2024
Management of postinfectious inflammatory arthritis
Baker H, Amaral J, Schoen R. Management of postinfectious inflammatory arthritis. Current Opinion In Rheumatology 2024, 36: 155-162. PMID: 38411201, DOI: 10.1097/bor.0000000000001009.Peer-Reviewed Original ResearchConceptsTreatment of acute infectionsAcute infectionInflammatory arthritisBenefits of antimicrobial therapyTreatment of infectionsTargeted synthetic DMARDsSpectrum of diseasesRefractory arthritisAntimicrobial therapySynthetic DMARDsFraction of casesTreatment optionsConventional therapyDisease-modifying treatmentsReactive arthritisInflammatory arthritidesInflammatory processPrompt identificationSelf-limitingChronic arthritisArthritisInfectionTreatmentTherapyArthralgia
2012
Contemporary Evaluation and Management of the Diabetic Foot
Sumpio BE. Contemporary Evaluation and Management of the Diabetic Foot. Scientifica 2012, 2012: 435487. PMID: 24278695, PMCID: PMC3820495, DOI: 10.6064/2012/435487.Peer-Reviewed Original ResearchDiabetic footNegative pressure wound therapyMajor public health issueMainstay of therapyDiabetic foot diseaseGood functional outcomeHospitalization of patientsHealth care workersPressure wound therapyTreatment of infectionsMoist wound carePublic health issueComplex clinical problemWidespread clinical practiceAbnormal foot structureAggressive debridementSuperimposed infectionFrequent debridementLimb salvageFoot ulcersChronic inflammationCostly complicationFunctional outcomeFoot problemsIschemic limbsDiabetic Foot Ulceration and Management
Blume P, Jain A, Sumpio B. Diabetic Foot Ulceration and Management. Contemporary Diabetes 2012, 63-91. DOI: 10.1007/978-1-62703-158-5_6.Peer-Reviewed Original ResearchFoot ulcersMajor public health issueGrowth factorDiabetic foot diseaseDiabetic foot ulcerationHospitalization of patientsGood clinical careTreatment of infectionsMoist wound carePublic health issueComplex clinical problemWidespread clinical practiceAbnormal foot structureAdjuvant therapySuperimposed infectionFoot ulcerationFrequent debridementLimb salvagePathophysiologic mechanismsChronic inflammationDiabetic footCostly complicationFoot problemsIschemic limbsClinical trials
2006
The management of deep sternal wound infections using vacuum assisted closure™ (V.A.C.®) therapy
Fleck T, Gustafsson R, Harding K, Ingemansson R, Lirtzman MD, Meites HL, Moidl R, Price P, Ritchie A, Salazar J, Sjögren J, Song DH, Sumpio BE, Toursarkissian B, Waldenberger F, Wetzel‐Roth W. The management of deep sternal wound infections using vacuum assisted closure™ (V.A.C.®) therapy. International Wound Journal 2006, 3: 273-280. PMID: 17199763, PMCID: PMC7951489, DOI: 10.1111/j.1742-481x.2006.00273.x.Peer-Reviewed Original ResearchConceptsDeep sternal wound infectionSternal wound infectionWound infectionV.A.C. therapyThorough wound irrigationPrinciples of treatmentVacuum-assisted closureTreatment of infectionsSurgical debridementClinical guidelinesEarly recognitionWound irrigationAssisted closureCurrent evidenceSurgical supervisionTherapyInfectionAdequate experienceInternational expertsTreatmentInternational groupDebridementGroupGroup discussionsClinicians
2005
Role of the ABC Transporter MRPA (PGPA) in Antimony Resistance in Leishmania infantum Axenic and Intracellular Amastigotes
Fadili K, Messier N, Leprohon P, Roy G, Guimond C, Trudel N, Saravia NG, Papadopoulou B, Légaré D, Ouellette M. Role of the ABC Transporter MRPA (PGPA) in Antimony Resistance in Leishmania infantum Axenic and Intracellular Amastigotes. Antimicrobial Agents And Chemotherapy 2005, 49: 1988-1993. PMID: 15855523, PMCID: PMC1087671, DOI: 10.1128/aac.49.5.1988-1993.2005.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntimonyAntimony Sodium GluconateATP-Binding Cassette TransportersCell LineCysteineDNA, ProtozoanDrug ResistanceGlutathioneLeishmania infantumMembrane GlycoproteinsMicroscopy, ConfocalMonocytesOligonucleotide Array Sequence AnalysisProtozoan ProteinsRibonucleoproteinsSaccharomyces cerevisiae ProteinsSpermidineTransfectionConceptsABC transporter MRPAAntimony resistanceSodium stibogluconate (SSG) resistanceTreatment of infectionsMRPA geneSodium stibogluconateAntimonial compoundsMain drugsAmastigote parasitesPutative alterationsIntracellular amastigotesLevel of expressionProtozoan parasite LeishmaniaIntracellular parasitesAxenic amastigotesButhionine sulfoximineLevels of cysteineAmastigote stageDNA microarraysS-adenosylhomocysteine hydrolaseParasite LeishmaniaPotassium antimonyl tartrateAmastigotesLeishmaniaGenes
1991
Modulation of Neonatal Neutrophil Function by Pentoxifylline
Krause P, Maderazo E, Contrino J, Eisenfeld L, Herson V, Greca N, Bannon P, Kreutzer D. Modulation of Neonatal Neutrophil Function by Pentoxifylline. Pediatric Research 1991, 29: 123-127. PMID: 2014147, DOI: 10.1203/00006450-199102000-00002.Peer-Reviewed Original ResearchConceptsPMN functionNitroblue tetrazolium reductionImpaired PMN functionsNeonatal neutrophil functionTetrazolium reductionTreatment of infectionsPolymorphonuclear leukocyte chemotaxisF-actin contentDose-dependent effectPotential clinical useCertain disease processesSimilar dose-dependent responseDose-dependent responseNeutrophil functionNewborn infantsPMN activityPMN deformabilityPMN chemotaxisDisease processPentoxifyllineLeukocyte chemotaxisMethylxanthine pentoxifyllinePhagocytic activityNeonatesClinical use
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