2024
Biological and Procedural Predictors of Outcome in the Stroke Preclinical Assessment Network (SPAN) Trial
Morais A, Imai T, Jin X, Locascio J, Boisserand L, Herman A, Chauhan A, Lamb J, Nagarkatti K, Diniz M, Kumskova M, Dhanesha N, Kamat P, Khan M, Dhandapani K, Patel R, Sutariya B, Shi Y, van Leyen K, Kimberly W, Hess D, Aronowski J, Leira E, Koehler R, Chauhan A, Sansing L, Lyden P, Ayata C. Biological and Procedural Predictors of Outcome in the Stroke Preclinical Assessment Network (SPAN) Trial. Circulation Research 2024, 135: 575-592. PMID: 39034919, PMCID: PMC11428171, DOI: 10.1161/circresaha.123.324139.Peer-Reviewed Original ResearchConceptsMiddle cerebral artery occlusionFilament middle cerebral artery occlusionHigh-fat dietProcedural variablesHigh-fatOlder ageStroke outcomeBlood flow monitoringCerebral blood flow monitoringPredictors of outcomeBody weightProspective designInfluence stroke outcomeAssociated with smaller infarctsCerebral artery occlusionExperimental focal cerebral ischemiaFocal cerebral ischemiaLonger anesthesia durationExperimental stroke modelsBlood flow dropAcute stroke interventionExperimental stroke outcomesMulticenter prospective designProcedural predictorsPreclinical studiesGeographic access to cardiac rehabilitation and cardiovascular disease outcomes: A study of rural United States counties
Chen E, Varghese M, Wu W. Geographic access to cardiac rehabilitation and cardiovascular disease outcomes: A study of rural United States counties. Current Problems In Cardiology 2024, 49: 102740. PMID: 38972468, DOI: 10.1016/j.cpcardiol.2024.102740.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseCardiac rehabilitationCardiovascular disease outcomesUnited States countiesHospitalization ratesStroke mortalityStroke deathsStroke hospitalizationsStates countiesRural-urban disparitiesCR facilitiesGeographic accessReduce barriersSocio-DemographicHeart failureDisease outcomeNonmetro countiesRural areasComorbid conditionsHospitalStroke outcomeRehabilitationHeart diseaseMortality rateStrokePredictors of stroke literacy among African Americans in the “buckle of the stroke belt”
Sunmonu N, Malek A, Jenkins C, Hyacinth H. Predictors of stroke literacy among African Americans in the “buckle of the stroke belt”. Frontiers In Stroke 2024, 3: 1331085. DOI: 10.3389/fstro.2024.1331085.Peer-Reviewed Original ResearchKnowledge of stroke signsStroke literacyStroke signsStroke BeltStroke signs and symptomsReduce stroke-related disabilityAssociated with racial disparitiesStroke-related disabilityAfrican American adultsHigh school educationStroke knowledgeHealth disparitiesAcute stroke treatmentSocioeconomic statusRacial disparitiesSocioeconomic factorsSociodemographic aspectsAmerican adultsEducation levelAdequate knowledgeAfrican AmericansEducation programsSchool educationStroke outcomeEmergency room
2023
Trained immunity induced by high‐salt diet impedes stroke recovery
Lin T, Jiang D, Chen W, Lin J, Zhang X, Chen C, Hsu C, Lai L, Chen P, Yang K, Sansing L, Chang C. Trained immunity induced by high‐salt diet impedes stroke recovery. EMBO Reports 2023, 24: e57164. PMID: 37965920, PMCID: PMC10702837, DOI: 10.15252/embr.202357164.Peer-Reviewed Original ResearchConceptsInnate immune memoryMonocyte-derived macrophagesStroke recoveryInflammatory responseBone marrowImmune memoryHigh-salt dietCause of morbidityInitial inflammatory responsePotential therapeutic targetLoss of Nr4a1Stroke outcomeStroke brainIntracerebral hemorrhageBrain recoverySterile inflammationHealthy miceTissue injurySevere formTherapeutic targetAlternative activationImmune primingReparative functionsProgenitor cellsNR4A familyAssociation between blood pressure variability and outcomes after endovascular thrombectomy for acute ischemic stroke: An individual patient data meta-analysis
Palaiodimou L, Joundi R, Katsanos A, Ahmed N, Kim J, Goyal N, Maier I, de Havenon A, Anadani M, Matusevicius M, Mistry E, Khatri P, Arthur A, Sarraj A, Yaghi S, Shoamanesh A, Catanese L, Psychogios M, Malhotra K, Spiotta A, Vassilopoulou S, Tsioufis K, Sandset E, Alexandrov A, Petersen N, Tsivgoulis G. Association between blood pressure variability and outcomes after endovascular thrombectomy for acute ischemic stroke: An individual patient data meta-analysis. European Stroke Journal 2023, 9: 88-96. PMID: 37921233, PMCID: PMC10916831, DOI: 10.1177/23969873231211157.Peer-Reviewed Original ResearchBlood pressure variabilitySymptomatic intracranial hemorrhageAcute ischemic strokeEndovascular thrombectomyFunctional impairmentIschemic strokeHighest tertileAIS patientsPressure variabilityIndividual BP measurementsMean BP levelsDiastolic BP levelsIndividual patient dataLogistic mixed-effects modelsSBP-CVSBP-SDIntravenous thrombolysisStroke outcomeStroke severitySuccessful recanalizationBP levelsIntracranial hemorrhageBP measurementsHigh mortalityTertileMost Promising Approaches to Improve Stroke Outcomes: The Stroke Treatment Academic Industry Roundtable XII Workshop
Wechsler L, Adeoye O, Alemseged F, Bahr-Hosseini M, Deljkich E, Favilla C, Fisher M, Grotta J, Hill M, Kamel H, Khatri P, Lyden P, Mirza M, Nguyen T, Samaniego E, Schwamm L, Selim M, Silva G, Yavagal D, Yenari M, Zachrison K, Boltze J, Yaghi S, Roundtable O. Most Promising Approaches to Improve Stroke Outcomes: The Stroke Treatment Academic Industry Roundtable XII Workshop. Stroke 2023, 54: 3202-3213. PMID: 37886850, DOI: 10.1161/strokeaha.123.044279.Peer-Reviewed Original ResearchRationale and design of the GOLDEN BRIDGE II: a cluster-randomised multifaceted intervention trial of an artificial intelligence-based cerebrovascular disease clinical decision support system to improve stroke outcomes and care quality in China
Li Z, Zhang X, Ding L, Jing J, Gu H, Jiang Y, Meng X, Du C, Wang C, Wang M, Xu M, Zhang Y, Hu M, Li H, Gong X, Dong K, Zhao X, Wang Y, Liu L, Xian Y, Peterson E, Fonarow G, Schwamm L, Wang Y. Rationale and design of the GOLDEN BRIDGE II: a cluster-randomised multifaceted intervention trial of an artificial intelligence-based cerebrovascular disease clinical decision support system to improve stroke outcomes and care quality in China. Stroke And Vascular Neurology 2023, 9: 723-729. PMID: 37699726, PMCID: PMC11791641, DOI: 10.1136/svn-2023-002411.Peer-Reviewed Original ResearchClinical decision support systemVascular eventsIntervention trialsIntervention groupControl groupGuideline-based treatment recommendationsCare qualityNew vascular eventsStroke care qualityAcute ischemic strokeComposite vascular eventsII trialUsual careIschemic strokeStroke etiologyStroke onsetStroke outcomePrimary outcomeTreat principleClinical outcomesStroke careCerebrovascular diseaseEligible participantsTreatment recommendationsIntervention studiesEnhancing Enrollment in Acute Stroke Trials: Current State and Consensus Recommendations
Broderick J, Silva G, Selim M, Kasner S, Aziz Y, Sutherland J, Jauch E, Adeoye O, Hill M, Mistry E, Lyden P, Mocco J, Smith E, Hernandez-Jimenez M, Deljkich E, Kamel H, Alemseged F, Bates K, Bhatt N, Boltze J, Campbell B, Favilla C, Fiorella D, Grotta J, Haddad W, Heidt J, Liebeskind D, Lightfoot N, Jubin R, Khatri P, Lansberg M, Lynch J, Margolin D, Nguyen T, Nogueira R, Samaniego E, Saver J, Schwamm L, Sheth K, Smith W, Wadhwa M, Wakhloo A, Wechsler L, Xiong Y, Zachrison K. Enhancing Enrollment in Acute Stroke Trials: Current State and Consensus