysiol.2004.071712.Peer-Reviewed Original ResearchConceptsLocal ACh releaseACh releaseGABAergic neuronesCholinergic neuronesSeptohippocampal cholinergicMedial septum/diagonal bandHistamine-induced activationGABAergic cell typesReceptor-selective antagonistHippocampal theta rhythmIndirect mechanismsConcentration-dependent mannerAtropine methylbromideHippocampal arousalGABAergic functionHistaminergic systemTuberomammillary nucleusCholinergic systemReceptor subtypesDiagonal bandHistamine effectSelective antagonistAlzheimer's diseaseGABAergic nucleusNeurodegenerative disordersHippocampal theta rhythm is reduced by suppression of the H‐current in septohippocampal GABAergic neurons
Xu C, Datta S, Wu M, Alreja M. Hippocampal theta rhythm is reduced by suppression of the H‐current in septohippocampal GABAergic neurons. European Journal Of Neuroscience 2004, 19: 2299-2309. PMID: 15090056, DOI: 10.1111/j.0953-816x.2004.03316.x.Peer-Reviewed Original ResearchConceptsHippocampal theta rhythmSeptohippocampal GABAergic neuronsGABAergic neuronsTheta rhythmH-currentMedial septum/diagonal bandRat brain slicesCholinergic neuronsGABAergic projectionsLocal infusionSpontaneous firingSelective blockadeDiagonal bandBrain slicesTheta burstsHippocampal learningNeuronsZD7288Underlying mechanismRhythmMemory taskGABAergicHippocampusBlockadeInfusionModulation of septo-hippocampal θ activity by GABAA receptors: an experimental and computational approach11Supplementary data associated with this article can be found at doi:10.1016/j.neuroscience.2004.03.043.
Hajós M, Hoffmann W, Orbán G, Kiss T, Érdi P. Modulation of septo-hippocampal θ activity by GABAA receptors: an experimental and computational approach11Supplementary data associated with this article can be found at doi:10.1016/j.neuroscience.2004.03.043. Neuroscience 2004, 126: 599-610. PMID: 15183510, DOI: 10.1016/j.neuroscience.2004.03.043.Peer-Reviewed Original ResearchConceptsGABAA receptorsMedial septum/diagonal bandExtracellular single-unit recordingsPositive allosteric modulator diazepamTheta activitySepto-hippocampal activityTypes of neuronsSingle-unit recordingsSepto-hippocampal systemTheta oscillationsSepto-hippocampal circuitryEEG theta activitySeptal neuronsUnwanted side effectsSystemic administrationDiagonal bandAnesthetized ratsGABAA transmissionTheta frequency oscillationsPharmacological modulationSide effectsUnit recordingsAnxiolytic drugsPharmacological toolsCognitive function
2003
Regulation of Septo-Hippocampal Activity by 5-Hydroxytryptamine2C Receptors
Hajos M, Hoffmann W, Weaver J. Regulation of Septo-Hippocampal Activity by 5-Hydroxytryptamine2C Receptors. Journal Of Pharmacology And Experimental Therapeutics 2003, 306: 605-615. PMID: 12734389, DOI: 10.1124/jpet.103.051169.Peer-Reviewed Original ResearchConceptsSepto-hippocampal systemTheta wave activitySerotonin neuronsTonic regulationAnesthetized ratsHippocampal neuronsTheta oscillationsMedial septum/vertical limbExtracellular single unitSepto-hippocampal activityHippocampal EEG activityHippocampal EEG recordingsSeptal neuronsTonic inhibitionHippocampal CA1Receptor antagonistControl ratsDentate gyrusPharmacological interactionsReceptor agonistMedial septumDiagonal bandReceptor subtypesIntravenous administrationSerotonin system
2002
Norepinephrine but not Serotonin Reuptake Inhibitors Enhance Theta and Gamma Activity of the Septo-Hippocampal System
Hajós M, Hoffmann W, Robinson D, Yu J, Hajós-Korcsok É. Norepinephrine but not Serotonin Reuptake Inhibitors Enhance Theta and Gamma Activity of the Septo-Hippocampal System. Neuropsychopharmacology 2002, 28: 857-864. PMID: 12637957, DOI: 10.1038/sj.npp.1300116.Peer-Reviewed Original ResearchConceptsSerotonin reuptake inhibitor fluvoxamineReuptake inhibitorsSepto-hippocampal systemAntidepressant drugsSelective serotonin reuptake inhibitor fluvoxamineMedial septum/diagonal bandExtracellular single-unit recordingsOscillatory activitySelective NE reuptake inhibitorNorepinephrine reuptake inhibitorsEffective antidepressant drugsTheta frequencyExtracellular NE levelsHippocampal EEG recordingsNE reuptake inhibitorSingle-unit recordingsHippocampal oscillatory activityGamma wave activityNE levelsSystemic administrationAcute effectsDiagonal bandHuman depressionHippocampal formationHippocampal EEGSynaptically Released Acetylcholine Evokes Ca2+Elevations in Astrocytes in Hippocampal Slices
Araque A, Martín E, Perea G, Arellano J, Buño W. Synaptically Released Acetylcholine Evokes Ca2+Elevations in Astrocytes in Hippocampal Slices. Journal Of Neuroscience 2002, 22: 2443-2450. PMID: 11923408, PMCID: PMC6758296, DOI: 10.1523/jneurosci.22-07-02443.2002.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAnimalsAstrocytesCalciumCholinergic FibersDiagonal Band of BrocaElectric StimulationGlutamic AcidHippocampusIn Vitro TechniquesIntracellular FluidNeurons, AfferentNeurotransmitter AgentsPatch-Clamp TechniquesRatsRats, WistarReceptors, GlutamateReceptors, MuscarinicSeptum of BrainSignal TransductionSynapsesConceptsAstrocytic responseIntracellular Ca2Stratum oriens/alveusHippocampal stratum oriensOriens/alveusMuscarinic cholinergic receptorsGlutamate receptor antagonistsGlutamate transporter activityWhole-cell membrane currentsDifferent brain areasLevels of astrocytesCholinergic receptorsHippocampal astrocytesMuscarinic receptorsCholinergic activityReceptor antagonistStratum oriensAcetylcholine actsCholinergic afferentsAxonal inputsHippocampal slicesDiagonal bandGlial cellsTransporter antagonistsBrain slices
2000
Cholinergic Excitation of Septohippocampal GABA But Not Cholinergic Neurons: Implications for Learning and Memory
Wu M, Shanabrough M, Leranth C, Alreja M. Cholinergic Excitation of Septohippocampal GABA But Not Cholinergic Neurons: Implications for Learning and Memory. Journal Of Neuroscience 2000, 20: 3900-3908. PMID: 10804229, PMCID: PMC6772671, DOI: 10.1523/jneurosci.20-10-03900.2000.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAction PotentialsAnimalsAntibodies, MonoclonalCholinergic AgentsCognitionConditioning, PsychologicalElectrophysiologygamma-Aminobutyric AcidHippocampusImmunotoxinsIn Vitro TechniquesMaleMemoryMuscarineMuscarinic AgonistsN-Glycosyl HydrolasesNeural InhibitionNeuronsRatsRats, Sprague-DawleyReceptor, Nerve Growth FactorReceptors, MuscarinicRibosome Inactivating Proteins, Type 1SaporinsSeptal NucleiSynaptic TransmissionTetrodotoxinTheta RhythmVasodilator AgentsConceptsMedial septum/diagonal bandSeptohippocampal cholinergic neuronsCholinergic neuronsCognition-enhancing effectsMuscarinic agonistsMuscarinic drugsContinuous theta rhythmHippocampal ACh releaseMuscarinic receptor antagonistMuscarinic cholinergic agonistRat brain slicesNovel fluorescent labelling techniqueDouble-labeling techniqueCholinergic excitationSeptohippocampal pathwayAcetylcholine releaseACh releaseDisinhibitory mechanismGABAergic pathwayReceptor antagonistUnlabeled neuronsCholinergic agonistsSystemic administrationDiagonal bandImpulse flow
1997
Aromatase in axonal processes of early postnatal hypothalamic and limbic areas including the cingulate cortex
Horvath T, Roa-Pena L, Jakab R, Simpson E, Naftolin F. Aromatase in axonal processes of early postnatal hypothalamic and limbic areas including the cingulate cortex. The Journal Of Steroid Biochemistry And Molecular Biology 1997, 61: 349-357. PMID: 9365210, DOI: 10.1016/s0960-0760(97)80032-5.Peer-Reviewed Original ResearchConceptsAxonal processesLimbic areasStria terminalisCritical perinatal periodMedial preoptic areaPostnatal day 5Limbic cortexArcuate nucleusHypothalamic areaNeuronal perikaryaLimbic structuresMedial septumPerinatal periodPreoptic areaDiagonal bandMedial nucleusAxon terminalsImmunoreactive elementsPerikaryal labelingPeriventricular regionLateral septumBed nucleusParacrine actionRat brainLateral habenula
1992
Reversed-phase liquid chromatographic purification and isolation of a radio-iodinated selective probe for mu opioid receptors in the brain
Miller M, Gould B, Joshi D, Bennett H, James S, Billiar R. Reversed-phase liquid chromatographic purification and isolation of a radio-iodinated selective probe for mu opioid receptors in the brain. Journal Of Neuroscience Methods 1992, 41: 93-99. PMID: 1314320, DOI: 10.1016/0165-0270(92)90052-f.Peer-Reviewed Original ResearchConceptsAdrenocorticotropin hormoneBlock ligand bindingOpioid receptorsMouse corpus striatumN-methyl-Phe4Nucleus accumbens septiGly-ol5 enkephalinDiagonal band of BrocaDecreased ligand bindingLight microscopic autoradiographyPresence of agonistAccumbens septiHigh-performance liquid chromatography columnLigand bindingD-Ala2Beta-endorphinCorpus striatumRadioligand bindingLiquid chromatography columnDiagonal bandCingulate cortexAnalysis of ligandsIncreasing dosesIodine reagentsLiquid chromatographic purification
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