2023
Inflammation, anti-inflammatory agents, and the role of colchicine in carotid artery stenosis.
Chlorogiannis D, Pargaonkar S, Papanagiotou P, Bakogiannis N, Bakoyiannis C, Kokkinidis D. Inflammation, anti-inflammatory agents, and the role of colchicine in carotid artery stenosis. Vasa 2023, 53: 4-12. PMID: 38079179, DOI: 10.1024/0301-1526/a001104.Peer-Reviewed Original ResearchConceptsCarotid artery stenosisArtery stenosisAnti-inflammatory medicationsRole of inflammationCoronary artery diseaseAnti-inflammatory agentsRole of colchicineArtery diseaseOngoing trialsOptimal treatmentCardiovascular diseaseStenosis developmentMedicationsInflammationAvailable evidenceMajor causeStenosisDiseaseColchicineMorbidityPatientsMortalityProgressionTrialsRole of Inflammatory Processes in Hemorrhagic Stroke
Ohashi S, DeLong J, Kozberg M, Mazur-Hart D, van Veluw S, Alkayed N, Sansing L. Role of Inflammatory Processes in Hemorrhagic Stroke. Stroke 2023, 54: 605-619. PMID: 36601948, DOI: 10.1161/strokeaha.122.037155.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHemorrhagic strokeIntracerebral hemorrhageInflammatory processCerebral amyloid angiopathy-related haemorrhageAngiopathy-related hemorrhageRole of inflammationCerebral amyloid angiopathyInflammatory immune responseEffective therapeutic strategyCentral nervous systemBrain residentAmyloid angiopathyImmune cellsTissue injuryCommon causeImmune responseHemorrhageTherapeutic strategiesNervous systemMajor subtypesDisease pathologyStrokeOlder individualsTissue recoveryDeadliest form
2021
Mutations in GBA and LRRK2 Are Not Associated with Increased Inflammatory Markers
Thaler A, Omer N, Giladi N, Gurevich T, Bar-Shira A, Gana-Weisz M, Goldstein O, Kestenbaum M, Shirvan J, Cedarbaum J, Orr-Urtreger A, Regev K, Shenhar-Tsarfaty S, Mirelman A. Mutations in GBA and LRRK2 Are Not Associated with Increased Inflammatory Markers. Journal Of Parkinson’s Disease 2021, 11: 1285-1296. PMID: 33998549, PMCID: PMC8461659, DOI: 10.3233/jpd-212624.Peer-Reviewed Original ResearchConceptsNon-manifesting carriersRole of inflammationGBA-PDParkinson's diseaseGenetic Parkinson's diseaseLRRK2-PDPD patientsCerebrospinal fluidNon-manifesting mutation carriersAnti-inflammatory treatmentProdromal Parkinson's diseaseGeneral medical conditionsIdiopathic Parkinson's diseaseLRRK2-PD patientsCSF cytokinesGBA-NMCLRRK2-NMCPeripheral cytokinesInflammatory markersIL-10Inflammatory measuresDisease characteristicsIL-1βIL-6Peripheral bloodRole of inflammation in benign gynecologic disorders: from pathogenesis to novel therapies†
AlAshqar A, Reschke L, Kirschen GW, Borahay MA. Role of inflammation in benign gynecologic disorders: from pathogenesis to novel therapies†. Biology Of Reproduction 2021, 105: 7-31. PMID: 33739368, PMCID: PMC8256101, DOI: 10.1093/biolre/ioab054.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsBenign gynecologic disordersRole of inflammationGynecologic disordersClinical sequelaeCardiometabolic risk factorsNF-κB inhibitorCardiometabolic medicationsInflammatory markersSystemic complicationsGynecologic malignanciesVitamin DInflammatory pathwaysLesion progressionRisk factorsCardiovascular diseaseCyclooxygenase-2Uterine leiomyomaPathophysiological perspectiveSex steroidsHormonal treatmentDiagnostic adjunctTherapeutic implicationsNumerous cytokinesImmune systemInflammationComputed tomography imaging of macrophage phagocytic activity in abdominal aortic aneurysm
Toczek J, Boodagh P, Sanzida N, Ghim M, Salarian M, Gona K, Kukreja G, Rajendran S, Wei L, Han J, Zhang J, Jung JJ, Graham M, Liu X, Sadeghi MM. Computed tomography imaging of macrophage phagocytic activity in abdominal aortic aneurysm. Theranostics 2021, 11: 5876-5888. PMID: 33897887, PMCID: PMC8058712, DOI: 10.7150/thno.55106.Peer-Reviewed Original ResearchConceptsAbdominal aortic aneurysmExiTron nano 12000AAA outcomePhagocytic activityII infusionAng IIAortic aneurysmAortic wall enhancementAng II infusionCT enhancementAngiotensin II infusionRole of inflammationFeasibility of CTMacrophage phagocytic activityNon-invasive toolAAA inductionCD68 expressionModulatory interventionsMacrophage cell lineInflammatory signalsPatient managementVascular pathologyOutcome studiesAdventitial macrophagesComputed tomography
2020
Effects of Cytokines and Nitric Oxide on Bicarbonate Secretion by Cholangiocytes
Spirlì C, Okolicsanyi L, Strazzabosco M. Effects of Cytokines and Nitric Oxide on Bicarbonate Secretion by Cholangiocytes. 2020, 81-88. DOI: 10.1201/9780367813888-7.Peer-Reviewed Original ResearchInflammatory mediatorsBiliary epitheliumRole of inflammationSecretory mechanismElectrolyte transportEffects of cytokinesPathophysiology of cholangiopathiesProgressive cholestasisFibrogenetic processInhibition of cAMPProliferative responseBicarbonate secretionPathogenetic sequenceCholestasisDuctal cholestasisCAMP formationCholangiopathyNitric oxideAvailable evidenceCell damageAdenylyl cyclaseCytokinesMediatorsCholangiocytesEpithelium
2016
Type 1 Interferon Regulates Inflammation Associated RBC Alloimmunization By Promoting Monocyte-Derived Dendritic Cell Erythrophagocytosis in Mice
Gibb D, Natarajan P, Liu J, Santhanakrishnan M, Iwasaki A, Hendrickson J. Type 1 Interferon Regulates Inflammation Associated RBC Alloimmunization By Promoting Monocyte-Derived Dendritic Cell Erythrophagocytosis in Mice. Blood 2016, 128: 19. DOI: 10.1182/blood.v128.22.19.19.Peer-Reviewed Original ResearchMonocyte-derived dendritic cellsReactivity of seraPeak antibody responseWT miceIfnar1-/- miceType 1 interferonDendritic cellsRBC transfusionPeripheral bloodAntibody responseRBC alloimmunizationAlloimmune responseSpecific IgGIgG antibodiesInflammatory diseasesMouse modelRBC antigensIndividual miceCCR2-/- miceFrequency of alloimmunizationHuman KEL glycoproteinFlow cytometric crossmatchActivation marker expressionDendritic cell activationRole of inflammation
2014
“Inflammation and arterial stiffness in humans”
Jain S, Khera R, Corrales–Medina V, Townsend RR, Chirinos JA. “Inflammation and arterial stiffness in humans”. Atherosclerosis 2014, 237: 381-390. PMID: 25463062, DOI: 10.1016/j.atherosclerosis.2014.09.011.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPrimary inflammatory diseaseArterial stiffnessArterial stiffeningInflammatory diseasesPrimary inflammatory conditionsAnti-inflammatory interventionsRole of inflammationAnti-inflammatory therapyEffect of statinsEffects of inflammationPotential therapeutic targetCardiovascular morbiditySubclinical inflammationInflammatory conditionsGeneral populationTherapeutic targetInflammationEstablished markerNormal adultsPotential mechanismsDiseaseHypertensionMorbidityStatinsArteryFuture Directions in Idiopathic Pulmonary Fibrosis Research. An NHLBI Workshop Report
Blackwell TS, Tager AM, Borok Z, Moore BB, Schwartz DA, Anstrom KJ, Bar-Joseph Z, Bitterman P, Blackburn MR, Bradford W, Brown KK, Chapman HA, Collard HR, Cosgrove GP, Deterding R, Doyle R, Flaherty KR, Garcia CK, Hagood JS, Henke CA, Herzog E, Hogaboam CM, Horowitz JC, King TE, Loyd JE, Lawson WE, Marsh CB, Noble PW, Noth I, Sheppard D, Olsson J, Ortiz LA, O’Riordan T, Oury TD, Raghu G, Roman J, Sime PJ, Sisson TH, Tschumperlin D, Violette SM, Weaver TE, Wells RG, White ES, Kaminski N, Martinez FJ, Wynn TA, Thannickal VJ, Eu JP. Future Directions in Idiopathic Pulmonary Fibrosis Research. An NHLBI Workshop Report. American Journal Of Respiratory And Critical Care Medicine 2014, 189: 214-222. PMID: 24160862, PMCID: PMC3983890, DOI: 10.1164/rccm.201306-1141ws.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsIdiopathic pulmonary fibrosisAlveolar epithelial injuryEffective medical therapyRole of inflammationTime of diagnosisPatient advocacy groupsMedian survivalMedical therapyEpithelial injuryPulmonary fibrosisPulmonary fibrosis researchIPF therapyIPF researchPreclinical modelingDrug AdministrationPatient communityU.S. FoodNHLBITranslation of discoveriesClinical researchersPatientsFibrosis researchTherapyDiseaseAberrant repairInterplay between DNA repair and inflammation, and the link to cancer
Kidane D, Chae WJ, Czochor J, Eckert KA, Glazer PM, Bothwell AL, Sweasy JB. Interplay between DNA repair and inflammation, and the link to cancer. Critical Reviews In Biochemistry And Molecular Biology 2014, 49: 116-139. PMID: 24410153, PMCID: PMC4300235, DOI: 10.3109/10409238.2013.875514.Peer-Reviewed Original Research
2012
Evidence for an association between tumor necrosis factor-alpha levels and lithium response
Guloksuz S, Altinbas K, Cetin E, Kenis G, Gazioglu S, Deniz G, Oral E, van Os J. Evidence for an association between tumor necrosis factor-alpha levels and lithium response. Journal Of Affective Disorders 2012, 143: 148-152. PMID: 22749155, DOI: 10.1016/j.jad.2012.04.044.Peer-Reviewed Original ResearchConceptsTNF-α levelsBipolar patientsLithium responsePartial responseTumor necrosis factor-alpha levelsBipolar disorderTreatment-resistant bipolar patientsNecrosis factor-alpha levelsRole of inflammationPotential pathophysiological mechanismsAdditional inflammatory markersAssessment of responseGood responseEnzyme-linked immunosorbentEuthymic bipolar patientsImmune imbalanceImmune alterationsInflammatory markersImmune changesPathophysiological mechanismsPotential confoundersLithium therapyNatural coursePoor responseTreatment response
2011
P1-01-15: Do Serum Cytokines Predict Breast Cancer Behavior?
Lush E, Dedert E, Daup M, Dhabhar F, Spiegel D, Tillie J, McMasters K, Sephton S, Chagpar A. P1-01-15: Do Serum Cytokines Predict Breast Cancer Behavior? Cancer Research 2011, 71: p1-01-15-p1-01-15. DOI: 10.1158/0008-5472.sabcs11-p1-01-15.Peer-Reviewed Original ResearchSerum cytokine levelsHormone receptor statusLymph node statusCytokine levelsReceptor statusTumor sizeBreast cancer behaviorSerum cytokinesNode statusCancer behaviorIFN-gamma serum levelsMedian patient ageMedian tumor sizeSerum IFN-gammaSerum inflammatory cytokinesProgesterone receptor statusRole of inflammationFinal pathologic resultsPresence of metastasesBreast cancer patientsBreast cancer developmentVariety of cytokinesCohort of interestLymphovascular invasionPatient ageEffect of Hydroxyurea on Elevated Pulmonary Artery Pressures in Children with Sickle Cell Disease
Pashankar F, Manwani D, Lee M, Green N. Effect of Hydroxyurea on Elevated Pulmonary Artery Pressures in Children with Sickle Cell Disease. Blood 2011, 118: 4841. DOI: 10.1182/blood.v118.21.4841.4841.Peer-Reviewed Original ResearchTricuspid regurgitant jet velocityElevated pulmonary artery pressurePulmonary artery pressureSickle cell diseaseArtery pressureCell diseaseEffect of hydroxyureaPulmonary hypertensionElevated tricuspid regurgitant jet velocityWhite blood cell countMean reticulocyte countTotal daily doseRegurgitant jet velocityRole of inflammationMean oxygen saturationBlood cell countFetal hemoglobinMean corpuscular volumeRepeat echocardiogramAverage followEndothelial dysfunctionDaily doseEndothelial functionPersistent elevationMean ageModern concepts on the role of inflammation in pulmonary fibrosis.
Homer RJ, Elias JA, Lee CG, Herzog E. Modern concepts on the role of inflammation in pulmonary fibrosis. Archives Of Pathology & Laboratory Medicine 2011, 135: 780-8. PMID: 21631273, DOI: 10.5858/2010-0296-ra.1.BooksConceptsRole of inflammationIdiopathic pulmonary fibrosisPulmonary fibrosisTherapeutic interventionsResult of inflammationCell deathLung transplantationCytokine environmentMacrophage polarizationInflammationFibrosisLethal diseaseLimited biomarkersClinical contextDisease biomarkersBiomarkersDeathInterventionUnpublished researchTransplantationLungDisease
2007
The Role of Inflammation and Immunity in the Pathogenesis of Liver Fibrosis
Mehal W, Friedman S. The Role of Inflammation and Immunity in the Pathogenesis of Liver Fibrosis. 2007, 111-121. DOI: 10.1007/978-1-59745-518-3_10.Peer-Reviewed Original ResearchHepatic fibrosisChronic liver diseaseRole of inflammationWound healing responseViral hepatitisLiver diseaseFibrosis progressionAutoimmune diseasesChronic injuryLiver fibrosisCellular sourceFibrosisExtracellular matrixDiseaseRealistic expectationsUbiquitous responseMajor advancesTranscriptional eventsHepatitisInflammationPatientsPathophysiologyPathogenesisInjuryLiver
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