2022
Genetic liability to suicidal thoughts and behaviors and risk of suicide attempt in US military veterans: moderating effects of cumulative trauma burden
Nichter B, Koller D, De Angelis F, Wang J, Girgenti M, Na P, Hill M, Norman S, Krystal J, Gelernter J, Polimanti R, Pietrzak R. Genetic liability to suicidal thoughts and behaviors and risk of suicide attempt in US military veterans: moderating effects of cumulative trauma burden. Psychological Medicine 2022, 53: 6325-6333. PMID: 36444557, DOI: 10.1017/s0033291722003646.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresUS military veteransLifetime suicide attemptsSuicide attemptsTrauma exposureTrauma burdenGenetic liabilityMilitary veteransDrug repurposing analysisPopulation-based sampleCumulative trauma exposureLifetime trauma exposureLow trauma exposureSuicide prediction modelsChronic inflammationInflammatory processNervous system developmentRisk scorePsychiatric characteristicsSuicidal behaviorExposure interactionsLarge genome-wide association studiesHigh levelsVeteransSuicidality
2019
Association of MAOA genetic variants and resilience with psychosocial stress: A longitudinal study of Syrian refugees
Clukay CJ, Dajani R, Hadfield K, Quinlan J, Panter-Brick C, Mulligan CJ. Association of MAOA genetic variants and resilience with psychosocial stress: A longitudinal study of Syrian refugees. PLOS ONE 2019, 14: e0219385. PMID: 31314763, PMCID: PMC6636744, DOI: 10.1371/journal.pone.0219385.Peer-Reviewed Original ResearchConceptsPsychosocial stressPerceived Stress ScaleTrauma exposureProtective factorsGenetic variantsLow trauma exposureHigh trauma exposureMental health measuresMental health trajectoriesAdult mental healthSymptom scoresPsychosocial healthPsychosocial factorsEarly childhood traumaHealth measuresHealth trajectoriesMental healthTraumaMonoamine oxidaseTime pointsPsychosocial wellbeingLifelong effectsChildhood traumaHigher resilience levelsLongitudinal study
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