Recommendations. Stroke 2023, 54: 2698-2707. PMID: 37694403, PMCID: PMC10542906, DOI: 10.1161/strokeaha.123.044149.Peer-Reviewed Original ResearchConceptsAcute stroke trialsStroke trialsStroke Treatment Academic Industry RoundtableEnrollment of participantsNational Institute of Neurological DisordersImprove patient outcomesImproving trial efficiencySite championsPharmacist availabilityStroke physiciansStudy teamStudy coordinatorsEligibility criteriaEnhance enrollmentImprove enrollmentStudy proceduresPatient outcomesConsent proceduresUS Food and Drug AdministrationAction itemsConsensus recommendationsFood and Drug AdministrationStroke outcomeEnrollmentNational InstituteDevelopment and validation of a model predicting mild stroke severity on admission using electronic health record data
Waddell K, Myers L, Perkins A, Sico J, Sexson A, Burrone L, Taylor S, Koo B, Daggy J, Bravata D. Development and validation of a model predicting mild stroke severity on admission using electronic health record data. Journal Of Stroke And Cerebrovascular Diseases 2023, 32: 107255. PMID: 37473533, DOI: 10.1016/j.jstrokecerebrovasdis.2023.107255.Peer-Reviewed Original ResearchConceptsInitial stroke severityStroke severityElectronic health record dataHealth record dataSevere strokeIschemic strokeStroke careSample patientsMortality risk stratificationRecord dataVeterans Affairs hospitalMild stroke severityMultiple logistic regressionObservational cohortStroke outcomeIndependent predictorsRisk stratificationEHR data elementsPrimary analysisLogistic regressionStrokeValidation sampleSeverityPotent modifierEHR dataComputational Image-Based Stroke Assessment for Evaluation of Cerebroprotectants with Longitudinal and Multi-Site Preclinical MRI
Cabeen R, Mandeville J, Hyder F, Sanganahalli B, Thedens D, Arbab A, Huang S, Bibic A, Tarakci E, Mihailovic J, Morais A, Lamb J, Nagarkatti K, Toga A, Lyden P, Ayata C. Computational Image-Based Stroke Assessment for Evaluation of Cerebroprotectants with Longitudinal and Multi-Site Preclinical MRI. 2023, 00: 1-5. DOI: 10.1109/isbi53787.2023.10230408.Peer-Reviewed Original ResearchMiddle cerebral artery occlusionData analytics approachManual annotationStroke assessmentRodent modelsCerebral artery occlusionData qualityCoronal MRI slicesPotential therapeutic interventionsMRI slicesNetworkAssessment NetworkOutcome quantificationInfarct volumeArtery occlusionIschemic strokeStroke outcomeBrain atrophyMidline shiftMRI dataLeading causeRodent preclinical studiesStroke expertsPreclinical studiesLesion extentEffect of COVID-19 on Acute Ischemic Stroke Severity and Mortality in 2020: Results From the 2020 National Inpatient Sample
de Havenon A, Zhou L, Yaghi S, Frontera J, Sheth K. Effect of COVID-19 on Acute Ischemic Stroke Severity and Mortality in 2020: Results From the 2020 National Inpatient Sample. Stroke 2023, 54: e194-e198. PMID: 37021563, PMCID: PMC10121243, DOI: 10.1161/strokeaha.122.041929.Peer-Reviewed Original ResearchConceptsHealth Stroke ScaleStroke ScaleStroke severityLowest quartileCOVID-19Acute ischemic stroke outcomesAcute ischemic stroke severityHigher stroke severityHospital stroke mortalityIschemic stroke outcomeHigher National InstitutesNational Inpatient SampleCross-sectional cohortIschemic stroke severityCOVID-19 statusNational InstituteHospital mortalityAdjusted riskHospital dischargeIschemic strokeStroke outcomeStroke mortalityAIS severityInpatient SampleExposure status
2022
Clinical and Demographic Characteristics Associated With Poor Posterior Circulation Stroke Outcomes: Greater Cincinnati/Northern Kentucky Stroke Study (P10-10.009)
Chervak L, Demel S, Sucharew H, Jasne A, Woo D, Martini S, Madsen T, Mistry E, Kleindorfer D, Kissela B. Clinical and Demographic Characteristics Associated With Poor Posterior Circulation Stroke Outcomes: Greater Cincinnati/Northern Kentucky Stroke Study (P10-10.009). Neurology 2022, 98 DOI: 10.1212/wnl.98.18_supplement.396.Peer-Reviewed Original ResearchInhibition of the enzyme autotaxin reduces cortical excitability and ameliorates the outcome in stroke
Bitar L, Uphaus T, Thalman C, Muthuraman M, Gyr L, Ji H, Domingues M, Endle H, Groppa S, Steffen F, Koirala N, Fan W, Ibanez L, Heitsch L, Cruchaga C, Lee JM, Kloss F, Bittner S, Nitsch R, Zipp F, Vogt J. Inhibition of the enzyme autotaxin reduces cortical excitability and ameliorates the outcome in stroke. Science Translational Medicine 2022, 14: eabk0135. PMID: 35442704, DOI: 10.1126/scitranslmed.abk0135.Peer-Reviewed Original ResearchConceptsStroke outcomeExperimental strokeGlutamatergic transmissionCortical excitabilityATX concentrationsAstrocyte-specific deletionDifferent time pointsStroke eventsPerisynaptic processesExcess glutamateTherapeutic approachesAnimal modelsTransgenic miceEnzyme autotaxinLPA signalingATX inhibitionPharmacological inhibitionStrokeTranslational potentialTime pointsSingle nucleotide polymorphismsAutotaxinOutcomesExcitabilityInhibition
2021
Associations of Medicaid Expansion With Access to Care, Severity, and Outcomes for Acute Ischemic Stroke
McGee B, Seagraves K, Smith E, Xian Y, Zhang S, Alhanti B, Matsouaka R, Reeves M, Schwamm L, Fonarow G. Associations of Medicaid Expansion With Access to Care, Severity, and Outcomes for Acute Ischemic Stroke. Circulation Cardiovascular Quality And Outcomes 2021, 14: e007940. PMID: 34587752, DOI: 10.1161/circoutcomes.121.007940.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeLow-income cohortSkilled nursing facilitiesIschemic strokeMedicaid expansionStroke admissionsNonexpansion statesNursing facilitiesLow-income US populationHigh stroke burdenPrimary stroke preventionOdds of dischargeIschemic stroke admissionsExpansion statesSeverity of presentationLevel of disabilityReceipt of rehabilitationHealth insurance statusHealth insurance coverageHospital mortalityUninsured hospitalizationsStroke preventionDischarge dispositionStroke burdenStroke outcomeRace/Ethnicity Considerations in the Prevention and Treatment of Stroke
Forman R, Sheth K. Race/Ethnicity Considerations in the Prevention and Treatment of Stroke. Current Treatment Options In Neurology 2021, 23: 33. DOI: 10.1007/s11940-021-00684-2.Peer-Reviewed Original ResearchStroke risk factorsGreater Cincinnati/Northern Kentucky Stroke StudyRisk factorsBlack individualsRate of strokeHospital arrival timeWhite individualsTreatment of strokeRecent FindingsMultiple studiesPurpose of ReviewToHigh mortality rateStroke outcomeHemorrhagic strokeStroke treatmentWhite patientsBlack patientsStroke disparitiesStroke patientsStroke StudyTimely treatmentMortality rateGreater incidenceGreater severityEthnic disparitiesStrokeExogenous inter-α inhibitor proteins prevent cell death and improve ischemic stroke outcomes in mice
McCullough LD, Roy-O’Reilly M, Lai YJ, Patrizz A, Xu Y, Lee J, Holmes A, Kraushaar DC, Chauhan A, Sansing LH, Stonestreet BS, Zhu L, Kofler J, Lim YP, Venna VR. Exogenous inter-α inhibitor proteins prevent cell death and improve ischemic stroke outcomes in mice. Journal Of Clinical Investigation 2021, 131: e144898. PMID: 34580244, PMCID: PMC8409590, DOI: 10.1172/jci144898.Peer-Reviewed Original ResearchConceptsInter-α inhibitor proteinsIschemic strokeStroke outcomeStroke modelComplement activationBeneficial effectsMultiple stroke modelsNeutralization of histonesPost-stroke administrationIschemic stroke outcomeExperimental ischemic strokeIschemic stroke patientsExperimental stroke modelsModel of sepsisPotential therapeutic candidateExcess complement activationIaIp levelsStroke onsetStroke patientsProinflammatory cytokinesAged miceExtracellular histonesClinical relevanceTherapeutic candidateTherapeutic efficacyPCSK9 Inhibiting Monoclonal Antibodies
