2022
Platelet in thrombo-inflammation: Unraveling new therapeutic targets
Sharma S, Tyagi T, Antoniak S. Platelet in thrombo-inflammation: Unraveling new therapeutic targets. Frontiers In Immunology 2022, 13: 1039843. PMID: 36451834, PMCID: PMC9702553, DOI: 10.3389/fimmu.2022.1039843.Peer-Reviewed Original ResearchConceptsRole of plateletsViral infectionPlatelet activationCoagulation pathwayThrombo-inflammatory disordersAcute ischemic strokeContribution of plateletsAnti-inflammatory potentialThrombo-inflammatory diseasesCoronavirus disease 2019Sickle cell diseaseNon-pathologic conditionsNew therapeutic targetsRecruitment of leukocytesPathologic platelet activationPlatelet surface receptorsFormation of thrombiInitial platelet activationSuperficial thrombophlebitisAntiphospholipid syndromeIschemic strokeMicrovascular thrombosisClinical manifestationsInflammatory processCell disease
2018
111 Role of platelets in the differentiation of monocytes into dendritic cell-like antigen presenting cells
Han P, Hanlon D, Filler R, Robinson E, Zhang K, Fan R, Iwasaki A, Fahmy T, Edelson R. 111 Role of platelets in the differentiation of monocytes into dendritic cell-like antigen presenting cells. Journal Of Investigative Dermatology 2018, 138: s19. DOI: 10.1016/j.jid.2018.03.115.Peer-Reviewed Original Research
2007
Impact of Baseline Platelet Count in Patients Undergoing Primary Percutaneous Coronary Intervention in Acute Myocardial Infarction (from the CADILLAC Trial)
Nikolsky E, Grines CL, Cox DA, Garcia E, Tcheng JE, Sadeghi M, Mehran R, Lansky AJ, Na Y, Stone GW. Impact of Baseline Platelet Count in Patients Undergoing Primary Percutaneous Coronary Intervention in Acute Myocardial Infarction (from the CADILLAC Trial). The American Journal Of Cardiology 2007, 99: 1055-1061. PMID: 17437727, DOI: 10.1016/j.amjcard.2006.11.066.Peer-Reviewed Original ResearchMeSH KeywordsAbciximabAgedAngioplasty, Balloon, CoronaryAntibodies, MonoclonalCause of DeathCoronary AngiographyCoronary RestenosisCoronary ThrombosisCreatine KinaseFemaleFollow-Up StudiesForecastingHumansImmunoglobulin Fab FragmentsMaleMiddle AgedMyocardial InfarctionPlatelet Aggregation InhibitorsPlatelet CountPlatelet Glycoprotein GPIIb-IIIa ComplexProspective StudiesRecurrenceStentsTreatment OutcomeConceptsPrimary percutaneous coronary interventionBaseline platelet countAcute myocardial infarctionPrimary PCIHigher baseline platelet countPercutaneous coronary interventionPlatelet countCoronary interventionMyocardial infarctionAngiographic success rateTarget vessel thrombosisPowerful independent predictorMedian platelet countRole of plateletsCADILLAC trialCardiac mortalityAngiographic outcomesIndependent predictorsAngiographic resultsHighest quartileMultivariable analysisVessel thrombosisVascular responsesReinfarctionPatients
2006
Platelet depletion in mice increases mortality after thermal injury
Fujimi S, MacConmara MP, Maung AA, Zang Y, Mannick JA, Lederer JA, Lapchak PH. Platelet depletion in mice increases mortality after thermal injury. Blood 2006, 107: 4399-4406. PMID: 16467203, PMCID: PMC1895793, DOI: 10.1182/blood-2005-09-3776.Peer-Reviewed Original ResearchConceptsControl miceFull-thickness total body surface areaHost responseThermal injuryTotal body surface areaExperimental control miceSystemic inflammatory responsePlatelet-depleted miceRole of plateletsBody surface areaCause of deathCritical protective rolePeripheral blood monocytesImportance of plateletsSham injuryIL-6MCP-1Plasma levelsPlatelet depletionInflammatory responseImmune responseAdaptive immunityBlood monocytesMouse modelProtective role
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply