2023
F71. NETWORK OF CO-METHYLATION ASSOCIATED WITH GREY MATTER MATURATION IN HUMAN ADOLESCENCE
Jensen D, Chen J, Turner J, Stephen J, Wang Y, Wilson T, Calhoun V, Liu J. F71. NETWORK OF CO-METHYLATION ASSOCIATED WITH GREY MATTER MATURATION IN HUMAN ADOLESCENCE. European Neuropsychopharmacology 2023, 75: s258-s259. DOI: 10.1016/j.euroneuro.2023.08.455.Peer-Reviewed Original ResearchStructural MRIBrain maturationNeuronal systemsCo-methylation network analysisPeriod of brain maturationAdolescent brain developmentAdolescent brain maturationPhases of neurodevelopmentIndependent component analysisGray matterHuman brain structureGM maturationDNAm changesCo-methylation modulesPrefrontal cortexExecutive functionFrontal poleGM volumeTime pointsSubjects aged 9Brain structuresCpG sitesSynaptic pruningBrain developmentDNA methylation
2021
From Molecule to Behavior: Hypocretin/orexin Revisited From a Sex-dependent Perspective
Gao XB, Horvath TL. From Molecule to Behavior: Hypocretin/orexin Revisited From a Sex-dependent Perspective. Endocrine Reviews 2021, 43: 743-760. PMID: 34792130, PMCID: PMC9277634, DOI: 10.1210/endrev/bnab042.Peer-Reviewed Original ResearchActivation of Hypocretin Neurons in Endometriosis
Mamillapalli R, Dang T, Habata S, Gao XB, Taylor HS. Activation of Hypocretin Neurons in Endometriosis. Reproductive Sciences 2021, 29: 243-249. PMID: 34279849, DOI: 10.1007/s43032-021-00682-4.Peer-Reviewed Original ResearchConceptsBody mass indexCAMP-responsive element binding proteinBody weightLower body mass indexNeuronal systemsHypocretin/orexin neuronsBehavioral changesPrevious murine studiesHigh-fat dietExpression of phosphorylationOrexin activitySham miceOrexin neuronsPain sensitizationGynecologic symptomsHypocretin neuronsMass indexHcrt cellsEndometriosis miceFat dietLateral hypothalamusPain perceptionReproductive ageGynecological diseasesMurine studies
2019
Deletion of the Creatine Transporter (Slc6a8) in Dopaminergic Neurons Leads to Hyperactivity in Mice
Abdulla ZI, Pahlevani B, Lundgren KH, Pennington JL, Udobi KC, Seroogy KB, Skelton MR. Deletion of the Creatine Transporter (Slc6a8) in Dopaminergic Neurons Leads to Hyperactivity in Mice. Journal Of Molecular Neuroscience 2019, 70: 102-111. PMID: 31520365, PMCID: PMC7001766, DOI: 10.1007/s12031-019-01405-w.Peer-Reviewed Original ResearchConceptsCr transporter deficiencyDopaminergic neuronsMotor functionLocomotor activityChallenging beam testSpontaneous activity testMonths of ageAttention deficit hyperactivity disorderCerebral Cr deficiencySpecific neuronal systemsUnique metabolic demandsCerebral creatineHindlimb stepsControl miceNeurological effectsSpontaneous activityMice ageSLC6A8 geneTransporter deficiencyNeurodegenerative disordersDopamine transporterNeuronal systemsMiceCreatine transporterHuntington's disease
2018
Positive Connectivity Predicts the Dynamic Intrinsic Topology of the Human Brain Network
Qian J, Diez I, Ortiz-Terán L, Bonadio C, Liddell T, Goñi J, Sepulcre J. Positive Connectivity Predicts the Dynamic Intrinsic Topology of the Human Brain Network. Frontiers In Systems Neuroscience 2018, 12: 38. PMID: 30214399, PMCID: PMC6125351, DOI: 10.3389/fnsys.2018.00038.Peer-Reviewed Original ResearchFunctional connectivity MRIHuman brain functional connectomeBrain functional connectomeNegative connectionFunctional connectomePositive connectionBrain network organizationStrength of negative correlationBrain areasFunctional connectivityNeuropsychiatric diseasesConnection path lengthsNeuroimaging biomarkersVoxel pairsNeuronal systemsConnectivity patternsFunctional negative correlationNegative correlationNetwork organizationCoincident interactionsPositive couplingConnectomeThe Role of Melanin-Concentrating Hormone in the Regulation of the Sleep/Wake Cycle: Sleep Promoter or Arousal Modulator?
Gao X. The Role of Melanin-Concentrating Hormone in the Regulation of the Sleep/Wake Cycle: Sleep Promoter or Arousal Modulator? 2018, 57-74. DOI: 10.1007/978-3-319-75765-0_3.Peer-Reviewed Original ResearchMelanin-concentrating hormoneLower vertebratesHigher animalsNeuropeptide melanin-concentrating hormonePhysiological functionsRole of MCHPhysiological implicationsCritical brain functionsHomeostatic functionsRegulation of sleepSleep/wake cycleRegulationLateral hypothalamusSleep promoterBrain circuitryNeuronal systemsBrain functionSleep homeostasisWake cycleMCH systemRecent evidenceNeural activityVertebratesAnimalsPromoter
2017
Sleep regulation of the distribution of cortical firing rates
Levenstein D, Watson B, Rinzel J, Buzsáki G. Sleep regulation of the distribution of cortical firing rates. Current Opinion In Neurobiology 2017, 44: 34-42. PMID: 28288386, PMCID: PMC5511069, DOI: 10.1016/j.conb.2017.02.013.Peer-Reviewed Original Research
2015
Neural plasticity in hypocretin neurons: the basis of hypocretinergic regulation of physiological and behavioral functions in animals
Gao XB, Hermes G. Neural plasticity in hypocretin neurons: the basis of hypocretinergic regulation of physiological and behavioral functions in animals. Frontiers In Systems Neuroscience 2015, 9: 142. PMID: 26539086, PMCID: PMC4612503, DOI: 10.3389/fnsys.2015.00142.Peer-Reviewed Original ResearchHypocretin systemNormal physiological functionPhysiological functionsNeural plasticityHypocretin-containing neuronsPF/LHSubstantial plastic changesCritical brain functionsPathological conditionsLong-term behavioral changesHypocretin neuronsLateral hypothalamusDaily functionNeuronal activityPlastic changesLong-term changesPlasticityMental health implicationsNeuronal systemsRecent evidenceBrain functionBehavioral functionsNeural activityHealth implicationsDaily fluctuations
2007
Cytisine, a partial agonist of high-affinity nicotinic acetylcholine receptors, has antidepressant-like properties in male C57BL/6J mice
Mineur YS, Somenzi O, Picciotto MR. Cytisine, a partial agonist of high-affinity nicotinic acetylcholine receptors, has antidepressant-like properties in male C57BL/6J mice. Neuropharmacology 2007, 52: 1256-1262. PMID: 17320916, PMCID: PMC1959230, DOI: 10.1016/j.neuropharm.2007.01.006.Peer-Reviewed Original ResearchConceptsAntidepressant-like effectsAntidepressant-like propertiesAntidepressant efficacyNicotinic acetylcholine receptorsPartial agonistBasolateral amygdalaAcetylcholine receptorsHigh-affinity nicotinic acetylcholine receptorsC-Fos immunoreactivityNovel antidepressant drugsC-fos expressionPotential neurobiological correlatesAlpha3/Classical antidepressantsAntidepressant drugsRodent modelsImmunohistochemical analysisNeuronal activityAnimal modelsFull agonistAgonistsNeuronal systemsEfficacyNeurobiological correlatesCytisine
2006
Uncoupling protein 2/3 immunoreactivity and the ascending dopaminergic and noradrenergic neuronal systems: Relevance for volume transmission
Rivera A, Agnati LF, Horvath TL, Valderrama JJ, de La Calle A, Fuxe K. Uncoupling protein 2/3 immunoreactivity and the ascending dopaminergic and noradrenergic neuronal systems: Relevance for volume transmission. Neuroscience 2006, 137: 1447-1461. PMID: 16387447, DOI: 10.1016/j.neuroscience.2005.05.051.Peer-Reviewed Original ResearchConceptsConfocal laser microscopy analysisReactive oxygen species productionLaser microscopy analysisProtein 2/3Oxygen species productionUncouple oxidative phosphorylationOxidative phosphorylationATP synthesisProteinSpecies productionDouble immunolabelingImportant roleMicroscopy analysisPhosphorylationMitochondriaRegulationCell groupsPlastic changesLocalizationIslandsAnimal modelsMagnaTyrosine hydroxylaseNeuronal systems
2005
Neurobiology of anorexia nervosa: Clinical implications of alterations of the function of serotonin and other neuronal systems
Kaye W, Frank G, Bailer U, Henry S. Neurobiology of anorexia nervosa: Clinical implications of alterations of the function of serotonin and other neuronal systems. International Journal Of Eating Disorders 2005, 37: s15-s19. PMID: 15852312, DOI: 10.1002/eat.20109.Peer-Reviewed Original Research
2002
Neuronal Systems Underlying Behaviors Related to Nicotine Addiction: Neural Circuits and Molecular Genetics
Picciotto MR, Corrigall WA. Neuronal Systems Underlying Behaviors Related to Nicotine Addiction: Neural Circuits and Molecular Genetics. Journal Of Neuroscience 2002, 22: 3338-3341. PMID: 11978809, PMCID: PMC6758396, DOI: 10.1523/jneurosci.22-09-03338.2002.Peer-Reviewed Original ResearchConceptsAction of nicotineNicotine addictionNicotinic acetylcholine receptor subunitsAcetylcholine receptor subunitsStudies of miceSerotonergic nucleiNicotine effectsDopaminergic activityDopaminergic systemNicotine dependenceBrainstem cholinergicNeural circuitsNeuronal systemsReceptor subunitsBehavioral effectsNicotineAddictionRecent studiesNeural systemsInitial observationsCholinergicGABAergicMolecular geneticsMice
2001
Prenatal exposure to cocaine reduces the number and enhances reactivity of A10 dopaminergic neurons to environmental stress
Morrow B, Elsworth J, Roth R. Prenatal exposure to cocaine reduces the number and enhances reactivity of A10 dopaminergic neurons to environmental stress. Synapse 2001, 41: 337-344. PMID: 11494404, DOI: 10.1002/syn.1090.Peer-Reviewed Original ResearchConceptsA10 dopamine neuronsDopamine neuronsDopaminergic neuronsPrenatal exposurePrenatal saline controlsTyrosine hydroxylase immunoreactiveA10 dopaminergic neuronsCocaine-induced reductionRat dopaminergic neuronsCocaine-exposed ratsPoor cognitive performanceYoung adult offspringUnderlying biochemical changesDopaminergic functionA9 regionSaline controlsIntravenous modelPerinatal lossAdult offspringIntermittent footshockImmediate early genesCognitive deficitsNeuronal systemsBehavioral effectsCell groups
2000
Research Units on Pediatric Psychopharmacology (Rupp) Autism Network Background and Rationale for an Initial Controlled Study of Risperidone
McDougle C, Scahill L, McCracken J, Aman M, Tierney E, Arnold L, Freeman B, Martin A, McGough J, Cronin P, Posey D, Riddle M, Ritz L, Swiezy N, Vitiello B, Volkmar F, Votolato N, Walson P. Research Units on Pediatric Psychopharmacology (Rupp) Autism Network Background and Rationale for an Initial Controlled Study of Risperidone. Child And Adolescent Psychiatric Clinics Of North America 2000, 9: 201-224. PMID: 10674197, DOI: 10.1016/s1056-4993(18)30142-1.Peer-Reviewed Original ResearchConceptsOpen-label trialDA neuronal systemsSafety of risperidoneStudy of RisperidonePlacebo-controlled studyUse of risperidoneExtrapyramidal side effectsTarget of pharmacotherapyTreatment of childrenImpaired social behaviorLong-term effectivenessPreclinical evidenceReceptor blockadeTypical antipsychoticsControlled StudyFirst drugPathophysiology of autismLower riskShort-term benefitsSide effectsRisperidonePotent effectsSymptoms of autismNeuronal systemsEnhanced efficacy
1996
Ionic Currents Underlying Developmental Regulation of Repetitive Firing in Aplysia Bag Cell Neurons
Nick T, Kaczmarek L, Carew T. Ionic Currents Underlying Developmental Regulation of Repetitive Firing in Aplysia Bag Cell Neurons. Journal Of Neuroscience 1996, 16: 7583-7598. PMID: 8922415, PMCID: PMC6579091, DOI: 10.1523/jneurosci.16-23-07583.1996.Peer-Reviewed Original ResearchConceptsBag cell neuronsRepetitive firingCell neuronsEgg-laying behaviorJuvenile neuronsTetraethyl ammonium chlorideDevelopmental regulationSpecific ionic currentsAplysia bag cell neuronsAfterdischargesElectrical stimulationVariety of stimuliDevelopmental controlNeuronal systemsProlonged depolarizationBehavioral effectsNeuronsIonic currentsDevelopmental mechanismsSelective regulationAdultsAplysia californicaFiringRegulationDepolarizationThe biological basis of panic disorder.
Krystal JH, Deutsch DN, Charney DS. The biological basis of panic disorder. The Journal Of Clinical Psychiatry 1996, 57 Suppl 10: 23-31; discussion 32-3. PMID: 8917129.Peer-Reviewed Original ResearchConceptsPanic disorderMultiple neuronal systemsRelated brain regionsFunctional imaging studiesOvert historyPharmacologic mechanismsTreatment optionsPharmacologic challengePanicogenic agentPreclinical investigationsNeurochemical substratesPanic attacksChallenge studiesBrain regionsImaging studiesAnatomical basisNeuronal systemsAnxiety disordersDisordersHeritable predispositionBiological basisFurther evidence
1982
Assessment of Brain Function in Clinical Pediatric Research: Behavioral and Biological Strategies
Young J, Cohen D, Shaywitz S, Caparulo B, Kavanagh M, Hunt R, Leckman J, Anderson G, Detlor J, Harcherik D, Shaywitz B. Assessment of Brain Function in Clinical Pediatric Research: Behavioral and Biological Strategies. Schizophrenia Bulletin 1982, 8: 205-235. PMID: 6180470, DOI: 10.1093/schbul/8.2.205.Peer-Reviewed Original ResearchConceptsBrain functionPharmacological challenge testsSerious neuropsychiatric disorderClinical pediatric researchClinical research methodsSpecific neuronal systemsAttention deficit disorderClinical syndromeMetabolic dysfunctionTourette syndromeChallenge testClinical protocolsNew treatmentsClinical disordersNeuropsychiatric disordersNeuronal systemsClinical researchPediatric researchSyndromeDeficit disorderBest treatmentDisordersNovel biological strategiesLanguage disordersChildren
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