Ahmed Z, Juthani P, Lee M, Desai N. PCSK9 Inhibiting Monoclonal Antibodies. Stroke Revisited 2021, 125-133. DOI: 10.1007/978-981-16-3923-4_11.Peer-Reviewed Original ResearchProprotein convertase subtilisin/kexin type 9Lipid-lowering medicationsSubset of patientsIschemic strokeLower PCSK9Low-density lipoprotein cholesterolConvertase subtilisin/kexin type 9Subtilisin/kexin type 9Monoclonal antibodiesCoenzyme A (HMG-CoA) reductase inhibitorsComponents of dyslipidemiaHigh-intensity statinsStroke risk reductionModifiable risk factorsHealthy lifestyle modificationsLDL-C levelsRisk of strokeStatin-induced myopathyTreatment of hyperlipidemiaA Reductase InhibitorsLifestyle modificationStatin useLipoprotein cholesterolPCSK9 inhibitorsStroke outcomeReperfusion Treatment and Stroke Outcomes in Hospitals With Telestroke Capacity
Wilcock A, Schwamm L, Zubizarreta J, Zachrison K, Uscher-Pines L, Richard J, Mehrotra A. Reperfusion Treatment and Stroke Outcomes in Hospitals With Telestroke Capacity. JAMA Neurology 2021, 78: 527-535. PMID: 33646272, PMCID: PMC7922240, DOI: 10.1001/jamaneurol.2021.0023.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeReperfusion treatmentIschemic strokeShort-term acute carePatients 85 yearsLow-volume hospitalsYear of admissionHospital emergency departmentTraditional Medicare beneficiariesClinical characteristicsCritical access hospitalsStroke outcomeAcute careControl hospitalsEmergency departmentMean ageFunctional statusPrimary diagnosisStroke expertiseHospital characteristicsMAIN OUTCOMEMedicare beneficiariesPatientsHospitalCare patterns
2020
Retrograde Autologous Priming in Cardiac Surgery: Results From a Systematic Review and Meta-analysis.
Hensley N, Gyi R, Zorrilla-Vaca A, Choi C, Lawton J, Brown C, Frank S, Grant M, Cho B. Retrograde Autologous Priming in Cardiac Surgery: Results From a Systematic Review and Meta-analysis. Anesthesia & Analgesia 2020, 132: 100-107. PMID: 32947294, DOI: 10.1213/ane.0000000000005151.Peer-Reviewed Original ResearchConceptsAllogeneic red cell transfusionRed cell transfusionAcute kidney injuryCardiac surgical patientsCell transfusionCardiopulmonary bypassObservational studySystematic reviewAutologous primingRAP patientsSurgical patientsCardiac surgeryAdditional high-quality prospective studiesPerioperative allogeneic red cell transfusionIntraoperative red cell transfusionsHigh-quality prospective studiesSignificant increased oddsAllogeneic transfusionKidney injuryAdverse eventsControl patientsSecondary outcomesStroke outcomeOrgan injuryPrimary outcomeAcute ischemic stroke: improving access to intravenous tissue plasminogen activator
Turner A, Schwamm L, Etherton M. Acute ischemic stroke: improving access to intravenous tissue plasminogen activator. Expert Review Of Cardiovascular Therapy 2020, 18: 277-287. PMID: 32323590, DOI: 10.1080/14779072.2020.1759422.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeIschemic stroke patientsIschemic strokeStroke patientsTreatment windowAcute ischemic stroke patientsIntravenous tissue plasminogen activatorTreatment ratesUnknown symptom onsetAcute stroke careTissue plasminogen activatorQuality improvement initiativesHealth care resourcesUnited States FoodStroke outcomeSymptom onsetStroke careStroke specialistsStroke systemsTelestroke networkDrug AdministrationAlteplasePatientsPlasminogen activatorStates Food
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply