Association of gestational and childhood circulating C-peptide concentrations in the hyperglycemia and adverse pregnancy outcomes follow-up study
Rajamoorthi A, Zheng H, Skowronski A, Zork N, Reddy U, Tung P, Kupsco A, Gallagher D, Salem R, Leibel R, LeDuc C, Thaker V. Association of gestational and childhood circulating C-peptide concentrations in the hyperglycemia and adverse pregnancy outcomes follow-up study. Diabetes Research And Clinical Practice 2024, 220: 111967. PMID: 39716665, PMCID: PMC11840794, DOI: 10.1016/j.diabres.2024.111967.Peer-Reviewed Original ResearchConceptsOral glucose tolerance testC-peptide concentrationsC-peptideInsulin sensitivityCord bloodFollow-up studyInsulinogenic indexHOMA-IRCirculating C-peptide concentrationsCord blood C-peptideMaternal glucose concentrationsBlood C-peptideBMI z-scoreGlucose tolerance testPancreatic beta-cell developmentBeta-cell developmentGestational ageOGTT glucoseMaternal fastingAssociations of gestationalPubertal stageTolerance testInsulin resistanceZ-scoreMaternal covariates1965-LB: Metabolomic and Transcriptomic Signatures of Gestational Diabetes Mellitus (GDM) Suggest Nutritional and Inflammatory Pathways in Intergenerational Transfer of Risk
THAKER V, FIRESTEIN M, MASSON C, LIU Z, REDDY U, GALLAGHER D, LEDUC C. 1965-LB: Metabolomic and Transcriptomic Signatures of Gestational Diabetes Mellitus (GDM) Suggest Nutritional and Inflammatory Pathways in Intergenerational Transfer of Risk. Diabetes 2024, 73 DOI: 10.2337/db24-1965-lb.Peer-Reviewed Original ResearchGestational diabetes mellitusMetabolic riskC-peptideCord blood C-peptideCord blood metabolitesBlood C-peptideMother-baby dyadsCord plasmaCord bloodSteroid hormone signalingMaternal milieuTransport abnormalitiesPlacental tissuePregnancy ageDiabetes mellitusOffspring birthweightPlacental transcriptomePlasma fructosamineInflammatory pathwaysInflammatory processPlacenta tissueINSR expressionCordMetabolite profilesObesity
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