2024
Association between high risk of obstructive sleep apnea and inflammatory markers in a population sample of young and middle-aged adults in the Miami Heart Study.
Khosla A, Nasir K, Saxena A, Aneni E, Ali S, Valero-Elizondo J, Cainzos-Achirica M, Feldman T, Fialkow J, Walia H. Association between high risk of obstructive sleep apnea and inflammatory markers in a population sample of young and middle-aged adults in the Miami Heart Study. Journal Of Clinical Sleep Medicine 2024, 20: 1895-1903. PMID: 38975989, PMCID: PMC11609831, DOI: 10.5664/jcsm.11274.Peer-Reviewed Original ResearchHigh risk of obstructive sleep apneaRisk of obstructive sleep apneaObstructive sleep apneaHs-CRPCardiovascular disease risk factorsFree of cardiovascular diseaseInflammatory markersHigh riskCardiovascular diseaseIL-6Sleep apneaLow risk of obstructive sleep apneaTNF-aObstructive sleep apnea screeningLow riskRisk factorsLevels of inflammatory markersLevels of hs-CRPTNF-a levelsCVD-free participantsHeart StudyBerlin questionnaireIndividuals free of cardiovascular diseaseSubclinical inflammationPoisson regression analysisPrenatal exposure to per- and polyfluoroalkyl substances (PFAS) and their influence on inflammatory biomarkers in pregnancy: Findings from the LIFECODES cohort
Siwakoti R, Harris S, Ferguson K, Hao W, Cantonwine D, Mukherjee B, McElrath T, Meeker J. Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and their influence on inflammatory biomarkers in pregnancy: Findings from the LIFECODES cohort. Environment International 2024, 194: 109145. PMID: 39550829, PMCID: PMC11663107, DOI: 10.1016/j.envint.2024.109145.Peer-Reviewed Original ResearchC-reactive proteinNested case-control study of preterm birthCase-control study of preterm birthInflammatory biomarkersIL-10TNF-aInterquartile range increaseNested Case-Control StudyStudy of preterm birthPre-pregnancy BMIQuantile-based g-computation approachIL-6Prenatal PFAS exposureInflammatory processPregnancy plasma samplesMeasurement of inflammatory biomarkersBirth outcomesLinear mixed modelsInverse associationRange increaseMaternal raceMaternal demographicsTNF-a levelsAdverse pregnancyAfrican AmericansRelationship between plasma TNF-α levels and agitation symptoms in first episode patients with schizophrenia
Wang X, Chen W, Gou M, Li W, Li N, Tong J, Zhou Y, Xie T, Yu T, Feng W, Li Y, Chen S, Tian B, Tan S, Wang Z, Pan S, Luo X, Zhang P, Huang J, Tian L, Li C, Tan Y. Relationship between plasma TNF-α levels and agitation symptoms in first episode patients with schizophrenia. BMC Psychiatry 2024, 24: 480. PMID: 38956509, PMCID: PMC11218378, DOI: 10.1186/s12888-024-05796-y.Peer-Reviewed Original ResearchConceptsPositive and Negative Syndrome ScalePlasma TNF-a levelsAgitation symptomsPANSS-ECEpisode patientsTNF-a levelsPositive and Negative Syndrome Scale total scorePANSS-EC scoreNegative Syndrome ScaleSymptoms of schizophreniaPathophysiology of schizophreniaEnzyme-linked immunosorbent assayTNF-aR1 levelSyndrome ScalePlasma levels of tumor necrosis factor-alphaLevels of tumor necrosis factor-alphaSchizophreniaTotal scoreTumor necrosis factor-alphaNecrosis factor-alphaPlasma TNF-aHealthy controlsFEPImmune abnormalitiesBenefits of calorie restriction in mice are mediated via energy imbalance, not absolute energy or protein intake
Smith D, Mitchell S, Johnson M, Gibbs V, Dickinson S, Henschel B, Li R, Kaiser K, Chusyd D, Brown A, Allison D, Speakman J, Nagy T. Benefits of calorie restriction in mice are mediated via energy imbalance, not absolute energy or protein intake. GeroScience 2024, 46: 4809-4826. PMID: 38850387, PMCID: PMC11336014, DOI: 10.1007/s11357-024-01166-4.Peer-Reviewed Original ResearchProtein intakeCaloric restrictionPair-fedTNF-a levelsMale C57BL/6J miceBenefits of CRFat massC57BL/6J miceLean massTNF-aIGF-1Energy imbalanceMiceCalorie restrictionBenefits of calorie restrictionPhysical activityIntakeLongevity benefitsBody temperatureProtein intake per sePhysiological benefitsProteinLeptinExtended longevityHypothalamus
2022
Downregulation of Sirt6 by CD38 promotes cell senescence and aging
Zhou H, Liu S, Zhang N, Fang K, Zong J, An Y, Chang X. Downregulation of Sirt6 by CD38 promotes cell senescence and aging. Aging 2022, 14: 9730-9757. PMID: 36490326, PMCID: PMC9792202, DOI: 10.18632/aging.204425.Peer-Reviewed Original ResearchConceptsCD38 expressionSIRT6 expressionC3GCD38 siRNACell senescenceIncreased SIRT6 expressionMechanism of CD38H9c2 cellsInduced to senescenceTelomerase reverse transcriptase levelsReverse transcriptase levelsNK cell levelsPresence of C3GNicotinamide adenine dinucleotidePromote cell senescenceReduced reactive oxygen speciesTNF-a levelsDecreased SIRT6 expressionReactive oxygen speciesD-gal induced senescenceHexokinase 2OSS-128167Myocardial H9c2 cellsStimulate cell proliferationSiRNA
2016
Human dental pulp stem cells transplantation combined with treadmill training in rats after traumatic spinal cord injury
Nicola F, Rodrigues L, Crestani T, Quintiliano K, Sanches E, Willborn S, Aristimunha D, Boisserand L, Pranke P, Netto C. Human dental pulp stem cells transplantation combined with treadmill training in rats after traumatic spinal cord injury. Brazilian Journal Of Medical And Biological Research 2016, 49: e5319. PMID: 27509306, PMCID: PMC4988478, DOI: 10.1590/1414-431x20165319.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCombined Modality TherapyDental PulpEnzyme-Linked Immunosorbent AssayExercise TherapyFlow CytometryHumansLocomotionMalePhysical Conditioning, AnimalRandom AllocationRats, WistarRecovery of FunctionSpinal Cord InjuriesStem Cell TransplantationTime FactorsTooth ExfoliationTreatment OutcomeTumor Necrosis Factor-alphaConceptsStem cell transplantationSpinal cord injuryTNF-a levelsCell transplantationCord injuryDental pulp stem cell transplantationEffects of stem cellsHuman exfoliated deciduous teethExfoliated deciduous teethExperimental spinal cord injuryGlial scarSpinal cord lesionsSpinal cord injury groupTraumatic spinal cord injuryAnti-inflammatory actionSHED transplantationMotor functionNYU impactorImprovement of motor functionCord lesionsDeciduous teethBBB scaleWistar ratsCystic cavityEffective treatment
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